1. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study
- Author
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Mave, V, Chandanwale, A, Kinikar, A, Khadse, S, Kagal, A, Gupte, N, Suryavanshi, N, Nimkar, S, Koli, H, Khwaja, S, Bharadwaj, R, Joshi, S, Horng, H, Benet, LZ, Ramachandran, G, Dooley, KE, Gupta, A, and Gandhi, M
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Rare Diseases ,Orphan Drug ,Infectious Diseases ,Pediatric ,Tuberculosis ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Good Health and Well Being ,Antitubercular Agents ,Child ,Child ,Preschool ,Chromatography ,Liquid ,Drug Monitoring ,Female ,Hair ,Humans ,Isoniazid ,Longitudinal Studies ,Male ,Patient Compliance ,Proof of Concept Study ,Prospective Studies ,Tandem Mass Spectrometry ,tuberculosis ,paediatric TB ,therapeutic drug monitoring ,isoniazid drug concentrations ,hair assays ,Cardiorespiratory Medicine and Haematology ,Microbiology ,Cardiovascular medicine and haematology ,Clinical sciences ,Epidemiology - Abstract
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged
- Published
- 2016