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The purpose of this paper is to investigate the ground state solutions for the following nonlinear Schrödinger equations involving the fractional p-Laplacian (−Δ)psu(x)+λV(x)u(x)p−1=u(x)q−1,u(x)≥0,x∈RN,{\left(-\Delta )}_{p}^{s}u\left(x)+\lambda V\left(x)u{\left(x)}^{p-1}=u{\left(x)}^{q-1},\hspace{1em}u\left(x)\ge 0,\hspace{0.33em}x\in {{\mathbb{R}}}^{N}, where λ>0\lambda \gt 0 is a parameter, 1

Liver cancer exhibits a high degree of heterogeneity and involves intricate mechanisms. Recent research has revealed the significant role of histone lysine methylation and acetylation in the epigenetic regulation of liver cancer development. In this study, five inhibitors capable of targeting both histone lysine methyltransferase nuclear receptor-binding SET domain 2 (NSD2) and histone deacetylase 2 (HDAC2) were identified using a structure-based virtual screening approach. Notably, DT-NH-1 displayed a potent inhibition of NSD2 (IC50 = 0.08 ± 0.03 μM) and HDAC2 (IC50 = 5.24 ± 0.87 nM). DT-NH-1 also demonstrated a strong anti-proliferative activity against various liver cancer cell lines, particularly HepG2 cells, and exhibited a high level of biological safety. In an experimental xenograft model involving HepG2 cells, DT-NH-1 showed a significant reduction in tumour growth. Consequently, these findings indicate that DT-NH-1 will be a promising lead compound for the treatment of liver cancer with epigenetic dual-target inhibitors. [ABSTRACT FROM AUTHOR]

Safety climate has been extensively studied using survey-based approaches, providing significant insights into safety perceptions and behaviors. However, understanding its dynamics in construction projects requires methods that address temporal and trade-specific variability. This study employs a longitudinal, mixed-methods design to explore safety climate dynamics. Quantitative data analyzed with ANOVA revealed stable overall safety climate scores across project phases, while Item Response Theory (IRT) identified survey items sensitive to safety climate changes. Positive perceptions were associated with management commitment and regular safety meetings, while negative perceptions highlighted challenges such as workplace congestion and impractical safety rules. Qualitative data from semi-structured interviews uncovered trade-specific and phase-specific safety challenges, including issues tied to site logistics and workforce dynamics. For instance, transitioning from structural to interior work introduced congestion-related risks and logistical complexities, underscoring the need for phase-adapted strategies. This combination of quantitative stability and qualitative variability provides empirical evidence of safety climate dynamics in construction. The findings emphasize the importance of tailoring safety interventions to address trade-specific and phase-specific risks. This study advances the understanding of the safety climate in dynamic work environments and offers actionable recommendations for improving construction safety management through targeted, proactive strategies. [ABSTRACT FROM AUTHOR]

To enhance the CO2 hydrogenation activity and low‐carbon olefin selectivity of Fe‐based catalysts, a strategy involving the use of metal promoters to modulate the structure of active metal centers in catalyst preparation was proposed. The incipient wetness impregnation method was used to introduce modifying agents K and/or Co into the Fe/Al2O3 catalyst. Characterization techniques such as XRD, BET, SEM, HRTEM, H2‐TPR, XPS, CO2‐TPD, NH3‐TPD, and TG were employed to investigate the effects of the modifying agents on the dispersion, reducibility, electronic properties, and acid–base properties of active metal species. Furthermore, the influence of K and Co modification on the CO2 hydrogenation activity and low‐carbon olefin selectivity of Fe/Al2O3 catalysts was explored. The results revealed that the introduction of K generated more basic sites and electron‐rich active metal centers in the catalyst, facilitating the adsorption and activation of CO2, while suppressing the hydrogenation of olefins and the formation of methane, thus improving the selectivity towards low‐carbon olefins. Co promoter facilitated the dispersion of Fe species, exposing more active sites and enhancing the FTS reaction activity, leading to more CO being converted into C2+ hydrocarbon products. Under the synergistic effect of K and Co, the CO2 conversion activity of the Fe‐based catalyst significantly increased, achieving a CO2 conversion rate of 37%, while the selectivity towards C2‐C4= increased to 31.9%. [ABSTRACT FROM AUTHOR]