Search

Introduction: The use of chest Computed Tomography (CT) scans has significantly increased in recent times, and it is also considered the preferred investigation method in various cases, including occult pneumothorax and interstitial lung diseases. Aim: To assess the relationship between chest CT scan findings/outcomes, clinicians’ expectations, and their influence on treatment outcomes. Materials and Methods: The present retrospective analytical observational study was conducted in the Department of Radiodiagnosis and Respiratory Medicine at a tertiary-level hospital, Adesh Medical College and Hospital, Kurukshetra, Haryana, India. The findings of the selected chest CT scans were classified as normal, incidental, or pathological. The response of the consulting physicians to these scans was divided into three grades: highly expected, moderately expected, and unexpected. The impact of these scans on patients’ treatment was divided into three categories: major, minor, and none. The collected data were analysed using the Statistical Package for Social Sciences (SPSS) version 28.0, and the Chi-square test was used to assess the association between different variables. Results: The mean age of study participants was approximately 58±15 years. Out of the total 74 scans (each belonging to a different individual), the findings of the chest CT scans revealed that 59 (79.7%) scans were pathological, 11 (14.9%) were incidental, and only 4 (5.4%) were normal. The outcomes of these scans were highly expected in 42 (56.7%) cases, moderately expected in 25 (33.8%), and unexpected in 7 (9.5%). These scans had a major impact on the patient’s treatment course in 28 (37.8%) cases, minor impact in 40 (54%), and no influence in 6 (8.1%) cases. The Chi-square test showed a significant association between chest CT scan outcomes and clinicians’ expectations, chest CT scan outcomes and their influence on treatment, as well as clinicians’ expectations and the effect of scans on treatment. The p-value

Tuberculosis (TB) is prevalent throughout the world and is a major public health problem in most developing countries. In India, standardised and Directly Observed Treatment (DOT) under National Tuberculosis Elimination Programme (NTEP) is being recommended currently for drug-sensitive pulmonary TB. TB being a major health issue in developing nations like India, causes enormous death and morbidity every year. Anti-Tuberculosis Treatment (ATT) given for TB has been highly effective in fighting the disease and is generally well tolerated, with few minor side-effects. We report a 76-year-old male who was diagnosed with pulmonary TB and was on first-line four-drug anti-tubercular therapy ATT since seven days. He presented to the emergency department with loss of weight and appetite, chest tightness and vomiting. Liver Function Tests (LFT) was deranged, suggesting ATT-induced hepatitis. After normalisation of LFT, rifampicin reintroduction was initiated. Complete Blood Count (CBC) revealed pancytopenia. In bone marrow biopsy, normoblastic maturation with few micronormoblasts and megaloblast picture was seen that did not reveal any granuloma, thereby ruling out the presence of Mycobacterium tuberculosis (MTB). Iron profile and vitamin B12 levels were within normal limits. Rifampicin-induced pancytopenia is rare but its possibility should always be kept in mind while treating with ATT.

Introduction: Immunoglobulin E (IgE) plays a crucial role in various allergic diseases. These antibodies are produced in response to allergenic environmental stimuli, and their blood levels strongly correlate with allergy manifestations. Elevated IgE levels have been considered a powerful predictor of future asthma development. While several studies have explored the association between total serum IgE levels and demographic and environmental factors, no such study has been conducted in this region of India. Aim: To estimate total serum IgE levels and examine their association with age and gender in the adult population of Haryana, India. Materials and Methods: A cross-sectional study was conducted in the Department of Respiratory Medicine, Adesh Medical College and Hospital, Shahabad (M), Kurukshetra, Haryana, India. The records of patients, who visited the department between September 2015 and December 2020 were screened. Data on serum total IgE levels, age, and gender were collected from 360 patients (21-80 years, both sexes) with available information. Statistical analyses were performed using Statistical Package for Social Sciences (SPSS) version 23.0 software. Results: The mean age of the study participants was 36.80±18.30 years. Out of total 360 patients included, 198 (55%) were males and 162 (45%) were females. Male gender (odds ratio=1.68) was a significant (p0.05) risk factors for abnormal serum total IgE levels. Conclusion: Significant gender variation was observed in total serum IgE levels, while age showed insignificant variation. Physicians should consider these factors when examining the relationship between serum total IgE levels, allergy markers, and airways disease.

Introduction: Diabetes Mellitus (DM) and Obesity are the biggest public health challenges of 21st century. Both these disorders are associated with several co-morbidities like hypertension, hyperlipidemia, Cardiovascular Diseases (CVD) etc., that may be linked to the underlying insulin resistance, hyperglycaemia, dyslipidemia, hyperinsulinemia and altered levels of adipocytederived hormones. Furthermore, clinical studies in humans have suggested the possible correlation of plasma concentration of several adipocytokines and measures of adiposity, insulin resistance and endothelial function in humans. Aim: To estimate and compare the serum levels of leptin and adiponectin in patients with Type 2 Diabetes Mellitus (T2DM) and in non-diabetic subjects with and without obesity. Materials and Methods: In the study, 200 T2DM patients (with and without obesity) and 200 non-diabetic subjects (with and without obesity) aged between 30-70 years of either sex were included. In all the subjects included in the study, serum leptin and adiponectin levels were estimated using Enzyme Linked Immunosorbent Assay (ELISA) method. Results: It was observed that the serum adiponectin levels decreased while leptin levels increased significantly (p

We present a case of 50 year old male patient with coexistence of Pneumothorax and Chilaiditi sign. Chilaiditi sign is an incidental radiographic finding of a usually asymptomatic condition in which a part of intestine is located between the liver and diaphragm; however, the term “Chilaiditi syndrome” is used for symptomatic hepatodiaphragmatic interposition. The patient had no symptoms of abdominal pain, constipation, diarrhea, or emesis. Incidentally, Chilaiditi sign was diagnosed on chest radiography. Pneumothorax is defined as air in the pleural space. Pneumothoraces are classified as spontaneous or traumatic. Spontaneous pneumothorax is labelled as primary when no underlying lung disease is present, or secondary, when it is associated with pre-existing lung disease. Our case is the rare in the literature indicating the coexistence of Chilaiditi sign and pneumothorax.