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11 results on '"Nikowitz, Janet"'

1. Leveraging an Informatics Approach to Identify an Unmet Clinical Need for BRCA1/2 Testing Among Patients With Ovarian Cancer

Author

Gray, Stacy W., Ottesen, Rebecca A., Currey, Madeline, Cristea, Mihaela, Nikowitz, Janet, Shehayeb, Susan, Lozano, Vanessa, Hom, Julie, Kilburn, Julie, Lopez, Lisa N., Wing, Sam, Sosa, Ernesto, Shen, Jenny, Morris, Michael, Dilsizian, Bedros, Joseph, Thomas, Shen, James, Adeimy, Camille, Phillips, Tanyanika, Bahadini, Bahareh, and Niland, Joyce C.

Published
2022
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2. Supplementary Data from Double-hit Signature with TP53 Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-cell Lymphoma Treated with R-CHOP

Author

Song, Joo Y., primary, Perry, Anamarija M., primary, Herrera, Alex F., primary, Chen, Lu, primary, Skrabek, Pamela, primary, Nasr, Michel R., primary, Ottesen, Rebecca A., primary, Nikowitz, Janet, primary, Bedell, Victoria, primary, Murata-Collins, Joyce, primary, Li, Yuping, primary, McCarthy, Christine, primary, Pillai, Raju, primary, Wang, Jinhui, primary, Wu, Xiwei, primary, Zain, Jasmine, primary, Popplewell, Leslie, primary, Kwak, Larry W., primary, Nademanee, Auayporn P., primary, Niland, Joyce C., primary, Scott, David W., primary, Gong, Qiang, primary, Chan, Wing C., primary, and Weisenburger, Dennis D., primary

Published
2023
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4. Leveraging an Informatics Approach to Identify an Unmet Clinical Need for BRCA1 / 2 Testing Among Patients With Ovarian Cancer.

Author

Gray, Stacy W., Ottesen, Rebecca A., Currey, Madeline, Cristea, Mihaela, Nikowitz, Janet, Shehayeb, Susan, Lozano, Vanessa, Hom, Julie, Kilburn, Julie, Lopez, Lisa N., Wing, Sam, Sosa, Ernesto, Shen, Jenny, Morris, Michael, Dilsizian, Bedros, Joseph, Thomas, Shen, James, Adeimy, Camille, Phillips, Tanyanika, and Bahadini, Bahareh

Subjects
NATURAL language processing, MEDICAL informatics, OVARIAN cancer, CANCER patients, BRCA genes, GENETIC testing, ELECTRONIC health records
Abstract

PURPOSE: Although BRCA1 / 2 testing in ovarian cancer improves outcomes, it is vastly underutilized. Scalable approaches are urgently needed to improve genomically guided care. METHODS: We developed a Natural Language Processing (NLP) pipeline to extract electronic medical record information to identify recipients of BRCA testing. We applied the NLP pipeline to assess testing status in 308 patients with ovarian cancer receiving care at a National Cancer Institute Comprehensive Cancer Center (main campus [MC] and five affiliated clinical network sites [CNS]) from 2017 to 2019. We compared characteristics between (1) patients who had/had not received testing and (2) testing utilization by site. RESULTS: We found high uptake of BRCA testing (approximately 78%) from 2017 to 2019 with no significant differences between the MC and CNS. We observed an increase in testing over time (67%-85%), higher uptake of testing among younger patients (mean age tested = 61 years v untested = 65 years, P =.01), and higher testing among Hispanic (84%) compared with White, Non-Hispanic (78%), and Asian (75%) patients (P =.006). Documentation of referral for an internal genetics consultation for BRCA pathogenic variant carriers was higher at the MC compared with the CNS (94% v 31%). CONCLUSION: We were able to successfully use a novel NLP pipeline to assess use of BRCA testing among patients with ovarian cancer. Despite relatively high levels of BRCA testing at our institution, 22% of patients had no documentation of genetic testing and documentation of referral to genetics among BRCA carriers in the CNS was low. Given success of the NLP pipeline, such an informatics-based approach holds promise as a scalable solution to identify gaps in genetic testing to ensure optimal treatment interventions in a timely manner. [ABSTRACT FROM AUTHOR]

Published
2022
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5. Double-hit Signature with TP53 Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-cell Lymphoma Treated with R-CHOP

Author

Song, Joo Y., primary, Perry, Anamarija M., additional, Herrera, Alex F., additional, Chen, Lu, additional, Skrabek, Pamela, additional, Nasr, Michel R., additional, Ottesen, Rebecca A., additional, Nikowitz, Janet, additional, Bedell, Victoria, additional, Murata-Collins, Joyce, additional, Li, Yuping, additional, McCarthy, Christine, additional, Pillai, Raju, additional, Wang, Jinhui, additional, Wu, Xiwei, additional, Zain, Jasmine, additional, Popplewell, Leslie, additional, Kwak, Larry W., additional, Nademanee, Auayporn P., additional, Niland, Joyce C., additional, Scott, David W., additional, Gong, Qiang, additional, Chan, Wing C., additional, and Weisenburger, Dennis D., additional

Published
2021
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6. Double-Hit Signature with TP53 Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-Cell Lymphoma Treated with R-CHOP

Author

Song, Joo Y, primary, Perry, Anamarija M., additional, Herrera, Alex F., additional, Chen, Lu, additional, Skrabek, Pam, additional, Nasr, Michel, additional, Ottesen, Rebecca, additional, Nikowitz, Janet, additional, Bedell, Victoria, additional, Murata-Collins, Joyce, additional, Li, Yuping, additional, McCarthy, Christine, additional, Pillai, Raju, additional, Wang, Jinhui, additional, Wu, Xiwei, additional, Zain, Jasmine M., additional, Popplewell, Leslie L., additional, Kwak, Larry W, additional, Nademanee, Auayporn P., additional, Niland, Joyce, additional, Scott, David W., additional, Gong, Qiang, additional, Chan, Wing (John) C., additional, and Weisenburger, Dennis D., additional

Published
2020
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7. New Genomic Model Integrating Clinical Factors and Gene Mutations to Predict Overall Survival in Patients with Diffuse Large B-Cell Lymphoma Treated with R-CHOP

Author

Song, Joo Y., primary, Perry, Anamarija M., additional, Herrera, Alex F., additional, Chen, Lu, additional, Skrabek, Pam, additional, Nasr, Michel, additional, Ottesen, Rebecca, additional, Nikowitz, Janet, additional, Bedell, Victoria, additional, Murata-Collins, Joyce, additional, Chen, Yuan Yuan, additional, Li, Yuping, additional, Gomez Luna, Carlos, additional, McCarthy, Christine, additional, Pillai, Raju, additional, Wang, Jinhui, additional, Wu, Xiwei, additional, Zain, Jasmine, additional, Nademanee, Auayporn P., additional, Niland, Joyce, additional, Gong, Qiang, additional, Chan, Wing C, additional, and Weisenburger, Dennis D., additional

Published
2018
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8. Mutations in the Phosphoinositide 3-Kinase Pathway (PI3K) Are Associated with Poor Overall Survival (OS) in Patients with Diffuse Large B-Cell Lymphoma Treated with R-CHOP

Author

Song, Joo Y., Perry, Anamarija M., Herrera, Alex F., Skrabek, Pam, Nasr, Michel, Ottesen, Rebecca, Nikowitz, Janet, Bedell, Victoria, Murata-Collins, Joyce, Chen, Yuan Yuan, Li, Yuping, Gomez Luna, Carlos, McCarthy, Christine, Pillai, Raju, Wang, Jinhui, Wu, Xiwei, Zain, Jasmine M., Nademanee, Auayporn P., Niland, Joyce, Gong, Qiang, Chan, Wing C, and Weisenburger, Dennis D.

Published
2017
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9. Double-Hit Signature with TP53Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-Cell Lymphoma Treated with R-CHOP

Author

Song, Joo Y, Perry, Anamarija M., Herrera, Alex F., Chen, Lu, Skrabek, Pam, Nasr, Michel, Ottesen, Rebecca, Nikowitz, Janet, Bedell, Victoria, Murata-Collins, Joyce, Li, Yuping, McCarthy, Christine, Pillai, Raju, Wang, Jinhui, Wu, Xiwei, Zain, Jasmine M., Popplewell, Leslie L., Kwak, Larry W, Nademanee, Auayporn P., Niland, Joyce, Scott, David W., Gong, Qiang, Chan, Wing (John) C., and Weisenburger, Dennis D.

Abstract

Background:In diffuse large B-cell lymphoma (DLBCL), the presence of MYCand BCL2and/or BCL6translocations, so-called double-hit lymphoma (DH), has been associated with an aggressive clinical course. Recently, it was reported that gene expression profiling (GEP) could also identify cases with the biological and clinical characteristics of DH lymphoma, including some without the requisite translocations (DHITsig-positive cases)1. The purpose of this study was to develop a molecular subtyping schema for germinal center B-cell type (GCB) DLBCL using genomic studies such as fluorescence in situhybridization (FISH) cytogenetic analysis, GEP, and mutation analysis to risk-stratify patients with GCB DLBCL.

Published
2020
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10. Integration of mutation analysis as a risk predictor in patients with diffuse large B-cell lymphoma treated with R-CHOP

Author

Joo Song, Perry, Anamarija, Herrera, Alex F., Skrabek, Pamela, Nasr, Michel, Ottesen, Rebecca, Nikowitz, Janet, Chen, Lu, Bedell, Victoria, Murata-Collins, Joyce, Chen, Yuan Yuan, Li, Yuping, Luna, Carlos Gomez, Mccarthy, Christine, Pillai, Raju, Wang, Jinhui, Wu, Xiwei, Zain, Jasmine, Nademanee, Auayporn P., Niland, Joyce, Gong, Qiang, Chan, Wing Chung, and Weisenburger, Dennis D.

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