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Objective: The inverse problem of computing conductivity distributions in 2D and 3D objects interrogated by low frequency electrical signals, which is called Electrical Impedance Tomography (EIT), is treated using a Method-of-Moment technique. Methods: A Point-Matching-Method-of-Moment technique is used to formulate a global integral equation solver. Radial Basis Functions are adopted to express the conductivity distribution. Single-step quadratic-norm (L2) and iterative total variation (L1) regularization techniques are exploited to solve the inverse problem. Results: Simulation and experimental tests on a circular reconstruction domain show satisfactory performance in deriving conductivity distribution, achieving a Correlation Coefficient (CC) up to 0:863 for 70 dB voltage SNR and 0:842 for 40 dB voltage SNR. The proposed methodology with L2-norm regularization provided better results than traditional iterative Gauss-Newtons approach, whereas with L1-norm regularization it showed promising performance. Moreover, 3D reconstructions on a cylindrical cavity demonstrated superior results near the electrodes planes compared to those of the conventional linearized approach. Finally, application to EIT medical data for dynamic lung imaging successfully revealed the breath-cycle conductivity changes. Conclusion: The results show that the proposed method can be effective for both 2D and 3D EIT and applicable to many applications. Significance: Strong conductivity variations are successfully tackled with a very good Correlation Coefficient. In contrast to conventional EIT solutions based on weak-form and linearization on small conductivity changes, the proposed method requires only one step to converge with L2-norm regularization. The proposed method with L1-norm regularization also achieves good reconstruction quality with a low number of iterations.

Objective : Near-field microwave radiometry has emerged as a tool for real-time passive monitoring of local brain activation, possibly attributed to local changes in blood flow that correspond to temperature and/or conductivity changes. The aim of this study is to design and evaluate a prototype system based on microwave radiometry intended to detect local changes of temperature and conductivity in depth in brain tissues. A novel radiometric system that comprises a four port total power Dicke-switch sensitive receiver that operates at 1.5 GHz has been developed. Methods and Results : The efficacy of the system was assessed through simulation and experiment on brain tissue mimicking phantoms under different setup conditions, where temperature and conductivity changes were accurately detected. In order to validate the radiometer's capability to sense low power signals occurring spontaneously from regions in the human brain, the somatosensory cortices of one volunteer were measured under pain-inducing psychophysiological conditions. The promising results from the initial in vivo measurements prove the system's potential for more extensive investigative trials. Conclusion and Significance : The significance of this study lies on the development of a compact and sensitive radiometer for totally passive monitoring of local brain activation as a potential complementary tool for contributing to the research effort for investigating brain functionality.

Electrical impedance tomography is a low-cost, safe, and high temporal resolution medical imaging modality which finds extensive application in real-time thoracic impedance imaging. Thoracic impedance changes can reveal important information about the physiological condition of patients’ lungs. In this way, electrical impedance tomography can be a valuable tool for monitoring patients. However, this technique is very sensitive to measurement noise or possible minor signal errors, coming from either the hardware, the electrodes, or even particular biological signals. Thus, the design of a good performance electrical impedance tomography hardware setup which properly interacts with the tissue examined is both an essential and a challenging concept. In this paper, we adopt an extensive simulation approach, which combines the system’s analogue and digital hardware, along with equivalent circuits of 3D finite element models that represent thoracic cavities. Each thoracic finite element model is created in MATLAB based on existing CT images, while the tissues’ conductivity and permittivity values for a selected frequency are acquired from a database using Python. The model is transferred to a multiport RLC network, embedded in the system’s hardware which is simulated at LT SPICE. The voltage output data are transferred to MATLAB where the electrical impedance tomography signal sampling and digital processing is also simulated. Finally, image reconstructions are performed in MATLAB, using the EIDORS library tool and considering the signal noise levels and different electrode and signal sampling configurations (ADC bits, sampling frequency, number of taps).

A low-cost 1 kHz–400 kHz operating frequency fully-active electrode bioimpedance measurement module, based on Howland current source, is presented in this paper. It includes a buffered positive feedback Howland current source, implemented with operational amplifiers, as well as an AD8421 instrumentation amplifier, for the differential voltage measurements. Each active electrode module can be connected to others, assembling a wearable active electrode module array. From this array, 2 electrodes can be selected to be driven from a THS413 fully differential amplifier, activating a mirrored Howland current source. This work performs a complete circuit analysis, verified with MATLAB and SPICE simulations of the current source’s transconductance and output impedance over the frequency range between 1 kHz and 1 MHz. Resistors’ tolerances, possible mismatches, and the operational amplifiers’ non-idealities are considered in both the analysis and simulations. A comparison study between four selected operational amplifiers (ADA4622, OPA2210, AD8034, and AD8672) is additionally performed. The module is also hardware-implemented and tested in the lab for all four operational amplifiers and the transconductance is measured for load resistors of 150 Ω, 660 Ω, and 1200 Ω. Measurements showed that, using the AD8034 operational amplifier, the current source’s transconductance remains constant for frequencies up to 400 KHz for a 150 Ω load and 250 kHz for a 1200 Ω load, while lower performance is achieved with the other 3 operational amplifiers. Finally, transient simulations and measurements are performed at the AD8421 output for bipolar measurements on the 3 aforementioned load resistor values.