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2,177 results on '"Nishi, T."'

1. Validation and Improvement of the Saga Fall Risk Model: A Multicenter Retrospective Observational Study

Author

Tago M, Hirata R, Katsuki NE, Nakatani E, Tokushima M, Nishi T, Shimada H, Yaita S, Saito C, Amari K, Kurogi K, Oda Y, Shikino K, Ono M, Yoshimura M, Yamashita S, Tokushima Y, Aihara H, Fujiwara M, and Yamashita SI

Subjects
accidental falls, inpatients, validation study, accident prevention, Geriatrics, RC952-954.6
Abstract

Masaki Tago,1 Risa Hirata,1 Naoko E Katsuki,1 Eiji Nakatani,2 Midori Tokushima,1 Tomoyo Nishi,1 Hitomi Shimada,3 Shizuka Yaita,1 Chihiro Saito,4 Kaori Amari,5 Kazuya Kurogi,6 Yoshimasa Oda,7 Kiyoshi Shikino,8,9 Maiko Ono,10 Mariko Yoshimura,11 Shun Yamashita,1 Yoshinori Tokushima,1 Hidetoshi Aihara,1 Motoshi Fujiwara,1 Shu-ichi Yamashita1 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan; 3Shimada Hospital of Medical Corporation Chouseikai, Saga, Japan; 4Shizuoka General Hospital, Shizuoka, Japan; 5Department of Emergency Medicine, Saga-Ken Medical Centre Koseikan, Saga, Japan; 6Department of General Medicine, National Hospital Organization Ureshino Medical Center, Saga, Japan; 7Department of General Medicine, Yuai-Kai Foundation and Oda Hospital, Saga, Japan; 8Department of General Medicine, Chiba University Hospital, Chiba, Japan; 9Department of Community-Oriented Medical Education, Chiba University Graduate School of Medicine, Chiba, Japan; 10Department of General Medicine, Karatsu Municipal Hospital, Saga, Japan; 11Safety Management Section, Saga University Hospital, Saga, JapanCorrespondence: Masaki Tago, Department of General Medicine, Saga University Hospital, 5-1-1 Nabeshima, Saga, 849-8501, Japan, Tel +81 952 34 3238, Fax +81 952 34 2029, Email tagomas@cc.saga-u.ac.jpPurpose: We conducted a pilot study in an acute care hospital and developed the Saga Fall Risk Model 2 (SFRM2), a fall prediction model comprising eight items: Bedriddenness rank, age, sex, emergency admission, admission to the neurosurgery department, history of falls, independence of eating, and use of hypnotics. The external validation results from the two hospitals showed that the area under the curve (AUC) of SFRM2 may be lower in other facilities. This study aimed to validate the accuracy of SFRM2 using data from eight hospitals, including chronic care hospitals, and adjust the coefficients to improve the accuracy of SFRM2 and validate it.Patients and Methods: This study included all patients aged ≥ 20 years admitted to eight hospitals, including chronic care, acute care, and tertiary hospitals, from April 1, 2018, to March 31, 2021. In-hospital falls were used as the outcome, and the AUC and shrinkage coefficient of SFRM2 were calculated. Additionally, SFRM2.1, which was modified from the coefficients of SFRM2 using logistic regression with the eight items comprising SFRM2, was developed using two-thirds of the data randomly selected from the entire population, and its accuracy was validated using the remaining one-third portion of the data.Results: Of the 124,521 inpatients analyzed, 2,986 (2.4%) experienced falls during hospitalization. The median age of all inpatients was 71 years, and 53.2% were men. The AUC of SFRM2 was 0.687 (95% confidence interval [CI]:0.678– 0.697), and the shrinkage coefficient was 0.996. SFRM2.1 was created using 81,790 patients, and its accuracy was validated using the remaining 42,731 patients. The AUC of SFRM2.1 was 0.745 (95% CI: 0.731– 0.758).Conclusion: SFRM2 showed good accuracy in predicting falls even on validating in diverse populations with significantly different backgrounds. Furthermore, the accuracy can be improved by adjusting the coefficients while keeping the model’s parameters fixed.Keywords: accidental falls, inpatients, validation study, accident prevention

Published
2024

4. Novel multi-layer plastic-scintillator-based solid active proton target for inverse-kinematics experiments

Author

Tran, D. T., Terashima, S., Ong, H. J., Hirakawa, K., Matsuda, Y., Aoi, N., Harakeh, M. N., Itoh, M., Kawabata, T., Kohda, A., Matsumoto, S. Y., Nishi, T., Okamoto, J., and Tanihata, I.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment, Physics - Accelerator Physics
Abstract

We have constructed and tested a novel plastic-scintillator-based solid-state active proton target for use in nuclear spectroscopic studies with nuclear reactions induced by an ion beam in inverse kinematics. The active target system, named Stack Structure Solid organic Scintillator Active Target (S4AT), consists of five layers of plastic scintillators, each with a 1-mm thickness. To determine the reaction point in the thickness direction, we exploit the difference in the energy losses due to the beam particle and the charged reaction product(s) in the scintillator material. S4AT offers the prospect of a relatively thick target while maintaining a good energy resolution. By considering the relative energy loss between different layers, the energy loss due to unreacted beam particles can be eliminated. Such procedure, made possible by the multi-layer structure, is essential to eliminate the effect of unreacted accompanying beam particles, thus enabling its operation at a moderate beam intensity of up to a few Mcps. We evaluated the performance of S4AT by measuring the elastic proton-proton scattering using a 70-MeV proton beam at Cyclotron and Radioisotope Center (CYRIC), Tohoku University., Comment: 32 pages, 14 figures

Published
2019
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5. Spectroscopy of pionic atoms in $\mathbf{{}^{122}{\textbf Sn}({\textit d},{}^3{\textbf He})}$ reaction and angular dependence of the formation cross sections

Author

Nishi, T., Itahashi, K., Berg, G. P. A., Fujioka, H., Fukuda, N., Fukunishi, N., Geissel, H., Hayano, R. S., Hirenzaki, S., Ichikawa, K., Ikeno, N., Inabe, N., Itoh, S., Iwasaki, M., Kameda, D., Kawase, S., Kubo, T., Kusaka, K., Matsubara, H., Michimasa, S., Miki, K., Mishima, G., Miya, H., Nagahiro, H., Nakamura, M., Noji, S., Okochi, K., Ota, S., Sakamoto, N., Suzuki, K., Takeda, H., Tanaka, Y. K., Todoroki, K., Tsukada, K., Uesaka, T., Watanabe, Y. N., Weick, H., Yamakami, H., and Yoshida, K.

Subjects
Nuclear Experiment
Abstract

We observed the atomic $1s$ and $2p$ states of $\pi^-$ bound to ${}^{121}{\rm Sn}$ nuclei as distinct peak structures in the missing mass spectra of the ${}^{122}{\rm Sn}(d,{}^3{\rm He})$ nuclear reaction. A very intense deuteron beam and a spectrometer with a large angular acceptance let us achieve potential of discovery, which includes capability of determining the angle-dependent cross sections with high statistics. The $2p$ state in a Sn nucleus was observed for the first time. The binding energies and widths of the pionic states are determined and found to be consistent with previous experimental results of other Sn isotopes. The spectrum is measured at finite reaction angles for the first time. The formation cross sections at the reaction angles between 0 and $2^\circ$ are determined. The observed reaction-angle dependence of each state is reproduced by theoretical calculations. However, the quantitative comparison with our high-precision data reveals a significant discrepancy between the measured and calculated formation cross sections of the pionic $1s$ state.

Published
2017
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6. Missing-mass spectroscopy of the ${}^{12}{\rm C}(p,d)$ reaction near the $\eta^\prime$-meson production threshold

Author

Tanaka, Y. K., Itahashi, K., Fujioka, H., Ayyad, Y., Benlliure, J., Brinkmann, K. -T., Friedrich, S., Geissel, H., Gellanki, J., Guo, C., Gutz, E., Haettner, E., Harakeh, M. N., Hayano, R. S., Higashi, Y., Hirenzaki, S., Hornung, C., Igarashi, Y., Ikeno, N., Iwasaki, M., Jido, D., Kalantar-Nayestanaki, N., Kanungo, R., Knoebel, R., Kurz, N., Metag, V., Mukha, I., Nagae, T., Nagahiro, H., Nanova, M., Nishi, T., Ong, H. J., Pietri, S., Prochazka, A., Rappold, C., Reiter, M. P., Rodríguez-Sánchez, J. L., Scheidenberger, C., Simon, H., Sitar, B., Strmen, P., Sun, B., Suzuki, K., Szarka, I., Takechi, M., Tanihata, I., Terashima, S., Watanabe, Y. N., Weick, H., Widmann, E., Winfield, J. S., Xu, X., Yamakami, H., and Zhao, J.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Excitation-energy spectra of $^{11}$C nuclei near the $\eta^\prime$-meson production threshold have been measured by missing-mass spectroscopy using the $^{12}$C($p$,$d$) reaction. A carbon target has been irradiated with a 2.5 GeV proton beam supplied by the synchrotron SIS-18 at GSI to produce $\eta^\prime$ meson bound states in $^{11}$C nuclei. Deuterons emitted at $0^\circ$ in the reaction have been momentum-analyzed by the fragment separator (FRS) used as a high-resolution spectrometer. No distinct structure due to the formation of $\eta^\prime$-mesic states is observed although a high statistical sensitivity is achieved in the experimental spectra. Upper limits on the formation cross sections of $\eta^\prime$-mesic states are determined, and thereby a constraint imposed on the $\eta^\prime$-nucleus interaction is discussed., Comment: 13 pages, 14 figures, accepted for publication in Physical Review C

Published
2017
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7. Measurement of excitation spectra in the ${}^{12}$C$(p,d)$ reaction near the $\eta'$ emission threshold

Author

Tanaka, Y. K., Itahashi, K., Fujioka, H., Ayyad, Y., Benlliure, J., Brinkmann, K. -T., Friedrich, S., Geissel, H., Gellanki, J., Guo, C., Gutz, E., Haettner, E., Harakeh, M. N., Hayano, R. S., Higashi, Y., Hirenzaki, S., Hornung, C., Igarashi, Y., Ikeno, N., Iwasaki, M., Jido, D., Kalantar-Nayestanaki, N., Kanungo, R., Knöbel, R., Kurz, N., Metag, V., Mukha, I., Nagae, T., Nagahiro, H., Nanova, M., Nishi, T., Ong, H. J., Pietri, S., Prochazka, A., Rappold, C., Reiter, M. P., Rodríguez-Sánchez, J. L., Scheidenberger, C., Simon, H., Sitar, B., Strmen, P., Sun, B., Suzuki, K., Szarka, I., Takechi, M., Tanihata, I., Terashima, S., Watanabe, Y. N., Weick, H., Widmann, E., Winfield, J. S., Xu, X., Yamakami, H., and Zhao, J.

Subjects
Nuclear Experiment
Abstract

Excitation spectra of $^{11}$C were measured in the $^{12}$C$(p,d)$ reaction near the $\eta'$ emission threshold. A proton beam extracted from the synchrotron SIS-18 at GSI with an incident energy of 2.5 GeV impinged on a carbon target. The momenta of deuterons emitted at 0 degrees were precisely measured with the fragment separator FRS operated as a spectrometer. In contrast to theoretical predictions on the possible existence of deeply bound $\eta'$ mesic states in carbon nuclei, no distinct structures were observed associated with the formation of bound states. The spectra were analyzed to set stringent constraints on the formation cross section and on the hitherto barely-known $\eta'$-nucleus interaction., Comment: 6 pages, 4 figures

Published
2016
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8. Spectroscopy of $\eta'$-nucleus bound states at GSI and FAIR --- very preliminary results and future prospects ---

Author

Fujioka, H., Ayyad, Y., Benlliure, J., Brinkmann, K. -T., Friedrich, S., Geissel, H., Gellanki, J., Guo, C., Gutz, E., Haettner, E., Harakeh, M. N., Hayano, R. S., Higashi, Y., Hirenzaki, S., Hornung, C., Igarashi, Y., Ikeno, N., Itahashi, K., Iwasaki, M., Jido, D., Kalantar-Nayestanaki, N., Kanungo, R., Knoebel, R., Kurz, N., Metag, V., Mukha, I., Nagae, T., Nagahiro, H., Nanova, M., Nishi, T., Ong, H. J., Pietri, S., Prochazka, A., Rappold, C., Reiter, M. P., Rodríguez-Sánchez, J. L., Scheidenberger, C., Simon, H., Sitar, B., Strmen, P., Sun, B., Suzuki, K., Szarka, I., Takechi, M., Tanaka, Y. K., Tanihata, I., Terashima, S., Watanabe, Y. N., Weick, H., Widmann, E., Winfield, J. S., Xu, X., Yamakami, H., and Zhao, J.

Subjects
Nuclear Experiment, Nuclear Theory, 81V05
Abstract

The possible existence of \eta'-nucleus bound states has been put forward through theoretical and experimental studies. It is strongly related to the \eta' mass at finite density, which is expected to be reduced because of the interplay between the $U_A(1)$ anomaly and partial restoration of chiral symmetry. The investigation of the C(p,d) reaction at GSI and FAIR, as well as an overview of the experimental program at GSI and future plans at FAIR are discussed., Comment: 7 pages, 3 figures; talk at the International Conference on Exotic Atoms and Related Topics (EXA2014), Vienna, Austria, 15-19 September 2014. in Hyperfine Interactions (2015)

Published
2015
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9. Search for {\eta}'(958)-nucleus bound states by (p,d) reaction at GSI and FAIR

Author

Fujioka, H., Ayyad, Y., Benlliure, J., Brinkmann, K. -T., Friedrich, S., Geissel, H., Gellanki, J., Guo, C., Gutz, E., Haettner, E., Harakeh, M. N., Hayano, R. S., Higashi, Y., Hirenzaki, S., Hornung, C., Igarashi, Y., Ikeno, N., Itahashi, K., Iwasaki, M., Jido, D., Kalantar-Nayestanaki, N., Kanungo, R., Knoebel, R., Kurz, N., Metag, V., Mukha, I., Nagae, T., Nagahiro, H., Nanova, M., Nishi, T., Ong, H. J., Pietri, S., Prochazka, A., Rappold, C., Reiter, M. P., Rodríguez-Sánchez, J. L., Scheidenberger, C., Simon, H., Sitar, B., Strmen, P., Sun, B., Suzuki, K., Szarka, I., Takechi, M., Tanaka, Y. K., Tanihata, I., Terashima, S., Watanabe, Y. N., Weick, H., Widmann, E., Winfield, J. S., Xu, X., Yamakami, H., and Zhao, J.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The mass of the {\eta}' meson is theoretically expected to be reduced at finite density, which indicates the existence of {\eta}'-nucleus bound states. To investigate these states, we perform missing-mass spectroscopy for the (p, d) reaction near the {\eta}' production threshold. The overview of the experimental situation is given and the current status is discussed., Comment: 6 pages, 3 figures; talk at II Symposium on applied nuclear physics and innovative technologies, September 24th - 27th, 2014, Jagiellonian University, Krak\'ow Poland; to appear in Acta Physica Polonica B

Published
2015
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11. New ion-optical operating modes of the BigRIPS and ZeroDegree spectrometer for the production and separation of high-quality rare isotopes beams and high-resolution spectrometer experiments

Author

Takeda, H., Tanaka, Y.K., Suzuki, H., Ahn, D.S., Franczak, B., Fukuda, N., Geissel, H., Haettner, E., Inabe, N., Itahashi, K., Komatsubara, T., Kubo, T., Kusaka, K., Matsumoto, S.Y., Murai, D., Nishi, T., Ohtake, M., Scheidenberger, C., Shimizu, Y., Sumikama, T., Ueno, H., Uesaka, T., Yanagisawa, Y., and Yoshida, K.

Published
2020
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14. Characterization of nanoscale mechanical heterogeneity in a metallic glass by dynamic force microscopy

Author

Liu, Y. H., Wang, D., Nakajima, K., Zhang, W., Hirata, A., Nishi, T., Inoue, A., and Chen, M. W.

Subjects
Condensed Matter - Disordered Systems and Neural Networks, Condensed Matter - Materials Science
Abstract

We report nano-scale mechanical heterogeneity of a metallic glass characterized by dynamic atomic force microscopy. Apparent energy dissipation with the variation of ~12%, originating from non-uniform distribution of local viscoelasticity, was characterized. The correlation length of heterogeneous viscoelasticity was measured to be ~2.5{\pm}0.3 nm, which is well consistent with the dimension of shear transformation zones for plastic flow. This study provides the first experimental observation on the nano-scale mechanical heterogeneity in a metallic glass, and may fill the gap between atomic models and the macroscopic properties of metallic glasses.

Published
2011
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16. Infrared spectroscopy under multi-extreme conditions: Direct observation of pseudo gap formation and collapse in CeSb

Author

Nishi, T., Kimura, S., Takahashi, T., Mori, Y., Kwon, Y. S., Im, H. J., and Kitazawa, H.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Infrared reflectivity measurements of CeSb under multi-extreme conditions (low temperatures, high pressures and high magnetic fields) were performed. A pseudo gap structure, which originates from the magnetic band folding effect, responsible for the large enhancement in the electrical resistivity in the single-layered antiferromagnetic structure (AF-1 phase) was found at a pressure of 4 GPa and at temperatures of 35 - 50 K. The optical spectrum of the pseudo gap changes to that of a metallic structure with increasing magnetic field strength and increasing temperature. This change is the result of the magnetic phase transition from the AF-1 phase to other phases as a function of the magnetic field strength and temperature. This result is the first optical observation of the formation and collapse of a pseudo gap under multi-extreme conditions., Comment: 5 pages, 3 figures, accepted for publication in Phys. Rev. B

Published
2005
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17. The origin of the phase separation in partially deuterated $\kappa$-(ET)$_2$Cu[N(CN)$_2$]Br studied by infrared magneto-optical imaging spectroscopy

Author

Nishi, T., Kimura, S., Takahashi, T., Ito, T., Im, H. J., Kwon, Y. S., Miyagawa, K., Taniguchi, H., Kawamoto, A., and Kanoda, K.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

The direct observation of the phase separation between the metallic and insulating states of 75 %-deuterated $\kappa$-(ET)$_2$Cu[N(CN)$_2$]Br ($d33$) using infrared magneto-optical imaging spectroscopy is reported, as well as the associated temperature, cooling rate, and magnetic field dependencies of the separation. The distribution of the center of spectral weight ($< \omega >$) of $d33$ did not change under any of the conditions in which data were taken and was wider than that of the non-deuterated material. This result indicates that the inhomogenity of the sample itself is important as part of the origin of the metal - insulator phase separation., Comment: 4 pages, 3 figures, accepted for publication in Solid State Commun

Published
2005
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19. Choroidal structure determined by binarizing optical coherence tomography images in eyes with reticular pseudodrusen

Author

Masuda N, Kojima M, Yamashita M, Nishi T, and Ogata N

Subjects
reticular pesudodrusen, age-related macular degeneration, choroidal structure, binarization method, Ophthalmology, RE1-994
Abstract

Naonori Masuda, Masashi Kojima, Mariko Yamashita, Tomo Nishi, Nahoko Ogata Department of Ophthalmology, Nara Medical University, Nara, Japan Purpose: To compare the choroidal structure beneath the macular area in eyes with reticular pseudodrusen (RPD) and age-matched controls.Methods: This study was performed at Nara Medical University Hospital, Japan. Twenty eyes of 14 patients (82.3±4.2 years, mean ± standard deviation) with RPD and 35 eyes of 20 age-matched controls (81.5±6.0 years) were studied. The choroidal structure was determined by binarizing the images obtained by enhanced depth imaging optical coherence tomography in all patients and controls. The total, luminal, and stromal choroidal areas were quantified by the binarization method.Results: The total choroidal area of the eyes with RPD was significantly smaller than that of control eyes (P=0.001, unpaired t-test). Both the luminal and stromal areas in eyes with RPD were significantly smaller than that of control eyes (P=0.001, paired t-test), but there was no significant difference in the luminal/stromal ratio between eyes with RPD and control eyes.Conclusion: The total, luminal, and stromal choroidal areas in eyes with RPD were smaller than those of the control eyes. The reduction of the choroidal luminal and stromal areas may be due to a loss of the oxygen demand of the choroid due to RPE dysfunction. Keywords: reticular pseudodrusen, age-related macular degeneration, choroidal structure, binarization method

Published
2017

21. Soil Sorption Experiments for Amphetamine-Type Substances

Author

Nishi, T. and Nishi, T.

Abstract

Dumping of illicit drug production waste, namely amphetamine-type substances (ATS), is an issue that Dutch authorities continually grapple with due to the concentrated production of such drugs in the Netherlands. This production waste is often discovered by happenstance, having been haphazardly and surreptitiously dumped into nature preserves or near surface water bodies. In the former case, drug waste containers may occasionally leak into the soil, potentially discharging high concentrations of ATS chemicals into the subsurface and posing a threat to groundwater contamination. This thesis set out to perform an array of soil sorption experiments that would provide empirical data that enhances the understanding of how these chemicals behave in the soil system.

Published
2023

28. Safety of Once-Daily Single-Inhaler Triple Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol in Japanese Patients with Asthma: A Long-Term (52-Week) Phase III Open-Label Study

Author

Hozawa S, Ohbayashi H, Tsuchiya M, Hara Y, Lee LA, Nakayama T, Tamaoki J, Fowler A, and Nishi T

Subjects
safety, treatment outcome, inhalers, asthma, Immunologic diseases. Allergy, RC581-607, japan
Abstract

Soichiro Hozawa,1 Hiroyuki Ohbayashi,2 Michiko Tsuchiya,3 Yu Hara,4 Laurie A Lee,5 Takashi Nakayama,6 Jun Tamaoki,6 Andrew Fowler,7 Takanobu Nishi6 1Hiroshima Allergy and Respiratory Clinic, Hiroshima, Japan; 2Tohno Chuo Clinic, Gifu, Japan; 3Department of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan; 4Department of Pulmonology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan; 5GSK, Collegeville, PA, USA; 6GSK, Tokyo, Japan; 7GSK, Brentford, Middlesex, UKCorrespondence: Takanobu NishiGlaxoSmithKline K.K., 1-8-1 Akasaka, Minato-ku, Tokyo, 107-0052, JapanTel +81-70-4135-5303Fax +81-3-4231-5974Email takanobu.2.nishi@gsk.comPurpose: The pivotal CAPTAIN study reported a favorable safety profile with once-daily inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2-agonist (ICS/LAMA/LABA) triple combination of fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) in patients with inadequately controlled asthma, some of whom were Japanese. Here, we evaluate the long-term (52 weeks) safety of FF/UMEC/VI in Japanese patients with asthma.Patients and Methods: This was a Phase III, 52-week, multicenter, non-comparator, non-randomized, open-label study (NCT03184987) in Japanese adults receiving maintenance therapy with ICS/LABA, with or without LAMA. At enrollment, patients were allocated to either FF/UMEC/VI 100/62.5/25mcg (Group 1) or 200/62.5/25mcg (Group 2). Patients in Group 1 could have their treatment stepped up to 200/62.5/25mcg at Week 24 if their Asthma Control Questionnaire (ACQ)-7 score was > 0.75. The primary endpoint was the incidence of adverse events (AEs) and serious AEs (SAEs). Secondary endpoints included vital signs, electrocardiogram measurements, and clinical laboratory tests (biochemistry, hematology, urinalysis). Efficacy was assessed as “other” endpoints.Results: A total of 111 Japanese patients were included in the intention-to-treat (ITT) population. Overall, 77 (69%) patients reported ≥ 1 AE (Group 1: n=30 [64%]; step-up group: n=7 [78%]; Group 2: n=40 [73%]). SAEs were reported for 1 (2.1%) and 2 (3.6%) patients in Groups 1 and 2, respectively. All SAEs were considered unrelated to study treatment. One AE and one SAE led to study withdrawal: oropharyngeal discomfort (Group 1); eosinophilic granulomatosis with polyangiitis (Group 2). No new safety concerns were identified throughout the 52-week treatment period.Conclusion: In this uncontrolled open-label study, no new safety concerns were observed with long-term (52 weeks) treatment with once-daily FF/UMEC/VI among 111 Japanese patients with asthma.Keywords: asthma, inhalers, Japan, safety, treatment outcome

Published
2021

29. SHARAQ spectrometer for high-resolution studies for RI-induced reactions

Author

Michimasa, S., Takaki, M., Sasamoto, Y., Dozono, M., Nishi, T., Kawabata, T., Ota, S., Baba, H., Baba, T., Fujii, T., Go, S., Kawase, S., Kikuchi, Y., Kisamori, K., Kobayashi, M., Kubota, Y., Lee, C.S., Matsubara, H., Miki, K., Miya, H., Noji, S., Tokieda, H., Tsumura, M., Yako, K., Yokoyama, R., Takeda, H., Yanagisawa, Y., Kubo, T., Inabe, N., Fukuda, N., Kameda, D., Suzuki, H., Shimizu, Y., Sato, H., Ichihara, T., Stolz, A., Zegers, R.G.T., Sakai, H., Uesaka, T., and Shimoura, S.

Published
2013
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30. BigRIPS as a high resolution spectrometer for pionic atoms

Author

Nishi, T., Berg, G.P.A., Dozono, M., Fujioka, H., Fukuda, N., Furuno, T., Geissel, H., Hayano, R.S., Inabe, N., Itahashi, K., Itoh, S., Kameda, D., Kubo, T., Matsubara, H., Michimasa, S., Miki, K., Miya, H., Murakami, Y., Nakamura, M., Nakatsuka, N., Noji, S., Okochi, K., Ota, S., Suzuki, H., Suzuki, K., Takaki, M., Takeda, H., Tanaka, Y.K., Todoroki, K., Tsukada, K., Uesaka, T., Watanabe, Y.N., Weick, H., Yamada, H., and Yoshida, K.

Published
2013
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31. Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab

Author

Yamashita M, Nishi T, Hasegawa T, and Ogata N

Subjects
Ophthalmology, RE1-994
Abstract

Mariko Yamashita, Tomo Nishi, Taiji Hasegawa, Nahoko Ogata Department of Ophthalmology, Nara Medical University, Kashihara, Nara, Japan Purpose: To report the effects of aflibercept on eyes with large retinal pigment epithelial detachment (PED) associted with polypoidal choroidal vasculopathy (PCV). Methods: We reviewed the medical records of patients with PEDs associated with PCV that were treated with aflibercept after intravitreal ranibizumab had failed. Results: Three eyes of patients aged 72, 79, and 80 years were studied. Reflective material was seen in the PED along the outer surface of the retinal pigment epithelium (RPE) by spectral-domain optical coherence tomography (SD-OCT). A complete resolution of the serous PEDs was found after two aflibercept injections; however, all eyes had a fibrovascular PED. In addition, one eye developed a retinal hemorrhage and a recurrent PED just after the third injection of aflibercept. The visual acuity in this eye decreased from 10/20 to 2/20. Conclusion: The reflective material below the outer surface of the RPE in serous PED suggests the presence of neovascularization. Intravitreal aflibercept could be considered for large PEDs in eyes with PCV but should be carefully applied. Keywords: age-related macular degeneration, retinal pigment epithelial detachment, polypoidal choroidal vasculopathy, aflibercept

Published
2014

32. Comparisons of amplitude of pseudoaccommodation with aspheric yellow, spheric yellow, and spheric clear monofocal intraocular lenses

Author

Nishi T, Taketani F, Ueda T, and Ogata N

Subjects
Ophthalmology, RE1-994
Abstract

Tomo Nishi, Futoshi Taketani, Tetsuo Ueda, Nahoko Ogata Department of Ophthalmology, Nara Medical University, Kashihara City, Nara, Japan Purpose: To determine the amplitude of pseudoaccommodation and higher-order aberrations with three types of implanted monofocal intraocular lenses (IOLs): aspheric yellow (IQ); spheric yellow (NT); and spheric clear (AT). Setting: Department of Ophthalmology, Nara Medical University, Nara, Japan. Methods: We studied 60 patients who underwent small incision phacoemulsification with the implantation of a monofocal IQ, NT, or AT IOL. The pseudoaccommodation was measured by the lens-loading method, and the postoperative ocular higher-order aberrations were measured with a Hartmann–Shack wavefront analyzer through natural and 4 mm pupils. Results: Sixty eyes of 60 patients were studied. The average amplitude of the pseudoaccommodation was 0.45±0.24 D with the IQ IOL, which was significantly lower than that with the AT IOL at 0.81±0.37 D (Tukey's test; P0.05). The degree of spherical aberration was significantly different for the IQ, NT, and AT lenses (analysis of variance, P=0.016). The spherical aberration through the IQ IOL was significantly lower than that through the NT and the AT IOLs (Tukey's test; P

Published
2013

47. Magneto-optical property and magnetic anisotropy of (100) oriented R0.5Bi2.5Fe5O12 (R = Eu, Sm, and Pr) thin films prepared by metal–organic decomposition.

Author

Urakawa, R., Asano, W., Nishikawa, M., Kawahara, M., Nishi, T., Oshima, D., Kato, T., and Ishibashi, T.

Subjects
MAGNETIC anisotropy, THIN films, MAGNETIC properties, MILITARY communications, FERROMAGNETIC resonance, RARE earth metals
Abstract

Bi-substituted rare-earth iron garnets, R3−xBixFe5O12 (Bi:RIG), where R represents one of the rare-earth elements, exhibit the excellent magneto-optical (MO) properties that increase with Bi content x. In addition, magnetic properties of Bi:RIGs, such as the magnetization, the magnetic anisotropy, and the magnetostriction, could be controlled by choosing rare-earth elements. In this paper, we report on R0.5Bi2.5Fe5O12 (Bi2.5:RIG, R = Pr, Sm, and Eu) thin films on Gd3Ga5O12 (GGG) (100) single crystal substrates prepared by the metal–organic decomposition method. XRD analysis reveals that Bi2.5:RIG thin films are grown along the same orientation with GGG substrates, and their lattice constants are dependent on the ionic radii of the rare-earth ions. MO measurements show that Faraday spectra of the Bi2.5:RIG thin films have a typical spectral structure observed for Bi:RIGs. The magnetic anisotropy constants, the uniaxial magnetic anisotropy energy Ku, and the magnetocrystalline anisotropy energy K1 of Bi2.5:RIG (R = Y, Pr, Nd, Sm, and Eu) thin films are investigated by using the ferromagnetic resonance measurement. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Peripheral Oxygen Extraction and Exercise Limitation in Asymptomatic Patients with Diabetes Mellitus

Author

Kobayashi, Y, Christle, JW, Contrepois, K, Nishi, T, Moneghetti, K, Cauwenberghs, N, Myers, J, Kuznetsova, T, Palaniappan, L, Haddad, F, Kobayashi, Y, Christle, JW, Contrepois, K, Nishi, T, Moneghetti, K, Cauwenberghs, N, Myers, J, Kuznetsova, T, Palaniappan, L, and Haddad, F

Abstract

Patients with diabetes mellitus (DM) frequently present reduced exercise capacity. We aimed to explore the extent to which peripheral extraction relates to exercise capacity in asymptomatic patients with DM. We prospectively enrolled 98 asymptomatic patients with type-2 DM (mean age of 59 ± 11 years and 56% male sex), and compared with 31 age, sex and body mass index-matched normoglycemic controls. Cardiopulmonary exercise testing with resting followed by stress echocardiography was performed. Exercise response was assessed using peak oxygen uptake (peak VO2) and ventilatory efficiency was measured using the slope of the relationship between minute ventilation and carbon dioxide production (VE/VCO2). Peripheral extraction was calculated as the ratio of VO2 to cardiac output. Cardiac function was evaluated using left ventricular longitudinal strain, E/e', and relative wall thickness. Among patients with DM, 26 patients (27%) presented reduced percent-predicted-peak VO2(<80%) and 18 (18%) presented abnormal VE/VCO2slope (>34). There was no significant difference in peak cardiac output; however, peripheral extraction was lower in patients with DM compared to controls. Higher peak E/e' (beta = -0.24, p = 0.004) was associated with lower peak VO2 along with age, sex and body mass index (R2 = 0.53). A cluster analysis found left ventricular longitudinal strain, E/e', relative wall thickness and peak VO2 in different clusters. In conclusion, impaired peripheral extraction may contribute to reduced peak VO2in asymptomatic patients with DM. Furthermore, a cluster analysis suggests that cardiopulmonary exercise testing and echocardiography may be complementary for defining subclinical heart failure in patients with DM.

Published
2021

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