374 results on '"Nikolaus, Susanna"'
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2. HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis
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Akar, Alaa, Flemming, Cornelius, Felix, Flomm, Flosbach, Markus, Jäger, Julia, Jeromin, Niklas, Jung, Johannes, Ohms, Mareike, Reinshagen, Konrad, Rische, Johann, Sagebiel, Adrian, Sandfort, Deborah, Steinert, Fenja, Tomuschat, Christian, Wesche, Jasmin, Shifteh Abedian, Abraham, Clara, Achkar, Jean-Paul, Ahmad, Tariq, Alberts, Rudi, Alizadeh, Behrooz, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Annese, Vito, Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Barclay, Murray, Barrett, Jeffrey C., Bethge, Johannes, Bewshea, Claire, Bis, Joshua C., Bitton, Alain, BK, Thelma, Boucher, Gabrielle, Brain, Oliver, Brand, Stephan, Brant, Steven R., Cheon, Jae Hee, Chew, Angela, Cho, Judy H., Cleynen, Isabelle, Cohain, Ariella, Cooney, Rachel, Croft, Anthony, Daly, Mark J., D'Amato, Mauro, Danese, Silvio, Daryani, Naser Ebrahim, Datta, Lisa Wu, Degenhardt, Frauke, Denapiene, Goda, Denson, Lee A., Devaney, Kathy L., Dewit, Olivier, D'Inca, Renata, Drummond, Hazel E., Dubinsky, Marla, Duerr, Richard H., Edwards, Cathryn, Ellinghaus, David, Ellul, Pierre, Esaki, Motohiro, Essers, Jonah, Ferguson, Lynnette R., Festen, Eleonora A., Fleshner, Philip, Florin, Tim, Franchimont, Denis, Franke, Andre, Fuyuno, Yuta, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jürgen, Goyette, Philippe, Green, Todd, Griffiths, Anne M., Guthery, Stephen L., Hakonarson, Hakon, Halfvarson, Jonas, Hanigan, Katherine, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hayward, Nicholas K., Hedl, Matija, Henderson, Paul, Hold, Georgina L., Hong, Myhunghee, Hu, Xinli, Huang, Hailiang, Hugot, Jean-Pierre, Hui, Ken Y., Imielinski, Marcin, Jazayeri, Omid, Jonaitis, Laimas, Jostins, Luke, Juyal, Garima, Chandra Juyal, Ramesh, Kalla, Rahul, Karlsen, Tom H., Kennedy, Nicholas A., Khan, Mohammed Azam, Kim, Won Ho, Kitazono, Takanari, Kiudelis, Gediminas, Kubo, Michiaki, Kugathasan, Subra, Kupcinskas, Limas, Lamb, Christopher A., de Lange, Katrina M., Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lee, James C., Lees, Charlie W., Leja, Marcis, Lewis, Nina, Van Limbergen, Johan, Lionetti, Paolo, Liu, Jimmy Z., Louis, Edouard, Luo, Yang, Mahy, Gillian, Malekzadeh, Masoud Mohammad, Malekzadeh, Reza, Mansfield, John, Marriott, Suzie, Massey, Dunecan, Mathew, Christopher G., Matsui, Toshiyuki, McGovern, Dermot P.B., van der Meulen, Andrea, Midha, Vandana, Milgrom, Raquel, Mirzaei, Samaneh, Mitrovic, Mitja, Montgomery, Grant W., Mowat, Craig, Müller, Christoph, Newman, William G., Ng, Aylwin, Ng, Siew C., Evelyn Ng, Sok Meng, Nikolaus, Susanna, Ning, Kaida, Nöthen, Markus, Oikonomou, Ioannis, Okou, David, Orchard, Timothy R., Palmieri, Orazio, Parkes, Miles, Phillips, Anne, Ponsioen, Cyriel Y., Potocnik, Urõs, Poustchi, Hossein, Prescott, Natalie J., Proctor, Deborah D., Radford-Smith, Graham, Rahier, Jean- Francois, Regueiro, Miguel, Reinisch, Walter, Rieder, Florian, Rioux, John D., Roberts, Rebecca, Rogler, Gerhard, Russell, Richard K., Sanderson, Jeremy D., Sans, Miquel, Satsangi, Jack, Schadt, Eric E., Scharl, Michael, Schembri, John, Schreiber, Stefan, Schumm, L. Philip, Scott, Regan, Seielstad, Mark, Shah, Tejas, Sharma, Yashoda, Silverberg, Mark S., Simmons, Alison, Simms, Lisa A., Singh, Abhey, Skieceviciene, Jurgita, van Sommeren, Suzanne, Song, Kyuyoung, Sood, Ajit, Spain, Sarah L., Steinhart, A. Hillary, Stempak, Joanne M., Stronati, Laura, Sung, Joseph J.Y., Targan, Stephan R., Taylor, Kirstin M., Theatre, Emilie, Torkvist, Leif, Torres, Esther A., Tremelling, Mark, Uhlig, Holm H., Umeno, Junji, Vahedi, Homayon, Vasiliauskas, Eric, Velde, Anje ter, Ventham, Nicholas T., Vermeire, Severine, Verspaget, Hein W., De Vos, Martine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Weersma, Rinse K., Wei, Zhi, Whiteman, David, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Wong, Sunny H., Xavier, Ramnik J., Yamazaki, Keiko, Yang, Suk-Kyun, Ye, Byong Duk, Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhang, Hu, Zhang, Wei, Zhao, Hongyu, Zhao, Zhen Z., Baumdick, Martin E., Niehrs, Annika, Schwerk, Maria, Hinrichs, Ole, Jordan-Paiz, Ana, Padoan, Benedetta, Wegner, Lucy H.M., Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Illig, Christin, Schröder-Schwarz, Jennifer, Möller, Kimberly J., Martin, Maureen P., Yuki, Yuko, Ozawa, Mikki, Sauter, Jürgen, Schmidt, Alexander H., Perez, Daniel, Giannou, Anastasios D., Carrington, Mary, Davis, Randall S., Schumacher, Udo, Sauter, Guido, Huber, Samuel, Puelles, Victor G., Melling, Nathaniel, Altfeld, Marcus, and Bunders, Madeleine J.
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- 2023
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3. I-CARE, a European Prospective Cohort Study Assessing Safety and Effectiveness of Biologics in Inflammatory Bowel Disease
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Gornet, Jean-Marc, Beaugerie, Laurent, Shaji, Sebastian, Peyrin-Biroulet, Laurent, Reimund, Jean-Marie, Hebuterne, Xavier, Amiot, Aurélien, Armelao, Franco, Blanc, Pierre, Papi, Claudio, De Chambrun, Guillaume Pineton, Roblin, Xavier, Chu, Karmiris, Konstantinos, Shariq, Sohail, Viazis, Nikolaos, Limdi, Jimmy, Eder H, Piotr, Michalopoulos, Georgios, Bell, Andrew, Biancone, Livia, Dewitte, Marie, Mazhar, Zia, Franchimont, Denis, Nancey, Stephane, Macaigne, Gilles, Principi, Maria Beatrice, Fumery, Mathurin, Parkes, Gareth, Valats, Jean-Christophe, Doherty, Glen, Bouguen, Guillaume, Molnar, Tamás, Tsai, Hersin, Gangi, Mohsin, Pedersen, Natalia, Heluwaert, Frédéric, Shenderey, Richard, Zeissig, Sebastian, Butterworth, Jeffrey, Castiglione, Fabiana, Corless, Lynsey, Zallot, Camille, Baert, Filip, Singh, Salil, Sonwalkar, Sunil, Clayton, Elizabeth, Rahier, Jean-François, Vani, Deven, Bellaiche, Guy, De Vos, Martine, Kirchgesner, Julien, Kopylov, Uri, Lobaton, Triana, Locher, Christophe, Mantzaris, Gerassimos, Abouda, George, Smith, Katie, Sprakes, Michael, Theodoropoulou, Angeliki, Wesley, Emma, Bonnet, Joëlle, Elphick, David, Gilletta, Cyrielle, Gordon, John, Laharie, David, Nakad, Antoine, Orlando, Ambrogio, Dubois, Patrick, Hasselblatt, Peter, Michiels, Christophe, Preston, Cathryn, Staicu, Anca, Vuitton, Lucine, Kaassis, Mehdi, Speight, Ally, Ghosh, Deb, Löwenberg, Mark, Mathieu, Nicolas, Pelletier, Anne-Laure, Phillips, Anne, Magro, Fernando, Altwegg, Romain, Avni, Irit, biron, Landy, Jonathon, Nachury, Maria, Shenoy, Achuth, Trang, Caroline, Abitbol, Vered, Bamias, Georgios, Farkas, Klaudia, Maaser, Christian, Shitrit, Ariella, Siegmund, Britta, Filippi, Jérôme, O'morain, Colm, Yanai, Henit, Costes, Laurent, Hobday, David, Szepes, Zoltán, Calabrese, Emma, Dallal, Helen, Fung, Michael, Ramadas, Arvind, Baburajan, Bijay, Koss, Konrad, Barberis, Christophe, Buisson, Anthony, Amil, Morgane, Balestrieri, Paola, Johnson, Matthew, Tzouvala, Maria, Viennot, Stéphanie, Nagy, Ferenc, Thompson, Nick, Alric, Laurent, Samuel, Sunil, Bourrier, Anne, Chanteloup, Elise, Del Tedesco, Emilie, Harbord, Marcus, Lobo, Alan, Myers, Sally, Pollok, Richard, Ahmad, Tariq, Chaudhary, Rakesh, Karakoidas, Christos, Soliman, Ashraf, Stefanescu, Carmen, Theocharis, Georgios, Branden, Stijn Vanden, Beltran, Belén, Bouhnik, Yoram, Bourreille, Arnaud, Branco, Joana, Colleypriest, Ben, Eliakim, Rami, Knight, Paul, O'toole, Aoibhlinn, Robles, Virgina, Triantafyllou, Konstantinos, Bosca, Marta Maia, Lambrecht, Guy, Mosquera, Lucia Marquez, Panter, Simon, Pappa, Aikaterini, Simon, Marion, Sivaji, Ganesh, Bellanger, Christophe, Belle, Arthur, Borruel, Natalia, Egan, Laurence, Peeters, Harald, Sharpstone, Daniel, Arasaradnam, Ramesh, Benitez, José Manuel, Dahlerup, Jens Frederik, Giouleme, Olga, Gisbert, Javier P., Helwig, Ulf, Minguez, Miguel, Tsironi, Eftychia, Variola, Angela, Allen, Patrick, Boivineau, Lucille, Cole, Andy, Dib, Nina, Gomollon, Fernando, Johnston, Richard, Katsanos, Konstantinos, Kennedy, Nick, Kiszka-Kanowitz, Marianne, Marin-Jimenez, Ignacio, Miheller, Pál, Nos, Pilar, Saraj, Othman, Vinter-Jensen, Lars, Zittan, Eran, Baudry, Clotilde, Calvet, Xavier, Cazelles-Boudier, Marie-Christine, Coenegrachts, Jean-Louis, Cullen, Garret, Daperno, Marco, Dhar, Anjan, Gerard, Romain, Jensen, Nanna, Maharshak, Nitsan, Mcalindon, Mark, Mcloughlin, Simon, Parkes, Miles, Patel, Kamal, Peixoto, Armando, Polymeros, Dimitrios, Portela, Francisco, Rocca, Rodolfo, Seksik, Philippe, Subramanian, Sreedhar, Tennenbaum, Ruth, Atreya, Raja, Bachmann, Oliver, Berger, Arthur, Bor, Renáta, Buckley, Maire, Carpio, Daniel, Chaparro, María, Costa, Francesco, Domenech, Eugeni, Esteve, Maria, Foley, Stephen, Guardiola, Jordi, Koutroubakis, Ioannis, Kuehbacher, Tanja, Landman, Cécilia, Lavagna, Alessandro, Manceñido, Noemí, Mañosa, Míriam, Martín-Arranz, Maria Dolores, Plastaras, Laurianne, Scribano, Maria Lia, Sengupta, Subhasish, Teich, Nils, Tran-Minh, My-Linh, Zampeli, Evanthia, Amininejad, Leila, Arroyo, Teresa, Attar, Alain, Backman, Ann-Sofie, Bálint, Anita, Beckly, John, Ben Horin, Shomron, Bernardo, Sónia, Caillo, Ludovic, Caron, Bénédicte, Shanika de Silva, María, FábiáN, Anna, Fiorino, Gionata, Gutierrez, Ana, Lahat, Adi, Masmoudi, Mohamed, Mendolaro, Marco, Muls, Vinciane, Poullenot, Florian, Probert, Christopher, Reenaers, Catherine, Rutka, Mariann, Sarwari, Zaman, Sayer, Joanne, Sicilia, Beatriz, Sousa, Helena, van Kemseke, Catherine, Zabana, Yamile, Astegiano, Marco, Banim, Paul, Bettenworth, Dominik, Boualit, Médina, Brodersen, Jacob Broder, Christidou, Angeliki, Cooney, Rachel, Pinto, João Cortez, Cravo, Portugal Marília, Cremer, Anneline, Danese, Silvio, di Sabatino, Antonio, Fallingborg, Jan, Ferronato, Antonio, Planella, Esther Garcia, Gupta, Sanjay, Halfvarson, Jonas, Israeli, Eran, Kestenbaum, Samantha, Larsen, Lone, Macken, Elisabeth, Mathou, Nicoletta, Milassin, Ágnes, Pofelski, Joanna, Ricci, Chiara, Rodriguez-Moranta, Francisco, Schmidt-Lauber, Martin, Shaw, Ian, Soares, Marta, Soliman, Heithem, Triantos, Christos, Zografos, Konstantinos, Agrawal, Anurag, Armuzzi, Alessandro, Aubourg, Alexandre, Acosta, Manuel Barreiro-de, Barrio, Jesús, Bergemalm, Daniel, Bermejo, Fernando, Bodini, Giorgia, Bohr, Johan, Bossuyt, Peter, Christodoulou, Dimitrios, Claessens, Christophe, Collins, Paul, de Francisco, Ruth, Garcia, Santiago, Georgopoulos, Sotirios, Goutorbe, Felix, Kalantzis, Chrisostomos, Kourikou, Anastasia, Mace, Vincent, Malamut, Georgia, Ministro, Paula, Larmurier, Isabelle Nion, Ricart, Elena, Serrero, Mélanie, Sheridan, Juliette, Weimers, Petra, Andersen, Vibeke, Arroja, Bruno, Bokemeyer, Bernd, Bujanda, Luis, Degand, Thibault, Eriksson, Carl, Garceau, Cécile, Glerup, Henning, Goren, Idan, Jackson, Lucina, Koch, Stéphane, Mesonero, Francisco, Ordas, Ingrid, Riviere, Pauline, Saibeni, Simone, Soares, João, Tavernier, Noémie, Theede, Klaus, Ungar, Bella, Bästlein, Elke, Gasbarrini, Antonio, Protopapas, Andreas, Reindl, Wolfgang, Bossa, Fabrizio, Hart, Ailsa, Heil, Franz-Josef, O'Connor, Anthony, Oldenburg, Bas, Pastorelli, Luca, Stephen patchett, Ramakrishnan, Subramaniam, de Caestecker, John, Echarri, Ana, Kevans, David, Büning, Jürgen, Coelho, Rosa, Jansen, Jeroen, Koslowski, Benjamin, Wells, Christopher, Ceballos, Daniel, König, Ingrid, Padmanabhan, Hari, Patani, Timi, Qureshi, Raheel, Zagorowicz, Edyta, Allez, Matthieu, Archavlis, Emmanouil, Bonnet, Delphine, Guidi, Luisa, Mcnamara, Deirdre, Vernia, Piero, Weidenhiller, Michael, Alon, Lang, Boysen, Trine, Delattre, Charlotte, Farrell, Richard, Krüger, Rolf-Achim, Paupard, Thierry, Vind, Ida, Caprioli, Flavio, Gancho, Vladimir, Quentin, Vincent, Avidan, Benjamin, D’Haens, Geert, Mccarthy, Jane, Snook, Jonathon, Soufleris, Konstantinos, Zerbib, Frank, Carter, Dan, Depla, Annekatrien, Eisenbach, Thomas, Fries, Walter, Grammatikos, Nikolaos, Ilegems, Saskia, Lopez-Sanroman, Antonio, Moreau, Jacques, Riegler, Gabriele, Rietdijk, Svend, Rocha, Marta, Rosa, Isabelle, Ryan, Barbara, Yeremenko, Yelena, Boruchowicz, Arnaud, Damião, Filipe, Laoudi, Foteini, Lügering, Andreas, Macarri, Giampiero, Thomopoulos, Konstantinos, Barros, Luísa, Blixt, Thomas, Garros, Aurélien, Khorrami, Sam, Sokol, Harry, Sturm, Andreas, Livovsky, Dan, Maul, Jochen, Miks, Heinrich, Papadopoulos, Vasileios, Schmidt, Carsten, Snir, Yifat, Svenningsen, Lise, Ahmed, Wafaa, Broitman, Yelena, Cuillerier, Emmanuel, Kant, Prashant, Leyden, Jan, Lichtenstein, Lev, Lopes, Susana, Martineau, Chloé, Mulcahy, Hugh, Schweitzer, Axel, Van Schaik, Fiona, Banai, Hagar, Danion, Pauline, Dulery, Charlotte, Fidder, Herma, Gay, Claire, Hagege, Hervé, Harnois, Florence, Jørgensen, Søren Peter, Müller-Ziehm, Jens, Oikonomou, Michail, Palmela, Carolina, Schulze/Röske, Jörg, Smith, Mark, Thurm, Tamar, Bresso, Francesca, Brixi, Hedia, Jones, John, Macmathuna, Padraig, Painchart, Claire, Ron, Yulia, Vester-Andersen, Marianne, Alexandrino, Gonçalo, Börner, Norbert, Cardoso, Mariana, Chagas, Cristina, Dignaß, Axel, Dotan, Iris, Hedin, Charlotte, Karatzas, Pantelis, Kasapidis, Panagiotis, Palatka, Károly, Sakizlis, Georgios, Wilson, Ana, Bosanko, Nick, Caldeira, Paulo, Gagniere, Charlotte, Libier, Louise, Meunier, Camille, Moog, Gero, Pasquion, Audrey, Pica, Roberta, Akbar, Ayesha, Arab, Nadia, Cadiot, Guillaume, Carvalho, João, Charpignon, Claire, Fellermann, Laus, Fishman, Sigal, Fraser, Gerald, Gluck, Nathan, Hoesl, Mark, Kierkus, Jarosław, Klopocka, Maria, Arranz, Eduardo Martin, Menchen, Luis, Nikolaus, Susanna, Petrache, Anca, Ponsioen, Cyriel, Riestra, Sabino, Robledo, Pilar, Rodriguez, Cristina, Samer, Misheal, Tischer, Matthias, Wypych, Joanna, Baudon, Julien, Bezzio, Cristina, Boschetti, Gilles, Burisch, Johan, Creed, Tom, Demarzo, Maria Giulia, Festa, Stefano, Figueroa, Andrés, Julsgaard, Mette, Navarro, Pablo, Perez-Galindo, Pablo, Rouillon, Cléa, Sablich, Emanuele, Tosca, Joan, Vidon, Mathias, Vidon, Marine, Vitte, René-Louis, Wampach, Anne, Baumann, Cédric, Urmes, Isabelle Clerc, Rousseau, Hélène, Borie, Marc, Uzzan, Mathieu, Chatten, Kelly, Peter, Rimmer, Tariq, Iqbal, Cossignani, Marta, Cañete, Fiorella, Holvoet, Tom, Krasz, Susanne, Dias, Sandra, Abalia, Hadas, Abaza, Aziza, Abramovich, Gal, Ackzell, Ingrid, Adams, Carol, Addleton, Catherine, Alfambra, Erika, Algaba, Alicia, Allcock, Clare, Allison, Joanna, Amouriaux, Karine, Anderson, Julie, Anderson, Emma, Appelmans, Saskia, Armstrong, Lisa, Atkins, Stacey, Attaran-Bandarabadi, Masoumeh, Bailey, Yvonne, Bardot, Stephanie, Beck, Natasha, Bennett, Lillie, Bergfeld, Jonathan Phil, Berkane, Ramdane, Boey, Hanne, Bowlas, Louise, Bradley-Potts, Joanne, Brear, Tracy, Bretlander-Peters, Nicole, Brown, Ellen, Brown, Johanna, Buckingham, Elizabeth, Buellens, Katrien, Bull, Rhian, Burke, Maura, Burns, Leighanne, Burton, Julie, Bwalya, Agness, Cabanas, Karine, Callaghan, Muriel, Camou, Océane, Campbell, Debbie, Capoferro, Elvira, Carnahan, Mandy, Carnio, Cornelia, Carter, Anne, Clack, Concetta Casali, Chedouba, Leïla, Cipriano, Bessie, Claeys, Sophie, Closset, Manon, Coban, Dilek, Cococcia, Sara, Coe, Carolann, Cole, Helen, Collet, Emilie, Collins, Kayleigh, Combes, Isabelle, Connor, Emma, Constantin, Kathryn, Cooke, Susan, Cornet, Nathanaëlle, Corrihons, Estelle, Corsino, Pilar, Cortaville, Rosie, Cotterill, Donna, Cowton, Amanda, Cox, Harriet, Cripps, Viktoria, Crowder, Amanda, Cukier, Tzufit, Daniel, Amelia, Dawe, Chris, de Haan, Jose, Croix, Rosanna de la, Dejonckheere, Evva, Villanegro, Juan Delare, Delaval, Guillaume, Delliponti, Mariangela, Delommez, Aude, Detry, Emilie, Dhanaratne, Melanie, Galan, Laura Diez, Dodel, Marie, Dooks, Emma, Du Cheyron, Joseph, Duane, Linda, Vulgo Cochran, Jennifer Dulling, Dyer, Simona, Dymond, Harvey, Ekblad, Charlotte, Elliott, Kerry, Emmerson, Ingrid, Eugene-Jolchine, Irène, Fleming, Lorna, Fletcher, Eve, Ford, Sarah, Forshaw, Greg, Foulds, Angela, Francois, Caroline, Fuge, Nicole, Gafni, Gal, Ganon, Miri, Nuñez, Olga Garcia, Ramirez, Laura Garcia, Gelder, Sophie, Gettkowski, Raimonda, Gilardi, Daniela, Giuffrida, Paolo, Gobert, Vincent, Godden, Jo, Godwin, Nuala, Goulden, Kay, Graham, Sharon, Green, Charlotte, Green, Marie, Gueye, Aboubakar, Guler, Tuba, Gustavsson, Ida, Hadjisavvas, Helena, Hammonds, Fiona, Hantzi, Christina, Hauke, Marion, Haydock, Julie, Hayes, Orla, Nislev, Lizette Helbo, Hochstodter, Jessica, Hogg, Ashleigh, Hölbing, Manuela, Holland, Maureen, Holsbergen, Maartje, Howard, Linda, Hoyda, Aviya, Hull, Robert, Irish, Jane, Jackson, Wendy, Janssen, Wendy, Jeffrey, Lesley, Jourdan, Sofia, Jutrowska, Izabela, Kaniel, Chava, Karezos, Theofilos, Kelly, Niamh, Kelly, Jessica, Kennedy, Mary, Kennedy, Una, Kibaru, Joyce, Kirkman, Gemma, Klaproth, Janine, Kneese, Corinna, Koch, Andrea, Kokke, Kathleen, Koppelow, Martha, Krause, Sabine, Krauspe, Sabine, Kwakkenbos, Petra, Labarile, Nunzia, Lang, Hannah, Lassailly, Marianne, Leconte, Martine, Lepczynski, Linda, Levell, Emma, Levhar, Nina, Lindhort, Kerstin, Lisle, Jessica, Cauce, Beatriz Lopez, Lorenz, Gabriele, Lovati, Ambra, Lowry, Tracey, Lund, Margareta, Vorderbrügge, Anne Lutz, Maansson, Suzanne, Madapathage, Videsheka, Cheviakoff, Maelys, Magness, Alison, Manley, Orla, Manyoni, Catherine, Marg, Ingke, Marra, Antonella, Martins, Carole, Massella, Arianna, Mathias, Aurore, Mervyn, Danielle, Minsart, Charlotte, Mitchell, Sally, Monks, Kathleen, Montero, Mélanie, Moore, Alson, Moser, Maren, Moss, Alison, Mullen, Angela, Murciano, M. Francisca, Naylor, Deanna, Nehus, Ansgar, Nicholson, Anne, Nöding, Sarah, Nolan, Sinead, Nörenberg, Janet, Northcott, Clare, O'Connell, Jim, O’Kelly, Alison, Orbach-Zingboim, Noam, Orobitg, Judit, Otieno, Charlene, Owen, Charlotte, Patch, Sarah, Pauker, Maor, Pauli, Renate, Pearson, Harriet, Peggy, Falgon, Petit, Séverine, Petrissans, Christine, Piergallini, Simona, Pippard, Lucy, Pitt, Laura, Pócsik, Gabriella, Poher, Yoann, Pomes, Chloé, Pritchard, Lucy, Puchades, Laura, Quaid, Sheena, Rana, Aleem, Raynard, Dana, Reilly, Mykla, Reinert, Sonja, Reinknecht, Manuela, Renner, Baerbel, Reynolds, Rob, Rizzuto, Giulia, Robinson, Matthew, Robrechts, Joke, Rodriguez, Eva M., Rosenblum, Efrat, Russel, Tamlyn, Sadare, Ibiyemi, Salama, Noa, Schakel, Toos, Schauer, Anja, Schiavoni, Elisa, Shaw, Caroline, Shelton, Sarah, Sicart, Virginie, Siouville, Elodie, Smith, Orla, Soude, Théo, Stephenson, Sophie, Stephenson, Elaine, Steppe, Marjan, Sterkx, An, Stickley, Jo, Sugrue, Kathleen, Swietec, Natalia, Tasiaux, Charlotte, Thamu, Bhavneet, Thomas, Susane, Tobi, Ogwa, Touabi, Kahina, Tovi, Shifra, Tregonning, Julie, Turchini, Laura, Unkhoff, Julia, Unruh, Olesya, Uzun, Nurcan, Van Aert, Frauke, Bergh, Sandrine Vanden, Vandenbroucke, Louise, Vansteenkiste, Laura, Vardit, Shay, Vergriete, Valentin, Walker, Elaine, Warner, Eleanor, Watchorn, Olivia, Watson, Ekaterina, Wauthier, Marie-Claire, Weetman, Belgium Maria, Weston, Margaret, West-Petroschka, Wiebke, Wienecke, Susann, Wierling, Kerstin, Wiestler, Miriam, Wilcox, Rebecca, Wilhelmsen, Elva, Williams, Angharad, Williamson, Georgina, Wilson, Deborah, Wistance, Kate, Wortmann, Nicolas, Wurie, Subie, Yadgar, Karin, Young, Gail, Young, Megan, Aucouturier, Julien, Bertin, Marie- Jo, Bougrine, Hasnae, Coisnon, Marie, Defrance, Antoine, Gutierrez, Kati, Harouz, Amel, Jerber, Laure, Khlifi, Aida, Kirati, Amina, Liworo, Nasaladjine, Logoltat, Maude, Mailhat, Charlotte, M'Bayi, Chancely, Medane, Yasmina, Merkhoufa, Dalal, Elhad, Saouda Mohamed, Monthe, Bertille, Moyon, Fanny, Rabiega, Pascaline, Sekela, Jennifer, Thilloy, Charlotte, Hamamouche, Naima, Partisotti, Frederic, Blandin, Patrick, Mokhtari, Hocine, Coutard, Laure, and Doherty, Glen A.
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- 2023
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4. Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
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Mishra, Neha, Aden, Konrad, Blase, Johanna I., Baran, Nathan, Bordoni, Dora, Tran, Florian, Conrad, Claudio, Avalos, Diana, Jaeckel, Charlot, Scherer, Michael, Sørensen, Signe B., Overgaard, Silja H., Schulte, Berenice, Nikolaus, Susanna, Rey, Guillaume, Gasparoni, Gilles, Lyons, Paul A., Schultze, Joachim L., Walter, Jörn, Andersen, Vibeke, Dermitzakis, Emmanouil T., Schreiber, Stefan, and Rosenstiel, Philip
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- 2022
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5. DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon
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Fazio, Antonella, Bordoni, Dora, Kuiper, Jan W. P., Weber-Stiehl, Saskia, Stengel, Stephanie T., Arnold, Philipp, Ellinghaus, David, Ito, Go, Tran, Florian, Messner, Berith, Henning, Anna, Bernardes, Joana P., Häsler, Robert, Luzius, Anne, Imm, Simon, Hinrichsen, Finn, Franke, Andre, Huber, Samuel, Nikolaus, Susanna, Aden, Konrad, Schreiber, Stefan, Sommer, Felix, Natoli, Gioacchino, Mishra, Neha, and Rosenstiel, Philip
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- 2022
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6. Contrast-Enhanced Endoscopic Ultrasound Detects Early Therapy Response Following Anti-TNF Therapy in Patients with Ulcerative Colitis
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Ellrichmann, Mark, primary, Schulte, Berenice, additional, Conrad, Claudio C, additional, Schoch, Stephan, additional, Bethge, Johannes, additional, Seeger, Marcus, additional, Huber, Robert, additional, Goeb, Madita, additional, Arlt, Alexander, additional, Nikolaus, Susanna, additional, Röcken, Christoph, additional, and Schreiber, Stefan, additional
- Published
- 2024
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7. Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies
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Ellinghaus, David, Zhang, Hu, Zeissig, Sebastian, Lipinski, Simone, Till, Andreas, Jiang, Tao, Stade, Björn, Bromberg, Yana, Ellinghaus, Eva, Keller, Andreas, Rivas, Manuel A, Skieceviciene, Jurgita, Doncheva, Nadezhda T, Liu, Xiao, Liu, Qing, Jiang, Fuman, Forster, Michael, Mayr, Gabriele, Albrecht, Mario, Häsler, Robert, Boehm, Bernhard O, Goodall, Jane, Berzuini, Carlo R, Lee, James, Andersen, Vibeke, Vogel, Ulla, Kupcinskas, Limas, Kayser, Manfred, Krawczak, Michael, Nikolaus, Susanna, Weersma, Rinse K, Ponsioen, Cyriel Y, Sans, Miquel, Wijmenga, Cisca, Strachan, David P, McArdle, Wendy L, Vermeire, Séverine, Rutgeerts, Paul, Sanderson, Jeremy D, Mathew, Christopher G, Vatn, Morten H, Wang, Jun, Nöthen, Markus M, Duerr, Richard H, Büning, Carsten, Brand, Stephan, Glas, Jürgen, Winkelmann, Juliane, Illig, Thomas, Latiano, Anna, Annese, Vito, Halfvarson, Jonas, D'Amato, Mauro, Daly, Mark J, Nothnagel, Michael, Karlsen, Tom H, Subramani, Suresh, Rosenstiel, Philip, Schreiber, Stefan, Parkes, Miles, and Franke, Andre
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Biomedical and Clinical Sciences ,Clinical Sciences ,Nutrition and Dietetics ,Biotechnology ,Genetics ,Inflammatory Bowel Disease ,Autoimmune Disease ,Human Genome ,Clinical Research ,Digestive Diseases ,Crohn's Disease ,Aetiology ,2.1 Biological and endogenous factors ,Oral and gastrointestinal ,Inflammatory and immune system ,Adolescent ,Adult ,Case-Control Studies ,Colitis ,Ulcerative ,Crohn Disease ,Exome ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Male ,Mutation ,Missense ,Nuclear Proteins ,Polymorphism ,Single Nucleotide ,Positive Regulatory Domain I-Binding Factor 1 ,Quantitative Trait Loci ,Repressor Proteins ,Young Adult ,Whole-Exome Sequencing ,Complex Disease ,CD ,Crohn’s disease ,GWAS ,IBD ,IFN ,NF-κB ,PBL ,PBMC ,SNP ,SNV ,TLR ,Toll-like receptor ,UC ,WT ,eQTL ,expression quantitative trait locus ,genome-wide association studies ,inflammatory bowel disease ,interferon ,nuclear factor κB ,peripheral blood lymphocyte ,peripheral blood mononuclear cell ,qRT-PCR ,quantitative reverse-transcription polymerase chain reaction ,single nucleotide polymorphism ,single nucleotide variant ,ulcerative colitis ,wild-type ,Neurosciences ,Paediatrics and Reproductive Medicine ,Gastroenterology & Hepatology ,Clinical sciences ,Nutrition and dietetics - Abstract
Background & aimsGenome-wide association studies (GWAS) have identified 140 Crohn's disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We aimed to identify variants that cause CD through detailed sequencing, genetic association, expression, and functional studies.MethodsWe sequenced whole exomes of 42 unrelated subjects with CD and 5 healthy subjects (controls) and then filtered single nucleotide variants by incorporating association results from meta-analyses of CD GWAS and in silico mutation effect prediction algorithms. We then genotyped 9348 subjects with CD, 2868 subjects with ulcerative colitis, and 14,567 control subjects and associated variants analyzed in functional studies using materials from subjects and controls and in vitro model systems.ResultsWe identified rare missense mutations in PR domain-containing 1 (PRDM1) and associated these with CD. These mutations increased proliferation of T cells and secretion of cytokines on activation and increased expression of the adhesion molecule L-selectin. A common CD risk allele, identified in GWAS, correlated with reduced expression of PRDM1 in ileal biopsy specimens and peripheral blood mononuclear cells (combined P = 1.6 × 10(-8)). We identified an association between CD and a common missense variant, Val248Ala, in nuclear domain 10 protein 52 (NDP52) (P = 4.83 × 10(-9)). We found that this variant impairs the regulatory functions of NDP52 to inhibit nuclear factor κB activation of genes that regulate inflammation and affect the stability of proteins in Toll-like receptor pathways.ConclusionsWe have extended the results of GWAS and provide evidence that variants in PRDM1 and NDP52 determine susceptibility to CD. PRDM1 maps adjacent to a CD interval identified in GWAS and encodes a transcription factor expressed by T and B cells. NDP52 is an adaptor protein that functions in selective autophagy of intracellular bacteria and signaling molecules, supporting the role of autophagy in the pathogenesis of CD.
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- 2013
8. No Association between Microsomal Triglyceride Transfer Protein (MTP) Haplotype and Longevity in Humans
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Nebel, Almut, Stiegeler, Rieke, Nikolaus, Susanna, Krawczak, Michael, Schreiber, Stefan, and Kunkel, Louis M.
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- 2005
9. Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases
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Nikolaus, Susanna, Waetzig, Georg H., Butzin, Sven, Ziolkiewicz, Monika, Al-Massad, Natalie, Thieme, Florian, Lövgren, Ulf, Rasmussen, Birgitte B., Reinheimer, Torsten M., Seegert, Dirk, Rosenstiel, Philip, Szymczak, Silke, and Schreiber, Stefan
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- 2018
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10. Stark reduzierte Impftiter nach mRNA SARS-CoV-2 Impfung bei Patienten unter TNF-Blocker Therapie
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Geisen, Ulf, Sümbül, Melike, Tran, Florian, Berner, Dennis, Reid, Hayley, Vullriede, Lena, Ciripoi, Maria, Longardt, Ann, Hoff, Paula, Morrison, Peter, Schneider, Verena, Zeuner, Rainald, Schirmer, Jan, Steinbach, Andrea, Nikolaus, Susanna, Gerdes, Sascha, Schreiber, Stefan, and Bacher, Petra
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Medicine and health - Abstract
Einleitung: Impfungen gegen SARS-CoV-2 sind das Mittel der Wahl bei der Bekämpfung der Covid-19-Pandemie. Dennoch gibt es nach der Einführung der neuartigen mRNA Impfstoffe immer noch Unsicherheiten bezüglich der Wirksamkeit bei Patienten mit bestimmten Grunderkrankungen oder Therapien. [zum vollständigen Text gelangen Sie über die oben angegebene URL]
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- 2022
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11. Interobserver Reliability of the Nancy Index for Ulcerative Colitis: An Assessment of the Practicability and Ease of Use in a Single-Centre Real-World Setting
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Le, Huy Duc, primary, Pflaum, Theresa, additional, Labrenz, Johannes, additional, Sari, Soner, additional, Bretschneider, Fabienne, additional, Tran, Florian, additional, Lassen, Arne, additional, Nikolaus, Susanna, additional, Szymczak, Silke, additional, Kormilez, Diana, additional, Rosenstiel, Philip, additional, Schreiber, Stefan, additional, Aden, Konrad, additional, and Röcken, Christoph, additional
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- 2022
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12. Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease
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Häsler, Robert, Sheibani-Tezerji, Raheleh, Sinha, Anupam, Barann, Matthias, Rehman, Ateequr, Esser, Daniela, Aden, Konrad, Knecht, Carolin, Brandt, Berenice, Nikolaus, Susanna, Schäuble, Sascha, Kaleta, Christoph, Franke, Andre, Fretter, Christoph, Müller, Werner, Hütt, Marc-Thorsten, Krawczak, Michael, Schreiber, Stefan, and Rosenstiel, Philip
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- 2017
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13. Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases
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Štambuk, Jerko, primary, Vučković, Frano, additional, Habazin, Siniša, additional, Hanić, Maja, additional, Novokmet, Mislav, additional, Nikolaus, Susanna, additional, Tran, Florian, additional, Schreiber, Stefan, additional, Franke, Andre, additional, Rosenstiel, Philip, additional, Lauc, Gordan, additional, Aden, Konrad, additional, and Pezer, Marija, additional
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- 2022
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14. Su1553: THE ROAD TO DISEASE CONTROL: COMBINATION OF HISTOLOGIC AND ENDOSCOPIC REMISSION PREDICTS LONG-TERM DISEASE OUTCOME IN ULCERATIVE COLITIS
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Bretschneider, Fabienne, primary, Kormilez, Diana, additional, Sari, Soner, additional, Pflaum, Theresa, additional, Le, Huy Duc, additional, Nikolaus, Susanna, additional, Lassen, Arne, additional, Rosenstiel, Philip, additional, Röcken, Christoph, additional, Szymczak, Silke, additional, Schreiber, Stefan, additional, and Aden, Konrad, additional
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- 2022
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15. Mo1517: LONGITUDINAL MULTI-OMICS ANALYSIS IDENTIFIES EARLY BLOODBASED PREDICTORS OF ANTI-TNF THERAPY RESPONSE IN INFLAMMATORY BOWEL DISEASE
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Mishra, Neha, primary, Aden, Konrad, additional, Blase, Johanna I., additional, Bordoni, Dora, additional, Conrad, Claudio C., additional, Avalos, Diana, additional, Jaeckel, Charlot, additional, Baran, Nathan, additional, Scherer, Michael, additional, Sørensen, Signe Bek, additional, Overgaard, Silja H., additional, Nikolaus, Susanna, additional, Rey, Guillaume, additional, Gasparoni, Gilles, additional, Lyons, Paul, additional, Schultze, Joachim, additional, Walter, Jörn, additional, Andersen, Vibeke, additional, Dermitzakis, Emmanouil T, additional, Schreiber, Stefan, additional, and Rosenstiel, Philip, additional
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- 2022
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16. Mo1083: ON THE WAY TO DISEASE CONTROL: FATIGUE AS PART OF A NOVEL COMPOSITE ENDPOINT IN AN ANALYSIS OF A PROSPECTIVE OPEN LABEL OBSERVATION TRIAL
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Tran, Florian, primary, Nikolaus, Susanna, additional, Schrinner, Florian, additional, Kümpers, Julia, additional, Lessing, Anna Sophie, additional, Lessing, Matthias, additional, Sievers, Laura K., additional, Rosenstiel, Philip, additional, Franke, Andre, additional, Aden, Konrad, additional, and Schreiber, Stefan, additional
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- 2022
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17. The Gastrointestinal Immune System — An Overview
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Schreiber, Stefan, Nikolaus, Susanna, Zbar, Andrew P., editor, Guillou, Pierre J., editor, Bland, Kirby I., editor, and Syrigos, Konstantinos N., editor
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- 2002
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18. Detailed transcriptional landscape of peripheral blood points to increased neutrophil activation in treatment-naïve inflammatory bowel disease
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Juzenas, Simonas, Hübenthal, Matthias, Lindqvist, Carl Mårten, Kruse, Robert, Steiert, Tim Alexander, Degenhardt, Frauke, Schulte, Dominik, Nikolaus, Susanna, Zeissig, Sebastian, Bergemalm, Daniel, Almer, Sven, Hjortswang, Henrik, Bresso, Francesca, Strüning, Nina, Kupcinskas, Juozas, Keller, Andreas, Lieb, Wolfgang, Rosenstiel, Philip, Schreiber, Stefan, D'Amato, Mauro, Halfvarson, Jonas, Hemmrich-Stanisak, Georg, Franke, Andre, Juzenas, Simonas, Hübenthal, Matthias, Lindqvist, Carl Mårten, Kruse, Robert, Steiert, Tim Alexander, Degenhardt, Frauke, Schulte, Dominik, Nikolaus, Susanna, Zeissig, Sebastian, Bergemalm, Daniel, Almer, Sven, Hjortswang, Henrik, Bresso, Francesca, Strüning, Nina, Kupcinskas, Juozas, Keller, Andreas, Lieb, Wolfgang, Rosenstiel, Philip, Schreiber, Stefan, D'Amato, Mauro, Halfvarson, Jonas, Hemmrich-Stanisak, Georg, and Franke, Andre
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BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the gastrointestinal tract, which generally manifests as Crohn's disease (CD) or ulcerative colitis (UC). These subtypes are heterogeneous in terms of disease location and histological features, while sharing common clinical presentation, genetic associations and thus, common immune regulatory pathways. METHODS: Using miRNA and mRNA coupled transcriptome profiling and systems biology approaches, we report a comprehensive analysis of blood transcriptomes from treatment-naïve (n=110) and treatment-exposed (n=177) IBD patients as well as symptomatic- (n=65) and healthy controls (n=95). RESULTS: Broadly, the peripheral blood transcriptomes of CD and UC patients were similar. However, there was an extensive gene deregulation in the blood of IBD patients, while only a slight deregulation in symptomatic controls, when compared with healthy controls. The deregulated mRNAs and miRNAs are mainly involved in the innate immunity and are especially enriched in neutrophil activation-related pathways. Oxidative phosphorylation and neutrophil activation-related modules were found to be differentially co-expressed among treatment-naïve IBD as compared to healthy controls. In the deregulated neutrophil activation-related co-expression module, the IL1B was identified as the central gene. The co-expression levels among IL1B and chemosensing receptor (CXCR1/2 and FPR1/2) genes were reduced in the blood of IBD patients when compared with healthy controls. CONCLUSIONS: Immune dysregulation seen in peripheral blood transcriptomes of treatment-naïve IBD patients is mainly driven by neutrophil activation., Funding agency:German Research Foundation (DFG) EXC 2167
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- 2022
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19. Interobserver Reliability of the Nancy Index for Ulcerative Colitis: An Assessment of the Practicability and Ease of Use in a Single-Centre Real-World Setting.
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Le, Huy Duc, Pflaum, Theresa, Labrenz, Johannes, Sari, Soner, Bretschneider, Fabienne, Tran, Florian, Lassen, Arne, Nikolaus, Susanna, Szymczak, Silke, Kormilez, Diana, Rosenstiel, Philip, Schreiber, Stefan, Aden, Konrad, and Röcken, Christoph
- Abstract
Background Histological disease severity assessment in ulcerative colitis [UC] has become a mainstay in the definition of clinical endpoints ['histological remission'] in clinical trials of UC. Several scores have been established in the microscopic assessment of disease activity, but the Nancy index [NI] stands out as being the histological index with the fewest scoring items. To what extent histological assessment using the NI is affected by interobserver reliability in a real-word setting is poorly understood. We therefore performed a single-centre retrospective analysis of NI assessment in patients with UC. Methods We retrospectively evaluated the NI in two independent cohorts [total: 1085 biopsies, 547 UC patients] of clinically diagnosed UC patients, who underwent colonoscopy between 2007 and 2020. Cohort #1 consisted of 637 biopsies from 312 patients, while Cohort #2 consisted of 448 biopsies from 235 patients. Two blinded pathologists with different levels of expertise scored all biopsies from each cohort. A consensus conference was held for cases with discrepant scoring results. Finally, an overall consensus scoring was obtained from both cohorts. Results The interobserver agreement of the NI was substantial after the assessment of 1085 biopsy samples (κ = 0.796 [95% confidence interval, CI: 0.771–0.820]). An improvement of the interobserver agreement was found with increasing numbers of samples evaluated by both observers (Cohort #1: κ = 0.772 [95% CI: 0.739–0.805]; Cohort #2: κ = 0.829 [95% CI: 0.793–0.864]). Interobserver discordance was highest in NI grade 1 [observer 1: n = 128; observer 2: n = 236]. Interobserver discordance was lowest in NI grades 0 [observer 1: n = 504; observer 2: n = 479] and 3 [observer 1: n = 71; observer 2: n = 66]. Conclusion The NI is an easy-to-use index with high interobserver reliability for assessment of the histological disease activity of UC patients in a real-world setting. While NI grades 0 and 3 had a high level of agreement between observers, NI grade 1 had a poorer level of agreement. This highlights the clinical need to specify histological characteristics leading to NI grade 1. [ABSTRACT FROM AUTHOR]
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- 2023
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20. Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease
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Noth, Rainer, Stüber, Eckhard, Häsler, Robert, Nikolaus, Susanna, Kühbacher, Tanja, Hampe, Jochen, Bewig, Burkhard, Schreiber, Stefan, and Arlt, Alexander
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- 2012
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21. Predictors for subsequent need for immunosuppressive therapy in early Crohn's disease
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Wenger, Sandra, Nikolaus, Susanna, Howaldt, Stefanie, Bokemeyer, Bernd, Sturm, Andreas, Preiss, Jan C., Schoepfer, Alain M., Stallmach, Andreas, and Schmidt, Carsten
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- 2012
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22. Longitudinal monitoring of STAT3 phosphorylation and histologic outcome of tofacitinib therapy in patients with ulcerative colitis
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Verstockt, Bram, primary, Volk, Valery, additional, Jaeckel, Charlot, additional, Alsoud, Dahham, additional, Sabino, João, additional, Nikolaus, Susanna, additional, Outtier, An, additional, Krönke, Nicole, additional, Feuerhake, Friedrich, additional, De Hertogh, Gert, additional, Rosenstiel, Philip, additional, Vermeire, Séverine, additional, Schreiber, Stefan, additional, Ferrante, Marc, additional, and Aden, Konrad, additional
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- 2022
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23. Additional file 2 of Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
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Mishra, Neha, Aden, Konrad, Blase, Johanna I., Baran, Nathan, Bordoni, Dora, Tran, Florian, Conrad, Claudio, Avalos, Diana, Jaeckel, Charlot, Scherer, Michael, Sørensen, Signe B., Overgaard, Silja H., Schulte, Berenice, Nikolaus, Susanna, Rey, Guillaume, Gasparoni, Gilles, Lyons, Paul A., Schultze, Joachim L., Walter, Jörn, Andersen, Vibeke, Dermitzakis, Emmanouil T., Schreiber, Stefan, and Rosenstiel, Philip
- Abstract
Additional file 2: Figure S1. Baseline signatures of the discovery cohort. Figure S2. Transcriptomic changes in response to therapy and induction of remission in the discovery cohort. Figure S3. DNA methylation patterns in response to therapy and induction of remission in the discovery cohort. Figure S4. Integration of DNA methylation and transcriptome data. Figure S5. Molecular comparisons between discovery and replication cohorts and baseline signatures of replication cohort. Figure S6. Replication of molecular signatures. Figure S7. Comparison of IBD subtypes.
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- 2022
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24. Association of F0X03A Variation with Human Longevity Confirmed in German Centenarians
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Flachsbart, Friederike, Caliebe, Amke, Kleindorp, Rabea, Blanché, Hélène, von Eller-Eberstein, Huberta, Nikolaus, Susanna, Schreiber, Stefan, Nebel, Almut, and Kenyon, Cynthia J.
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- 2009
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25. Genome-Wide Association Study for Crohn's Disease in the Quebec Founder Population Identifies Multiple Validated Disease Loci
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Raelson, John V., Little, Randall D., Ruether, Andreas, Fournier, Hélène, Paquin, Bruno, Van Eerdewegh, Paul, Bradley, W. E. C., Croteau, Pascal, Nguyen-Huu, Quynh, Segal, Jonathan, Debrus, Sophie, Allard, René, Rosenstiel, Philip, Franke, Andre, Jacobs, Gunnar, Nikolaus, Susanna, Vidal, Jean-Michel, Szego, Peter, Laplante, Nathalie, Clark, Hilary F., Paulussen, René J., Hooper, John W., Keith, Tim P., Belouchi, Abdelmajid, and Schreiber, Stefan
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- 2007
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26. Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapies
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Geisen, Ulf M, primary, Sümbül, Melike, additional, Tran, Florian, additional, Berner, Dennis K, additional, Reid, Hayley M, additional, Vullriede, Lena, additional, Ciripoi, Maria, additional, Longardt, Ann C, additional, Hoff, Paula, additional, Morrison, Peter J, additional, Schneider, Verena E, additional, Zeuner, Rainald, additional, Schirmer, Jan H, additional, Steinbach, Andrea, additional, Nikolaus, Susanna, additional, Gerdes, S, additional, Schreiber, Stefan, additional, Bacher, Petra, additional, and Hoyer, Bimba F, additional
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- 2021
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27. PopGen : Population-Based Recruitment of Patients and Controls for the Analysis of Complex Genotype-Phenotype Relationships
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Krawczak, Michael, Nikolaus, Susanna, von Eberstein, Huberta, Croucher, Peter J.P., Mokhtari, Nour Eddine El, and Schreiber, Stefan
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- 2006
28. Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease
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Schreiber, Stefan, primary, Aden, Konrad, additional, Bernardes, Joana P., additional, Conrad, Claudio, additional, Tran, Florian, additional, Höper, Hanna, additional, Volk, Valery, additional, Mishra, Neha, additional, Blase, Johanna Ira, additional, Nikolaus, Susanna, additional, Bethge, Johannes, additional, Kühbacher, Tanja, additional, Röcken, Christoph, additional, Chen, Minhu, additional, Cottingham, Ian, additional, Petri, Niclas, additional, Rasmussen, Birgitte B., additional, Lokau, Juliane, additional, Lenk, Lennart, additional, Garbers, Christoph, additional, Feuerhake, Friedrich, additional, Rose-John, Stefan, additional, Waetzig, Georg H., additional, and Rosenstiel, Philip, additional
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- 2021
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29. Heritability of chronic venous disease
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Fiebig, Andreas, Krusche, Petra, Wolf, Andreas, Krawczak, Michael, Timm, Birgitt, Nikolaus, Susanna, Frings, Norbert, and Schreiber, Stefan
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- 2010
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30. Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men
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Friedrichs, Frauke, Brescianini, Sonia, Annese, Vito, Latiano, Anna, Berger, Klaus, Kugathasan, Subra, Broeckel, Ulrich, Nikolaus, Susanna, Daly, Mark J., Schreiber, Stefan, Rioux, John D., and Stoll, Monika
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- 2006
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31. mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohnʼs disease
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Derer, Stefanie, Till, Andreas, Haesler, Robert, Sina, Christian, Grabe, Nils, Jung, Sascha, Nikolaus, Susanna, Kuehbacher, Tanja, Groetzinger, Joachim, Rose-John, Stefan, Rosenstiel, Philip C, and Schreiber, Stefan
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- 2013
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32. Genetic Variation in the CYP2C Monooxygenase Enzyme Subfamily Shows No Association With Longevity in a German Population
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Flachsbart, Friederike, Ufer, Mike, Kleindorp, Rabea, Nikolaus, Susanna, Schreiber, Stefan, and Nebel, Almut
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- 2011
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33. Mechanisms in failure of infliximab for Crohn's disease
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Nikolaus, Susanna, Raedler, Andreas, Kuhbacher, Tanja, Sfikas, Nicolaos, Folsch, Ulrich R., and Schreiber, Stefan
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- 2000
34. Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases
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Aden, Konrad, primary, Rehman, Ateequr, additional, Waschina, Silvio, additional, Pan, Wei-Hung, additional, Walker, Alesia, additional, Lucio, Marianna, additional, Nunez, Alejandro Mena, additional, Bharti, Richa, additional, Zimmerman, Johannes, additional, Bethge, Johannes, additional, Schulte, Berenice, additional, Schulte, Dominik, additional, Franke, Andre, additional, Nikolaus, Susanna, additional, Schroeder, Johann Oltmann, additional, Vandeputte, Doris, additional, Raes, Jeroen, additional, Szymczak, Silke, additional, Waetzig, Georg H., additional, Zeuner, Rainald, additional, Schmitt-Kopplin, Philippe, additional, Kaleta, Christoph, additional, Schreiber, Stefan, additional, and Rosenstiel, Philip, additional
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- 2019
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35. Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity
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Ufer, Mike, Häsler, Robert, Jacobs, Gunnar, Haenisch, Sierk, Lächelt, Sandra, Faltraco, Frank, Sina, Christian, Rosenstiel, Philip, Nikolaus, Susanna, Schreiber, Stefan, and Cascorbi, Ingolf
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- 2009
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36. Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
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Flachsbart, Friederike, Croucher, Peter JP., Nikolaus, Susanna, Hampe, Jochen, Cordes, Christina, Schreiber, Stefan, and Nebel, Almut
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- 2006
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37. Recombinant erythropoietin for the treatment of anemia in inflammatory bowel disease
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Schreiber, Stefan, Howaldt, Stefanie, Schnoor, Mareille, Nikolaus, Susanna, Bauditz, Jurgen, Gasche, Christoph, Lochs, Herbert, and Raedler, Andreas
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Inflammatory bowel diseases -- Drug therapy ,Erythropoietin, Recombinant -- Evaluation ,Iron deficiency anemia -- Drug therapy ,Hemoglobin -- Measurement - Abstract
Therapy with iron and recombinant erythropoietin appears to raise hemoglobin levels in anemic patients with inflammatory bowel disease resistant to iron and vitamin therapy. Researchers administered oral doses of iron and injections of recombinant erythropoietin, a synthetic hormone that stimulates red blood cell production, to 17 patients with ulcerative colitis or Crohn's disease. A second group of 17 patients received iron and placebo medication (the control group). After 12 weeks of treatment, hemoglobin levels had risen more than 1.0 gram per deciliter among 82% of the erythropoietin group, compared to 24% among the control group. Excessive decreases in hemoglobin levels, defined as treatment failure, occurred in five control patients and two erythropoietin patients. Treating anemic patients may be more difficult due to a relative deficiency of erythropoietin.
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- 1996
38. Tumour necrosis factor [small alpha, Greek] and interleukin 1[small beta, Greek] in relapse of Crohn's disease
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Schreiber, Stefan, Nikolaus, Susanna, Hampe, Jochen, Hamling, Jens, Koop, Irmtraut, Groessner, Birte, Lochs, Heribert, and Raedler, Andreas
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- 1999
39. A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology
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Helbig Katherine L, Nothnagel Michael, Hampe Jochen, Balschun Tobias, Nikolaus Susanna, Schreiber Stefan, Franke Andre, and Nöthlings Ute
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Gene-environment interaction ,Case-only ,Crohn's disease ,NOD2/CARD15 ,Cigarette smoking ,Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background Genetic variation in NOD2 and cigarette smoking are well-established risk factors for the development of Crohn's disease (CD). However, little is known about a potential interaction between these risk factors. We investigated gene-environment interactions between CD-associated NOD2 alleles and cigarette smoking in a large sample of patients with CD. Methods Three previously reported CD-associated variants in NOD2 (R702W, G908R, 1007fs) were genotyped in 1636 patients with CD continuously recruited between 1995 and 2010 based on physician referral. Data on history of smoking behaviour was obtained for all participants through a written questionnaire. Using a case-only design, we performed logistic regression analyses to investigate statistical interactions between NOD2 risk alleles and smoking status. Results We detected a significant negative interaction between carriership of at least one of the NOD2 risk alleles and history of ever having smoked (OR = 0.71; p = 0.005) as well as smoking at the time of CD diagnosis (OR = 0.68; p = 0.005). Subsequent separate analyses of the three variants revealed a significant negative interaction between the 1007fs variant and history of ever having smoked (OR = 0.64; p = 9 × 10-4) and smoking at the time of CD diagnosis (OR = 0.53; p = 7 × 10-5). Conclusions The observed significant negative gene-environment interaction suggests that the risk increase for CD conferred simultaneously by cigarette smoking and the 1007fs NOD2 polymorphism is smaller than expected and may point to a biological interaction. Our findings warrant further investigation in epidemiological and functional studies to elucidate pathophysiology as well as to aid in the development of recommendations for disease prevention.
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- 2012
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40. Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study
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Hampe, Jochen, Grebe, Jochen, Nikolaus, Susanna, Solberg, Camilla, Croucher, Peter JP, Mascheretti, Silvia, Jahnsen, Jörgen, Moum, Björn, Klump, Bodo, Krawczak, Michael, Mirza, Muddassar M, Foelsch, Ulrich R, Vatn, Morten, and Schreiber, Stefan
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- 2002
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41. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
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Goyette, Philippe, Boucher, Gabrielle, Mallon, Dermot, Ellinghaus, Eva, Jostins, Luke, Huang, Hailiang, Ripke, Stephan, Gusareva, Elena S., Annese, Vito, Hauser, Stephen L., Oksenberg, Jorge R., Thomsen, Ingo, Leslie, Stephen, Daly, Mark J., Van Steen, Kristel, Duerr, Richard H., Barrett, Jeffrey C., Mcgovern, Dermot P. B., Schumm, L. Philip, Traherne, James A., Carrington, Mary N., Kosmoliaptsis, Vasilis, Karlsen, Tom H., Franke, Andre, Rioux, John D., Abraham, Clara, Achkar, Jean Paul, Ahmad, Tariq, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Balschun, Tobias, Bampton, Peter A., Barclay, Murray, Bayless, Theodore M., Bethge, Johannes, Bis, Joshua C., Bitton, Alain, Brand, Stephan, Brant, Steven R., Buning, Carsten, Chew, Angela, Cho, Judy H., Cleynen, Isabelle, Cohain, Ariella, Croft, Anthony, D'Amato, Mauro, Danese, Silvio, De Jong, Dirk, De Vos, Martine, Denapiene, Goda, Denson, Lee A., Devaney, Kathy L., Dewit, Olivier, D'Inca, Renata, Dubinsky, Marla, Edwards, Cathryn, Ellinghaus, David, Essers, Jonah, Ferguson, Lynnette R., Festen, Eleonora A., Fleshner, Philip, Florin, Tim, Franchimont, Denis, Fransen, Karin, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jurgen, Green, Todd, Griffiths, Anne M., Guthery, Stephen L., Hakonarson, Hakon, Halfvarson, Jonas, Hanigan, Katherine, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hayward, Nicholas K., Hedl, Matija, Henderson, Paul, Xinli, Hu, Hui, Ken Y., Imielinski, Marcin, Ippoliti, Andrew, Jonaitis, Laimas, Kennedy, Nicholas A., Khan, Mohammed Azam, Kiudelis, Gediminas, Kugathasan, Subra, Kupcinskas, Limas, Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lee, James C., Lees, Charlie W., Leja, Marcis, Van Limbergen, Johan, Lionetti, Paolo, Liu, Jimmy Z., Louis, Edouard, Mahy, Gillian, Mansfield, John, Massey, Dunecan, Mathew, Christopher G., Milgrom, Raquel, Mitrovic, Mitja, Montgomery, Grant, Mowat, Craig, Newman, Wwilliam, Aylwin, Ng, Siew C., Ng, Evelyn Ng, Sok Meng, Nikolaus, Susanna, Ning, Kaida, Nothen, Markus, Oikonomou, Ioannis, Palmieri, Orazio, Parkes, Miles, Phillips, Anne, Ponsioen, Cyriel Y., Potocnik, Uros, Prescott, Natalie J., Proctor, Deborah D., Radford Smith, Graham, Rahier, Jean Francois, Raychaudhur, Soumya, Regueiro, Miguel, Rieder, Florian, Roberts, Rebecca, Russell, Richard K., Sanderson, Jeremy D., Sans, Miquel, Satsangi, Jack, Schadt, Eric E., Schreiber, Stefan, Scott, Regan, Seielstad, Mark, Sharma, Yashoda, Silverberg, Mark S., Simms, Lisa A., Skieceviciene, Jurgita, Spain, Sarah L., Steinhart, A. Hillary, Stempak, Joanne M., Stronati, Laura, Sventoraityte, Jurgita, Targan, Stephan R., Taylor, Kirstin M., Ter Velde, Anje, Theatre, Emilie, Torkvist, Leif, Tremelling, Mark, Van Der Meulen, Andrea, Van Sommeren, Suzanne, Vasiliauskas, Eric, Vermeire, Severine, Verspaget, Hein W., Walters, Thomas, Wwang, Kai, Wwang, Ming Hsi, Wweersma, Rinse K., Wei, Zhi, Whiteman, David, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Xavier, Ramnik J., Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhang, Hu, Zhang, Wwei, Zhao, Hongyu, Zhao, Zhen Z., Gastroenterology and Hepatology, Traherne, James [0000-0002-6003-8559], Kosmoliaptsis, Vasilis [0000-0001-7298-1387], and Apollo - University of Cambridge Repository
- Subjects
Heterozygote ,Genotype ,Genotyping Techniques ,Genetic Linkage ,Ulcerative ,Human leukocyte antigen ,Biology ,Major histocompatibility complex ,Polymorphism, Single Nucleotide ,Article ,Primary sclerosing cholangitis ,Major Histocompatibility Complex ,Alleles ,Chromosome Mapping ,Colitis, Ulcerative ,Crohn Disease ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,HLA-DRB1 Chains ,Humans ,Inflammatory Bowel Diseases ,Phenotype ,Genetics ,medicine ,HLA-DR ,Polymorphism ,Colitis ,HLA-DRB1 ,Crohn's disease ,Single Nucleotide ,medicine.disease ,Ulcerative colitis ,digestive system diseases ,Immunology ,biology.protein - Abstract
Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD.
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- 2015
42. Tumour necrosis factor inhibition by oxpentifylline and intestinal inflammation in Crohn's disease
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Bauditz, Jurgen, Ruckert, Yvonne, Raedler, Andreas, Nikolaus, Susanna, Lochs, Herbert, and Schreiber, Stefan
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- 1995
43. Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active crohn's disease
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Schreiber, Stefan, Nikolaus, Susanna, Malchow, Herbert, Kruis, Wolfgang, Lochs, Herbert, Raedler, Andreas, Hahn, Eckhart G., Krummenerl, Thomas, and Steinmann, Gerhard
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- 2001
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44. Quality of care in inflammatory bowel disease: results of a prospective controlled cohort study in Germany (NETIBD)
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Langbrandtner,Jana, Hüppe,Angelika, Jessen,Petra, Büning,Jürgen, Nikolaus,Susanna, Raspe,Heiner, and Bokemeyer,Bernd
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Clinical and Experimental Gastroenterology - Abstract
Jana Langbrandtner,1,* Angelika Hüppe,1,* Petra Jessen,2 Jürgen Büning,3 Susanna Nikolaus,4 Heiner Raspe,5 Bernd Bokemeyer6 1Institute of Social Medicine and Epidemiology, University of Luebeck, Ratzeburger Allee, Luebeck, 2Gastroenterology Practice Altenholz-Kiel, Erdbeerfeld, Altenholz, 3Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee, Luebeck, 4Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstraße, Kiel, 5Center for Population Medicine and Health Services Research, University of Luebeck, Ratzeburger Allee, Luebeck, 6Gastroenterology Practice Minden, Uferstraße, Minden, Germany *These authors contributed equally to this work Background/aims: Patients with inflammatory bowel disease (IBD) need comprehensive, interdisciplinary and cross-sectoral health care. In Germany, evidence-based care pathways have been developed to improve the quality of care of IBD patients. We aimed to evaluate the effects of the implementation of some of these recommendations on patient-related outcomes.Methods: In a region of North Germany, outpatients with IBD were recruited by gastroenterologists (intervention group). Three activities based on the recommendations of the IBD pathways were implemented, namely, 1) patient participation in a questionnaire-based assessment of 22 somatic and psychosocial problems combined with individualized care recommendations (patient activation procedure); 2) patient invitation to participate in a 2-day patient education program and 3) invitation to their gastroenterologists to participate in periodic interdisciplinary case conferences. For the control group, IBD patients receiving standard care at gastroenterology practices outside the specified region were recruited by their doctors. At baseline, 6- and 12-month follow-up, study patients were invited to complete questionnaires. Generic health-related quality of life, social participation and self-management skills were the main outcomes.Results: At baseline, 349 patients were included in the study (intervention group: 189; control group: 160); 142 patients from the former and 140 from the latter group returned completed questionnaires at the 12-month follow-up. Over time, improvement in health-related quality of life and social participation was similar in both groups. Participants of the intervention group demonstrated improved self-management skills and more often followed steroid-free medication regimens.Conclusion: In a real-world clinical context, patient activation procedure combined with patient education and case conferences was less effective than expected. The observed beneficial effects, however, encourage the evaluation of more intensive and addressee-centered activities. Keywords: Crohn’s disease, ulcerative colitis, IBD care pathways, quality of care, implementation, evaluation, health services research
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- 2017
45. Genetic Variation in the CYP2C Monooxygenase Enzyme Subfamily Shows No Association With Longevity in a German Population
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Flachsbart, Friederike, Ufer, Mike, Kleindorp, Rabea, Nikolaus, Susanna, Schreiber, Stefan, and Nebel, Almut
- Abstract
Cytochrome P450 enzymes, especially the CYP2C subfamily, are involved in the generation of reactive oxygen species and are regarded as susceptibility factors for age-related diseases. Furthermore, the CYP2C-encoding genes are known to be highly polymorphic, with a number of variants leading to changes in enzyme activity. These observations prompted us to investigate whether allelic variation in the CYP2C-encoding genes was associated with human longevity. In a comprehensive haplotype tagging approach, we genotyped 56 single nucleotide polymorphisms located in the CYP2C gene family (CYP2C8, CYP2C9, CYP2C18, and CYP2C19) in our extensive collection of 1,384 long-lived individuals (centenarians and nonagenarians) and 945 younger controls. None of the tested single nucleotide polymorphisms showed a significant association with the longevity phenotype at the allele, genotype, or haplotype level. These results suggest that there is no notable influence of sequence variation in the CYP2C genes on longevity in the examined German population
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- 2017
46. Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease
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Schreiber, Stefan, Fedorak, Richard N., Nielsen, Ole Haagen, Wild, Gary, Williams, C.Noel, Nikolaus, Susanna, Jacyna, Meron, Lashner, Bret A., Gangl, Alfred, Rutgeerts, Paul, Isaacs, Kim, Van Deventer, Sander J.H., Koningsberger, Jacob C., Cohard, Marielle, LeBeaut, Alesandre, and Hanauer, Stephen B.
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- 2000
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47. Reply
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Schreiber, Stefan, primary, Nikolaus, Susanna, additional, Waetzig, Georg H., additional, and Rosenstiel, Philip, additional
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- 2018
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48. Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease
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Zeissig, Sebastian, primary, Rosati, Elisa, additional, Dowds, C Marie, additional, Aden, Konrad, additional, Bethge, Johannes, additional, Schulte, Berenice, additional, Pan, Wei Hung, additional, Mishra, Neha, additional, Zuhayra, Maaz, additional, Marx, Marlies, additional, Paulsen, Maren, additional, Strigli, Anne, additional, Conrad, Claudio, additional, Schuldt, Dörthe, additional, Sinha, Anupam, additional, Ebsen, Henriette, additional, Kornell, Sabin-Christin, additional, Nikolaus, Susanna, additional, Arlt, Alexander, additional, Kabelitz, Dieter, additional, Ellrichmann, Mark, additional, Lützen, Ulf, additional, Rosenstiel, Philip C, additional, Franke, Andre, additional, and Schreiber, Stefan, additional
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- 2018
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49. Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases
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Nikolaus, Susanna, primary, Schulte, Berenice, additional, Al-Massad, Natalie, additional, Thieme, Florian, additional, Schulte, Dominik M., additional, Bethge, Johannes, additional, Rehman, Ateequr, additional, Tran, Florian, additional, Aden, Konrad, additional, Häsler, Robert, additional, Moll, Natalie, additional, Schütze, Gregor, additional, Schwarz, Markus J., additional, Waetzig, Georg H., additional, Rosenstiel, Philip, additional, Krawczak, Michael, additional, Szymczak, Silke, additional, and Schreiber, Stefan, additional
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- 2017
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50. Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB
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Wichert, Rielana, primary, Ermund, Anna, additional, Schmidt, Stefanie, additional, Schweinlin, Matthias, additional, Ksiazek, Miroslaw, additional, Arnold, Philipp, additional, Knittler, Katharina, additional, Wilkens, Frederike, additional, Potempa, Barbara, additional, Rabe, Björn, additional, Stirnberg, Marit, additional, Lucius, Ralph, additional, Bartsch, Jörg W., additional, Nikolaus, Susanna, additional, Falk-Paulsen, Maren, additional, Rosenstiel, Philip, additional, Metzger, Marco, additional, Rose-John, Stefan, additional, Potempa, Jan, additional, Hansson, Gunnar C., additional, Dempsey, Peter J., additional, and Becker-Pauly, Christoph, additional
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- 2017
- Full Text
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