1. Possible Role of FDG-PET in the Early Prediction of Therapy Outcome in Liver Metastases of Colorectal Cancer
- Author
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Hans-Jürgen Biersack, Nina Metten, Nicole Bangard, Jörg Mezger, A. Schomburg, Michael Bangard, and Hans Bender
- Subjects
Male ,Antimetabolites, Antineoplastic ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,Immunology ,Leucovorin ,Adenocarcinoma ,Gastroenterology ,Metastasis ,Folinic acid ,Fluorodeoxyglucose F18 ,Predictive Value of Tests ,Internal medicine ,Genetics ,medicine ,Animals ,Humans ,Aged ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Middle Aged ,medicine.disease ,Surgery ,Treatment Outcome ,Positron emission tomography ,Fluorouracil ,Predictive value of tests ,Feasibility Studies ,Female ,Radiopharmaceuticals ,Colorectal Neoplasms ,business ,Tomography, Emission-Computed ,medicine.drug - Abstract
Nonresectable colorectal cancer metastases in the liver respond to chemotherapy in 20-25% only. Early identification of nonresponders might allow the use of other regimens. In a limited feasibility study, it should be determined whether (a) a single high-dose chemotherapy application has an early effect on glucose-utilization, detectable and quantitatable by noninvasive positron emission tomography using [18F]-Fluoro-deoxyglucose (FDG-PET) and (b) assess its value as a predictor of the final therapeutic outcome. A total of 10 patients with documented nonresectable liver metastases of a colorectal cancer were studied by FDG-PET, prior and 72 h after a single infusion of 5-Fluorouracil and Folinic acid (5-FU/FA). Glucose utilization was quantitated by determination of standard-uptake values and correlated with final therapy outcome following completion of the anticipated therapy cycle. Patients were followed up for at least 6 months. All metastases responding to therapy (n = 6) exerted a statistically significant decrease of FDG uptake (-22+/-10%), metastases (n = 2) showing a short-term effect (duration of tumor reduction
- Published
- 1999
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