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4 results on '"Nisargbhai Shah"'

1. Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade

Author

Joy A. Pai, Matthew D. Hellmann, Jennifer L. Sauter, Marissa Mattar, Hira Rizvi, Hyung Jun Woo, Nisargbhai Shah, Evelyn M. Nguyen, Fathema Z. Uddin, Alvaro Quintanal-Villalonga, Joseph M. Chan, Parvathy Manoj, Viola Allaj, Marina K. Baine, Umesh K. Bhanot, Mala Jain, Irina Linkov, Fanli Meng, David Brown, Jamie E. Chaft, Andrew J. Plodkowski, Mathieu Gigoux, Helen H. Won, Triparna Sen, Daniel K. Wells, Mark T.A. Donoghue, Elisa de Stanchina, Jedd D. Wolchok, Brian Loomis, Taha Merghoub, Charles M. Rudin, Andrew Chow, and Ansuman T. Satpathy

Subjects
Cancer Research, Oncology
Published
2023
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2. CD39 Identifies Tumor-Reactive CD8 T cells in Patients With Lung Cancer

Author

Andrew Chow, Fathema Z. Uddin, Levi Mangarin, Hira Rizvi, Anton Dobrin, Sam Tischfield, Alvaro Quintanal-Villalonga, Joseph M. Chan, Nisargbhai Shah, Viola Allaj, Parvathy Manoj, Marissa Mattar, Maximiliano Meneses, Michael Liu, Rebecca Landau, Mariana Ward, Amanda Kulick, Charlene Kwong, Matthew Wierzbicki, Jessica Yavner, Shweta S. Chavan, Abigail Farillas, Aliya Holland, Harsha Sridhar, Metamia Ciampricotti, Daniel Hirschhorn, Allison L Richards, Mark T.A. Donoghue, Glenn Heller, Christopher A. Klebanoff, Matthew D. Hellmann, Elisa de Stanchina, Triparna Sen, Jedd D. Wolchok, Taha Merghoub, and Charles M. Rudin

Abstract

The repertoire of tumor-infiltrating lymphocytes (TILs) can be vast, and many of these TILs are not endowed with tumor reactivity. While a number of reports have shown that tumor-reactive TILs express CD39, few reports have demonstrated that conversely, CD39 can be leveraged to serve as a proxy of tumor-reactive CD8 T cells. Using single-cell CITE/RNA/TCRseq, we show that CD39+ CD8 T cells in human lung cancers demonstrate transcriptional and proteomic features of exhaustion, tumor reactivity, and clonal expansion. Moreover, TCR cloning revealed that CD39 enriched for tumor-reactive CD8 T cell clones. Flow cytometry of 440 lung cancer specimens revealed that CD39 level on CD8 T cells is only weakly correlated with tumoral features that currently guide lung cancer therapy, such as histology, driver mutation, PD-L1 and tumor mutation burden. PD-1 axis blockade, but not cytotoxic chemotherapy, increased intratumoral CD39+ CD8 T cells. CD39 correlated with PD-1 expression on CD8 T cells and high pre-treatment/early-on-treatment levels were associated with improved clinical outcomes, but not immune-related adverse events, from immune checkpoint blockade therapy. This comprehensive profiling of the clinical, pathological and molecular features highlights the utility of CD39 as a proxy for tumor-reactive CD8 T cells in human lung cancer.

Published
2022
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3. The ectonucleotidase CD39 identifies tumor-reactive CD8

Author

Andrew, Chow, Fathema Z, Uddin, Michael, Liu, Anton, Dobrin, Barzin Y, Nabet, Levi, Mangarin, Yonit, Lavin, Hira, Rizvi, Sam E, Tischfield, Alvaro, Quintanal-Villalonga, Joseph M, Chan, Nisargbhai, Shah, Viola, Allaj, Parvathy, Manoj, Marissa, Mattar, Maximiliano, Meneses, Rebecca, Landau, Mariana, Ward, Amanda, Kulick, Charlene, Kwong, Matthew, Wierzbicki, Jessica, Yavner, Jacklynn, Egger, Shweta S, Chavan, Abigail, Farillas, Aliya, Holland, Harsha, Sridhar, Metamia, Ciampricotti, Daniel, Hirschhorn, Xiangnan, Guan, Allison L, Richards, Glenn, Heller, Jorge, Mansilla-Soto, Michel, Sadelain, Christopher A, Klebanoff, Matthew D, Hellmann, Triparna, Sen, Elisa, de Stanchina, Jedd D, Wolchok, Taha, Merghoub, and Charles M, Rudin

Abstract

Improved identification of anti-tumor T cells is needed to advance cancer immunotherapies. CD39 expression is a promising surrogate of tumor-reactive CD8

Published
2022

4. The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer

Author

Andrew Chow, Fathema Z. Uddin, Michael Liu, Anton Dobrin, Barzin Y. Nabet, Levi Mangarin, Yonit Lavin, Hira Rizvi, Sam E. Tischfield, Alvaro Quintanal-Villalonga, Joseph M. Chan, Nisargbhai Shah, Viola Allaj, Parvathy Manoj, Marissa Mattar, Maximiliano Meneses, Rebecca Landau, Mariana Ward, Amanda Kulick, Charlene Kwong, Matthew Wierzbicki, Jessica Yavner, Jacklynn Egger, Shweta S. Chavan, Abigail Farillas, Aliya Holland, Harsha Sridhar, Metamia Ciampricotti, Daniel Hirschhorn, Xiangnan Guan, Allison L. Richards, Glenn Heller, Jorge Mansilla-Soto, Michel Sadelain, Christopher A. Klebanoff, Matthew D. Hellmann, Triparna Sen, Elisa de Stanchina, Jedd D. Wolchok, Taha Merghoub, and Charles M. Rudin

Subjects
Infectious Diseases, Immunology, Immunology and Allergy
Published
2023
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