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1. Genome Instability Induced by Topoisomerase Misfunction.

2. Modeling allosteric mechanisms of eukaryotic type II topoisomerases.

3. Modeling Allosteric Mechanisms of Eukaryotic Type II Topoisomerases.

4. Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II.

5. RAD54L2 counters TOP2-DNA adducts to promote genome stability.

6. Naturally mutagenic sequence diversity in a human type II topoisomerase.

7. Using energy to go downhill - a genoprotective role for ATPase activity in DNA topoisomerase II.

8. Requirements for MRN endonuclease processing of topoisomerase II-mediated DNA damage in mammalian cells.

9. Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers.

10. Topoisomerase Assays.

11. A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation.

12. Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast.

13. DNA Damage by an essential enzyme: A delicate balance act on the tightrope.

14. Detection of Topoisomerase Covalent Complexes in Eukaryotic Cells.

15. TDP1 is required for efficient non-homologous end joining in human cells.

16. The western-type diet induces anti-HMGB1 autoimmunity in Apoe(-/-) mice.

17. TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.

18. Twisting and ironing: doxorubicin cardiotoxicity by mitochondrial DNA damage.

19. Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).

20. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.

21. Tdp2: a means to fixing the ends.

22. End-processing during non-homologous end-joining: a role for exonuclease 1.

23. Yeast Tdp1 regulates the fidelity of nonhomologous end joining.

24. UnTTrapping the ends: a new player in overcoming protein linked DNA damage.

25. Enhancing drug accumulation in Saccharomyces cerevisiae by repression of pleiotropic drug resistance genes with chimeric transcription repressors.

26. Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison.

27. Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.

28. Roles of nonhomologous end-joining pathways in surviving topoisomerase II-mediated DNA damage.

29. Gimatecan (sigma-tau industrie farmaceutiche riunite/novartis).

30. A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.

31. A dual mechanism of action of the anticancer agent F 11782 on human topoisomerase II alpha.

32. Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.

33. Overexpression of type I topoisomerases sensitizes yeast cells to DNA damage.

34. Yeast systems for demonstrating the targets of anti-topoisomerase II agents.

35. A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines.

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