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We report a patient with mitochondrial diabetes mellitus associated with the A3243G mutation (MDM3243). The patient is a 77-year man with diabetes. At age 68, he noticed diplopia, due to superior rectus muscle palsy of the right eye. At age 70, he noticed lipoma on the right arm. The pathology of his muscle revealed some ragged-red fibers, and focal cytochrome c oxidase deficiency. Hence, he may have a pathogenetic mechanism in common with CPEO (chronic progressive external ophthalmoplegia) or mitochondria-related autoimmune disorder associated with mononeuropathy. He had the rate of 0.102% for heteroplasmy of 3243 mitochondrial DNA mutation in leukocytes. This case's heteroplasmy level is the smallest among the reported cases of MDM3243 in the literature. 3243 mitochondrial DNA mutation is known to induce a lack of uridine-modification in tRNA(Leu(UUR)) at the first letter of the anticodon, with which the third letter of the codon pairs, and decline of the pairing of the anticodon of tRNA with the codon of mRNA, suggesting the termination of polypeptide-elongation to generate premature proteins. Therefore, we speculate that these premature proteins may accumulate overtime, thereby affecting cells in target organs. [ABSTRACT FROM AUTHOR]

[Objective] The purpose of this investigation was to assess the weight loss patterns in Japanese junior wrestlers. [Methods] A survey using a self-assessed questionnaire was designed to assess the weight control and behavior of junior wrestlers. The subjects were 124 junior wrestlers (male: n=101, female: n=23) who participated in JOC junior wrestling competitions in 2003. [Results] Weight loss started an average 10 days before the weigh-in. Body weight before the weight loss was about 5kg over. Weight loss methods used included diet, fluid restriction, and sauna suits during the wrestling season. Fluid restriction was started 3 days before the weigh-in. Most of the junior wrestlers began weight control at the age of 15. The frequency of weight loss was almost 3 to 5 times a year. For 60% of the wrestlers, their athletic condition was reduced during weight loss. They also had insufficient physiological and nutritional knowledge about weight control. [Conclusion] The majority of junior wrestlers engaged in harmful weight loss methods during the wrestling season. Fasting and various methods of dehydration were the primary methods of rapid weight loss. These data suggest that it is necessary for junior wrestlers to establish a weight loss program. [ABSTRACT FROM AUTHOR]

We report a patient with mitochondrial diabetes mellitus associated with the A3243G mutation (MDM3243). The patient is a 77-year man with diabetes. At age 68, he noticed diplopia, due to superior rectus muscle palsy of the right eye. At age 70, he noticed lipoma on the right arm. The pathology of his muscle revealed some ragged-red fibers, and focal cytochrome c oxidase deficiency. Hence, he may have a pathogenetic mechanism in common with CPEO (chronic progressive external ophthalmoplegia) or mitochondria-related autoimmune disorder associated with mononeuropathy.He had the rate of 0.102% for heteroplasmy of 3243 mitochondrial DNA mutation in leukocytes. This case’s heteroplasmy level is the smallest among the reported cases of MDM3243 in the literature. 3243 mitochondrial DNA mutation is known to induce a lack of uridine-modification in tRNALeu(UUR) at the first letter of the anticodon, with which the third letter of the codon pairs, and decline of the pairing of the anticodon of tRNA with the codon of mRNA, suggesting the termination of polypeptide–elongation to generate premature proteins. Therefore, we speculate that these premature proteins may accumulate overtime, thereby affecting cells in target organs. [Copyright &y& Elsevier]

Static and dynamical properties of Cu spins in the overdoped single-crystals of La[sub 2-x]Sr[sub x]Ou[sub 1-y]Zn[sub y]O[sub 4] have been investigated by the muom-spin-relaxation (µSR) method. In the Zn-substituted single-crystal with x = 0.21 and y = 0.01, where the high-T[sub c] superconductivity is anomalously suppressed, a coexisting state of statically ordered Cu-spins and localized holes has been found at low temperatures below about 2 K. The dynamical depolarization rate of the muon spin at 3.0 K has been found to be nearly proportional to minus-root-square of the external magnetic-field applied along the initial muon-spin polarization. This field-dependence can be explained by assuming the existence of an excited state of the Cu spins diffusing in a one-dimensional direction. The present study suggests a high possibility of the existence of a new one-dimensional stripe ordered state of the Cu spins and doped holes at x = 0.21 in the overdoped region of La[sub 2-x]Sr[sub x]Cu[sub 1-y]Zn[sub y]O[sub 4]. [ABSTRACT FROM AUTHOR]