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1,137 results on '"Nishimura, Junichi"'

1. Efficacy and safety of dexamethasone sparing for the prevention of nausea and vomiting associated with moderately emetogenic chemotherapy: a systematic review and meta-analysis of Clinical Practice Guidelines for Antiemesis 2023 from Japan Society of Clinical Oncology

Author

Nakashima, Kazuhisa, Yokomizo, Ayako, Murakami, Michiyasu, Okita, Kenji, Wada, Makoto, Iino, Keiko, Akechi, Tatsuo, Iihara, Hirotoshi, Imamura, Chiyo K., Okuyama, Ayako, Ozawa, Keiko, Kim, Yong-il, Sasaki, Hidenori, Satomi, Eriko, Takeda, Masayuki, Tanaka, Ryuhei, Nakajima, Takako Eguchi, Nakamura, Naoki, Nishimura, Junichi, Noda, Mayumi, Hayashi, Kazumi, Higashi, Takahiro, Boku, Narikazu, Matsumoto, Koji, Matsumoto, Yoko, Yamamoto, Nobuyuki, Aogi, Kenjiro, and Abe, Masakazu

Published
2024
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2. Clinical benefits of adding olanzapine to 5-HT3 receptor antagonist, NK1 receptor antagonist, and dexamethasone for the prevention of nausea and vomiting in highly emetogenic chemotherapy: a systematic review and meta-analysis of the Clinical Practice Guidelines for Antiemesis 2023 from the Japan Society of Clinical Oncology

Author

Murakami, Michiyasu, Miyata, Yoshiharu, Nakashima, Kazuhisa, Abe, Masakazu, Nishimura, Junichi, Wada, Makoto, Iino, Keiko, Akechi, Tatsuo, Iihara, Hirotoshi, Imamura, Chiyo K., Okuyama, Ayako, Ozawa, Keiko, Kim, Yong-il, Sasaki, Hidenori, Satomi, Eriko, Takeda, Masayuki, Tanaka, Ryuhei, Nakamura, Naoki, Noda, Mayumi, Hayashi, Kazumi, Higashi, Takahiro, Boku, Narikazu, Matsumoto, Koji, Matsumoto, Yoko, Okita, Kenji, Yamamoto, Nobuyuki, Aogi, Kenjiro, and Nakajima, Takako Eguchi

Published
2024
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3. Efficacy and safety of multi-day antiemetic treatment for patients undergoing multi-day chemotherapy: a systematic review of Clinical Practice Guidelines for Antiemesis 2023 from Japan Society of Clinical Oncology

Author

Nakashima, Kazuhisa, Harashima, Saki, Kaneko, Rena, Tanaka, Ryuhei, Abe, Masakazu, Wada, Makoto, Iino, Keiko, Akechi, Tatsuo, Iihara, Hirotoshi, Imamura, Chiyo K., Okuyama, Ayako, Ozawa, Keiko, Kim, Yong-il, Satomi, Eriko, Takeda, Masayuki, Nakajima, Takako Eguchi, Nakamura, Naoki, Nishimura, Junichi, Noda, Mayumi, Hayashi, Kazumi, Higashi, Takahiro, Boku, Narikazu, Matsumoto, Koji, Matsumoto, Yoko, Okita, Kenji, Yamamoto, Nobuyuki, Aogi, Kenjiro, and Sasaki, Hidenori

Published
2024
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4. Efficacy and safety of dexamethasone sparing for the prevention of nausea and vomiting associated with highly emetogenic risk antineoplastic agents: a systematic review and meta-analysis of the Clinical Practice Guidelines for Antiemesis 2023 from the Japan Society of Clinical Oncology

Author

Yokomizo, Ayako, Nakashima, Kazuhisa, Iba, Arisa, Okita, Kenji, Wada, Makoto, Iino, Keiko, Akechi, Tatsuo, Iihara, Hirotoshi, Imamura, Chiyo K., Okuyama, Ayako, Ozawa, Keiko, Kim, Yong-Il, Sasaki, Hidenori, Satomi, Eriko, Takeda, Masayuki, Tanaka, Ryuhei, Nakajima, Takako Eguchi, Nakamura, Naoki, Nishimura, Junichi, Noda, Mayumi, Hayashi, Kazumi, Higashi, Takahiro, Boku, Narikazu, Matsumoto, Koji, Matsumoto, Yoko, Yamamoto, Nobuyuki, Aogi, Kenjiro, and Abe, Masakazu

Published
2024
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5. Defining the clinical benefits of adding a neurokinin-1 receptor antagonist to control chemotherapy-induced nausea and vomiting in moderately emetogenic chemotherapy: a systematic review and meta-analysis of the clinical practice guidelines for antiemesis 2023 from the Japan society of clinical oncology

Author

Hayashi, Toshinobu, Yamamoto, Shun, Miyata, Yoshiharu, Takeda, Masayuki, Abe, Masakazu, Wada, Makoto, Iino, Keiko, Akechi, Tatsuo, Imamura, Chiyo K., Okuyama, Ayako, Ozawa, Keiko, Kim, Yong-Il, Sasaki, Hidenori, Satomi, Eriko, Tanaka, Ryuhei, Nakajima, Takako Eguchi, Nakamura, Naoki, Nishimura, Junichi, Noda, Mayumi, Hayashi, Kazumi, Higashi, Takahiro, Boku, Narikazu, Matsumoto, Koji, Matsumoto, Yoko, Okita, Kenji, Yamamoto, Nobuyuki, Aogi, Kenjiro, and Iihara, Hirotoshi

Published
2024
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6. 2023 Japan Society of clinical oncology clinical practice guidelines update for antiemesis

Author

Iihara, Hirotoshi, Abe, Masakazu, Wada, Makoto, Iino, Keiko, Akechi, Tatsuo, Imamura, Chiyo K., Okuyama, Ayako, Ozawa, Keiko, Kim, Yong-Il, Sasaki, Hidenori, Satomi, Eriko, Takeda, Masayuki, Tanaka, Ryuhei, Nakajima, Takako Eguchi, Nakamura, Naoki, Nishimura, Junichi, Noda, Mayumi, Hayashi, Kazumi, Higashi, Takahiro, Boku, Narikazu, Matsumoto, Koji, Matsumoto, Yoko, Okita, Kenji, Yamamoto, Nobuyuki, and Aogi, Kenjiro

Published
2024
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7. Non-pharmacological treatments for anticipatory nausea and vomiting during chemotherapy: a systematic review and meta-analysis of the Clinical Practice Guidelines for Antiemesis 2023

Author

Kobayashi, Masamitsu, Kako, Jun, Iba, Arisa, Okuyama, Ayako, Ozawa, Keiko, Abe, Masakazu, Wada, Makoto, Akechi, Tatsuo, Iihara, Hirotoshi, Imamura, Chiyo K., Kim, Yong-Il, Sasaki, Hidenori, Satomi, Eriko, Takeda, Masayuki, Tanaka, Ryuhei, Nakajima, Takako Eguchi, Nakamura, Naoki, Nishimura, Junichi, Noda, Mayumi, Hayashi, Kazumi, Higashi, Takahiro, Boku, Narikazu, Matsumoto, Koji, Matsumoto, Yoko, Okita, Kenji, Yamamoto, Nobuyuki, Aogi, Kenjiro, and Iino, Keiko

Published
2024
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9. The clinical significance of the lymph node ratio as a recurrence indicator in ampullary cancer after curative pancreaticoduodenectomy

Author

Hasegawa, Shinichiro, Wada, Hiroshi, Kubo, Masahiko, Mukai, Yosuke, Mikamori, Manabu, Akita, Hirofumi, Matsuura, Norihiro, Kitakaze, Masatoshi, Masuike, Yasunori, Sugase, Takahito, Shinno, Naoki, Kanemura, Takashi, Hara, Hisashi, Sueda, Toshinori, Nishimura, Junichi, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, and Ohue, Masayuki

Published
2024
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10. Significance of Comprehensive Analysis of Preoperative Sarcopenia Based on Muscle Mass, Muscle Strength, and Physical Function for the Prognosis of Patients with Esophageal Cancer

Author

Kanemura, Takashi, Takeoka, Tomohira, Sugase, Takahito, Urakawa, Shinya, Masuike, Yasunori, Shinno, Naoki, Hara, Hisashi, Kitakaze, Masatoshi, Kubo, Masahiko, Mukai, Yousuke, Sueda, Toshinori, Hasegawa, Shinichiro, Akita, Hirofumi, Nishimura, Junichi, Wada, Hiroshi, Yasui, Masayoshi, Omori, Takeshi, and Miyata, Hiroshi

Published
2024
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11. The emerging emetogenicity of trifluridine/tipiracil (TAS‑102) from patient self-reporting: a multicenter, prospective, observational study

Author

Fujii, Hironori, Tsuchiya, Masami, Watanabe, Daichi, Otsuka, Ryo, Hirate, Daisuke, Takahashi, Katsuyuki, Go, Makiko, Kudo, Toshihiro, Shimomura, Kazuhiro, Ando, Yosuke, Tani, Shinya, Takahashi, Takao, Hayashi, Katsuhisa, Chin, Miki, Matsunami, Naomi, Takahashi, Masaya, Hasegawa, Akiko, Uchida, Takashi, Hashimoto, Hironobu, Kubo, Akiko, Matsuhashi, Nobuhisa, Suzuki, Akio, Nishimura, Junichi, Inui, Naoki, and Iihara, Hirotoshi

Published
2024
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12. Prognostic impact of dysphagia scores in patients with advanced resectable esophageal cancer who underwent radical esophagectomy after preoperative treatment

Author

Sugase, Takahito, Kanemura, Takashi, Matsuura, Norihiro, Ushimaru, Yuki, Masuike, Yasunori, Yanagimoto, Yoshitomo, Mori, Ryota, Kitakaze, Masatoshi, Amisaki, Masataka, Kubo, Masahiko, Mukai, Yosuke, Komatsu, Hisateru, Sueda, Toshinori, Kagawa, Yoshinori, Nishimura, Junichi, Wada, Hiroshi, Yasui, Masayoshi, Omori, Takeshi, and Miyata, Hiroshi

Published
2024
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13. A striking elevation of CA19-9 after preoperative therapy negates prognostic benefit from radical surgery in resectable and borderline resectable pancreatic cancer

Author

Akita, Hirofumi, Mukai, Yosuke, Kubo, Masahiko, Takahashi, Hidenori, Hasegawa, Shinichiro, Kitakaze, Masatoshi, Matsuura, Norihiro, Masuike, Yasunori, Sugase, Takahito, Shinno, Naoki, Kanemura, Takashi, Hara, Hisashi, Sueda, Toshinori, Nishimura, Junichi, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, and Wada, Hiroshi

Published
2024
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16. Influence of the rotation of the diverting loop ileostomy in rectal cancer surgery on small-bowel obstruction: A multicenter prospective study conducted by the Clinical Study Group of Osaka University, Colorectal Group

Author

Miyo, Masaaki, Uemura, Mamoru, Ozato, Yuki, Nishimura, Junichi, Nakata, Ken, Suzuki, Yozo, Kagawa, Yoshinori, Hata, Taishi, Munakata, Koji, Tei, Mitsuyoshi, Sawada, Genta, Yoshioka, Shinichi, Takahashi, Yusuke, Oba, Koji, Hata, Tsuyoshi, Ogino, Takayuki, Miyoshi, Norikatsu, Yamamoto, Hirofumi, Murata, Kohei, Doki, Yuichiro, and Eguchi, Hidetoshi

Published
2024
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17. DUPAN-II normalisation as a biological indicator during preoperative chemoradiation therapy for resectable and borderline resectable pancreatic cancer

Author

Hasegawa, Shinichiro, Takahashi, Hidenori, Akita, Hirofumi, Mukai, Yosuke, Mikamori, Manabu, Asukai, Kei, Yamada, Daisaku, Wada, Hiroshi, Fujii, Yoshiaki, Sugase, Takahito, Yamamoto, Masaaki, Takeoka, Tomohira, Shinno, Naoki, Hara, Hisashi, Kanemura, Takashi, Haraguchi, Naotsugu, Nishimura, Junichi, Matsuda, Chu, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, Ishikawa, Osamu, and Sakon, Masato

Published
2023
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18. Phase II dose titration study of regorafenib in progressive unresectable metastatic colorectal cancer

Author

Kato, Takeshi, Kudo, Toshihiro, Kagawa, Yoshinori, Murata, Kohei, Ota, Hirofumi, Noura, Shingo, Hasegawa, Junichi, Tamagawa, Hiroshi, Ohta, Katsuya, Ikenaga, Masakazu, Miyazaki, Susumu, Komori, Takamichi, Uemura, Mamoru, Nishimura, Junichi, Hata, Taishi, Matsuda, Chu, Satoh, Taroh, Mizushima, Tsunekazu, Ohno, Yuko, Yamamoto, Hirofumi, Doki, Yuichiro, and Eguchi, Hidetoshi

Published
2023
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20. The DOLFIN method: a novel laparoscopic Billroth-I gastroduodenostomy for gastric cancer with duodenal invasion

Author

Shinno, Naoki, Omori, Takeshi, Hara, Hisashi, Yamamoto, Masaaki, Fujita, Kohei, Kanemura, Takashi, Takeoka, Tomohira, Sugase, Takahito, Yasui, Masayoshi, Matsuda, Chu, Wada, Hiroshi, Nishimura, Junichi, Haraguchi, Naotsugu, Akita, Hirofumi, Hasegawa, Shinichiro, Nakai, Nozomu, Asukai, Kei, Mukai, Yousuke, Miyata, Hiroshi, Ohue, Masayuki, and Sakon, Masato

Published
2022
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22. Laparoscopic Proximal Gastrectomy with Novel Valvuloplastic Esophagogastrostomy vs. Laparoscopic Total Gastrectomy for Stage I Gastric Cancer: a Propensity Score Matching Analysis

Author

Yamamoto, Masaaki, Omori, Takeshi, Shinno, Naoki, Hara, Hisashi, Fujii, Yoshiaki, Mukai, Yosuke, Sugase, Takahito, Takeoka, Tomohira, Asukai, Kei, Kanemura, Takashi, Hasegawa, Shinichiro, Akita, Hirofumi, Haraguchi, Naotsugu, Nishimura, Junichi, Wada, Hiroshi, Matsuda, Chu, Yasui, Masayoshi, Miyata, Hiroshi, and Ohue, Masayuki

Published
2022
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25. The clinical impact of modified transpancreatic mattress sutures with polyglactin 910 woven mesh on postoperative pancreatic fistula in distal pancreatectomy

Author

Imamura, Hiroki, Takahashi, Hidenori, Akita, Hirofumi, Wada, Hiroshi, Mukai, Yosuke, Asukai, Kei, Hasegawa, Shinichiro, Fujii, Yoshiaki, Sugase, Takahito, Yamamoto, Masaaki, Takeoka, Tomohira, Shinno, Naoki, Hara, Hisashi, Kanemura, Takashi, Haraguchi, Naotsugu, Nishimura, Junichi, Matsuda, Chu, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, and Sakon, Masato

Published
2022
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26. Clinical importance of carcinoembryonic antigen messenger RNA level in peritoneal lavage fluids measured by transcription-reverse transcription concerted reaction for advanced gastric cancer in laparoscopic surgery

Author

Fujita, Kohei, Omori, Takeshi, Hara, Hisashi, Shinno, Naoki, Yamamoto, Masaaki, Aoyama, Yoshimasa, Sugimura, Keijiro, Kanemura, Takashi, Takeoka, Tomohira, Yasui, Masayoshi, Matsuda, Chu, Takahashi, Hidenori, Wada, Hiroshi, Nishimura, Junichi, Haraguchi, Naotsugu, Hasegawa, Shinichiro, Nakai, Nozomu, Asukai, Kei, Mukai, Yosuke, Miyata, Hiroshi, Ohue, Masayuki, and Sakon, Masato

Published
2022
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28. Tolerability and Safety Assessment of Adjuvant Chemoradiotherapy with S-1 after Limited Surgery for T1 or T2 Lower Rectal Cancer.

Author

Miyoshi, Norikatsu, Uemura, Mamoru, Noura, Shingo, Yasui, Masayoshi, Nishimura, Junichi, Tei, Mitsuyoshi, Matsuda, Chu, Morita, Shunji, Inoue, Akira, Tamagawa, Hiroki, Mokutani, Yukako, Yoshioka, Shinichi, Fujii, Makoto, Kato, Shinya, Sekido, Yuki, Ogino, Takayuki, Yamamoto, Hirofumi, Murata, Kohei, Doki, Yuichiro, and Eguchi, Hidetoshi

Subjects
THERAPEUTIC use of antineoplastic agents, PATIENT safety, ANUS, ADJUVANT treatment of cancer, EARLY detection of cancer, CHEMORADIOTHERAPY, TREATMENT effectiveness, CANCER patients, RECTUM tumors, LONGITUDINAL method, RESEARCH, PROGRESSION-free survival, DRUG tolerance, OVERALL survival
Abstract

Simple Summary: The study evaluated the long-term outcomes of chemoradiotherapy (CRT) with S-1 after limited surgery for T1 or T2 lower rectal cancer. The 3-year and 5-year relapse-free survival rates were 90.17% and 85.87%, respectively, showing favorable outcomes for T1 cancer patients, with effective anal function preservation. However, further treatment is needed to improve outcomes for T2 cancer patients. Background: The short-term outcomes of chemoradiotherapy (CRT) with S-1 (a combination of tegafur, gimeracil, and oteracil) following limited surgery for patients with T1 or T2 lower rectal cancer have shown encouraging results. Objectives: This study was designed to delve deeper into the long-term outcomes of CRT with S-1 after limited surgery, with the goal of evaluating both the long-term efficacy and potential risks associated with this treatment approach in patients diagnosed with T1 or T2 lower rectal cancer. Methods: This was conducted as a multicenter, single-arm, prospective phase II trial. The patient population consisted of individuals clinically diagnosed with either T1 or T2 lower rectal or anal canal cancer, with a maximum tumor diameter of 30 mm and classified as N0 or M0. Patients underwent local excision or endoscopic resection. After surgery, CRT with S-1 was administered to patients meeting several criteria, including the confirmation of well-differentiated or moderately differentiated adenocarcinoma, negative surgical margins, submucosal invasion depth of ≥1000 µm, and high tumor-budding grade (2/3). The primary endpoint of this study was relapse-free survival, while secondary endpoints included local recurrence-free survival, overall survival, anal sphincter preservation rate, and safety. Results: A total of 52 patients were included, with pathological diagnoses revealing T1 in 36 patients and T2 in 16 patients. The 3-year and 5-year relapse-free survival rates were 90.17% and 85.87%, respectively. The 3-year and 5-year local recurrence-free survival rates were 90.17% and 88.07%, respectively, while the 3-year and 5-year overall survival rates were 94.03% and 91.94%, respectively. Conclusions: CRT with S-1 after limited surgery for T1 lower rectal cancer demonstrated favorable outcomes in terms of recurrence, survival, and local control rates while effectively maintaining anal function in patients. However, further treatment approaches may be necessary to improve outcomes for patients diagnosed with stage T2 lower rectal cancer [ABSTRACT FROM AUTHOR]

Published
2024
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29. Postoperative aggressive diuresis prevents postoperative tissue edema and complications in patients undergoing distal pancreatectomy

Author

Imamura, Hiroki, Takahashi, Hidenori, Wada, Hiroshi, Mukai, Yosuke, Asukai, Kei, Hasegawa, Shinichiro, Yamamoto, Masaaki, Takeoka, Tomohira, Shinno, Naoki, Hara, Hisashi, Kanemura, Takashi, Nakai, Nozomu, Haraguchi, Naotsugu, Sugimura, Keijiro, Nishimura, Junichi, Matsuda, Chu, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, and Sakon, Masato

Published
2022
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30. Robotic total gastrectomy with thrombectomy and portal vein reconstruction for gastric cancer and portal vein tumor thrombus

Author

Yamamoto, Masaaki, Omori, Takeshi, Shinno, Naoki, Hara, Hisashi, Mukai, Yosuke, Sugase, Takahito, Takeoka, Tomohira, Asukai, Kei, Kanemura, Takashi, Nakai, Nozomu, Hasegawa, Shinichiro, Sugimura, Keijiro, Akita, Hirofumi, Haraguchi, Naotsugu, Nishimura, Junichi, Wada, Hiroshi, Takahashi, Hidenori, Matsuda, Chu, Yasui, Masayoshi, Miyata, Hiroshi, and Ohue, Masayuki

Published
2022
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33. Predictive value of preoperative echocardiographic assessment for postoperative atrial fibrillation after esophagectomy for esophageal cancer

Author

Nagatsuka, Yuta, Sugimura, Keijiro, Miyata, Hiroshi, Shinnno, Naoki, Asukai, Kei, Hara, Hisashi, Hasegawa, Shinichiro, Yamada, Daisaku, Yamamoto, Kazuyoshi, Haraguchi, Naotsugu, Nishimura, Junichi, Motoori, Masaaki, Wada, Hiroshi, Takahashi, Hidenori, Yasui, Masayoshi, Omori, Takeshi, Ohue, Masayuki, and Yano, Masahiko

Published
2021
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35. Prognostic impact of nodal status and lymphovascular invasion in patients undergoing neoadjuvant chemotherapy for esophageal squamous cell carcinoma.

Author

Miyata, Hiroshi, Sugimura, Keijirou, Kanemura, Takashi, Takeoka, Tomohira, Sugase, Takahito, Yasui, Masayoshi, Nishimura, Junichi, Wada, Hiroshi, Akita, Hiroshi, Yamamoto, Masaaki, Hara, Hisashi, Shinno, Naoki, Omori, Takeshi, and Yano, Masahiko

Subjects
NEOADJUVANT chemotherapy, CANCER prognosis, PROGNOSIS, OVERALL survival, SQUAMOUS cell carcinoma, ESOPHAGEAL cancer
Abstract

Nodal status is well known to be the most important prognostic factor for esophageal cancer patients, even if they are treated with neoadjuvant therapy. To establish an optimal postoperative adjuvant strategy for patients, we aimed to more accurately predict the prognosis of patients and systemic recurrence by using clinicopathological factors, including nodal status, in patients with esophageal cancer who received neoadjuvant chemotherapy. The clinicopathological factors associated with survival and systemic recurrence were investigated in 488 patients with esophageal squamous cell carcinoma who received neoadjuvant chemotherapy. Overall survival differed according to tumor depth, nodal status, tumor regression, and lymphovascular (LV) invasion. In the multivariate analysis, nodal status and LV invasion were identified as independent prognostic factors (P  < 0.0001, P  = 0.0008). Nodal status was also identified as an independent factor associated with systemic recurrence, although LV invasion was a borderline factor (P  = 0.066). In each pN stage, patients with LV invasion showed significantly worse overall survival than those without LV invasion (pN0: P  = 0.036, pN1: P  = 0.0044, pN2: P  = 0.0194, pN3: P  = 0.0054). Patients with LV invasion were also more likely to have systemic, and any recurrence than those without LV invasion in each pN stage. Pathological nodal status and LV invasion were the most important predictors of survival and systemic recurrence in patients with esophageal cancer who underwent neoadjuvant chemotherapy followed by surgery. This finding could provide useful information about selecting candidates for adjuvant therapy among these patients. Our analysis showed that LV invasion was an independent prognostic factor in patients with esophageal cancer who underwent neoadjuvant chemotherapy and that combining LV invasion with pathological nodal status makes it possible to stratify the prognosis in those patients. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Clinical implications of the serum CA19-9 level in “biological borderline resectability” and “biological downstaging” in the setting of preoperative chemoradiation therapy for pancreatic cancer

Author

Takahashi, Hidenori, Yamada, Daisaku, Asukai, Kei, Wada, Hiroshi, Hasegawa, Shinichiro, Hara, Hisashi, Shinno, Naoki, Ushigome, Hajime, Haraguchi, Naotsugu, Sugimura, Keijiro, Yamamoto, Kazuyoshi, Nishimura, Junichi, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, Yano, Masahiko, Sakon, Masato, and Ishikawa, Osamu

Published
2020
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37. Decreased CT-number in the pancreatic parenchyma is a reliable imaging biomarker of the presence of malignancies in patients with high-risk intraductal papillary mucinous neoplasm

Author

Abe, Tomoki, Yamada, Daisaku, Asukai, Kei, Hasegawa, Shinichiro, Tomokuni, Akira, Wada, Hiroshi, Fujii, Wataru, Ikezawa, Kenji, Fukutake, Nobuyasu, Ohkawa, Kazuyoshi, Shinno, Naoki, Hara, Hisashi, Yanagimoto, Yoshitomo, Takahashi, Yusuke, Sugimura, Keijiro, Yamamoto, Kazuyoshi, Ushigome, Hajime, Haraguchi, Naotsugu, Nishimura, Junichi, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, Yano, Masahiko, Sakon, Masato, and Takahashi, Hidenori

Published
2020
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40. Comparison of the intracorporeal triangular and delta-shaped anastomotic techniques in totally laparoscopic distal gastrectomy for gastric cancer: an analysis with propensity score matching

Author

Yanagimoto, Yoshitomo, Omori, Takeshi, Fujiwara, Yoshiyuki, Demura, Koichi, Jeong-Ho, Moon, Shinno, Naoki, Yamamoto, Kazuyoshi, Sugimura, Keijiro, Miyata, Hiroshi, Ushigome, Hajime, Takahashi, Yusuke, Nishimura, Junichi, Yasui, Masayoshi, Asukai, Kei, Yamada, Daisaku, Wada, Hiroshi, Takahashi, Hidenori, Ohue, Masayuki, Yano, Masahiko, and Sakon, Masato

Published
2020
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44. Laparoscopic-assisted disinvagination and polypectomy for multiple intussusceptions induced by small intestinal polyps in patients with Peutz-Jeghers syndrome: a case report

Author

Yamamoto, Masaaki, Iwamoto, Kazuya, Suzuki, Rei, Mukai, Yosuke, Takeoka, Tomohira, Asukai, Kei, Shinno, Naoki, Hara, Hisashi, Kanemura, Takashi, Nakai, Nozomu, Hasegawa, Shinichiro, Sugimura, Keijiro, Haraguchi, Naotsugu, Nishimura, Junichi, Wada, Hiroshi, Takahashi, Hidenori, Matsuda, Chu, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ohue, Masayuki, and Murata, Masaru

Published
2021
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45. A phase II study of the safety of olanzapine for oxaliplatin based chemotherapy in coloraectal patients

Author

Nishimura, Junichi, Hasegawa, Akiko, Kudo, Toshihiro, Otsuka, Tomoyuki, Yasui, Masayoshi, Matsuda, Chu, Haraguchi, Naotsugu, Ushigome, Hajime, Nakai, Nozomu, Abe, Tomoki, Hara, Hisashi, Shinno, Naoki, Asukai, Kei, Hasegawa, Shinichiro, Yamada, Daisaku, Sugimura, Keijiro, Yamamoto, Kazuyoshi, Wada, Hiroshi, Takahashi, Hidenori, Omori, Takeshi, Miyata, Hiroshi, and Ohue, Masayuki

Published
2021
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46. Exploratory analysis of lateral pelvic sentinel lymph node status for optimal management of laparoscopic lateral lymph node dissection in advanced lower rectal cancer without suspected lateral lymph node metastasis

Author

Yasui, Masayoshi, Ohue, Masayuki, Noura, Shingo, Miyoshi, Norikatsu, Takahashi, Yusuke, Matsuda, Chu, Nishimura, Junichi, Haraguchi, Naotsugu, Ushigome, Hajime, Nakai, Nozomu, Fujino, Shiki, Sugimura, Keijiro, Wada, Hiroshi, Takahashi, Hidenori, Omori, Takeshi, and Miyata, Hiroshi

Published
2021
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49. The utility of nutritional supportive care with an eicosapentaenoic acid (EPA)-enriched nutrition agent during pre-operative chemoradiotherapy for pancreatic cancer: Prospective randomized control study

Author

Akita, Hirofumi, Takahashi, Hidenori, Asukai, Kei, Tomokuni, Akira, Wada, Hiroshi, Marukawa, Satoko, Yamasaki, Tomoyuki, Yanagimoto, Yoshitomo, Takahashi, Yusuke, Sugimura, Keijiro, Yamamoto, Kazuyoshi, Nishimura, Junichi, Yasui, Masayoshi, Omori, Takeshi, Miyata, Hiroshi, Ochi, Ayami, Kagawa, Ayano, Soh, Yuko, Taniguchi, Yuko, Ohue, Masayuki, Yano, Masahiko, and Sakon, Masato

Published
2019
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50. Clinical Impact of Early Tumour Shrinkage in Metastatic or Unresectable Oesophageal Cancer Treated with Pembrolizumab plus Chemotherapy.

Author

Sugase, Takahito, Kanemura, Takashi, Takeoka, Tomohira, Matsuura, Norihiro, Masuike, Yasunori, Shinno, Naoki, Hara, Hisashi, Omori, Takeshi, Kitakaze, Masatoshi, Kubo, Masahiko, Mukai, Yosuke, Sueda, Toshinori, Hasegawa, Shinichiro, Akita, Hirofumi, Nishimura, Junichi, Wada, Hiroshi, Yasui, Masayoshi, and Miyata, Hiroshi

Subjects
THERAPEUTIC use of monoclonal antibodies, PREDICTIVE tests, IMMUNOTHERAPY, ESOPHAGEAL tumors, TREATMENT effectiveness, DESCRIPTIVE statistics, MULTIVARIATE analysis, METASTASIS, CANCER chemotherapy, LOG-rank test, PROGRAMMED cell death 1 receptors, COMBINED modality therapy, PROGRESSION-free survival, OVERALL survival
Abstract

Introduction: Metastatic or unresectable locally advanced oesophageal cancer remains a disease with high mortality. More recently, pembrolizumab plus chemotherapy has been indicated as the first-line treatment for those patients, but the predictive factors for treatment efficacy remain controversial. This study investigated the clinical utility of early tumour shrinkage (ETS) and depth of response (DpR) in metastatic or unresectable oesophageal cancer treated with pembrolizumab plus CF therapy. Methods: ETS and DpR, defined as the percent decreases at the second evaluation and the percentage of the maximal tumour shrinkage during treatment, were measured in 53 eligible patients. The ETS and DpR cut-off values were 20% and 30%, respectively, based on survival outcomes. Results: Twenty-seven patients (51%) were treatment naïve, while 26 (49%) had received any treatment before initiating pembrolizumab plus CF therapy. The median progression-free survival (PFS) and overall survival for ETS ≥20% and <20% were 12.7 and 5.5 months and 14.4 and 8.2 months and 12.7 and 4.9 months and 14.4 and 8.0 months for DpR ≥30% and <30%, respectively. ETS <20% showed early tumour growth, whereas ETS ≥20% had a good response rate with sufficient longer response duration. In addition, an ETS cut-off of 20% predicted the best overall response and was not associated with prior treatment. In multivariable analysis, ETS ≥20% and DpR ≥30% were independent factors of longer PFS. Conclusion: Our findings suggest that an ETS is a promising on-treatment marker for early prediction of further sensitivity to pembrolizumab plus CF therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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