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5. Abstracts of short lectures

Author

Rauwald, H. W., Conner, J., Gray, A., Reynolds, T., Waterman, P., Hartmann, T., Adolph, R. -D., Ehmke, A., Sander, H., Toppel, G., Witte, L., Nyiredy, Sz., Sticher, O., Erdelmeier, C. A. J., van Leeuwen, P. A. S., Kinghorn, A. D., Dallenbach-Tölke, K., Wink, M., Hennessy, Deirdre, Hook, Ingrid, Sheridan, Helen, Mersinger, R., Dornauer, H., Reinhard, E., Heide, L., Tabata, M., Knobloch, K., Jansen, H., Müller, B., Adzet, T., Vila, R., Cañigueral, S., Budzianowski, J., Bachmann, P., Czygan, F. -C., de Witte, P., Lemli, J., 't Hart, L. A., van Enckevort, P. H., Labadie, R. P., van der Heijden, R., de Keyzer, H. H. M., Verhey, E. R., Schripsema, J., Harkes, P. A. A., Verpoorte, R., Svendsen, A. Baerheim, Croom, Jr., E. M., Letchamo, W., Vömel, A., Bauer, R., Wray, V., Wagner, H., Marston, A., Hostettmann, K., Andersson, L., Bohlin, L., Iorizzi, M., Riccio, R., Minale, L., Moreno-Lopez, J., van Beek, T. A., van Bokhoven, H., Kraus, J., Blaschek, W., Franz, G., van den Berg, A. J. J., Radema, M. H., Corthout, J., Pieters, L., Claeys, M., Vanden Berghe, D., Vlietinck, A. J., Dungen, F. M. v. d., Vermeulen, N. P. E., Fischer, F. C., Gijbels, M. J. H., Caspers, P. W. J., Gijbels, M. J. M., Fung, S. Y., Herrebout, W. M., van Gelder, W. M. J., van der Graaf, G. M., Pennings, E. J. M., Huizer, H., van Zuilen, K., Kosasi, S., van der Leer, T., ten Hoope, S. M., van der Nat, J. M., van der Sluis, W. G., Bosch, R. v. d., Duine, J. A., Heijden, R. v. d., Leer, T. v. d., Pieters, L. A., Totté, J., Saleh, M. M., Abbas, R. Z., Zwaving, J. H., Sarer, E., Looman, A., Scheffer, J. J. C., Meijer, A. H., Langezaal, C. R., Simons, J. M., Hoof, L. Van, Vanden Berghe, D. A., Woerdenbag, H. J., Hendriks, H., van der Berg, K., van Stralen, R., Malingré, Th. M., Konings, A. W. T., Lemstra, W., Abdo, S., De Bernardi, M., Marinoni, G., Samaniego, S., Mellerio, G., Vidari, G., Adjibadé, Y., Kuballa, B., Cabalion, P., Anton, R., Ibáñez, C., Monasterio, I., Ayoub, S. M. Hussein, Yankov, L. K., Ovtcharov, R. O., Bartsch, C., BaŞaran, A. A., Calis, I., Nishibe, S., Berger, S., Junior, P., Kopanski, L., Beuscher, N., Billeter, M., Meier, B., Döll, M., Braunewell, H., Skrzypczak, L., Wesolowska, M., Gross, G. A., Winkler, T., Colombo, M. L., Tome, F., Crespi-Perellino, N., Guicciardi, A., Minghetti, A., Speroni, E., Vincieri, F., Vita-Finzi, P., Gabetta, B., Scilingo, A., Dorsaz, A. C., Hostettmann, M., Ebert, M., Economou, D., Nahrstedt, A., Schiebel, H. -M., McDowell, M., Eich, E., Kohaupt, G., Stopp, K., Maidhof, A., Müller, W. E. G., Schade, P., Müllen, K., Eilert, U., Wolters, B., El Tanbouly, N., Beck, J. P., Hanna, S., El Alfy, T., Ersöz, T., Chulia, A. J., Garcia, J., Frahm, A. W., Beutner, D., Gautier, P., Shongo, D., Vekemans, X., Van Koninckxloo, M., Van Haelen, M., Lefébvre, C., Gehrmann, B., Kraus, Lj., Giger, E., Baumann, T. W., Heinzer, F., Meusy, J. -P., Chavanne, M., Glombitza, K. -W., Knöss, W., Deutscher, B., Piepenbrink, G., Peter, J., Greinwald, R., Schultze, W., Gundidza, Mazuru, Hölzl, J., Hess, S., Holm, Y., Aho, E., Holopainen, M., Järvelä, K., Seppänen, T., von Schantz, M., Huhtikangas, A., Lapinjoki, S., Veräjänkorva, H., Heiskanen, J., Kauppinen, V., Lounasmaa, M., Huovinen, K., Härmälä, P., Ottoila, P., Jerga, Chr, Merfort, I., Willuhn, G., Jiménez, A., Manez, S., Villar, A., Kahlos, K., Kiviranta, J., Karppanen, H., Huovinen, H., Koch, A., Kreis, H., May, U., Kuštrak, P., Pepeljnjak, S., Antolić, A., Blažević, N., Laakso, I., Ekundayo, O., Oguntimein, B., Lorentzen, Bente, Rørdam, Anne Marie, Madaus, A., Marcinek, Chr, Martinelli, E. M., Seraglia, R., Briquez, M., Reginault, P., Máthé, Jr., I., Máthé, I., Máthé, A., Meiss, P., Meng, Qingchang, Zhu, Naijue, Chen, Weixin, Miething, H., Seger, V., Hänsel, R., Neuhöfer, H., Lurz, G., Noller, P., Oksman-Caldentey, K. -M., Vuorela, H., Isenegger, M., Strauss, A., Pachaly, P., Adnan, A. Z., Lansing, A., Sin, K. S., Pauli, A., Payá, M., Ivorra, M. D., Poginsky, B., Westendorf, J., Marquardt, H., Potterat, O., Stoeckli-Evans, H., Msonthi, J. D., Randriaminahy, M., Proksch, P., Reher, G., Samochowiec, L., Wójcicki, J., Kadlubowska, D., Kownacka, A., Şarer, E., Sayron-Atasü, E., Cihangir, V., Schmaus, G., Kubeczka, K. -H., Schütz, M., Schulz, G., Stahl-Biskup, E., Seidel, S., Sepasgosarian, J., Laitalainen, T., Światek, L., Grabias, B., Tanker, M., Kurucu, S., Tanker, N., Thron, U., Reichling, J., Martin, R., Vargas, D., Dominguez, X. A., Vollmann, C., Pernilä, H., Nystrand, N., Hinkkanen, R., Walker, J. R. L., Cole, A. L. J., Warncke, D., Kadlubowska, P., Ziegler, S. J., and Zogg, G.

Published
1987
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7. Surface Passivation: Layer Qualification Using Quantox

Author

Rothschild, A., Nishibe, S., Cui, J., Zhu, N., Debucquoy, M., Mamagkakis, S., Nagaswami, V., and John, J.

Subjects
Wafer-based Silicon Solar Cells and Materials Technology, Silicon Solar Cell Characterisation and Modelling
Abstract

26th European Photovoltaic Solar Energy Conference and Exhibition; 1418-1422, It has already been proven that Al2O3 can provide a high level of surface passivation for p and n-type crystalline silicon (c-Si) [1-4]. The passivation mechanism is considered to be related to two components: low interfacial trap density (Dit) and high amount of negative fixed charges (Qf), which induce a built-in electric field. In order to get understanding on the electrical and process parameters which govern the passivation quality, a Corona charging tool was employed. This technique enables to bring together spatially resolved information on charges and carrier lifetime. Furthermore, the injection level can be tuned, which allows decoupling the bulk and surface contribution in the carrier lifetime measurement. Two main process parameters: the Al2O3 thickness and the post deposition anneal were varied to evaluate the sensitivity of the technique. The carrier lifetime information extracted from the “Quantox” shows to be consistent with the one extracted by QSSPC-PL measurements. As a result, the “Quantox” tool appears to be an appropriate tool for solar applications in order to study the quality of any passivation layers and Al 2O3 in particular.

Published
2011
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8. In vitro metabolism of sesamin, a sesame seed lignin

Author

Heinonen, S.-M., Penalvo, J. L., Nurmi, T., Aura, Anna-Marja, Poutanen, Kaisa, Deyama, T., Nishibe, S., and Adlercreutz, H.

Subjects
SDG 3 - Good Health and Well-being
Abstract

IN VITRO METABOLISM OF SESAMIN, A SESAME SEED LIGNAN Sesame seed is a rich source of plant lignans, especially sesamin. This compound has been shown to exert several physiological activities, including anti-oxidative, anti-carcinogenic, blood pressure-lowering, and serum lipid lowering activities. However, the metabolism of sesamin has not been studied in detail and thus the nature of the active compounds behind the beneficial properties has not been fully established. In this study the in vitro metabolism of sesamin was investigated by fermenting pure standard with human fecal inoculum (5%) for 24 hours. The freeze-dried fermentation samples were extracted with diethyl ether and further purified with chromatography on Lipidex 5000. The metabolites of sesamin were identified by GC-MS with authentic reference compounds or by interpretation of mass spectra of trimethylsilylated derivatives. Five metabolites were identified in fecal fermentation extracts of sesamin: mammalian lignans enterolactone and enterodiol, and metabolites S1, S2 and S3. The identification of the metabolites by GC-MS is presented and the possible metabolic route of sesamin to mammalian lignans is proposed. It is concluded that sesamin is an important precursor of mammalian lignans, and sesame seeds are good sources of enterolactone, high plasma and urinary levels of which have been associated with a decreased risk of certain cancers and cardiovascular disease.

Published
2003

16. Phenylethanoid glycosides from Digitalis ferruginea subsp ferruginea (=D-aurea LINDLEY) (Scrophulariaceae)

Author

Calis, I., Tasdemir, Deniz, Sticher, O., Nishibe, S., Calis, I., Tasdemir, Deniz, Sticher, O., and Nishibe, S.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option

Published
1999
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19. Medical Screening of Subjects for Acceleration and Positive Pressure Breathing La Surveillance Medicale des Sujets Relative aux Accelerations et a la Surpression Ventilatoire)

Author

ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT NEUILLY-SUR-SEINE (FRAN CE), Gray, G., Bateman, W., Clere, J. M., Tachibana, S., Nishibe, S., ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT NEUILLY-SUR-SEINE (FRAN CE), Gray, G., Bateman, W., Clere, J. M., Tachibana, S., and Nishibe, S.

Abstract

The AGARD Aerospace Medical Panel sponsored a Workshop on the Medical Surveillance of Subjects for Acceleration Research. There remain unanswered questions about the possible long-term medical complications of repetitive exposure to G forces. The concept underlying the Workshop was that subjects for acceleration research form a highly medically screened cohort in whom medical concerns about G exposure might be addressed by pooling data. Workshop participants from Canada, France, Germany, Japan, the Netherlands, Poland, Sweden, the UK, and the US Navy and USAF, presented the current procedures in place for the medical screening of acceleration subjects. The outcomes of the Workshop included a consensus protocol for medical screening of subjects for acceleration research, and a protocol for a database to track medical occurrences of NATO centrifuges.

Published
1997

30. Increase of the catalytic activity of phospholipase C-gamma1 by tyrosine phosphorylation.

Author

Nishibe, S. and Wahl, M.I.

Subjects
*BIOCHEMISTRY
Abstract

Reports on research into the ability of tyrosine phosphorylation to activate the catalytic activity of phospholipase C-gamma1 (PLC-gamma1). Role of PLC-gamma1; Effects of epidermal growth factor; Increased catalytic activity; Decreased activity after treatment with tyrosine-specific phosphatase; Possible role of PLC-gamma1's catalytic activation.

Published
1990
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33. Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells

Author

Wahl, M I, Olashaw, N E, Nishibe, S, Rhee, S G, Pledger, W J, and Carpenter, G

Abstract

Platelet-derived growth factor (PDGF) stimulates the proliferation of quiescent fibroblasts through a series of events initiated by activation of tyrosine kinase activity of the PDGF receptor at the cell surface. Physiologically significant substrates for this or other growth factor receptor or oncogene tyrosine kinases have been difficult to identify. Phospholipase C (PLC), a key enzyme of the phosphoinositide pathway, is believed to be an important site for hormonal regulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate, which produces the intracellular second-messenger molecules inositol 1,4,5-trisphosphate and 1,2-diacylglycerol. Treatment of BALB/c 3T3 cells with PDGF led to a rapid (within 1 min) and significant (greater than 50-fold) increase in PLC activity, as detected in eluates of proteins from a phosphotyrosine immunoaffinity matrix. This PDGF-stimulated increase in phosphotyrosine-immunopurified PLC activity occurred for up to 12 h after addition of growth factor to quiescent cells. Interestingly, the PDGF stimulation occurred at 3 as well as 37 degrees C and in the absence or presence of extracellular Ca2+. Immunoprecipitation of cellular proteins with monoclonal antibodies specific for three distinct cytosolic PLC isozymes demonstrated the presence of a 145-kilodalton isozyme, PLC-gamma (formerly PLC-II), in BALB/c 3T3 cells. Furthermore, these immunoprecipitation studies showed that PLC-gamma is rapidly phosphorylated on tyrosine residues after PDGF stimulation. The results suggest that mitogenic signaling by PDGF is coincident with tyrosine phosphorylation of PLC-gamma.

Published
1989
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34. Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

Author

Wahl, M I, Nishibe, S, Suh, P G, Rhee, S G, and Carpenter, G

Abstract

Epidermal growth factor (EGF) rapidly stimulates the formation of inositol 1,4,5-trisphosphate in a variety of cell types. Previously we have found that in intact cells stimulation of phospholipase C (PLC) activity by EGF is correlated with the retention of increased amounts of PLC activity by a phosphotyrosine immunoaffinity matrix, suggesting that the EGF-receptor tyrosine kinase phosphorylates PLC. We now define parameters of the mechanism by which EGF addition to A-431 cells stimulates phosphotyrosine immunoisolation of PLC activity and demonstrate that EGF addition to A-431 cells increases tyrosine phosphorylation of PLC. EGF rapidly and reversibly stimulated the anti-phosphotyrosine recovery of increased PLC activity when cells were treated with growth factor at 3 degrees C, indicating that receptor internalization is not required and that the phosphorylation event occurs prior to formation of inositol 1,4,5-trisphosphate. Also, the EGF stimulation of anti-phosphotyrosine recovery of PLC activity occurred in the absence of extracellular Ca2+. Stimulation of PLC activity in intact cells by other agonists, such as bradykinin or ATP, did not result in increased anti-phosphotyrosine recovery of PLC activity, suggesting two separate mechanisms exist in A-431 cells for hormone-stimulated formation of inositol phosphates. Finally, using monoclonal antibodies that specifically recognize three distinct PLC isozymes, we show that an approximately 145-kDa PLC isozyme (PLC-II) is present in A-431 cells and that EGF treatment of A-431 cells stimulates phosphorylation of PLC-II on both tyrosine and serine residues.

Published
1989
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35. Tyrosine Phosphorylation of Phospholipase C-II in Vitroby the Epidermal Growth Factor Receptor

Author

Nishibe, S, Wahl, M I, Rhee, S G, and Carpenter, G

Abstract

In a number of cell lines, epidermal growth factor (EGF) rapidly stimulates the breakdown of inositol phospholipids. Phosphatidylinositol-specific phospholipase C (PLC), therefore, plays an important role in this biological response to EGF, but the mechanism by which EGF-receptor complexes modulate the activation of PLC is not understood. We have previously suggested that tyrosine phosphorylation of PLC or an unknown PLC-associated protein by the EGF receptor is involved in the activation process (Wahl, M. I., Daniel, T. O., and Carpenter, G. (1988) Science241, 968–970) and have recently shown by immunoprecipitation that the addition of EGF to 32P-labeled cells increases tyrosine and serine phosphorylation of PLC-II (Wahl, M. I., Nishibe, S., Suh, P.-G., Rhee, S. G., and Carpenter, G. (1989) Proc. Natl. Acad. Sci. U. S. A.86,1568–1572). In this communication we demonstrate that PLC-II (Mr= 145,000) purified from bovine brain can be phosphorylated in vitroin an EGF-dependent manner by the tyrosine kinase activity of the purified EGF receptor. While PLC-II is an efficient phosphorylation substrate for the purified EGF receptor, PLC-I is a poor substrate and PLC-IH is not phosphorylated to any detectable extent. Though all three PLC isozymes possess typical tyrosine phosphorylation sequences, the EGF receptor is surprisingly selective in vitrofor the phosphorylation of PLC-II. High performance liquid chromatography comparison of tryptic phosphotyrosyl peptides from PLC-II phosphorylated in vivoand in vitroindicated a similar pattern of multiple tyrosine phosphorylation sites. These findings show that the EGF receptor can directly phosphorylate PLC-II in an efficient and selective manner.

Published
1989
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45. Arctigenin-4′-β-gentiobioside from Trachelospermum asiaticum var. intermedium.

Author

Nishibe, S., Hisada, S., and Inagaki, I.

Abstract

Copyright of Experientia is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1973
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