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20 results on '"Ning Zhifeng"'

2. ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Author

Wei, Yaolu, primary, Li, Yan, additional, Chen, Yenan, additional, Liu, Pei, additional, Huang, Sheng, additional, Zhang, Yuping, additional, Sun, Yanling, additional, Wu, Zhe, additional, Hu, Meichun, additional, Wu, Qian, additional, Wu, Hongnian, additional, Liu, Fuxing, additional, She, Tonghui, additional, and Ning, Zhifeng, additional

Published
2022
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4. Metformin: A promising drug for human cancers (Review)

Author

Wu, Hongnian, primary, Huang, Dan, additional, Zhou, Hong, additional, Sima, Xueqin, additional, Wu, Zhe, additional, Sun, Yanling, additional, Wang, Long, additional, Ruan, Ying, additional, Wu, Qian, additional, Wu, Feng, additional, She, Tonghui, additional, Chu, Ying, additional, Huang, Qizhi, additional, Ning, Zhifeng, additional, and Zhang, Hao, additional

Published
2022
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6. Gut microbiota: Implications in pathogenesis and therapy to cardiovascular disease (Review).

Author

Lin, Li, Xiang, Shaowei, Chen, Yuan, Liu, Yan, Shen, Dingwen, Yu, Xiaoping, Wu, Zhe, Sun, Yanling, Chen, Kequan, Luo, Jia, Wei, Guilai, Wang, Zhiguo, and Ning, Zhifeng

Subjects
GUT microbiome, MYOCARDIAL infarction, BACTERIAL communities, GASTROINTESTINAL system, DYSBIOSIS
Abstract

The gut microbiota refers to the diverse bacterial community residing in the gastrointestinal tract. Recent data indicate a strong correlation between alterations in the gut microbiota composition and the onset of various diseases, notably cardiovascular disorders. Evidence suggests the gut-cardiovascular axis signaling molecules released by the gut microbiota play a pivotal role in regulation. This review systematically delineates the association between dysbiosis of the gut microbiota and prevalent cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction and heart failure. Furthermore, it provides an overview of the putative pathogenic mechanisms by which dysbiosis in the gut microbiota contributes to the progression of cardiovascular ailments. The potential modulation of gut microbiota as a preventive strategy against cardiovascular diseases through dietary interventions, antibiotic therapies and probiotic supplementation is also explored and discussed within the present study. [ABSTRACT FROM AUTHOR]

Published
2024
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7. PELP1 Suppression Inhibits Gastric Cancer Through Downregulation of c-Src-PI3K-ERK Pathway

Author

Liu Shangqin, Wuhan Xiao, Hongzhu Yan, Ma Zi, Yuanpeng Sun, Zhe Wu, Wu Qian, Ning Zhifeng, Yanling Sun, Yusi Liu, Meichun Hu, and Liu Fuxing

Subjects
0301 basic medicine, Cancer Research, Cell, Biology, medicine.disease_cause, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Western blot, oncogene, medicine, PELP1, chlorpromazine, PI3K/AKT/mTOR pathway, Original Research, Oncogene, medicine.diagnostic_test, gastric cancer, therapeutic target, Cancer, master gene, Cell cycle, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, Cell culture, 030220 oncology & carcinogenesis, Cancer research, c-Src-PI3K-ERK pathway, Carcinogenesis
Abstract

Background: Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), a co-activator of estrogen receptors alpha, was confirmed to be directly associated with the oncogenic process of multiple cancers, especially hormone-dependent cancers. The purpose of our research was to explore the biological function, clinical significance, and therapeutic targeted value of PELP1 in gastric cancer (GC). Methods: The expression status of PELP1 in GC cell lines or tissues was analyzed through bioinformatics data mining. Thirty-six GC tissue chip was applied to demonstrate the results of bioinformatics data mining assayed by immunohistochemical method. The expression status of PELP1 in GC cell lines was also analyzed using western blot. Correlation analysis between PELP1 expression and clinicopathological parameter was performed. Kaplan-Meier survival analysis was applied to analyze the relationship between PELP1 expression and total survival time. Three pairs of siRNA were designed to silence the expression of PELP1 in GC. After PELP1 was silenced by siRNA or activated by saRNA, the growth, plate colony formation, migration and invasion ability of the GC cell or normal gastric epithelium cell line was tested in vitro. Cell cycle was tested by flow cytometry. Nude mice xenograft experiment was performed after PELP1 was silenced. The downstream molecular pathway regulated by PELP1 was explored. Molecular docking tool was applied to combine chlorpromazine with PELP1. The inhibitory effect of chlorpromazine in GC was assayed, then it was tested whether PELP1 was a therapeutic target of chlorpromazine in GC. Results: PELP1 expression was elevated in GC cell lines and clinical GC tissue samples. PELP1 silence by siRNA compromised the malignant traits of GC. PELP1 expression positively correlated with tumor invasion depth, lymph node metastasis, tissue grade, TNM stage, but had no correlation with patient age, sex, tumor size, and tumor numbers. Kaplan-Meier survival analysis revealed high PELP1 expression had a shorter survival period in GC patients after follow-up. Q-PCR and western blot revealed PELP1 suppression in GC decreased expression of the c-Src-PI3K-ERK pathway. It was also implied that chlorpromazine (CPZ) can inhibit the malignant traits of GC and downregulate the expression of PELP1. Conclusions: In a word, PELP1 is an oncogene in gastric cancer and c-Src-PI3K-ERK pathway activation may be responsible for its tumorigenesis, PELP1 may be a potential therapeutic target of chlorpromazine in GC.

Published
2020

8. Stability and anti-tumor effect of oncolytic herpes simplex virus type 2

Author

Han Hu, Yuting Dong, Zhizheng Fang, Huajun Zheng, Jianwen Zou, Yanfei Li, Ning Zhifeng, Xiaotai Shi, Zeyong Mao, Sheng Hu, Jing Jin, Yang Wang, Zhen Wu, Wu Jiliang, Liu Fuxing, Shuang Dong, and Liu Binlei

Subjects
0301 basic medicine, Antitumor activity, Gene Modification, herpes simplex virus type 2, Biology, stability, anti-tumor effect, medicine.disease_cause, Virology, Virus, Oncolytic virus, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Herpes simplex virus, Animal model, Oncology, 030220 oncology & carcinogenesis, medicine, Physical stability, Cytotoxicity, Research Paper
Abstract

Oncolytic virotherapy is a new therapeutic strategy based on the inherent cytotoxicity of viruses and their ability to replicate and spread in tumors in a selective manner. We constructed a new type of oncolytic herpes simplex virus type 2 (oHSV-2, named OH2) to treat human cancers, but a systematic evaluation of the stability and oncolytic ability of this virus is lacking. In this study, we evaluated its physical stability, gene modification stability and biological characteristics stability, including its anti-tumor activity in an animal model. The physical characteristics as well as genetic deletions and insertions in OH2 were stable, and the anti-tumor activity remained stable even after passage of the virus for more than 20 generations. In conclusion, OH2 is a virus that has stable structural and biological traits. Furthermore, OH2 is a potent oncolytic agent against tumor cells.

Published
2018

11. Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis

Author

Wang, Lu, primary, Li, Kai, additional, Lin, Xianjie, additional, Yao, Zhimeng, additional, Wang, Shuhong, additional, Xiong, Xiao, additional, Ning, Zhifeng, additional, Wang, Jing, additional, Xu, Xiaozheng, additional, Jiang, Yi, additional, Liu, Ditian, additional, Chen, Yuping, additional, Zhang, Dianzheng, additional, and Zhang, Hao, additional

Published
2019
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13. Stability and anti-tumor effect of oncolytic herpes simplex virus type 2

Author

Wang, Yang, primary, Jin, Jing, additional, Wu, Zhen, additional, Hu, Sheng, additional, Hu, Han, additional, Ning, Zhifeng, additional, Li, Yanfei, additional, Dong, Yuting, additional, Zou, Jianwen, additional, Mao, Zeyong, additional, Shi, Xiaotai, additional, Zheng, Huajun, additional, Dong, Shuang, additional, Liu, Fuxing, additional, Fang, Zhizheng, additional, Wu, Jiliang, additional, and Liu, Binlei, additional

Published
2018
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16. Tumor suppression by miR-31 in esophageal carcinoma is p21-dependent

Author

Ning, Zhifeng, primary, Zhu, Hua, additional, Li, Feifei, additional, Liu, Qing, additional, Liu, Gefei, additional, Tan, Tao, additional, Zhang, Bo, additional, Chen, Shaobin, additional, Li, Guanwu, additional, Huang, Dongyang, additional, Meltzer, Stephen J, additional, and Zhang, Hao, additional

Published
2014
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20. Antitumor properties of griseofulvin and its toxicity.

Author

Yu N, Fu Y, Fan Q, Lin L, Ning Z, Leng D, Hu M, and She T

Abstract

Griseofulvin (GF), which is mainly extracted from Penicillium griseofulvum , is a heat-resistant, chlorine-containing non-polyene antifungal antibiotic. Previous research shows that GF has a variety of pharmacological effects, such as anti-inflammatory, antifungal, antiviral, and antitumor effects. In recent years, GF has received extensive attention for its antitumor effects as a natural compound, offering a low price, a wide range of uses, and other beneficial characteristics. However, no comprehensive review of GF pharmacological activity in tumors has been published so far. In order to fully elucidate the antitumor activities of GF, this review focuses on the antitumor potential and toxicity of GF and its derivatives, based on a literature search using PubMed, Web of Science, and other databases, to lay a good foundation for further research of GF and the development of new drugs for antitumor activities., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Yu, Fu, Fan, Lin, Ning, Leng, Hu and She.)

Published
2024
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