1. Short Communication: 18F-FDG PET Early After Radiotherapy in Lymphoma Patients
- Author
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Cinzia Pettinato, Andrea Moretti, Pier Luigi Zinzani, Romeo Canini, Lapo Alinari, Cristina Nanni, Mohsen Farsad, Paolo Castellucci, Stefano Fanti, Nino Monetti, Mario Marengo, Giuseppe Battista, Michele Baccarani, and Stefano Boschi
- Subjects
Pharmacology ,Cancer Research ,medicine.medical_specialty ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Fdg uptake ,General Medicine ,medicine.disease ,Lymphoma ,18f fdg pet ,Radiation therapy ,Oncology ,Positron emission tomography ,medicine ,Tracer uptake ,Radiology, Nuclear Medicine and imaging ,Radiology ,Nuclear medicine ,business ,Pathological - Abstract
Objective: The aim of this study was to evaluate the rate of postactinic inflammatory alterations that could lead to false-positive results in FDG-PET images, in a group of lymphoma patients studied with positron emission tomography (PET) early after the end of radiation therapy. Materials and methods: Sixteen (16) consecutive patients were referred to our center for malignant lymphoma; 14 of 16 patients had a mediastinal bulky mass at diagnosis. Each patient underwent chemotherapy and then radiotherapy (RT): for clinical reasons, shortly after RT (range, 25–56 days; mean, 38.7 days) a FDG PET scan was required to evaluate the effect of therapy. We intravenously injected 370 MBq of 18F-FDG, and after 60–90 minutes we recorded images. Results: Despite a relatively short time after RT, there was no pathological tracer uptake in 13 of 16 patients. In 3 cases, a mild increase in FDG uptake was observed, but no findings which would lead to a false-positive diagnosis. In 2 of 3 cases, postactinic pneumopathy wa...
- Published
- 2004