Background and Objective Analysis and prediction of rupture risk of abdominal aortic aneurysms (AAA) facilitates planning for surgical interventions and assessment of plausible treatment modalities. Present approach of using maximum diameter criterion, is giving way to hemodynamic and bio-mechanical based predictors in conjunction with Computational fluid dynamic (CFD) simulations. Detailed studies on hemodynamic and bio-mechanical parameters at the stage of maximum growth/rupture is of practical importance to the clinical community. However, understanding the changes in these parameters at different stages of growth, will be useful for clinicians, in planning routine monitoring to reduce the risk of sudden rupture. This is particularly useful in medical resource starved nations. Present study investigates the hemodynamic and bio-mechanical changes occurring during the growth stages of aortic aneurysms using fluid structure interaction (FSI) studies. MethodsSix idealized fusiform aneurysm models spanning high (shorter) and low (longer) values of the shape index ( D H r ), have been analysed at three different stages of growth viz, a D m a x of 3.5cm, 4.25cm, 5cm. Pulsatile Newtonian blood flow, passing through an elastic arterial vessel wall with uniform thickness is assumed. Two-way coupled fluid structure interaction have been employed for the numerical simulation of blood flow dynamics and arterial wall mechanics. ResultsWall shear stress (WSS) parameters and vonmises stress indicators, co-relating rupture and thrombus formation, have been extracted and reported, at each growth stage. When the aneurysm progresses in diameter, the areas recording abnormally low TAWSS, as well as areas of high/low OSI were found to increase at different rates for shorter and longer aneurysms. Moreover, drastic increase in the maximum wall stresses (MWS) and wall displacement were observed as the aneurysm approached the critical diameter. ConclusionHemodynamic predictors were found to be highly dependent on the shape index ( D H r ), when the aneurysm was small, whereas significant influence of D H r on the wall stresses happens, as the aneurysm approaches the critical diameter. Inconsistent variation of these indicators exhibited by shorter aneurysms (high D H r ) at different growth stages, demands routine monitoring (using scans), of such aneurysms, to prevent unexpected rupture.