Search

Your search keyword '"Nissinen, Markku J."' showing total 32 results
Start Over Author "Nissinen, Markku J."
32 results on '"Nissinen, Markku J."'

9. Validity of fatty liver disease indices in the presence of alcohol consumption

Author

Danielsson, Oscar, primary, Nano, Jana, additional, Pahkala, Katja, additional, Rospleszcz, Susanne, additional, Lehtimäki, Terho, additional, Schlett, Christopher L., additional, Kähönen, Mika, additional, Bamberg, Fabian, additional, Raitakari, Olli, additional, Peters, Annette, additional, Nissinen, Markku J., additional, and Åberg, Fredrik O., additional

Published
2022
Full Text
View/download PDF

19. Relation of cholesterol metabolism to pediatric gallstone disease

Author

University of Helsinki, Lastenkirurgian yksikkö, University of Helsinki, Department of Medicine, University of Helsinki, Gastroenterologia (-2009), Koivusalo, Antti, Pakarinen, Mikko, Gylling, Helena, Nissinen, Markku J., University of Helsinki, Lastenkirurgian yksikkö, University of Helsinki, Department of Medicine, University of Helsinki, Gastroenterologia (-2009), Koivusalo, Antti, Pakarinen, Mikko, Gylling, Helena, and Nissinen, Markku J.

Abstract

Background: Cholesterol metabolism may be involved in pediatric gallstone disease. We aimed to reveal cholesterol metabolites and phytosterols and their relation to stone composition of sterols in children having black pigment and cholesterol stones. Methods: We performed retrospective controlled clinical study, in which we examined parameters of cholesterol metabolism and liver function values in serum (n = 28) and gallstones (n = 46) of consecutively cholecystectomized children. Serum values of age-, body mass index-and sex-matched children (n = 82) and adult gallstones (n = 187) served as controls. Results: Surrogate markers of cholesterol synthesis in serum (squalene/cholesterol, cholestenol/cholesterol and lathosterol/cholesterol) were 26-52 % higher in both stone subclasses compared to controls (p <0.05 for all). Respectively, cholestanol/cholesterol and plant sterols campesterol/cholesterol and sitosterol/cholesterol (cholesterol absorption markers) had decreasing order in serum: black pigment stone group > controls > cholesterol stone group (p <0.05 for all). In black pigment stone group, stone cholestanol/cholesterol was associated with serum bile acids (r = 0.620, p = 0.018). In cholesterol stone group, surrogate markers of cholesterol synthesis in serum (e.g., lathosterol/cholesterol) inversely reflected those of absorption (r-range -0.633--0.706, p-range 0.036-0.015). In cholesterol stone group, serum and stone lathosterol/cholesterol and cholestanol/cholesterol were positively interrelated (r-range 0.727-0.847, p <0.05 for both). Conclusions: Gallstone subclasses shared enhanced cholesterol synthesis. Cholesterol stone children were low cholesterol absorbers with intact homeostasis of cholesterol metabolism. Black pigment stone group was characterized by deteriorated cholesterol metabolism, and accumulation of cholestanol, campesterol and sitosterol in serum and stones suggesting their participation in pathogenesis.

Published
2015

21. Diet and cardiovascular health in asymptomatic normo- and mildly-to-moderately hypercholesterolemic participants - baseline data from the BLOOD FLOW intervention study

Author

University of Helsinki, Clinicum, University of Helsinki, Gastroenterologia (-2009), University of Helsinki, Department of Medicine, Hallikainen, Maarit, Halonen, Janne, Konttinen, Jussi, Lindholm, Harri, Simonen, Piia, Nissinen, Markku J., Gylling, Helena, University of Helsinki, Clinicum, University of Helsinki, Gastroenterologia (-2009), University of Helsinki, Department of Medicine, Hallikainen, Maarit, Halonen, Janne, Konttinen, Jussi, Lindholm, Harri, Simonen, Piia, Nissinen, Markku J., and Gylling, Helena

Published
2013

22. The effects of plant stanol ester consumption on arterial stiffness and endothelial function in adults: a randomised controlled clinical trial

Author

University of Helsinki, Department of Medicine, University of Helsinki, Clinicum, University of Helsinki, Gastroenterologia (-2009), University of Helsinki, Department of Public Health, Gylling, Helena, Halonen, Janne, Lindholm, Harri, Konttinen, Jussi, Simonen, Piia, Nissinen, Markku J., Savolainen, Aslak, Talvi, Airi, Hallikainen, Maarit, University of Helsinki, Department of Medicine, University of Helsinki, Clinicum, University of Helsinki, Gastroenterologia (-2009), University of Helsinki, Department of Public Health, Gylling, Helena, Halonen, Janne, Lindholm, Harri, Konttinen, Jussi, Simonen, Piia, Nissinen, Markku J., Savolainen, Aslak, Talvi, Airi, and Hallikainen, Maarit

Published
2013

25. Parenteral Plant Sterols and Intestinal Failure–associated Liver Disease in Neonates

Author

Kurvinen, Annika, primary, Nissinen, Markku J., additional, Andersson, Sture, additional, Korhonen, Päivi, additional, Ruuska, Tarja, additional, Taimisto, Mari, additional, Kalliomäki, Marko, additional, Lehtonen, Liisa, additional, Sankilampi, Ulla, additional, Arikoski, Pekka, additional, Saarela, Timo, additional, Miettinen, Tatu A., additional, Gylling, Helena, additional, and Pakarinen, Mikko P., additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results