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Introduction: Fractures of the radial neck are very uncommon in children, accounting for 5–8.5% of all fractures around the elbow in children, and are sometimes found with dislocation of the elbow joint. Jeffery carefully studied and classified these types of radial neck fractures with displaced radial head into several types. Very few cases with Jeffrey fractures are reported in the literature, and most cases were treated by surgery. Only one case of successful closed reduction and cast and two cases of closed reduction and percutaneous pinning have been reported. Case Report: We report two cases of Jeffery Type 2 fractures treated by an open reduction in an 11-year-old and a 13-year-old boy. We describe the difficulties faced in the reduction of the fracture and the complications that occurred in the patients. Conclusion: Jeffery Type 2 fracture is an uncommon and difficult-to-treat injury with the possible complication of the radial head being turned upside down if treated conservatively. Therefore, prompt recognition and careful reduction are essential in this type of injury. Keywords: Jeffery fracture, elbow dislocation, radial neck fracture, pediatric elbow.

Nowadays the amount of information available on the internet has got a severe raise recently and people need some instruments to find and access appropriate information. One of such tool is called recommendation. Recommendation systems help to navigate quickly and receive the necessary information. Recommendation system are effective software technique to overcome the problem. Recommendation system can be used in various places one of them is Library. So, in this paper we are going to propose a Book Recommendation System using Collaborative filtering (CF)and Content Based Algorithm to recommend the books to the user according to their likes and information of the books ie. Ratings given by the existing users. The proposed system will give its users the ability to view and search the book, publications and genres category wise using the Support Vector Machine (SVM). SVM will list the most top-rated books based on the subject name given as input and give the ratings. It will also make sure user’s privacy to be maintained.

In India, the agricultural land has tremendously disintegrated which changed the land-use patterns. The agricultural land has declined continuously due to rapid urbanization in the country. In India, nearly 45% of the land cover comes under agriculture area, and 22% is under forest land, whereas this land was drastically decreasing day by day. The main aim of the study is to identify the urban growth along with the land use pattern of Chalisgaon city, situated in the Jalgaon district, of Maharashtra state. This is a comparative study from early 1990 to late 2020. The Landsat images have been used for the years 1990, 2000, 2010, and 2020 to identify the change in land use and land cover pattern. These images are processed and analyzed under GIS and maximum likelihood classification method. The Chalisgaon city covers a total of 1850 hectares area. In the last three decades, the total built-up area has increased from 556 hectares to 920 hectares. It is observed that, the urban expansion of the city is a major factor behind the declination the cultivational land area under study. In 1990 the agriculture area was about 1095 hectares that have been reduced to730 hectares in 2020. This study reveals the agricultural land gradually decreased due to encroachment of urban areas i.e., infrastructural, connectivity, population, and other related facilities.

Background: The pandemic of COVID-19 since its beginning has created havoc all-round the globe. The role of oxygen therapy remains constant. Various modalities have been studied for oxygen delivery to hypoxic patients but high flow nasal oxygen (HFNO) has lately gained importance in terms of non-invasive oxygen delivery, easy administration and great improvement in patient’s recovery. We conducted this retrospective analysis with the primary objective of looking for the proportion of patients who were successfully weaned off of HFNO or non-invasive ventilation (NIV) and the secondary aim was to look for duration of hospital stay and its effect on clinical recovery based on laboratory parameters. Methods: All patients, positive for COVID-19 infection by real-time reverse transcriptase polymerase chain reaction (RTPCR) were admitted to covid ICU or ward with oxygen requirement and were treated with either NIV or HFNO were enrolled for the study. Patients were grouped under H group (HFNO) or N group (NIV). Daily ABG readings, chest x-ray, respiratory rate, hemodynamic parameters and urine output were noted on 12 hourly intervals. Any changes in above parameters along with need for intubation were assessed. Results: Patients from both the groups showed significant improvement in their oxygen saturation by the fifth day of their treatment. Fourteen patients from the NIV group and 10 from the HFNO group had saturation >90% by Day 5. Of those who presented with saturation of

Endoscopic discectomy is a minimally invasive, day care spine surgery. Patient comfort is of utmost importance as it is performed under local anaesthesia and in prone position. Propofol and dexmedetomidine are titrable and short-acting and commonly used for conscious sedation. The objectives of the study are to study the effect of dexmedetomidine and propofol infusion on cardiorespiratory parameters and to evaluate the efficacy of dexmedetomidine and propofol infusion for conscious sedation.This is a prospective, randomized, patient-blinded study. Sixty adult patients were randomly recruited to 2 groups of 30 each, to receive an infusion of dexmedetomidine or propofol, titrated to bispectral index score 70-80. The intra-operative cardiorespiratory parameters and level of sedation, postoperative visual analogue scale score, time to discharge from post-anaesthesia care unit, and patient satisfaction were monitored.Both groups were comparable with respect to demographic parameters and surgical duration. The heart rate was significantly lower with dexmedetomidine whereas the intraoperative mean arterial pressure was higher with dexmedetomidine. Though the level of intraoperative sedation was higher with propofol, the respiratory parameters were comparable. Postoperative visual analogue scale score was significantly higher with propofol.Dexmedetomidine and propofol provide adequate sedation without any cardiorespiratory compromise when used for conscious sedation for minimally invasive spine surgeries performed in prone position. Dexmedetomidine provides an added advantage of postoperative analgesia and better patient satisfaction.

Aims and Objectives : To compare the efficacy of ultrasound-guided thoracic paravertebral block(TPVB) and ultrasound-guided pectoralis interfascial plane (PECS) block for Modified Radical Mastectomy (MRM). The primary objectives were to compare duration of post-operative analgesia and total post-operative analgesic consumption while the secondary objectives were to compare dermatomal spread, intraoperative anaesthesia requirement and patient satisfaction. Materials And Methods: Sixty female patients of American Society of Anaesthesiologists (ASA) physical status I and II, undergoing MRM under general anaesthesia, were randomly recruited to receive ultrasound-guided TPVB (Group T) or ultrasound-guided PECS block (Group P) with 25ml of 0.25% bupivacaine, in a prospective, observer-blinded, randomized study. Data was statistically analysed using Statistical Package for Social Sciences (SPSS) version 21.0. Categorical variables were compared using the Chi-square test or Fishers exact probability test continuous variables compared using unpaired t-test or Mann-Whitney U test. Results: All demographic variables were comparable. Intraoperative fentanyl consumption was lower in patients who received PECS block (72.50+27.35) than those who received TPVB (104.17+46.92) (p=0.0023). NRS was comparable in both groups till 2 hours post operatively. However, from 4 hours onwards, till 18 hours the Numerical Rating Scale (NRS) was significantly higher in TPVB group. Dermatomal spread was more extensive and postoperative analgesia requirement was lower in Group P. Patient satisfaction was comparable in both groups. Conclusion: PECS block is associated with superior postoperative analgesia and reduced analgesic requirement. The cranial dermatomal spread was better and intraoperative opioid requirement was less with PECS block.

Objective To acquaint with the presentation and management of the cystic artery aneurysm by enriching the reviewed literature with our own experience. Background Cystic artery pseudoaneurysm is an uncommon entity with varied clinical presentation. Inflammation and trauma are associated with most of the cases. Limited experience with the condition challenges the management of individual cases. Materials and methods We retrieved all the reported cases of cystic artery pseudoaneurysm, published up to December 2019, from the PubMed database and excluded those arising as postoperative complications. A total of 59 cases were analyzed, and we also included our experience of managing a case of cystic artery pseudoaneurysm. Results Abdominal pain (77.9%) was the most common presentation followed by upper GI bleed (64.4%), while 19 patients (32.2%) had presented with classic Quincke's Triad. Most of the cases were diagnosed following the rupture of the pseudoaneurysm (n = 49, 83.05%). Fifteen patients presented with shock. Hyperbilirubinemia (59.3%) and anemia (55.9%) were the commonest laboratory findings. Although CT angiogram remains the investigation of choice, a conventional angiogram is the gold standard and sufficed as the definitive management in 20 cases. Cholecystectomy formed the definitive management in the rest of the cases. We successfully managed a middle-aged female patient of cystic artery aneurysm with xanthogranulomatous cholecystitis by open cholecystectomy. Conclusion Cystic artery pseudoaneurysms are amenable to successful management with careful evaluation and timely cholecystectomy or angioembolization or a combination of both.

INTRODUCTION: The aim of current study was to assess safety of early drain removal after live donor hepatectomy (LDH). METHODS: 108 consecutive donors who met the inclusion criteria, were randomized to Early Drain Removal (EDR – post operative day (POD) 3 - if serous and the drain bilirubin level was less than 3 times of serum bilirubin - “3x3” rule) and Routine Drain Removal (RDR – drain output serous and less than 100ml). Primary outcome was to compare the safety. Secondary outcomes was to compare the post-operative morbidity. RESULTS: Pre-operative, intra-operative and postoperative parameters except for timing of drain removal were comparable. EDR was feasible in 46 out of 54 donors (85.14%) and none required re-intervention after EDR. There was significantly better pain relief with EDR (p=0.00). Overall complications, pulmonary complications, and hospital stay were comparableon intention-to-treat analysis. However, pulmonary complications (EDR - 1.9% Vs RDR -16.3% P= 0.030), overall complications (18.8% Vs 36.3%, P= 0.043) and hospital stay (8 Vs 9, P= 0.014) were more in RDR group on per treatment analysis. Bile leaks were seen in three donors (3.7% in EDR group Vs RDR 1.9% in P=0.558), none of them required endobiliary interventions. Re-Exploration for intestinal obstruction was required for 3 donors in RDR (0% vs 5.7%; p-0.079). CONCLUSION: EDR by “3x3” rule after LDH is safe and associated with significantly better pain relief. On per treatment analysis, EDR was associated with significantly less hospital stay, pulmonary and overall complications. Clinical Trial Registry: Clinical Trials.gov - NCT04504487.

Introduction Femoral neck fractures have been traditionally managed with hemiarthroplasty (HA) or conventional total hip arthroplasty (CTHA). There has been recent interest in using dual-mobility components (DMC) in total hip arthroplasty for patients with femoral neck fractures to provide increased stability and decrease the need for future revision. Methods We conducted a systematic review of the literature reporting on the use of DMC in the management of femoral neck fractures in geriatric patients. We included studies in which DMC were used alone and studies that included a comparison to total hip arthroplasty or HA. The outcomes of interest were postoperative dislocation, revision, and revision surgery rates. Two separate subgroup analyses were conducted. For the comparative studies, we analyzed the differences in outcomes using a random-effects model of relative risks. For the noncomparative studies, we estimated the cumulative incidence of the different outcomes. Results Eighteen studies met the inclusion criteria and were included in our analysis. Eleven noncomparative studies showed a cumulative incidence of dislocation to be 1.2% (95% confidence interval = 0.3% to 2.7%) when DMC were used alone. Subgroup analyses of the seven comparative studies yielded a relative risk of dislocation using DMC was 59% less than HA and 83% less than CTHA. DMC also compared favorably in terms of revision surgery and revision rates to HA. There was insufficient quality evidence to comment on revision surgery and revision rates when compared with CTHA in comparative studies, but among the noncomparative studies, there was a low rate of revision and revision surgery. Conclusions Our study revealed overall lower risk of dislocation using DMC compared with both CTHA and HA. There were also lower revision and revision surgery rates when DMC were used compared with HA. Further studies are required to elucidate cost-effectiveness and long-term outcomes of DMC in these scenarios. Level of evidence Level III-meta-analysis.

Background: Breast cancer is the most common cancer in India causing highest cancer deaths in India as per GLOBOCAN 2018. Early diagnosis and treatment helps in improving prognosis and prolonging life. BREAST-i LED machine is one of the technology, for screening breast cancer at early stage. The present study was undertaken to evaluate the feasibility of BREAST-i LED machine to screen breast cancer. Methods: Across-sectional study was conducted on 300 convenient selected women in the age group of 30-60 years. Data was collected by house-to-house survey and all the women in surveyed house were registered for the study. They were interviewed as per the interview schedule comprised of a) Socio-demographic profile b) reproductive profile c) cancer related history and sign/symptoms. . By using BREAST-i LED machine the breast examination was done and the clinical breast examination was done there after to screen any sign of breast cancer. Identified cases were referred for confirmation of diagnosis. The data entry and analysis was done on SPSS (version 20). Results: The majority of the participants were between the age of 40-50years (42%) and majority of them (89.33%) began their menstruation between the age of 11-15 years. More than half (53.66%) had their first pregnancy between the age of 21-30years More than half (58%) had not attained their menopause and 99.3% had no family history of breast cancer. A high level of suspicion of breast cancer using Breast-i-LED instrument was found among four women (1.33%). Same results were observed by clinical breast examinations as well. These women were referred for further confirmation of diagnosis. Conclusion: BREAST-i LED machine can be used in community for quick screening of suspicion of breast cancer.

In recent years, interest in the development of novel drug delivery systems using nanoparticles has gained more attention. The nanoparticles offer several advantages over other conventional drug delivery systems. Nanoparticles have gained importance in technological advancements due to their modifiable physical, chemical and biological properties with improved performance over their bulk foils. Nanoparticles can simply move in the body due to their small size and reach very complex organs through diverse routes. The high stability, controlled drug release makes nanoparticles the most suitable drug delivery system. Along with all these advantages, they offer variety in routes of administration. Both hydrophilic, as well as hydrophobic drugs, can be delivered in the form of nanoparticles. Nanoparticles have been used as a physical approach to modify and advance the pharmacokinetics and pharmacodynamics possessions of various types of drug molecules. Thesol-gel technique is a stress-free and very inexpensive process to formulate metal oxides and permits control over the doping process or adding of transition metals, as related to other research techniques. The study of different methods of synthesis of nanoparticles is essential to obtain desired nanoparticles with specific sizes and shapes. They are suitable candidates for various marketable and local applications, which include imaging, catalysis medical applications and environmental applications. This review mainly focuses on approaches used for the production of nanoparticles and different methods of synthesis of nanoparticles such as physical, chemical and biological method.

Objective: Herein, we report the effect of variation of hydrogen flow rate on the properties of Si:H films synthesized using PE-CVD method. Raman spectroscopy analysis show an increase in crystalline volume fraction and crystallite size implying that hydrogen flow in PE-CVD promotes the growth of crystallinity in nc-Si:H films with an expense of a reduction in deposition rate. Methods: FTIR spectroscopy analysis indicates that hydrogen content in the film increases with an increase in hydrogen flow rate and hydrogen is predominantly incorporated in Si-H2 and (Si-H2)n bonding configuration. The optical band gap determined using E04 method and Tauc method (ETauc) show an increasing trend with an increase in hydrogen flow rate and E04 is found higher than ETauc over the entire range of hydrogen flow rate studied. Results and Conclusion: We found that the defect density and Urbach energy increases with an increase in hydrogen flow rate. Photosensitivity (σPhoto /σDark) decreases from ~103 to ~1 when hydrogen flow rate is increased from 30 sccm to 100 sccm and can be attributed to amorphous-to-nanocrystallization transition in Si:H films. The results obtained from the present study demonstrated that hydrogen flow rate is an important deposition parameter in PECVD to synthesize nc-Si:H films.

Objective: Phosphorus doped hydrogenated nano-crystalline silicon (nc-Si:H) thin films were synthesized by catalytic chemical vapor deposition (Cat-CVD) method. Methods: The effect of deposition pressure on opto-electronic and structural properties was studied using various analysis techniques such as low angle XRD analysis, FTIR spectroscopy, Raman spectroscopy, UV-Visible spectroscopy, dark conductivity, etc. Results: From low angle XRD and Raman spectroscopy analysis, it is observed that an increase in deposition pressure causes Si:H films to transform and transit from amorphous to the crystalline phase. At optimized deposition pressure (300 mTorr), phosphorous doped nc- Si:H films having a crystallite size of ∼29 nm and crystalline volume fraction of ∼58% along with high deposition rate (∼29.7 Å/s) have been obtained. The band gap was found to be ∼1.98 eV and hydrogen content was as low as (∼1.72 at. %) for these films. Conclusion: The deposited films can be useful as an n-type layer for Si:H based p-i-n, tandem and c-Si hetero-junction solar cells.

Background: Thin films of PbS were prepared onto glass substrates by using a simple and cost-effective CBD method. Methods: The influence of deposition time on structural, morphology and optical properties have been investigated systematically. The XRD analysis revealed that PbS films are polycrystalline with preferred orientation in (200) direction. Enhancement in crystallinity and PbS crystallite size has been observed with an increase in deposition time. The formation of single-phase PbS thin films has been further confirmed by Raman spectroscopy. The surface morphology analysis revealed the formation of prismatic and pebble-like PbS particles and with an increase in deposition time, these PbS particles are separated from each other without secondary growth. The data obtained from the EDX spectra show the formation of high-quality but slightly sulfur-rich PbS thin films over the entire range of deposition time studied. Results and Conclusion: All films show an increase in absorption with an increase in deposition time and strong absorption in the visible and sub-bandgap regime of the NIR range of the spectrum with red-shift in band edge. The optical band gap shows a decreasing trend, as deposition time increases but it is higher than the bandgap of bulk PbS.

Aim: Although intestinal obstruction following living donor liver transplantation (LDLT) is relatively common, diaphragmatic hernia (DH) as the attributing cause is rarely reported. The study aimed to find out the incidence, clinical presentation, and management of DH after liver transplant in pediatric patients. Materials and Methods: A retrospective review of all cases of pediatric liver transplants was performed. Case sheets, operation records, and investigations including radiology were studied. Results: Out of 79 cases of pediatric liver transplants, two cases of posttransplant DH were identified. The first case is a 2-year-old male child who was transplanted for progressive familial intrahepatic cholestasis, and the second one is a 4-year-old boy who underwent LDLT for hepatitis A-induced acute liver failure. The first child presented abdominal symptoms and the second one with pulmonary symptoms. The DHs were diagnosed at 132 and 70 days, respectively, posttransplant by chest radiographs and computed tomography scan. The defects were located at the posteromedial aspect of the diaphragm in both the cases and were closed by primary closure with mesh reinforcement. Both the children are doing well with no recurrence. Conclusion: High index of clinical suspicion is mandated in pediatric patients after liver transplant and once the diagnosis is confirmed, urgent surgical exploration is mandatory.

Zinc oxide nano-sheets (ZNS) loaded with Zeolitic Imidazole Framework 8 (ZIF8) nanocrystals, i.e. (ZNS@ZIF8) thin films, were successfully synthesized using electrodeposition and facile chemical bath deposition (CBD) for photoelectrochemical (PEC) splitting of water. The formation of ZNS nano-sheets and ZIF8 nano-crystals has been confirmed by field emission scanning electron microscopy (FE-SEM), low angle X-ray diffraction (XRD), micro-Raman spectroscopy, and Fourier transform infrared (FTIR) spectroscopy analysis. PEC activity of ZNS@ZIF8 photoanodes was evaluated using the linear sweep voltammetry (LSV) technique, and the photocurrent density is significantly enhanced when ZNS are decorated with ZIF8 nanocrystals. Electrochemical impedance spectroscopy (EIS) revealed that ZNS@ZIF8 had low charge transfer resistance compared to pristine ZNS counterparts. This led to considerably improved PEC performance of ZNS@ZIF8. Mott–Schottky (M–S) analysis of ZNS and ZNS@ZIF8 revealed a shift of flat band potential for the ZNS and ZNS@ZIF8 photoanodes, respectively. The shift of flat band potential indicates a clear shift in the Fermi level towards the conduction band, leading to an efficient charge transfer process across the electrolyte. The carrier density of ZNS and ZNS@ZIF8 photoanodes increases from 3.67 × 1019 cm−3 to 4.11 × 1020 cm−3. The enhanced applied bias photon conversion efficiency (ABPE) of ZNS@ZIF8 photoanodes suggests that ZNS@ZIF8 can be a prospective candidate for PEC and optoelectronic applications.

Background: Early breast cancer with clinical or radiological node-negative axilla is treated with breast conservation surgery where lumpectomy with axillary dissection is done. Sentinel lymph node biopsy (SLNB) is an acceptable alternative to axillary clearance and has relatively lesser morbidity. SLNB methods include radioisotope (RI)-guided, blue dye-guided, or a combination of both. However, access to RI can be limited in certain geographic locations. Objective: This study aimed to determine the effectivity of methylene blue (MB) dye-guided SLNB as an alternative to RI. Methods: In this investigation, 43 clinically nodenegative early breast cancer patients were prospectively enrolled. SLNB was performed using MB dye (1%) administered to the peritumoral or periareolar region. The histopathology reports of the harvested nodes were studied, and the results were computed using SPSS and 2×2 contingency table. Results: The sensitivity, specificity, false-negative rate (FNR), and accuracy of MB-guided SLNB in our study were 92.8%, 100%, 7.14%, and 97.7%, respectively. Conclusion: The use of MB dye along with intraoperative palpation after meticulous lymph node dissection in each level is more effective and has lower FNR than RI.

MHV reconstruction is essential to avoid anterior sector congestion in adult live donor liver transplantation (LDLT) using a modified right lobe graft. The objective of this study is to evaluate the graft and patient outcomes with single orifice outflow reconstruction technique (SORT) (RHV + neo-MHV combined reconstruction on IVC) vs. dual outflow reconstruction technique (DORT) (RHV and neo-MHV separately reconstructed on IVC) in a modified right lobe LDLT. Prospectively collected data of consecutive patients undergoing LDLT from June 2011 to August 2018 were analyzed. The patients were divided into two groups: SORT (n = 207) and DORT (n = 108). The perioperative morbidity and mortality were compared between two groups. The two groups were comparable in baseline preoperative characteristics. Intraoperatively, warm ischemia time (27 vs. 45 min, p < 0.001), anhepatic phase (132 vs. 159 min, p < 0.001), and operative time (680 vs. 840 min, p < 0.001) were significantly shorter in SORT group. SORT group also had significantly lower GRWR (0.92 vs. 1.06, p < 0.001) and higher portal flow (2.4 vs. 2.7 L/min, p = 0.02). Postoperatively, SORT group had lower peak AST (177 vs. 209 IU/L, p < 0.001), ALT (163 vs. 189 IU/L, p = 0.004), creatinine levels (0.98 vs. 1.10, p = 0.01), rate of severe sepsis (13.7% vs. 22.9%, p = 0.03), major morbidity (50.7% vs. 62.6%, p = 0.03), shorter ICU (9 vs. 14 days, p < 0.001), and hospital stay (21 vs. 26 days, p = 0.03). Overall survival rates were comparable. A SORT leads to improved early graft function and perioperative morbidity in modified right lobe LDLT in spite of having lower GRWR and higher portal flow.

Background and Aims: Axillary brachial plexus block is commonly performed for surgeries on the hand and forearm. However, there are very few studies on the use of magnesium sulphate in axillary brachial plexus block and, hence, the study was designed to evaluate magnesium as an adjuvant to ropivacaine-induced axillary block with respect to onset and duration of sensorimotor block and postoperative analgesia. Methods: Sixty patients of the American Society of Anesthesiologists (ASA) physical status I and II, undergoing surgeries on the hand and forearm were randomly recruited to receive ultrasound-guided axillary block with either 150 mg magnesium sulphate or 1 mL normal saline added to 0.5% ropivacaine. The primary outcome measure was to compare block characteristics including postoperative analgesia and the secondary outcome was to compare the use of rescue analgesia and the side-effect profile. Data were statistically analysed using Statistical Package for Social Sciences (SPSS version 21.0). Categorical variables were compared using the Chi-square test or Fisher's exact probability test; continuous variables compared using unpaired t-test or Mann-Whitney U test. Results: Onset of sensory (9.93 ± 1.31 vs 8.83 ± 1.12 min) as well as motor block (13.37 ± 1.63 vs 11.57 ± 1.30 min) was significantly hastened with addition of magnesium to ropivacaine (p < 0.001) and so was the duration (sensory 386.60 ± 18.26 vs 526.37 ± 27.43, motor 323.73 ± 15.17 vs 436.97 ± 18.99 min) (p < 0.001) and postoperative analgesia (425 ± 21.39 vs 572.83 ± 32.04 min) (p < 0.001) which reflected in decreased requirement of rescue analgesic and total postoperative analgesic dosage. Conclusions: Magnesium is an effective and safe adjuvant to local anaesthetics and improves all characteristics of axillary brachial plexus block along with postoperative analgesia.

In this study an experimental investigation of effects of cutting parameters on surface roughness during drilling of silicon carbide particulate reinforced aluminium matrix composite material under minimum quantity lubrication (MQL) condition was carried out. Cutting speed , feed rate, flow rate and % SiC in aluminium matrix composites were chosen as cutting parameters. The experimental design adopted for this investigation was the central composite design of response surface methodology. Thirty one readings were taken on VMC machine for MQL condition and the surface roughness measured using Mitutoyo surface tester. Surface roughness values for MQL condition were lower with 30% SiC reinforced aluminium matrix composites when compared to 10 % and 20 % SiC reinforced aluminium matrix composites . As cutting speed increased Ra & Rz value also increased .% SiC was found most significant factor while drilling aluminium matrix composites.

In this study an experimental investigation of effects of cutting parameters on surface roughness during drilling of silicon carbide particulate reinforced aluminium matrix composite material under dry condition was carried out. Cutting speed , feed rate and % SiC in aluminium matrix composites were chosen as cutting parameters. The experimental design adopted for this investigation was the central composite design of response surface methodology. Thirty one readings were taken on VMC machine for dry condition and the surface roughness measured using Mitutoyo surface tester. Surface roughness values for dry condition were lower with 30% SiC reinforced aluminium matrix composites when compared to 10 % and 20 % SiC reinforced aluminium matrix composites . As cutting speed increased Ra & Rz value also increased .% SiC was found most significant factor while drilling aluminium matrix composites.

Herein, we report the synthesis of highly stable, Pb-free bismuth iodide (BiI3 or BI), stoichiometric methylammonium bismuth iodide [(CH3NH3)3Bi2I9 or MA3Bi2I9 or s-MBI] and non-stoichiometric methylammonium bismuth iodide [(CH3NH3)2BiI5 or MA2BiI5 or Ns-MBI] perovskite thin films for photodetector applications. These films are synthesized at room temperature by a single step solution process spin coating method. The structural, optical, and morphological properties of these films were investigated using different characterization techniques such as XRD, Raman spectroscopy, FE-SEM, UV-Visible spectroscopy, etc. Formation of BI, s-MBI and Ns-MBI thin films is confirmed by XRD and Raman spectroscopy measurements. XRD analysis reveals that BI has a hexagonal crystal structure and a P63/mmc hexagonal space group for s-MBI and Ns-MBI. The optical properties of BI thin films show a high absorption coefficient (∼104 cm−1) and a band gap of ∼1.74 eV. Similarly, s-MBI films have a high absorption coefficient (∼103 cm−1) and an indirect band gap of ∼1.8 eV. Moving from s-MBI to Ns-MBI, the value of absorption coefficient is ∼103 cm−1 and the band gap corresponds to ∼2 eV. Finally, photodetectors based on the synthesized BI, s-MBI and Ns-MBI perovskites have been directly fabricated on FTO substrates. All photodetectors exhibited highly stable photo-switching behaviour along with excellent photoresponsivity and detectivity, with a fast response and recovery time. Our work demonstrates that Pb-free BI, s-MBI and Ns-MBI perovskites have great potential in the future for realizing stable photodetectors.

Through trade, also known as import and export activities, countries around the globe have become more linked and interconnected in today's business world. The exchange rate is critical in allowing a monetary transaction to take place in a structured and coherent manner during a trading period. The support vector machine (SVM) has proven to be a successful method for estimating the financial markets after conducting research on various forecasting methods. In this research, the prediction of exchange rate of USD/AUD and other 59 countries was done. The forecast and analysis of the US dollar against other foreign currencies has been completed. This research has proven that SVM works best for relatively smaller data with respect to its accuracy.

Summary: Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, effector T cells must efficiently locate antigen-presenting cells (APC) for peripheral activation. We reveal that tissue entry and initial peripheral activation of Th1 effector T cells are tightly linked to perivascular positioning of chemokine-expressing APCs. Dermal inflammation induces tissue-wide de novo generation of discrete perivascular CXCL10+ cell clusters, enriched for CD11c+MHC-II+ monocyte-derived dendritic cells. These chemokine clusters are “hotspots” for both Th1 extravasation and activation in the inflamed skin. CXCR3-dependent Th1 localization to the cluster micro-environment prolongs T-APC interactions and boosts function. Both the frequency and range of these clusters are enhanced via a T helper 1 (Th1)-intrinsic, interferon-gamma (IFNγ)-dependent positive-feedback loop. Thus, the perivascular CXCL10+ clusters act as initial peripheral activation niches, optimizing controlled activation broadly throughout the tissue by coupling Th1 tissue entry with enhanced opportunities for Th1-APC encounter.

Dual-mobility (DM) articulations are increasingly utilized to prevent or manage hip instability after total hip arthroplasty (THA). DM cups offer enhanced stability due to the dual articulation resulting in larger jump distance and greater range of motion before impingement. Improvement in design features and biomaterials has contributed to increased interest in dual-mobility articulations due to lower risk of complications compared to their historic rates. The incidence of implant-specific complications like intra-prosthetic dislocation (IPD) and wear has reduced with newer-generation implants. DM THAs are used in primary THA in patients with high risk for dislocation, e.g. neuromuscular disorder, femoral neck fracture, spinopelvic deformity, etc. They offer an attractive alternative option to constrained liner for treatment of hip instability in revision THA. The medium- to short-term results with DM THA have been encouraging in primary and revision THA. However, there are concerns of fretting, corrosion and long-term survivorship with DM THA. Hence, longer-term studies and surveillance are required for the safe use of DM THA in clinical practice.

An important and integral effort toward understanding the formation and reorganization of mesoscale structures in functional organic thin films, being of fundamental importance to the development o...

Perforation is a rare but serious adverse event of endoscopic retrograde cholangiopancreatography (ERCP). The aim of this study was to determine the predictors of morbidity and mortality after surgical management of ERCP-related perforation (EP). The records of patients with EP requiring surgical intervention at a tertiary referral center in a 12-year period (2004–2016) were retrospectively analyzed for demography, indications for ERCP, risk factors, timing and type of surgical repair, post-operative course, hospital stay, and outcome. Multiple logistic regression was used to identify the parameters predicting survival. Of 25,300 ERCPs, 380 (1.5%) had EP. Non-operative management was successful in 330 (86.8%) patients. 50 (13.2%) patients were operated for EP. Out of 50, the perforation was detected during ERCP (intra-procedure) in 32 patients (64%). In 30 patients (60%), the surgery was performed within 24 h of ERCP. Twenty patients underwent delayed surgery (after 24 h of ERCP) following the failure of initial non-operative management. The delayed surgery after an unsuccessful medical treatment had a detrimental effect on morbidity, mortality and hospital stay. Post-operative duodenal leak was the only independent predictor of 90-day mortality (p = 0.02, OR = 9.1, 95% CI 1.52–54.64). Addition of T-tube duodenostomy (TTD) to the primary repair for either type I or type II perforations increased post-operative duodenal leak (type I, p = 0.048 and type II; p = 0.001) and mortality (type I, p = 0.009 and type II, p = 0.045). Although EP is a rare event, it has a serious impact on morbidity and mortality. Delaying of surgery following failed non-operative management worsens the prognosis. Addition of TTD to the repair is not helpful in these patients.