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13. Mannose Binding Lectin and C3 Serum Levels in Coronary Artery Disease: A Cross-Sectional Study.

Author

Meneghetti da Rosa, Juliana, Lidani, Kárita Cláudia Freitas, Andrade, Fabiana Antunes, Sena, Léia, Nisihara, Renato, Ambrosio, Altair Rogerio, and Messias-Reason, Iara J.

Subjects
CORONARY artery disease, CARDIOVASCULAR diseases risk factors, CORONARY angiography, COMPLEMENT activation, BODY mass index
Abstract

Background: The process of tissue injury in coronary artery disease (CAD) has been associated with activation of the complement system, partly due to the action of mannose-binding lectin (MBL) and C3, which are expressed in atherosclerotic lesions. Objective: The aim of this study was to evaluate the serum levels of MBL and C3 in patients with CAD and to compare them with healthy controls. Additionally, we aim to assess the correlation between MBL and C3 levels and cardiometabolic parameters. Methods: MBL and C3 serum concentration were determined by ELISA and immunoturbidimetry, respectively, in up to 119 patients undergoing coronary angiography for CAD evaluation, comprising 48 individuals diagnosed with acute myocardial infarction (MI) and 71 without MI. A total of 93 paired healthy controls were included in the study. Results: Individuals with CAD had MBL serum concentration higher than controls (p =.002), regardless of the presence of MI (p =.006). In addition, high concentration of MBL (>2000 ng/mL) was more frequent in patients with CAD (p =.007; OR = 2.6; 95% CI = 1.3–5.1). C3 levels were not significantly associated with any of the patient groups but were positively correlated with cardiometabolic parameters such as body mass index (BMI) and triglycerides levels. Conclusions: Higher concentrations of MBL were found to be associated with CAD, whereas C3 levels were found to be associated with cardiovascular risk factors. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Functional independence index of patients submitted to multiprofessional rehabilitation program after cerebrovascular accident/ Indice de independencia funcional de pacientes pos-acidente vascular cerebral submetidos a um programa de reabilitacao multiprofissional

Author

Gentilini, Gabriela Luiza, de Santa, Larissa Nicolini, Vedovatto, Monica Baratto, Hirai, Paula, Klaumann, Valquiria Custodio, Purim, Katia Sheylla Malta, and Nisihara, Renato Mitsunori

Published
2022
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22. Comparación entre artritis reumatoide seronegativa y artritis psoriásica poliarticular: estudio transversal en una cohorte brasileña.

Author

Perachi Costodio, Annelise, Mariussi Legramanti, Letícia, Paula Beckhauser, Ana, Kahlow, Barbara S., Nisihara, Renato, and Skare, Thelma

Subjects
CAROTID intima-media thickness, PSORIATIC arthritis, QUALITY of life, CENTER for Epidemiologic Studies Depression Scale, DYSLIPIDEMIA
Abstract

Copyright of Journal of the Argentine Society of Rheumatology/Revista de la Sociedad Argentina de Reumatología is the property of Editorial Biotecnologica S.R.L and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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37. Anormalidades em exames pré-operatórios de pacientes de cirurgia plástica

Author

BIGARELLI, LEONARDO BOSCOLO, BIGARELLI, LUIZ HENRIQUE CAMARGO, and NISIHARA, RENATO

Subjects
Patient care management, Diagnostic tests, routine, Reconstructive surgical procedures, Preoperative care, Testes diagnósticos de rotina, Administração dos cuidados ao paciente, Procedimentos cirúrgicos reconstrutivos, Cuidados pré-operatórios, Health care costs, Custos de cuidados de saúde
Abstract

RESUMO Introdução: Os exames pré-operatórios (EPO) visam detectar anormalidades e dar maior segurança ao procedimento. No entanto, a solicitação desses exames ainda é controversa, seja por não trazerem mudanças de conduta para o procedimento ou resultar em alguns malefícios para o paciente. O objetivo é avaliar a frequência de solicitações e de anormalidades dos EPO em pacientes de cirurgia plástica estética, verificar quais são estas anormalidades, qual conduta pré-operatória mediante o achado e associar os dados obtidos com o perfil do paciente e cirurgia prevista. Método: Estudo retrospectivo avaliando prontuários de pacientes de cirurgia plástica estética que realizaram EPO de rotina em um hospital de cirurgia plástica durante o ano de 2019. Resultados: Foram estudados 978 pacientes e 51% desses apresentaram alguma anormalidade nos EPO. 93,7% eram mulheres, com média de idade 46,5 anos. Foram realizados 12,3 exames por paciente e observada anormalidade em 6,1% dos EPO. Os exames que mais tiveram anormalidades foram o lipidograma (23,8%) e os da avaliação cardíaca (14,1%). Hipotireoidismo foi a comorbidade mais achada (18,4% dos pacientes); 70% dos diabéticos estavam com o nível glicêmico acima do recomendado. Apenas 3,4% dos pacientes sofreram alteração da conduta pré-operatória devido anormalidade dos EPO e em 57,9% desses casos houve adiamento da cirurgia. Alterações de exames foram mais frequentes em pacientes do sexo masculino (p

Published
2023

41. The Second Highest Prevalence of Celiac Disease Worldwide: Genetic and Metabolic Insights in Southern Brazilian Mennonites

Author

Oliveira, Luana Caroline, primary, Dornelles, Amanda Coelho, additional, Nisihara, Renato Mitsunori, additional, Bruginski, Estevan Rafael Dutra, additional, Santos, Priscila Ianzen dos, additional, Cipolla, Gabriel Adelman, additional, Boschmann, Stefanie Epp, additional, Messias-Reason, Iara José de, additional, Campos, Francinete Ramos, additional, Petzl-Erler, Maria Luiza, additional, and Boldt, Angelica Beate Winter, additional

Published
2023
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45. Adalimumab Serum Concentrations, Clinical and Endoscopic Disease Activity in Crohn’s Disease: A Cross-Sectional Multicentric Latin American Study

Author

de Souza, Letícia Rodrigues, primary, Magro, Daniela Oliveira, additional, Teixeira, Fábio Vieira, additional, Parra, Rogério Serafim, additional, Miranda, Eron Fábio, additional, Féres, Omar, additional, Saad-Hossne, Rogério, additional, Soares Prates Herrerias, Giedre, additional, Nisihara, Renato Mitsunori, additional, Coy, Claudio Saddy Rodrigues, additional, Sassaki, Ligia Yukie, additional, and Kotze, Paulo Gustavo, additional

Published
2023
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