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3. Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies

Author

Kamiya, M, Mizoguchi, F, Kawahata, K, Wang, D, Nishibori, M, Day, J, Louis, C, Wicks, IP, Kohsaka, H, Yasuda, S, Kamiya, M, Mizoguchi, F, Kawahata, K, Wang, D, Nishibori, M, Day, J, Louis, C, Wicks, IP, Kohsaka, H, and Yasuda, S

Abstract

Muscle cell death in polymyositis is induced by CD8+ cytotoxic T lymphocytes. We hypothesized that the injured muscle fibers release pro-inflammatory molecules, which would further accelerate CD8+ cytotoxic T lymphocytes-induced muscle injury, and inhibition of the cell death of muscle fibers could be a novel therapeutic strategy to suppress both muscle injury and inflammation in polymyositis. Here, we show that the pattern of cell death of muscle fibers in polymyositis is FAS ligand-dependent necroptosis, while that of satellite cells and myoblasts is perforin 1/granzyme B-dependent apoptosis, using human muscle biopsy specimens of polymyositis patients and models of polymyositis in vitro and in vivo. Inhibition of necroptosis suppresses not only CD8+ cytotoxic T lymphocytes-induced cell death of myotubes but also the release of inflammatory molecules including HMGB1. Treatment with a necroptosis inhibitor or anti-HMGB1 antibodies ameliorates myositis-induced muscle weakness as well as muscle cell death and inflammation in the muscles. Thus, targeting necroptosis in muscle cells is a promising strategy for treating polymyositis providing an alternative to current therapies directed at leukocytes.

Published
2022

11. Gender difference in tooth autotransplantation with complete root formation: a retrospective survey

Author

Yoshino, K., Ishizuka, Y., Sugihara, N., Kariya, N., Namura, D., Noji, I., Mitsuhashi, K., Kimura, H., Fukuda, A., Kikukawa, I., Hayashi, T., Yamazaki, N., Kimura, M., Tsukiyama, K., Yamamoto, K., Fukuyama, A., Hidaka, D., Shinoda, J., Mibu, H., Shimakura, Y., Saito, A., Ikumi, S., Umehara, K., Kamei, F., Fukuda, H., Toake, T., Takahashi, Y., Miyata, Y., Shioji, S., Toyoda, M., Hattori, N., Nishihara, H., Matsushima, R., Nishibori, M., Hokkedo, O., Nojima, M., Kimura, T., Fujiseki, M., Okudaira, S., Tanabe, K., Nakano, M., Ito, K., Kuroda, M., Fukai, K., and Matsukubo, T.

Published
2013
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12. Influence of age on tooth autotransplantation with complete root formation

Author

Yoshino, K., Kariya, N., Namura, D., Noji, I., Mitsuhashi, K., Kimura, H., Fukuda, A., Kikukawa, I., Hayashi, T., Yamazaki, N., Kimura, M., Tsukiyama, K., Yamamoto, K., Fukuyama, A., Hidaka, D., Shinoda, J., Mibu, H., Shimakura, Y., Saito, A., Ikumi, S., Umehara, K., Kamei, F., Fukuda, H., Toake, T., Takahashi, Y., Miyata, Y., Shioji, S., Toyoda, M., Hattori, N., Nishihara, H., Matsushima, R., Nishibori, M., Hokkedo, O., Nojima, M., Kimura, T., Fujiseki, M., Okudaira, S., Tanabe, K., Nakano, M., Ito, K., Kuroda, M., Takiguchi, T., Fukai, K., and Matsukubo, T.

Published
2013
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13. Comparison of prognosis of separated and non-separated tooth autotransplantation

Author

Yoshino, K., Kariya, N., Namura, D., Noji, I., Mitsuhashi, K., Kimura, H., Fukuda, A., Kikukawa, I., Hayashi, T., Yamazaki, N., Kimura, M., Tsukiyama, K., Yamamoto, K., Fukuyama, A., Hidaka, D., Shinoda, J., Mibu, H., Shimakura, Y., Saito, A., Ikumi, S., Umehara, K., Kamei, F., Fukuda, H., Toake, T., Takahashi, Y., Miyata, Y., Shioji, S., Toyoda, M., Hattori, N., Nishihara, H., Matsushima, R., Nishibori, M., Hokkedo, O., Nojima, M., Kimura, T., Fujiseki, M., Okudaira, S., Tanabe, K., Nakano, M., Ito, K., Kuroda, M., and Matsukubo, T.

Published
2013
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16. Risk factors affecting third molar autotransplantation in males: a retrospective survey in dental clinics

Author

YOSHINO, K., KARIYA, N., NAMURA, D., NOJI, I., MITSUHASHI, K., KIMURA, H., FUKUDA, A., KIKUKAWA, I., HAYASHI, T., YAMAZAKI, N., KIMURA, M., TSUKIYAMA, K., YAMAMOTO, K., FUKUYAMA, A., HIDAKA, D., SHINODA, J., MIBU, H., SHIMAKURA, Y., SAITO, A., IKUMI, S., UMEHARA, K., KAMEI, F., FUKUDA, H., TOAKE, T., TAKAHASHI, Y., MIYATA, Y., SHIOJI, S., TOYODA, M., HATTORI, N., NISHIHARA, H., MATSUSHIMA, R., NISHIBORI, M., HOKKEDO, O., NOJIMA, M., KIMURA, T., FUJISEKI, M., OKUDAIRA, S., TANABE, K., NAKANO, M., ITO, K., KURODA, M., and MATSUKUBO, T.

Published
2012
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18. A retrospective survey of autotransplantation of teeth in dental clinics

Author

YOSHINO, K., KARIYA, N., NAMURA, D., NOJI, I., MITSUHASHI, K., KIMURA, H., FUKUDA, A., KIKUKAWA, I., HAYASHI, T., YAMAZAKI, N., KIMURA, M., TSUKIYAMA, K., YAMAMOTO, K., FUKUYAMA, A., HIDAKA, D., SHINODA, J., MIBU, H., SHIMAKURA, Y., SAITO, A., IKUMI, S., UMEHARA, K., KAMEI, F., FUKUDA, H., TOAKE, T., TAKAHASHI, Y., MIYATA, Y., SHIOJI, S., TOYODA, M., HATTORI, N., NISHIHARA, H., MATSUSHIMA, R., NISHIBORI, M., HOKKEDO, O., NOJIMA, M., KIMURA, T., FUJISEKI, M., OKUDAIRA, S., TANABE, K., NAKANO, M., ITO, K., KURODA, M., and MATSUKUBO, T.

Published
2012
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36. Narrow-band Imaging System with Magnifying Endoscopy for Early Oral Cancer

Author

Yoshino, K, Ishizuka, Y, Sugihara, N, Kariya, N, Namura, D, Noji, I, Mitsuhashi, K, Kimura, H, Fukuda, A, Kikukawa, I, Hayashi, T, Yamazaki, N, Kimura, M, Tsukiyama, K, Yamamoto, K, Fukuyama, A, Hidaka, D, Shinoda, J, Mibu, H, Shimakura, Y, Saito, A, Ikumi, S, Umehara, K, Kamei, F, Fukuda, H, Toake, T, Takahashi, Y, Miyata, Y, Shioji, S, ToyodaM, Hattori, N, Nishihara, H, Matsushima, R, Nishibori, M, Hokkedo, O, Nojima, M, Kimura, T, Fujiseki, M, Okudaira, STanabe, K, Nakano, M, Ito, K, Kuroda, M, Takiguchi, T, Fukai, K, and Matsukubo, T

Published
2014

37. Procedures for treating spaces vacated by loss of transplanted teeth

Author

Yoshino, K, Kariya, N, Namura, D, Noji, I, Mitsuhashi, K, Kimura, H, Fukuda, A, Kikukawa, I, Hayashi, T, Yamazaki, N, Kimura, M, Tsukiyama, K, Yamamoto, K, Fukuyama, A, Hidaka, D, Shinoda, J, Mibu, H, Shimakura, Y, Saito, A, Ikumi, S, Umehara, K, Kamei, F, Fukuda, H, Toake, T, Takahashi, Y, Miyata, Y, Shioji, S, Toyoda, M, Hattori, N, Nishihara, H, Matsushima, R, Nishibori, M, Hokkedo, O, Nojima, M, Kimura, T, Fujiseki, M, Okudaira, S, Tanabe, K, Nakano, M, Ito, K, Kuroda, M, and Matsukubo, T.

Published
2013

38. Survival rate in autotransplanted premolars with complete root formation: a retrospective clinical survey

Author

Yoshino, K, Kariya, N, Namura, D, Noji, I, Mitsuhashi, K, Kimura, H, Fukuda, A, Kikukawa, I, Hayashi, T, Yamazaki, N, Kimura, M, Tsukiyama, K, Yamamoto, K, Fukuyama, A, Hidaka, D, Shinoda, J, Mibu, H, Shimakura, Y, Saito, A, Ikumi, S, Umehara, K, Kamei, F, Fukuda, H, Toake, T, Takahashi, Y, Miyata, Y, Shioji, S, Toyoda, M, Hattori, N, Nishihara, H, Matsushima, R, Nishibori, M, Hokkedo, O, Nojima, M, Kimura, T, Fujiseki, M, Okudaira, S, Tanabe, K, Nakano, M, Ito, K, Kuroda, M, Takiguchi, T, Fukai, K, and Matsukubo, T.

Published
2013

39. High mobility group box 1 complexed with heparin induced angiogenesis in a matrigel plug assay

Author

Wake, H., Mori, S., Liu, K., Hideo Takahashi, and Nishibori, M.

Subjects
Male, Vascular Endothelial Growth Factor A, HMGB1, Tumor Necrosis Factor-alpha, Neovascularization, Physiologic, chemical and pharmacologic phenomena, heparin, Matrix Metalloproteinases, Mice, Inbred C57BL, Drug Combinations, Mice, angiogenesis, Implants, Experimental, Animals, Cytokines, Proteoglycans, Collagen, Fibrinolysin, Laminin, RNA, Messenger, HMGB1 Protein
Abstract

Angiogenesis involves complex processes mediated by several factors and is associated with inflammation and wound healing. High mobility group box 1 (HMGB1) is released from necrotic cells as well as macrophages and plays proinflammatory roles. In the present study, we examined whether HMGB1 would exhibit angiogenic activity in a matrigel plug assay in mice. HMGB1 in combination with heparin strongly induced angiogenesis, whereas neither HMGB1 nor heparin alone showed such angiogenic activity. The heparin-dependent induction of angiogenesis by HMGB1 was accompanied by increases in the expression of tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor-A120 (VEGF-A120). It is likely that the dependence of the angiogenic activity of HMGB1 on heparin was due to the efficiency of the diffusion of the HMGB1-heparin complex from matrigel to the surrounding areas. VEGF-A165 possessing a heparin-binding domain showed a pattern of heparin-dependent angiogenic activity similar to that of HMGB1. The presence of heparin also inhibited the degradation of HMGB1 by plasmin in vitro. Taken together, these results suggested that HMGB1 in complex with heparin possesses remarkable angiogenic activity, probably through the induction of TNF-alpha and VEGF-A120.

Published
2009

40. Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column

Author

Nishibori, M., Hideo Takahashi, Katayama, H., Mori, S., Saito, S., Iwagaki, H., Tanakac, N., Morita, K., and Ohtsuka, A.

Subjects
polymixin B-immobilized column, monocyte, septic shock, adsorptive removal
Abstract

Lipopolysaccharide (LPS) is one of the major causes of septic shock. The polymyxin B-immobilized filter column (PMX) was developed for the adsorption of endotoxin by direct hemoperfusion and has been used for the treatment of LPS-induced septic shock. In this study, we demonstrated that PMX also specifically bound monocytes from the peripheral blood leukocytes of septic patients by mean of an analysis of bound cells using immunocytochemical and electron microscopic techniques. The specific removal of monocytes from septic patients may produce beneficial effects by reducing the interaction between monocytes and functionally associated cells including vascular endothelial cells.

Published
2009

42. Complete nucleotide sequence of the Coturnix chinensis (blue-breasted quail) mitochondrial genome and a phylogenetic analysis with related species

Author

Nishibori, M., Tsudzuki, M., Hayashi, T., Yamamoto, Y., and Yasue, H.

Subjects
Cladistic analysis -- Research, Mitochondrial diseases -- Research, Nucleotide sequence -- Research, Genetic research, Biological sciences
Abstract

A study on the phylogenetic analysis of the genome of the Coturnix chinensis (blue-breasted quail) with related species is lined out. The results revealed that blue breasted quail and the Coturnix japonica (Japanese quail) belonged to the same family tribe.

Published
2002

45. Solvent free oxidative coupling polymerization of 3-hexylthiophene (3HT) in the presence of FeCl3 particles

Author

Hirai, T., primary, Nagae, Y., additional, White, K. L., additional, Kamitani, K., additional, Kido, M., additional, Uchiyama, T., additional, Nishibori, M., additional, Konishi, Y., additional, Yokomachi, K., additional, Sugimoto, R., additional, Saigo, K., additional, Ohishi, T., additional, Higaki, Y., additional, Kojio, K., additional, and Takahara, A., additional

Published
2016
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48. Detection of <italic>APAF1</italic> mutation in Holstein cows and mummified foetuses in Japanese dairy herds.

Author

Ghanem, M. E., Nishibori, M., Isobe, N., and Hisaeda, K.

Subjects
*COWS, *GENETIC mutation, *ARTIFICIAL insemination, *PROGESTERONE, *MUMMIFIED animals, *REPRODUCTION
Abstract

Contents: Some of the highest genetic merit sires have been shown to harbour recessive mutations affecting fertility, which may spread rapidly in the population through AI. These disorders may result in abortion and decline in pregnancy per insemination in cows. This study was carried out on 240 Holstein‐Friesian cows and 15 mummified foetuses. Blood and tissue samples were collected from the cows and mummified foetuses, respectively, for DNA extraction. Allele‐specific PCR was designed for the detection of the cows and foetuses carrying the nonsense mutation (C/T) in apoptosis peptide activating factor 1 gene (APAF1). The mutant allele frequency of the APAF1 in carrier cows and mummified foetuses was calculated. Milk samples were taken from the carrier and non‐carrier cows for progesterone assay. The allele‐specific PCR reaction efficiently distinguished the C/T mutation in APAF1. Of 240 cows, seven cows (2.9%) were diagnosed to carry one copy of the mutant allele of APAF1. However, the carrier frequency was 33.3% in mummified foetuses (five of 15). The mutant allele frequency was 0.02 and 0.17 in the cows and mummified foetuses, respectively. Concentrations of progesterone did not differ between cows with APAF1 mutation and non‐carrier cows during 45 days post‐insemination. This study provided allele‐specific PCR for the detection of APAF1 mutation in cows. Moreover, it reports the carrier and mutant allele frequencies of APAF1 in dairy cows and mummified foetuses in Japan. [ABSTRACT FROM AUTHOR]

Published
2018
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49. ヒトリンパ球混合培養反応における、AGE誘導性接着分子発見、サイトカイン産生、リンパ球増殖に対するヒスタミンの抑制効果の検討

Author

Zhang, J, Takahashi, HK, Liu, K, Wake, H, Liu, R, Sadamori, H, Matsuda, H, Yagi, T, Yoshino, T, Mori, S, and Nishibori, M

Subjects
Glycation End Products, Advanced, Dose-Response Relationship, Drug, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Intercellular Adhesion Molecule-1, Research Papers, Cyclic AMP-Dependent Protein Kinases, Monocytes, Interferon-gamma, Cyclic AMP, Humans, Receptors, Histamine H2, Lymphocytes, Cell Proliferation, Histamine
Abstract

Post-transplant diabetes mellitus is a frequent complication among transplant recipients. Ligation of advanced glycation end products (AGEs) with their receptor on monocytes/macrophages plays important roles in the genesis of diabetic complications. The enhancement of adhesion molecule expression on monocytes/macrophages activates T-cells, reducing allograft survival. Out of four distinct AGE subtypes (AGE-2, AGE-3, AGE-4 and AGE-5), only AGE-2 and AGE-3 induced expression of intercellular adhesion molecules (ICAMs), output of cytokines and proliferation of lymphocytes, during the mixed lymphocyte reaction (MLR). Here we have assessed the role of histamine in the actions of AGEs during the MLR.Human peripheral blood cells were used in these experiments. Flow cytometry was used to examine the expression of the ICAM-1, B7.1, B7.2 and CD40. Production of the cytokine interferon-gamma, and levels of cAMP were determined by elisa. Lymphocyte proliferation was determined by [(3)H]-thymidine uptake.Histamine concentration dependently inhibited the action of AGE-2 and AGE-3. The actions of histamine were antagonized by an H(2)-receptor antagonist, famotidine, and mimicked by H(2)/H(4)-receptor agonists, dimaprit and 4-methylhistamine. The effects of histamine were reversed by a protein kinase A (PKA) inhibitor, H89, and mimicked by dibutyryl cAMP and an adenylate cyclase activator, forskolin.Histamine down-regulated AGE-2- and AGE-3-induced expression of adhesion molecules, cytokine production and lymphocyte proliferation via histamine H(2) receptors and the cAMP/PKA pathway.

Published
2010

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