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592 results on '"Nikolov, I."'

1. Association Between the Polymorphism of Angiotensin-Converting Enzyme Gene and Interleukin-1 Beta Gene and the Response to Erythropoietin Therapy in Dialysis Patients with Anemia

Author

Dzekova-Vidimliski P, Eftimovska-Otovikj N, Nikolov I G, Selim Gj, Rambabova-Bushljetik I, Pushevski V, Karanfilovski V, Matevska-Geshovska N, and Dimovski A

Subjects
anemia, dialysis, erythropoietin, gene, polymorphism, therapy, Genetics, QH426-470
Abstract

The polymorphism of the angiotensin-converting enzyme (ACE) gene and interleukin-1 beta (IL-1b) gene could be associated with resistance in the treatment of anemia in dialysis patients with recombinant human erythropoietin (rHuEPO). The aim of the study was to evaluate the association between the polymorphism of the ACE and IL-1b genes and the response to rHuEPO therapy in dialysis patients with anemia.

Published
2024
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2. Laser-induced ultrafast demagnetization and perpendicular magnetic anisotropy reduction in a Co$_{88}$Tb$_{12}$ thin film with stripe domains

Author

Hennes, M., Merhe, A., Liu, X., Weder, D., Schmising, C. von Korff, Schneider, M., Günther, C. M., Mahieu, B., Malinowski, G., Hehn, M., Lacour, D., Capotondi, F., Pedersoli, E., Nikolov, I. P., Chardonnet, V., Jal, E., Lüning, J., and Vodungbo, B.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We use time-resolved x-ray resonant magnetic scattering (tr-XRMS) at the Co M$_{2,3}$- and Tb O$_1$-edges to study ultrafast demagnetization in an amorphous Co$_{88}$Tb$_{12}$ alloy with stripe domains. Combining the femtosecond temporal with nanometer spatial resolution of our experiment, we demonstrate that the equilibrium spin texture of the thin film remains unaltered by the optical pump-pulse on ultrashort timescales ($<$1 ps). However, after $\simeq$ 4 ps, we observe the onset of a significant domain wall broadening, which we attribute to a reduction of the uniaxial magnetic anisotropy of the system, due to energy transfer to the lattice. Static temperature dependent magnetometry measurements combined with analytical modeling of the magnetic structure of the thin film corroborate this interpretation.

Published
2020
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3. Adjustable coupling and in-situ variable frequency EPR probe with loop-gap resonators for spectroscopy up to X-band

Author

Joshi, G., Kubasek, J., Nikolov, I., Sheehan, B., costa, T. A., Cassaro, R. A. A., and Friedman, J. R.

Subjects
Physics - Applied Physics, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

In standard electron paramagnetic resonance (EPR) spectroscopy, the frequency of an experiment is set and the spectrum is acquired using magnetic field as the independent variable. There are cases in which it is desirable instead to fix the field and tune the frequency such as when studying avoided level crossings. We have designed and tested an adjustable frequency and variable coupling EPR probe with loop-gap resonators (LGRs) that works at a temperature down to 1.8 K. The frequency is tuned by adjusting the height of a dielectric piece of sapphire inserted into the gap of an LGR; coupling of the microwave antenna is varied with the height of antenna above the LGR. Both coupling antenna and dielectric are located within the cryogenic sample chamber, but their motion is controlled with external micrometers located outside the cryostat. The frequency of the LGR can be adjusted by more than 1 GHz. To cover a wide range of frequencies, different LGRs can be designed to cover frequencies up to X-band. We demonstrate the operation of our probe by mapping out avoided crossings for the Ni$_4$ single-molecule magnet to determine the tunnel splittings with high precision.

Published
2019
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4. Coherent soft X-ray pulses from an echo-enabled harmonic generation free-electron laser

Author

Rebernik Ribič, P, Abrami, A, Badano, L, Bossi, M, Braun, HH, Bruchon, N, Capotondi, F, Castronovo, D, Cautero, M, Cinquegrana, P, Coreno, M, Couprie, ME, Cudin, I, Boyanov Danailov, M, De Ninno, G, Demidovich, A, Di Mitri, S, Diviacco, B, Fawley, WM, Feng, C, Ferianis, M, Ferrari, E, Foglia, L, Frassetto, F, Gaio, G, Garzella, D, Ghaith, A, Giacuzzo, F, Giannessi, L, Grattoni, V, Grulja, S, Hemsing, E, Iazzourene, F, Kurdi, G, Lonza, M, Mahne, N, Malvestuto, M, Manfredda, M, Masciovecchio, C, Miotti, P, Mirian, NS, Petrov Nikolov, I, Penco, GM, Penn, G, Poletto, L, Pop, M, Prat, E, Principi, E, Raimondi, L, Reiche, S, Roussel, E, Sauro, R, Scafuri, C, Sigalotti, P, Spampinati, S, Spezzani, C, Sturari, L, Svandrlik, M, Tanikawa, T, Trovó, M, Veronese, M, Vivoda, D, Xiang, D, Zaccaria, M, Zangrando, D, Zangrando, M, and Allaria, EM

Subjects
Physical Sciences, Mathematical Sciences, Optoelectronics & Photonics
Abstract

X-ray free-electron lasers (FELs), which amplify light emitted by a relativistic electron beam, are extending nonlinear optical techniques to shorter wavelengths, adding element specificity by exciting and probing electronic transitions from core levels. These techniques would benefit tremendously from having a stable FEL source, generating spectrally pure and wavelength-tunable pulses. We show that such requirements can be met by operating the FEL in the so-called echo-enabled harmonic generation (EEHG) configuration. Here, two external conventional lasers are used to precisely tailor the longitudinal phase space of the electron beam before emission of X-rays. We demonstrate high-gain EEHG lasing producing stable, intense, nearly fully coherent pulses at wavelengths as short as 5.9 nm (~211 eV) at the FERMI FEL user facility. Low sensitivity to electron-beam imperfections and observation of stable, narrow-band, coherent emission down to 2.6 nm (~474 eV) make the technique a prime candidate for generating laser-like pulses in the X-ray spectral region, opening the door to multidimensional coherent spectroscopies at short wavelengths.

Published
2019

8. Outcome After Azacitidine Treatment in Patients with High-Risk Myeolodysplastic Syndrome, Chronic Myelomonocytic Leukemia Type 2 and Acute Myeloid Leukemia – A Single Center Experience (Preliminary Data)

Author

Varbanova V., Anastasova-Postadzhiyan A., Nedeva A., Nikolov I., Kindekov I., Kuyumdzhieva Y., Petkova N., Vikentieva E., Lubomir M., and Raynov J.

Subjects
azacytidine, mds, aml, cmml-2, Medicine
Abstract

Introduction: Hypomethylating agents have become a standard therapy for certain myeloid malignancies.

Published
2020
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9. Association Between the Polymorphism of Angiotensin-Converting Enzyme Gene and Interleukin-1 Beta Gene and the Response to Erythropoietin Therapy in Dialysis Patients with Anemia

Author

Dzekova-Vidimliski, P, primary, Eftimovska-Otovikj, N, additional, Nikolov, I G, additional, Selim, Gj, additional, Rambabova-Bushljetik, I, additional, Pushevski, V, additional, Karanfilovski, V, additional, Matevska-Geshovska, N, additional, and Dimovski, A, additional

Published
2023
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12. Multimodal near-infrared-emitting PluS Silica nanoparticles with fluorescent, photoacoustic, and photothermal capabilities

Author

Biffi S, Petrizza L, Garrovo C, Rampazzo E, Andolfi L, Giustetto P, Nikolov I, Kurdi G, Danailov MB, Zauli G, Secchiero P, and Prodi L

Subjects
Dye-doped nanoparticles, Optical imaging, NIR imaging, Photoacoustic Imaging, Photothermal Therapy, PEGylated nanoparticles., Medicine (General), R5-920
Abstract

Stefania Biffi,1 Luca Petrizza,2 Chiara Garrovo,1 Enrico Rampazzo,2 Laura Andolfi,3 Pierangela Giustetto,4 Ivaylo Nikolov,5 Gabor Kurdi,5 Miltcho Boyanov Danailov,5 Giorgio Zauli,1 Paola Secchiero,6 Luca Prodi2 1Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, 2Department of Chemistry ‘‘G Ciamician’’, University of Bologna, Bologna, 3IOM-CNR TASC Laboratory, Basovizza, Trieste, 4Ephoran – Multi-Imaging Solutions, Bioindustry Park Silvano Fumero, Torino, 5Elettra-Sincrotrone Trieste, Trieste, 6Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy Purpose: The aim of the present study was to develop nanoprobes with theranostic features, including – at the same time – photoacoustic, near-infrared (NIR) optical imaging, and photothermal properties, in a versatile and stable core–shell silica-polyethylene glycol (PEG) nanoparticle architecture. Materials and methods: We synthesized core–shell silica-PEG nanoparticles by a one-pot direct micelles approach. Fluorescence emission and photoacoustic and photothermal properties were obtained at the same time by appropriate doping with triethoxysilane-derivatized cyanine 5.5 (Cy5.5) and cyanine 7 (Cy7) dyes. The performances of these nanoprobes were measured in vitro, using nanoparticle suspensions in phosphate-buffered saline and blood, dedicated phantoms, and after incubation with MDA-MB-231 cells. Results: We obtained core–shell silica-PEG nanoparticles endowed with very high colloidal stability in water and in biological environment, with absorption and fluorescence emission in the NIR field. The presence of Cy5.5 and Cy7 dyes made it possible to reach a more reproducible and higher doping regime, producing fluorescence emission at a single excitation wavelength in two different channels, owing to the energy transfer processes within the nanoparticle. The nanoarchitecture and the presence of both Cy5.5 and Cy7 dyes provided a favorable agreement between fluorescence emission and quenching, to achieve optical imaging and photoacoustic and photothermal properties. Conclusion: We obtained rationally designed nanoparticles with outstanding stability in biological environment. At appropriate doping regimes, the presence of Cy5.5 and Cy7 dyes allowed us to tune fluorescence emission in the NIR for optical imaging and to exploit quenching processes for photoacoustic and photothermal capabilities. These nanostructures are promising in vivo theranostic tools for the near future. Keywords: dye-doped nanoparticles, optical imaging, NIR imaging, photoacoustic imaging, photothermal therapy, PEGylated nanoparticles

Published
2016

13. Continued Professional Education of Bulgarian Pharmacists: Second Registration Period

Author

Petrova G., Nikolov I., Ivanova Z., Decheva Tz., Draganov G., Naydenov T., and Stoimenova A.

Subjects
pharmacists, continued education, bulgaria, Medicine
Abstract

The continuing professional education prepares the pharmacists for the requirements of the changed role of pharmacists in the society. Different approaches to continuous professional education ranging from lectures to peer-mentoring work shops and web tools have been developed throughout the last 25 years. The goal of the current analysis is to systematize the trends in accredited education events for pharmacists by the Quality Committee of the BPhU during 2010-2013. This study is a retrospective database analysis. The information concerning the accredited forms of continuing education of pharmacists as well as other activities related to continuing education was extracted from the official protocols, issued by the Quality Commission of the Bulgarian Pharmaceutical Union (BPhU). The continuing postgraduate education of pharmacists in Bulgaria is developing with new elements which allow competence development through individual forms of self-development such as publication activities, delivering presentations, individual training, etc. In the educational programs accredited during the second registration period, still prevailed the short courses, with focus on the new medicinal products.

Published
2014
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14. Nonlinear harmonics of a seeded free-electron laser as a coherent and ultrafast probe to investigate matter at the water window and beyond

Author

Penco, G., primary, Perosa, G., additional, Allaria, E., additional, Badano, L., additional, Bencivenga, F., additional, Brynes, A., additional, Callegari, C., additional, Capotondi, F., additional, Caretta, A., additional, Cinquegrana, P., additional, Dal Zilio, S., additional, Danailov, M. B., additional, De Angelis, D., additional, Demidovich, A., additional, Di Mitri, S., additional, Foglia, L., additional, Gaio, G., additional, Gessini, A., additional, Giannessi, L., additional, Kurdi, G., additional, Manfredda, M., additional, Malvestuto, M., additional, Masciovecchio, C., additional, Mincigrucci, R., additional, Nikolov, I., additional, Pedersoli, E., additional, Pelli Cresi, S., additional, Principi, E., additional, Rebernik, P., additional, Simoncig, A., additional, Spampinati, S., additional, Spezzani, C., additional, Sottocorona, F., additional, Trovó, M., additional, Zangrando, M., additional, Chardonnet, V., additional, Hennes, M., additional, Lüning, J., additional, Vodungbo, B., additional, Bougiatioti, P., additional, David, C., additional, Roesner, B., additional, Sacchi, M., additional, Roussel, E., additional, Jal, E., additional, and De Ninno, G., additional

Published
2022
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19. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder

Author

Williams, H J, Norton, N, Dwyer, S, Moskvina, V, Nikolov, I, Carroll, L, Georgieva, L, Williams, N M, Morris, D W, Quinn, E M, Giegling, I, Ikeda, M, Wood, J, Lencz, T, Hultman, C, Lichtenstein, P, Thiselton, D, Maher, B S, Malhotra, A K, Riley, B, Kendler, K S, Gill, M, Sullivan, P, Sklar, P, Purcell, S, Nimgaonkar, V L, Kirov, G, Holmans, P, Corvin, A, Rujescu, D, Craddock, N, Owen, M J, and O'Donovan, M C

Published
2011
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20. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype

Author

Craddock, N, Jones, L, Jones, I R, Kirov, G, Green, E K, Grozeva, D, Moskvina, V, Nikolov, I, Hamshere, M L, Vukcevic, D, Caesar, S, Gordon-Smith, K, Fraser, C, Russell, E, Norton, N, Breen, G, St Clair, D, Collier, D A, Young, A H, Ferrier, I N, Farmer, A, McGuffin, P, Holmans, P A, Donnelly, P, Owen, M J, and O'Donovan, M C

Published
2010
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24. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2

Author

O'Donovan, M C, Norton, N, Williams, H, Peirce, T, Moskvina, V, Nikolov, I, Hamshere, M, Carroll, L, Georgieva, L, Dwyer, S, Holmans, P, Marchini, J L, Spencer, C C A, Howie, B, Leung, H-T, Giegling, I, Hartmann, A M, Möller, H-J, Morris, D W, Shi, Y, Feng, G, Hoffmann, P, Propping, P, Vasilescu, C, Maier, W, Rietschel, M, Zammit, S, Schumacher, J, Quinn, E M, Schulze, T G, Iwata, N, Ikeda, M, Darvasi, A, Shifman, S, He, L, Duan, J, Sanders, A R, Levinson, D F, Adolfsson, R, Ösby, U, Terenius, L, Jönsson, E G, Cichon, S, Nöthen, M M, Gill, M, Corvin, A P, Rujescu, D, Gejman, P V, Kirov, G, Craddock, N, Williams, N M, and Owen, M J

Published
2009
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26. Laser-induced ultrafast demagnetization and perpendicular magnetic anisotropy reduction in a Co$_{88}$Tb$_{12}$ thin film with stripe domains

Author

Hennes, Marcel, Merhe, Aladine, Liu, Xuan, Weder, D., Schmising, C, Schneider, M, Günther, C., Mahieu, B., Malinowski, Grégory, Hehn, M., Lacour, D, Capotondi, F, Pedersoli, E, Nikolov, I, Chardonnet, Valentin, Jal, Emmanuelle, Lüning, Jan, Vodungbo, Boris, Laboratoire de Chimie Physique - Matière et Rayonnement (LCPMR), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Max-Born Institute for Nonlinear Optics and Short Pulse Spectroscopy (MBI), Technische Universität Berlin (TU), Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut Jean Lamour (IJL), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Elettra Sincrotrone Trieste, and ANR-15-CE24-0009,UMAMI,Comprendre les mécanismes de renversement de l'aimantation induit par excitation laser(2015)

Subjects
[PHYS]Physics [physics], Condensed Matter::Materials Science, [PHYS.PHYS]Physics [physics]/Physics [physics], Condensed Matter - Mesoscale and Nanoscale Physics, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), Physics::Optics, FOS: Physical sciences, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat]
Abstract

We use time-resolved x-ray resonant magnetic scattering (tr-XRMS) at the Co M$_{2,3}$- and Tb O$_1$-edges to study ultrafast demagnetization in an amorphous Co$_{88}$Tb$_{12}$ alloy with stripe domains. Combining the femtosecond temporal with nanometer spatial resolution of our experiment, we demonstrate that the equilibrium spin texture of the thin film remains unaltered by the optical pump-pulse on ultrashort timescales ($

Published
2020
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27. Erratum: Stage 2 of the Wellcome Trust UK–Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16–q21, 4q12–q21, 9p21, 10p14–p12 and 18q22

Author

Lambert, D, Middle, F, Hamshere, M L, Segurado, R, Raybould, R, Corvin, A, Green, E, O'Mahony, E, Nikolov, I, Mulcahy, T, Haque, S, Bort, S, Bennett, P, Norton, N, Owen, M J, Kirov, G, Lendon, C, Jones, L, Jones, I, Holmans, P, Gill, M, and Craddock, N

Published
2006
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36. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

Author

Kirov, G, Pocklington, A J, Holmans, P, Ivanov, D, Ikeda, M, Ruderfer, D, Moran, J, Chambert, K, Toncheva, D, Georgieva, L, Grozeva, D, Fjodorova, M, Wollerton, R, Rees, E, Nikolov, I, van de Lagemaat, L N, Bayés, À, Fernandez, E, Olason, P I, Böttcher, Y, Komiyama, N H, Collins, M O, Choudhary, J, Stefansson, K, Stefansson, H, Grant, S GN, Purcell, S, Sklar, P, OʼDonovan, M C, and Owen, M J

Published
2012
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