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Introduction: Coinfections of human immunodeficiency virus (HIV) and syphilis can be seen due to reasons such as common risk group and transmission routes. In our study, it was aimed to investigate the seroprevalence of syphilis and the clinical features of the patients living with HIV. Materials and Methods: Data of 277 HIV-infected patients in Health Sciences University Umraniye Education and Research Hospital between January 2016 and December 2021 were evaluated retrospectively. Results: A total of 277 patients living with HIV were included in the study. Two hundred thirty-five (85%) of the patients were male and the mean age was 42.86 ± 13.40 years. HIV/syphilis coinfections were detected in 15% of newly diagnosed HIV patients and 25% during follow-up period. Among patients with HIV/syphilis coinfection 94% of patients were in the latent stage of syphilis, 6% of them were in the secondary stage. Neurosyphilis was diagnosed in one patient. The rate of syphilis was found to be statistically significantly higher in male, and alcohol-consuming patients. In heterosexual cases, the rate of not detecting syphilis was statistically significant. Conclusion: In our region, HIV/syphilis seroprevalence was found to be 25% during the study period. Syphilis coinfection was found to be statistically significant in male, and alcohol-consuming patients living with HIV. Considering the increasing seroprevalence of syphilis and HIV co-infection in the world, close follow-up of patients with HIV-infected risk factors for syphilis is recommended.

Introduction: Since the beginning of the pandemic, factors associated with mortality in patients with corona virus infection disease 2019 (COVID-19) have been investigated. Comorbidities and increased age have been frequently reported to be associated with mortality. We aimed to evaluate the factors associated with unfavorable outcome of patients with COVID-19 at an early period of the pandemic. Methodology: This single center, retrospective, observational study was conducted among laboratory confirmed COVID-19 patients hospitalized between March 11 and May 5, 2020, at Umraniye Training and Research Hospital, Istanbul, Turkey. The effects of the severity of illness, comorbidities, symptoms, and laboratory findings on the clinical outcome were evaluated. Factors associated with unfavorable outcome (necessity of mechanical ventilation or death) were examined using Cox proportional hazards models. Results: Out of a total of 728 patients, 53.8% were men and median age 54 years. The 30-day mortality rate was 4.9% among all hospitalized patients. A logistic regression model identified six predictors of unfavorable clinical outcome: age, severity of illness, the numbers of comorbidities, lymphopenia, high levels of C-reactive protein, and procalcitonin. Conclusions: The mortality rate was lower among the patients with COVID-19, hospitalized during the early period of the pandemic. Older age, higher severity score on admission, the numbers of comorbidities, higher levels of C-reactive protein, procalcitonin, and lymphopenia were identified to be associated with unfavorable outcome of the hospitalized patients with COVID-19.

Amaç: Santral sinir sistemi enfeksiyonları, acil tanı ve tedavi gerektiren morbidite ve mortalitesi yüksek enfeksiyonlardır. Hastanemizde takip edilen toplum kaynaklı santral sinir sistemi (SSS) enfeksiyonları irdelenerek hasta yönetiminde yardımcı olmak amaçlanmıştır.Yöntem: Ümraniye Eğitim ve Araştırma Hastanesi’nde 2013 ve 2020 yılları arasında SSS enfeksiyonu tanısı konan 56 hasta retrospektif olarak değerlendirildi. Bulgular: Yedi yıl içinde SSS enfeksiyonu tanısı konan 56 hastanın klinik sınıflaması incelendi. En sık akut pürülan menenjit (%51.8), ikinci sırada aseptik menenjit-ensefalit (%35.7) ardından tüberküloz menenjiti (%12.5) olduğu görüldü. Akut pürülan menenjit hastalarının %82.9’unda BOS kültürü sterildi. Bos kültüründe üreme olan hastalarda S. pneumonia (%10.3) ve E. coli (%6.8) saptandı. Aseptik menenjit ve ensefalitte %10 oranında HSV1 PCR pozitifliği mevcuttu. Başvuru esnasında klinik ayırım yapılamadığı için ampirik olarak antiviral ve antibiyotik tedavisi beraber başlanan hasta oranı %21.4 idi.Sonuç: Çalışmamızda başvuru esnasında ensefalit ve menenjit ayrımı yapılamayan hastaların oranı dikkati çekicidir. Ayrıca hastaların çoğunluğunda etkenin izole edilemediği görülmüştür. Genel olarak kullanılan ampirik tedavilerin etken izolasyonunu etkileyebileceği kanaatine varılmıştır. Hastaların yönetiminde SSS enfeksiyonlarına neden olan etkenlerin dağılımının bilinmesi ampirik tedavi seçiminde yol gösterici olmaktadır.

Objective: Frontline healthcare workers (HCW) exposed to coronavirus disease-2019 (COVID-19) patients at their work environment are at a higher risk of acquiring the disease. The aim of this study was to research the COVID-19 risks due to the occupational exposure of HCW and the clinical characteristics of the affected. Material and Methods: In this retrospective study, HCW, employed by The Umraniye Research and Training Hospital, who were diagnosed with COVID-19 between 20th March 2020 to 20th May 2020 were analysed. Results: A total of 128 (3.8%) HCW were diagnosed with COVID-19. Most of the infected HCW were medical staff (34%), nurses (24%), physicians (22%) and staff with no patient contact (20%). Fifty-six percent of the infected HCW were working in COVID-19 wards and out-patient clinics. Twenty-nine percent acquired the infection in hospital from an index patient and 32% of them from an infected HCW. The highest transmission was during the sharing of the same environment (53%) like offices. Thirteen per cent of the HCW took the virus during examination or treatment, 31% of the individuals were unaware of the transmission. The number of the infected HCW was higher during the beginning of the outbreak in Turkey. The symptomatic cases were more (88%) than the asymptomatic cases (12%). A total of 28 (22%) HCW were hospitalised and only 4% of the cases were severe. Conclusion: The asymptomatic COVID-19 carrying HCW are to be considered as the source of the spread of the disease among their colleagues. Stricter measures should be implemented to prevent in-hospital transmission. © 2021 by Turkiye Klinikleri.

Introduction The human population is aging at an astonishing rate. The aim of this study is to capture a situation snapshot revealing the proportion of individuals aged 65 years and over among inpatients in healthcare institutions in Turkey and the prevalence and type of infections in this patient group in order to draw a road map. Materials and Methods Hospitalized patients over 65 years at any of the 62 hospitals in 29 cities across Turkey on February 9, 2017 were included in the study. Web-based SurveyMonkey was used for data recording and evaluation system. Results Of 17,351 patients 5871 (33.8%) were ≥65 years old. The mean age was 75.1 ± 7.2 years; 3075 (52.4%) patients were male. Infection was reason for admission for 1556 (26.5%) patients. Pneumonia was the most common infection. The median length of hospital stay was 5 days (IQR: 2–11 days). The Antibiotic therapy was initiated for 2917 (49.7%) patients at the time of admission, and 23% of the antibiotics prescribed were inappropriate. Healthcare-associated infections developed in 1059 (18%) patients. Urinary catheters were placed in 2388 (40.7%) patients with 7.5% invalid indication. Conclusion This study used real data to reveal the proportion of elderly patients in hospital admissions. The interventions done, infections developed during hospitalization, length of hospital stay, and excessive drug load emphasize the significant impact on health costs and illustrate the importance of preventive medicine in this group of patients.

OBJECTIVE: Turkey is one of the latest countries that COVID-19 disease was reported, with the first case on March 11, 2020, and since then, Istanbul became the epicenter of the pandemic in Turkey. Here, we reveal sequences of the virus isolated from three different patients with various clinical presentations. METHODS: Nasopharyngeal swab specimens of the patients were tested positive for the COVID-19 by qRT-PCR. Viral RNA extraction was performed from the same swab samples. Amplicon based libraries were prepared and sequenced using the Illumina NextSeq platform. Raw sequencing data were processed for variant calling and generating near-complete genome sequences. All three genomes were evaluated and compared with other worldwide isolates. RESULTS: The patients showed various clinics (an asymptomatic patient, patient with mild disease, and with severe pulmonary infiltration). Amplicon-based next-generation sequencing approach successfully applied to generate near-complete genomes with an average depth of 2.616. All three viral genomes carried the D614G variant (G clade according to GISAID classification) with implications for the origin of a spread first through China to Europe then to Istanbul. CONCLUSION: Here, we report the viral genomes circulating in Istanbul for the first time. Further sequencing of the virus isolates may enable us to understand variations in disease presentation and association with viral factors if there is any. In addition, the sequencing of more viral genomes will delineate the spread of disease and will guide and ease the necessary measures taken to stem the spread of the novel coronavirus.

© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.Protective neutralizing antibody titers reduce in time after COVID-19 vaccinations, as in individuals who have had COVID-19. This study aimed to evaluate the safety and immunogenicity of CoronaVac and TURKOVAC vaccines used as a booster dose after CoronaVac primary vaccination. This double-blind, randomized, controlled, phase II, multicenter study included healthy male and female adults (18–60 years) who were vaccinated with two doses of CoronaVac vaccine and did not exceed the duration of at least 90 days and a maximum of 270 days from the second dose of vaccination. Among 236 eligible volunteers, 222 were recruited for randomization between July 12, 2021 and September 10, 2021; 108 and 114 were randomized to the TURKOVAC and CoronaVac arms, respectively. The primary endpoint was adverse events (AEs) (ClinicalTrials.gov; Identifier: NCT04979949). On day 28, at the neutralizing antibody threshold of 1/6, the positivity rate reached 100% from 46.2% to 98.2% from 52.6% in the TURKOVAC and CoronaVac arms, respectively, against the Wuhan variant and the positivity rate reached 80.6% from 8.7% in the TURKOVAC arm vs. 71.9% from 14.0% in the CoronaVac arm against the Delta variant. IgG spike antibody positivity rate increased from 57.3% to 98.1% and from 57.9% to 97.4% in the TURKOVAC and CoronaVac arms, respectively. The TURKOVAC and CoronaVac arms were comparable regarding the frequency of overall AEs. Both vaccines administered as booster yielded higher antibody titers with acceptable safety profiles.

Central nervous system (CNS) infections are inflammation of the brain meninges and parenchyma that can develop with many different microorganisms. Early diagnosis and effective treatment are important in the survival of patients. In our study, it was aimed to examine the clinical features of the patients followed up with the diagnosis of CNS infection.The data of 98 patients diagnosed with community acquired CNS infection in Ümraniye Training and Research Hospital and Fatih Sultan Mehmet Training and Research Hospital between February 2013 and December 2020 were evaluated retrospectively.Of the 98 patients diagnosed with CNS infection, 62 % (61) were male, mean age was 53.5±7.4 years. According to the classification, 43 (44 %) of the patients were acute bacterial meningitis, 38 (39 %) aseptic meningitis encephalitis, eight (8 %) tuberculous meningitis, five (5 %) brain abscess, and four (4 %) fungal meningitis. A predisposing factor was observed in 80 % of patients with brain abscess, 50 % of patients with fungal meningitis, and 31% of patients diagnosed with acute bacterial meningitis. Streptococcus pneumoniae (14 %), Escherichia coli (7 %) and Listeria monocytogenes (7 %) were most commonly grown in the cerebrospinal fluid culture of the acute bacterial meningitis patient group. In the aseptic meningitis encephalitis group, the most frequently isolated agent was VZV (18 %), followed by HSV type 1 (5 %) and HSV type 2 (5 %). Cryptococcus neoformans was isolated in all patients followed up with the diagnosis of fungal meningitis. Complications developed 50 % of the patients followed up with tuberculous meningitis.In our study, S.pneumoniae was most common in patients with acute bacterial meningitis and VZV was most common in patients with aseptic meningitis-encephalitis. Our findings will guide the management of patients with CNS infection., Santral sinir sistemi (SSS) infeksiyonları farklı birçok mikroorganizma ile gelişebilen, beyin meninks ve parankiminin enflamasyonu ile karakterize hastalıklardır. Hastaların sağ kalımında erken tanı ve etkin tedavi uygulanması önem arz etmektedir. Çalışmamızda SSS infeksiyonu tanısıyla takip edilen hastaların klinik özelliklerinin irdelenmesi amaçlanmıştır.Ümraniye Eğitim ve Araştırma Hastanesi’nde ve Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi’nde Şubat 2013 ve Aralık 2020 yılları arasında toplum kökenli SSS infeksiyonu tanısı konan 98 hastanın verileri retrospektif olarak değerlendirilmiştir.SSS infeksiyonu tanısı konan 98 hastanın % 62’sinin (61) erkek, yaş ortalamasının 53,5±7,4 olduğu görülmüştür. Yapılan sınıflamaya göre hastaların 43’ü (% 44) akut bakteriyel menenjit, 38’i (% 39) aseptik menenjit ensefalit, sekizi (% 8) tüberküloz menenjiti, beşi (% 5) beyin absesi, dördü (% 4) fungal menenjit tanısı almıştır. Beyin absesi tanılı hastaların % 80’inde, fungal menenjit tanılı hastaların % 50’sinde, akut bakteriyel menenjit tanısı konan hastaların % 31’inde predispozan bir faktör olduğu görülmüştür. Akut bakteriyel menenjit hasta grubunun beyin omurilik sıvısı kültüründe en sık Streptococcus pneumoniae (% 14), Escherichia coli (% 7) ve Listeria monocytogenes (% 7) üremiştir. Aseptik menenjit ensefalit grubunda ise en sık belirlenen etken VZV (% 18) ardından HSV tip 1 (% 5) ve HSV tip 2 (% 5) olmuştur. Fungal menenjit tanısı ile takip edilen hastaların hepsinde Cryptococcus neoformans izole edilmiştir. Tüberküloz menenjiti ile takip edilen hastaların % 50’sinde komplikasyon gelişmiştir.Çalışmamızda, akut bakteriyel menenjit hastalarında en sık S.pneumoniae, aseptik menenjit-ensefalit hastalarında da en sık VZV izole edilmiştir. Bulgularımız SSS infeksiyonu tanılı hastaların yönetiminde yol gösterici olacaktır.

Lyme disease is a zoonosis that arises from Borrelia burgdorferi spp belonging to the Spirochaetales family, transmitted by Ixodes-type ticks. In the course of the disease, the heart, skin, nervous and musculoskeletal system may be affected. Central nervous system involvement, defined as neuroborreliosis, may be similar to Guillain- Barré syndrome (GBS), an immune-mediated acute neuropathy. In this article, a case that was followed up in the neurology clinic with GBS due to facial paralysis, muscle weakness and widespread muscle pain was shared. Neuroborreliosis was considered in the differential diagnosis of the patient whose clinical findings did not improve due to the presence of tick contact in history, and the diagnosis was confirmed by clinical and laboratory findings. In this case, it was emphasized that neuroborreliosis should be kept in mind in the differential diagnosis of the GBS.

Introduction: In this study, the characteristics of the injuries through which healthcare workers were exposed to blood and body fluids and their distribution as regards occupational groups and years were evaluated, and it was aimed to investigate measures taht could be taken to reduce these injuries. Materials and Methods: One hundred and ninety-three penetration-laceration and mucosal injuries occurred in 2015 and 2017 at Umraniye Training and Research Hospital were assessed retrospectively using Excel (Office 2007). Results: When occupational groups were examined, 193 injuries recorded within these two years were found to belong to trainee health workers (45.6%) and nurses (31%). The source of 69% of the injuries was certain. Serological examination of the specimens whose source was known revealed 4% HBsAg positivity, 4% antiHCV positivity and 1% antiHIV positivity. 95% of the injuries were percutaneous. When time of occurrence was examined, it was determined that 48.2% of the injuries occurred from morning to noon, 43% after lunch, and 8.8% during night shift. The most common injuries were during procedure with a rate of 47.7%. When health professionals were examined according to their years in profession, 78.2% were found to have been working for a year. Conclusion: Exposure to blood and body fluids is a great risk for healthcare workers. About half of the data we gathered had occurred in the occupational group of trainee health workers. According to the years of work, 78% of the injuries occurred in the first year of occupation. For this reason, we think that the practical and theoretical training given to health professionals who are at the beginning of their professions should be increased, and these people should be observed carefully in the field.

INTRODUCTION[|]Influenza is a disease that causes mortality, morbidity, and workforce productivity losses, especially in high-risk patients. Healthcare workers are among those at risk for exposure to the flu and for transmission of the virus to the patients. The aim of this study was to evaluate the attitudes and behavior of physicians at one hospital regarding the influenza vaccine. [¤]METHODS[|]A questionnaire comprising 11 questions was used to evaluate the attitudes and behaviors of the physicians working in one hospital with respect to the influenza vaccine. [¤]RESULTS[|]A total of 105 physicians participated in the study, and 74.3% of the respondents were not vaccinated for influenza virus. The most common reasons given were that it was viewed as unimportant and remissness (64%). The results indicated that 39% of the physicians surveyed did not recommend an influenza vaccine to their patients. Vaccination was most frequently recommended to the patients with chronic lung disease (83.9%). It was also observed that 94.3% of the physicians had not received any education on influenza in previous year. [¤]DISCUSSION AND CONCLUSION[|]The most important step in reducing the mortality due to influenza is to increase the rate of influenza vaccination. Awareness of physicians should be increased in order for vaccination programs to be successful throughout the country.[¤]

Background: As the Modified Anticoagulation and Risk Factors in Atrial Fibrillation Risk Score (M-ATRIA-RS) encompasses prognostic risk factors of novel coronavirus-2019 (COVID-19), it may be used to predict in-hospital mortality. We aimed to investigate whether M-ATRIA-RS was an independent predictor of mortality in patients hospitalized for COVID-19 and compare its discrimination capability with CHADS, CHA2DS2-VASc, and modified CHA2DS2-VASc (mCHA2DS2-VASc)-RS. Methods: A total of 1,001 patients were retrospectively analyzed and classified into three groups based on M-ATRIA-RS, designed by changing sex criteria of ATRIA-RS from female to male: Group 1 for points 0–1 (n = 448), Group 2 for points 2–4 (n = 268), and Group 3 for points ?5 (n = 285). Clinical outcomes were defined as in-hospital mortality, need for high-flow oxygen and/or intubation, and admission to intensive care unit. Results: As the M-ATRIA-RS increased, adverse clinical outcomes significantly increased (Group 1, 6.5%; Group 2, 15.3%; Group 3, 34.4%; p

Background: The current knowledge about novel coronavirus-2019 (COVID-19) indicates that the immune system and inflammatory response play a crucial role in the severity and prognosis of the disease. In this study, we aimed to investigate prognostic value of systemic inflammatory biomarkers including C-reactive protein/albumin ratio (CAR), prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with severe COVID-19. Methods: This single-center, retrospective study included a total of 223 patients diagnosed with severe COVID-19. Primary outcome measure was mortality during hospitalization. Multivariate logistic regression analyses were performed to identify independent predictors associated with mortality in patients with severe COVID-19. Receiver operating characteristic (ROC) curve was used to determine cut-offs, and area under the curve (AUC) values were used to demonstrate discriminative ability of biomarkers. Results: Compared to survivors of severe COVID-19, non-survivors had higher CAR, NLR, and PLR, and lower LMR and lower PNI ( P < .05 for all). The optimal CAR, PNI, NLR, PLR, and LMR cut-off values for detecting prognosis were 3.4, 40.2, 6. 27, 312, and 1.54 respectively. The AUC values of CAR, PNI, NLR, PLR, and LMR for predicting hospital mortality in patients with severe COVID-19 were 0.81, 0.91, 0.85, 0.63, and 0.65, respectively. In ROC analysis, comparative discriminative ability of CAR, PNI, and NLR for hospital mortality were superior to PLR and LMR. Multivariate analysis revealed that CAR (⩾0.34, P = .004), NLR (⩾6.27, P = .012), and PNI (⩽40.2, P = .009) were independent predictors associated with mortality in severe COVID-19 patients. Conclusions: The CAR, PNI, and NLR are independent predictors of mortality in hospitalized severe COVID-19 patients and are more closely associated with prognosis than PLR or LMR.

Objective: This study aimed to identify the effect of tocilizumab (TCZ) on clinical outcomes in severe COVID-19 patients. Material and Methods: We included hospitalized COVID-19 patients with an initial WHO scale ≥4. We matched the patients with baseline characteristics by using propensity scores. Then, we selected patients with C-reactive protein levels above 30 and showing an upward trend. We assessed the effect of TCZ in patients on clinical outcomes by using Mann – Whitney U and Chi-square tests. Results: Of 200 patients who had an initial WHO scale ≥ 4, 42 (21%) were given TCZ in addition to standard of care (SOC). Twentyfive patients (50%) needed mechanical ventilation (MV) in the TCZ group, compared with 35 (21%) of 158 patients with SOC (p

To describe the change in the epidemiology of health care-associated infections (HAI), resistance and predictors of fatality we conducted a nationwide study in 24 hospitals between 2015 and 2018. The 30-day fatality rate was 22% in 2015 and increased to 25% in 2018. In BSI, a significant increasing trend was observed for Candida and Enterococcus. The highest rate of 30-day fatality was detected among the patients with pneumonia (32%). In pneumonia, Pseudomonas infections increased in 2018. Colistin resistance increased and significantly associated with 30-day fatality in Pseudomonas infections. Among S. aureus methicillin, resistance increased from 31 to 41%. WOS:000617831800002 2-s2.0-85101454721 PubMed: 33586014

SummaryCOVID-19 is a viral respiratory disease caused by SARS-CoV-2 infection. Global efforts of genomic surveillance of the virus give chance to track the spread of the pandemic. Global emergence of some viral mutations called attention and various studies have been suggested about increased infectivity of the virus. Herein, we sequenced viral genomes isolated from 184 patients in Istanbul and analyzed clinical metadata for the investigation of any viral mutation which affects the disease course of the host. We did not detect any viral mutations affecting the disease outcome in our cohort. Besides, we observed intra-host mutations in 76% of the isolates. Insertion/deletion and stop-gain mutations are also significantly less common among intra-host variants compared to consensus viral genome mutations. Longitudinal genomic surveillance is essential for timely detection of any lineages that might affect clinical outcome, the performance of diagnostic assays, or even the immunological escape of the virus.

To describe the change in the epidemiology of health care-associated infections (HAI), resistance and predictors of fatality we conducted a nationwide study in 24 hospitals between 2015 and 2018. The 30-day fatality rate was 22% in 2015 and increased to 25% in 2018. In BSI, a significant increasing trend was observed for Candida and Enterococcus. The highest rate of 30-day fatality was detected among the patients with pneumonia (32%). In pneumonia, Pseudomonas infections increased in 2018. Colistin resistance increased and significantly associated with 30-day fatality in Pseudomonas infections. Among S. aureus methicillin, resistance increased from 31 to 41%.

INTRODUCTION[|]To evaluate the prevalence of Toxoplasma gondii, rubella and cytomegalovirus (CMV) among the pregnant Turkish women as well as Syrian refugees in Istanbul.[¤]METHODS[|]Among pregnant women who are admitted to \\\"xxxx\\\" Maternity and Children Hospital in İstanbul between January 2014 and January 2015, antibodies against Toxoplasma gondii, rubella and CMV were measured using the micro-elisa method. The test results were evaluated retrospectively.[¤]RESULTS[|]Out of total 1066 pregnant women screened in this study, 963 (90.3%) were Turkish, and 103 (9.7%) were Syrian refugees. IgM positivity rates of T. gondii rubella and CMV were determined as 0,2%, 0%, 0,2% in Turkish women and 0,1%, 0%, 0% in Syrian refugees, IgG positivity rates were determined as 26,3%, 93,8%, 99,5% in Turkish women and 58,3%, 87,4%, 100% in Syrian refugees. The seroprevalence of T. gondii was lower and the rubella seroprevalence was higher among pregnant Turkish women and among pregnant Syrian refugees and statistically significant ( p< 0.05).[¤]DISCUSSION AND CONCLUSION[|]Since immunity against T. gondii in pregnant Turkish women is lower than in Syrian refugees, who are in reproductive age group, should get routine screenings. Immunization against rubella should be considered for Syrian refugees who are in reproductive age group. [¤]

INTRODUCTION[|]Hyperbaric oxygen therapy (HBOT) is a medical treatment method applied by intermittently breathing 100% oxygen and a commonly used supportive therapy for patients with diabetic foot ulcer (DFU). Our study aimed to evaluate the efficacy of HBOT in patients with DFU. [¤]METHODS[|]Thirty patients with HBOT and 42 patients without HBOT who were followed-up between 2016 and 2018 in our hospital were randomly selected and the epidemiologic, clinical characteristics of both groups, clinical outcomes of the patients were compared at the end of treatment.[¤]RESULTS[|]26 patients (86.7%) in the HBOT group and 14 patients (33.3%) in the non-HBOT group were PEDIS 3-4 (p = 0.000). The rates of re-hospitalization were significantly higher in the HBOT group (p = 0.005). Major and minor amputations were found to be similar in both groups, but in the HBOT group (p = 0.035 vs. p = 0.128). [¤]DISCUSSION AND CONCLUSION[|]In our study, it was thought that the rate of recurrent hospitalization and the need for surgical intervention in HBOT receiving group may be related to the presence of advanced stage of diabetic foot ulcers (DFU) in these patients. Amputation rates are similar in both groups and randomized, multicentre prospective studies are needed to evaluate HBOT efficacy. [¤]

Study Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases convened a meeting to develop a consensus report on management of chronic hepatitis in special hosts and special situations. Relevant literature and international guidelines were reviewed, and recommendations agreed are presented at the end of each section such as therapy of chronic hepatitis B (CHB) in patients with compensated and decompensated cirrhosis, prevention and therapy of recurrent hepatitis B after liver transplantation, management of fulminant hepatitis B, therapy of CHB in hemodialysis patients, management of CHB in nonliver solid organ transplant recipients, management of CHB in immunosuppressed nontransplant patients, therapy of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection, management of HBV and hepatitis C virus (HCV) coinfection, management of CHB in alcoholic patients and injecting drug users, therapy of CHB in pregnancy and lactation period, extrahepatic manifestations in HBV infection, HBV, HCV and hepatitis D virus coinfection, therapy of chronic hepatitis C (CHC) in patients with compensated and decompensated cirrhosis, treatment of patients with recurrent HCV infection following liver transplantation, therapy of CHC in hemodialysis patients, management of CHC in nonliver solid organ transplant recipients, therapy of HCV, HBV and HIV coinfection, management of CHC in immunosuppressed nontransplant patients, HCV infection and biological agents, HCV infection and chemotherapy, management of CHC in alcoholic patients and injecting drug users, fatty liver and CHC, hemoglobinopathy and CHC, CHC in pregnancy and lactation period, extrahepatic manifestations in HCV infection. Klimik Dergisi © 2014, AVES Ibrahim Kara. All rights reserved.