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4. The Effect of Electroacupuncture Preconditioning on Regional Cerebral Oxygen Saturation Levels in Elderly Patients with Diabetes

Author

Ning,Jia-Qi, Luo,Jian-Sheng, Ding,Ling-Ling, Guo,Yu-Hong, Chen,Zhuo-Ya, Wang,Qi, Zhou,Rui-Ling, Ning,Jia-Qi, Luo,Jian-Sheng, Ding,Ling-Ling, Guo,Yu-Hong, Chen,Zhuo-Ya, Wang,Qi, and Zhou,Rui-Ling

Abstract

Jia-Qi Ning,1,2 Jian-Sheng Luo,1,2 Ling-Ling Ding,2 Yu-Hong Guo,3 Zhuo-Ya Chen,2 Qi Wang,2 Rui-Ling Zhou2 1Department of Anesthesiology, Capital Medical University, Beijing, 100069, People’s Republic of China; 2Department of Anesthesiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of China; 3Department of Emergency, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of ChinaCorrespondence: Ling-Ling Ding, Department of Anesthesiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of China, Tel/Fax +86 1087906647, Email dignlilbc@outlook.com; dinglingling301@126.comObjective: This study aimed to evaluate the effect of electroacupuncture preconditioning on regional cerebral oxygen saturation (rSO2) levels in elderly patients with diabetes.Methods: Forty patients undergoing elective diabetic foot surgery were enrolled in this study. All patients were aged 65 years and above and weighed 45– 75 kg. All were characterized as class II or III according to the American Society of Anesthesiologists’ physical status classification system. Patients were divided randomly into an electroacupuncture group (group E) and a control group (group C); both groups comprised 20 patients. In group E, the DU20 (Baihui), DU24 (Shenting), and EX-HN1 (Sishencong) acupoints were selected for electroacupuncture 30 min prior to administering anesthesia, while in group C, patients underwent routine anesthesia without electroacupuncture. The patients in both groups were anesthetized using a sciatic nerve block. The number of cases with increased or decreased regional oxygen saturation (rSO2) compared with the baseline as well as rSO2 variability in the two groups were recorded and compared.Results: There was no significant difference in the preoperative rSO2 values between the two groups (

Published
2022

5. [Effects of electroacupuncture pretreatment on NLRP3 inflammasome in mice with ventilator-induced lung injury].

Author

Ning JQ, Luo JS, Guo YH, Chen MJ, Yan RY, Zhou RL, and Ding LL

Subjects
Mice, Animals, Inflammasomes genetics, Inflammasomes metabolism, NLR Family, Pyrin Domain-Containing 3 Protein genetics, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, Interleukin-18, Mice, Inbred C57BL, Lung metabolism, Caspase 1, Electroacupuncture, Ventilator-Induced Lung Injury genetics, Ventilator-Induced Lung Injury therapy, Ventilator-Induced Lung Injury metabolism
Abstract

Objective: To observe the effect of electroacupuncture (EA) pretreatment on inflammatory response in ven-tilator-induced lung injury (VILI) mice, so as to explore the underlying mechanism of EA pretreatment on prevention of VILI., Methods: C57BL/6 mice were randomly divided into sham-operation group, model group, EA group and sham-acupoint group，with 8 mice in each group. The VILI model was established by ventilation with high tidal volume. Mice in the EA group and sham-acupoint group were given EA at "Zusanli" (ST36)and "Feishu"(BL13) or non-acupoints (located at 1-2 cm on both sides of the tail root of the proximal trunk) before mechanical ventilation, 30 min each time, once a day for 5 days. Arterial blood was collec-ted for blood gas analysis, the total protein content in bronchoalveolar lavage fluid (BALF) was detected by BCA method. The contents of interleukin-1β (IL-1β) and interleukin-18 (IL-18) in BALF were detected by ELISA. Lung injury score was determined after HE staining. The protein expression levels of nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3), apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC) and Caspase-1 in lung tissue was detected by Western blot., Results: Compared with the sham-operation group, the arterial partial pressure of oxygen and oxygenation index were decreased( P <0.05), the levels of total protein, IL-1β and IL-18 in BALF, the W/D value and the pathological injury score of lung tissue and the protein expression levels of NLRP3, Caspase-1 and ASC were increased( P <0.05)in the model group. Following the interventions, the above mentioned increased or decreased indicators were reversed( P <0.05) in the EA group rather than in the sham-acupoint group., Conclusion: EA pretreatment of ST36 and BL13 can reduce the damage of lung tissue caused by mechanical ventilation, which may be related to its effect in reducing the expression of NLPR3 inflammasome related proteins, reducing the activation of inflammasome, and thereby reducing the inflammatory response.

Published
2023
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