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1. Welcome from the ACM IMX 2024 Chairs

Author

Rostami, A. (Asreen), McMillan, D. (Donald), Viola, I. (Irene), Nishida, J. (Jun), Hook, J. (Jonathan), Raviselvam, S. (Sujithra), Chan, S. (Samantha), Rostami, A. (Asreen), McMillan, D. (Donald), Viola, I. (Irene), Nishida, J. (Jun), Hook, J. (Jonathan), Raviselvam, S. (Sujithra), and Chan, S. (Samantha)

Published
2024
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11. Persistence of recipient-derived as well as donor-derived clones of cytomegalovirus pp65-specific cytotoxic T cells long after allogeneic hematopoietic stem cell transplantation

Author

Terasako-Saito, K., Nakasone, H., Tanaka, Y., Yamazaki, R., Sato, M., Sakamoto, K., Ishihara, Y., Kawamura, K., Akahoshi, Y., Hayakawa, J., Wada, H., Harada, N., Nakano, H., Kameda, K., Ugai, T., Yamasaki, R., Ashizawa, M., Kimura, S.-I., Kikuchi, M., Tanihara, A., Kanda, J., Kako, S., Nishida, J., and Kanda, Y.

Published
2014
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18. Comparison of responsiveness of the Japanese Society for Surgery of the Hand version of the carpal tunnel syndrome instrument to surgical treatment with DASH, SF-36, and physical findings

Author

Uchiyama, S., Imaeda, T., Toh, S., Kusunose, K., Sawaizumi, T., Wada, T., Okinaga, S., Nishida, J., Omokawa, S., for the Clinical Outcomes Committee of the Japanese Orthopaedic Association, and the Impairment Evaluation Committee of the Japanese Society for Surgery of the Hand

Published
2007
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42. Fasting gastric pH of Japanese subjects stratified by IgG concentration against Helicobacter pylori and pepsinogen status

Author

Kishikawa, H, Nishida, J, Ichikawa, H, Kaida, S, Takarabe, S, Matsukubo, T, Miura, S, Morishita, T, and Hibi, T

Subjects
Adult, Aged, 80 and over, Male, Gastric Juice, Helicobacter pylori, Fasting, Hydrogen-Ion Concentration, Middle Aged, Antibodies, Bacterial, Endoscopy, Gastrointestinal, Helicobacter Infections, Asian People, Gastric Mucosa, Immunoglobulin G, Pepsinogen A, Humans, Female, Atrophy, Early Detection of Cancer, Aged
Abstract

The clinical significance of Helicobacter pylori antibody titer has been controversial, and the association between the extent of gastric atrophy or acid secretion and H. pylori antibody concentration has not been elucidated.Serum pepsinogen, H. pylori antibody concentration, and fasting gastric pH (as an indicator of acid secretion) were measured in 231 patients undergoing upper gastrointestinal endoscopy. "Atrophic" pepsinogen was defined as pepsinogen-I70 ng/mL and pepsinogen-I/II ratio3. Other levels of pepsinogen were defined as "normal". Fasting gastric pH was analyzed in subjects stratified by pepsinogen level and by H. pylori antibody concentration.Helicobacter pylori antibody concentration showed no significant relationship with fasting gastric pH when all subjects were analyzed together. In H. pylori-seronegative subjects, fasting gastric pH was within the normal range, irrespective of the extent of mucosal atrophy. In H. pylori-seropositive subjects, H. pylori antibody concentration was positively correlated with fasting gastric pH in subjects with "normal" pepsinogen, but inversely correlated in those with "atrophic" pepsinogen. Particularly in subjects with low H. pylori antibody concentration and atrophic mucosa, a group reportedly at high risk of noncardia cancer, the most impaired acid secretion was shown among subjects with atrophic mucosa. The relationship between acid secretion and H. pylori antibody concentration differs depending on the presence of mucosal atrophy. Our findings provide a possible rationalization for measuring both serum pepsinogen levels and H. pylori antibody concentration in gastric cancer screening.

Published
2011

46. Single-cell T-cell receptor-β analysis of HLA-A*2402-restricted CMV- pp65-specific cytotoxic T-cells in allogeneic hematopoietic SCT

Author

Nakasone, H, primary, Tanaka, Y, additional, Yamazaki, R, additional, Terasako, K, additional, Sato, M, additional, Sakamoto, K, additional, Yamasaki, R, additional, Wada, H, additional, Ishihara, Y, additional, Kawamura, K, additional, Machishima, T, additional, Ashizawa, M, additional, Kimura, S-i, additional, Kikuchi, M, additional, Tanihara, A, additional, Kanda, J, additional, Kako, S, additional, Nishida, J, additional, and Kanda, Y, additional

Published
2013
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50. Of the GATA-binding proteins, only GATA-4 selectively regulates the human IL-5 gene promoter in IL-5 producing cells which express multiple GATA-binding proteins

Author

Yamagata, T., Nishida, J., Ryuichi Sakai, Tanaka, T., Yazaki, Y., and Hirai, H.

Subjects
Binding Sites, Base Sequence, Transcription, Genetic, T-Lymphocytes, Zinc Fingers, GATA3 Transcription Factor, Regulatory Sequences, Nucleic Acid, Transfection, Recombinant Proteins, Cell Line, GATA4 Transcription Factor, DNA-Binding Proteins, GATA2 Transcription Factor, Trans-Activators, Humans, Tetradecanoylphorbol Acetate, Interleukin-5, Promoter Regions, Genetic, Calcimycin, Repetitive Sequences, Nucleic Acid, Transcription Factors
Abstract

Interleukin-5 (IL-5) is produced by T lymphocytes and known to support B cell growth and eosinophilic differentiation of the progenitor cells. Using ATL-16T cells which express IL-5 mRNA, we have identified a region, within the human IL-5 gene promoter, that regulates IL-5 gene transcription. This cis-acting sequence contains the core binding motif, (A/T)GATA(A/G), for GATA-binding family proteins and thus suggests the involvement of these family members. In this report, we describe the cloning of human GATA-4 (hGATA-4) and show that hGATA-4 selectively interacts with the -70 GATA site within the IL-5 proximal promoter region. By promoter deletion and mutation analyses, we established this region as a positive regulatory element. Cotransfection experiments revealed that both hGATA-4 and PMA/A23187 stimulation are necessary for the IL-5 promoter activation. The requirement of another regulatory element called CLE0, which lies downstream of the -70 GATA site, was also demonstrated. ATL-16T cells express mRNA of three GATA-binding proteins, hGATA-2, hGATA-3 and hGATA-4, and each of them has a potential to bind to the consensus (A/T)GATA(G/ A) motif. However, using ATL-16T nuclear extract, we demonstrated that GATA-4 is the only GATA-binding protein that forms specific DNA-protein complex with the -70 GATA site. The electrophoretic mobility shift assay with extracts of COS cells expressing GATA-binding proteins showed that GATA-4 has the highest binding affinity to the -70 GATA site among the three GATA-binding proteins. When the transactivation ability was compared among the three, GATA-4 showed the highest activity. These results demonstrate the selective role of GATA-4 in the transcriptional regulation of the IL-5 gene in a circumstance where multiple members of the GATA-binding proteins are expressed.

Published
1997

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