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3 results on '"Nina Gacheva"'

1. Towards elimination: measles susceptibility in Australia and 17 European countries

Author

Nick Andrews, Annedore Tischer, Annette Siedler, Richard G Pebody, Christopher Barbara, Suzanne Cotter, Arnis Duks, Nina Gacheva, Kriz Bohumir, Kari Johansen, Joel Mossong, Fernando de Ory, Katarina Prosenc, Margareta Sláciková, Heidi Theeten, Marios Zarvou, Adriana Pistol, Kalman Bartha, Dani Cohen, Jo Backhouse, and Algirdas Griskevicius

Subjects
Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: To evaluate age-specific measles susceptibility in Australia and 17 European countries. METHODS: As part of the European Sero-Epidemiology Network 2 (ESEN2), 18 countries collected large national serum banks between 1996 and 2004. These banks were tested for measles IgG and the results converted to a common unitage to enable valid intercountry comparisons. Historical vaccination and disease incidence data were also collected. Age-stratified population susceptibility levels were compared to WHO European Region targets for measles elimination of < 15% in those aged 2-4 years, < 10% in 5-9-year-olds and < 5% in older age groups. FINDINGS: Seven countries (Czech Republic, Hungary, Luxembourg, Spain, Slovakia, Slovenia and Sweden) met or came very close to the elimination targets. Four countries (Australia, Israel, Lithuania and Malta) had susceptibility levels above WHO targets in some older age groups indicating possible gaps in protection. Seven countries (Belgium, Bulgaria, Cyprus, England and Wales, Ireland, Latvia and Romania) were deemed to be at risk of epidemics as a result of high susceptibility in children and also, in some cases, adults. CONCLUSION: Although all countries now implement a two-dose measles vaccination schedule, if the WHO European Region target of measles elimination by 2010 is to be achieved higher routine coverage as well as vaccination campaigns in some older age cohorts are needed in some countries. Without these improvements, continued measles transmission and outbreaks are expected in Europe.

Published
2008

2. Towards elimination: measles susceptivility in Australia and 17 European countries

Author

Kari Johansen, Joël Mossong, Fernando de Ory, A. Tischer, Marios Zarvou, Katarina Prosenc, Margareta Slacikova, Dani Cohen, Richard Pebody, Nick Andrews, Adriana Pistol, Kriz Bohumir, Nina Gacheva, Jo Backhouse, Kalman Bartha, Christopher Barbara, Algirdas Griskevicius, Heidi Theeten, A. Siedler, Suzanne Cotter, and Arnis Duks

Subjects
Adult, Pediatrics, medicine.medical_specialty, Adolescent, Vaccination schedule, Measles Vaccine, Population, Vaccines, Attenuated, Measles, Seroepidemiologic Studies, Surveys and Questionnaires, Humans, Medicine, Child, education, education.field_of_study, Immunization Programs, business.industry, Transmission (medicine), Research, Public health, Australia, Public Health, Environmental and Occupational Health, Outbreak, medicine.disease, Europe, Vaccination, Child, Preschool, Blood Banks, Human medicine, Measles vaccine, business, Demography
Abstract

Objective To evaluate age-specific measles susceptibility in Australia and 17 European countries. Methods As part of the European Sero-Epidemiology Network 2 (ESEN2), 18 countries collected large national serum banks between 1996 and 2004. These banks were tested for measles IgG and the results converted to a common unitage to enable valid intercountry comparisons. Historical vaccination and disease incidence data were also collected. Age-stratified population susceptibility levels were compared to WHO European Region targets for measles elimination of < 15% in those aged 2-4 years, < 10% in 5-9-year-olds and < 5% in older age groups. Findings Seven countries (Czech Republic, Hungary, Luxembourg, Spain, Slovakia, Slovenia and Sweden) met or came very close to the elimination targets. Four countries (Australia, Israel, Lithuania and Malta) had susceptibility levels above WHO targets in some older age groups indicating possible gaps in protection. Seven countries (Belgium, Bulgaria, Cyprus, England and Wales, Ireland, Latvia and Romania) were deemed to be at risk of epidemics as a result of high susceptibility in children and also, in some cases, adults. Conclusion Although all countries now implement a two-dose measles vaccination schedule, if the WHO European Region target of measles elimination by 2010 is to be achieved higher routine coverage as well as vaccination campaigns in some older age cohorts are needed in some countries. Without these improvements, continued measles transmission and outbreaks are expected in Europe.

Published
2008
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3. Vaccinoprophylaxis of mumps using mumps vaccine, strain Sofia 6, in Bulgaria

Author

Hristo Odisseev and Nina Gacheva

Subjects
Paramyxoviridae, Guinea Pigs, Immunization, Secondary, Mumps Vaccine, Vaccine strain, Chlorocebus aethiops, Medicine, Animals, Humans, Bulgaria, Child, Mumps, Vero Cells, Cells, Cultured, Reactogenicity, General Veterinary, General Immunology and Microbiology, biology, business.industry, Immunogenicity, Public Health, Environmental and Occupational Health, Infant, biology.organism_classification, medicine.disease, Virology, Vaccination, Infectious Diseases, Mumps vaccine, Child, Preschool, Molecular Medicine, Viral disease, business, Meningitis
Abstract

A mumps vaccine, using strain Sofia 6 prepared in guinea-pig kidney primary cell cultures, was gradually introduced in Bulgaria to vaccinate 1- to 12-year-old children between 1972 and 1976. It was included in the national vaccine programme in 1977. The vaccine showed a slight reactogenicity, a good immunogenicity and a high epidemiological efficacy. Due to the increased morbidity of mumps, revaccination was carried out in 4- to 12-year-old children in 1982. A high level of side-effects, mainly meningitis, was registered, and led to suspension of the mumps vaccine in Bulgaria.

Published
1994

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