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19 results on '"Nikitin, Yevgeniy N."'

2. Pyridoxonium salts of chiral and cyclic dithiophosphoric and bisdithiophosphonic acids and their antimicrobial activities

Author

Nizamov, Ilyas S., primary, Belov, Timur G., additional, Nizamov, Ilnar D., additional, Nikitin, Yevgeniy N., additional, Akhmedova, Gulnaz R., additional, Shilnikova, Olga V., additional, Timushev, Ildus D., additional, Salikhov, Ramazan Z., additional, Shulaeva, Marina P., additional, Pozdeev, Oscar K., additional, Batyeva, Elvira S., additional, and Cherkasov, Rafael A., additional

Published
2020
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5. Pyridinium salts of dithiophosphoric acids on the basis of nicotinic acids and their isomers, 3-hydroxypyridine, and 3-pyridinemethanol

Author

Nizamov, Ilyas S., Salikhov, Ramazan Z., Ildus D. Timushev, Nikitin, Yevgeniy N., Ilnar D. Nizamov, Yakimov, Vladimir Yu., Shulaeva, Marina P., Pozdeev, Oscar K., Batyeva, Elvira S., Cherkasov, Rafael A., and Ponomareva, Anna S.

Abstract

A new series of chiral carboxypyridinium dithiophosphates were synthesized by the reactions of nicotinic, isonicotinic, and picolinic acids with dithiophosphoric acid on the basis (1S)-endo-(–)-borneol in benzene or ethanol. 5,5-Dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane reacted with 3-hydroxypyridine or 3-pyridinemethanol in EtOH to afford the 3-hydroxypyridinium and 3-hydroxymethylpyridinium 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinanes which possessed antifungal activity against Candida albicans.

Published
2019
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7. Pyridinium salts of dithiophosphoric acids on the basis of nicotinic acids and their isomers, 3-hydroxypyridine, and 3-pyridinemethanol

Author

Nizamov, Ilyas S., primary, Salikhov, Ramazan Z., additional, Timushev, Ildus D., additional, Nikitin, Yevgeniy N., additional, Nizamov, Ilnar D., additional, Yakimov, Vladimir Yu., additional, Shulaeva, Marina P., additional, Pozdeev, Oscar K., additional, Batyeva, Elvira S., additional, Cherkasov, Rafael A., additional, and Ponomareva, Anna S., additional

Published
2019
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8. Cinchona Alkaloids in the Synthesis of Chiral Salts of Phosphorus Dithioacids on the Basis of 1,2:3,4‐Di‐O‐isopropylidene‐α‐D‐galactopyranose

Author

Nizamov, Ilyas S., primary, Shumatbaev, Georgiy G., additional, Nizamov, Ilnar D., additional, Salikhov, Ramazan Z., additional, Nikitin, Yevgeniy N., additional, Shulaeva, Marina P., additional, Pozdeev, Oscar K., additional, Batyeva, Elvira S., additional, and Cherkasov, Rafael A., additional

Published
2019
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9. Pyridoxonium salts of chiral and cyclic dithiophosphoric and bisdithiophosphonic acids and their antimicrobial activities.

Author

Nizamov, Ilyas S., Belov, Timur G., Nizamov, Ilnar D., Nikitin, Yevgeniy N., Akhmedova, Gulnaz R., Shilnikova, Olga V., Timushev, Ildus D., Salikhov, Ramazan Z., Shulaeva, Marina P., Pozdeev, Oscar K., Batyeva, Elvira S., and Cherkasov, Rafael A.

Subjects
VITAMIN B6, ACIDS, SALTS, MENTHOL, ANTIFUNGAL agents
Abstract

Pyridoxonium salts of chiral linear and cyclic dithiophosphoric acids were obtained by the reactions of pyridoxine with bis{2-О-[2-methyl-(2S)-3-O-propionyl]}, bis{2-О-[1,4-О,О-dimethyl-(2S)-succinyl]}, and O,O-di-2-butyl dithiophosphoric acids, and cyclic dithiophosphoric acids of 1,3,2-dioxaphosphorinane, 1,3,2-dioxaphospholane, and 1,3,2-dioxaphosphepin structure. Syntheses of acetonide pyridoxonium О,О-dimenthyl dithiophosphates were carried out by the reaction of seven-membered pyridoxine acetonide with О,О-dimenthyl dithiophosphoric acids obtained from (–)-(1 R,2S,5R)-menthol and (+)-(1S,2R,5S)-menthol. Diacetonide pyridoxonium bisdithiophosphonate was also prepared. The antibacterial and antifungal activities of pyridoxonium chiral linear and cyclic dithiophosphates were evaluated. [ABSTRACT FROM AUTHOR]

Published
2021
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10. Triallyl ammonium amphiphiles: self-assembly and complexation with bovine serum albumin

Author

Kuznetsov, Denis M, Kuznetsova, Darya A, Gabdrakhmanov, Dinar R, Lukashenko, Svetlana S, Nikitin, Yevgeniy N, and Zakharova, Lucia Ya

Abstract

Currently, the investigation on the interaction of cationic surfactants with proteins attract the wide attention of researchers. Proteins participate in the majority of important biological processes; therefore, they are essential for a living organism. The addition of proteins to a surfactant solution can significantly modify the adsorption layer properties at liquid/fluid interfaces. In turn, surfactants can markedly affect the conformational behaviour of proteins. Therefore, in this study, the cationic amphiphiles triallyldodecylammonium bromide and triallyltetradecylammonium bromide have been synthesised. Their aggregation behaviour in an aqueous solution, solubilisation capacity towards the hydrophobic azo dye and complexation with bovine serum albumin (BSA) were evaluated. The lower homologue has demonstrated an unusual two-step aggregation behaviour, controlled morphology aggregates and various solubilisation capacities for Orange OT. The increase in the length of the hydrocarbon tail from dodecyl to tetradecyl has resulted in the disappearance of the second critical point and the enlargement of the particle size. Both of the amphiphiles that were investigated effectively interacted with BSA and were bound to the tryptophan amino acid residue of the protein. For surfactants/BSA systems, it was shown that by varying the length of the hydrophobic tail, the dominance of the various types of interactions can be achieved.

Published
2021
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11. Chiral methylbenzylammonium salts of aryldithiophosphonic acids containing glucofuranose, allofuranose, and galactopyranose diacetonide scaffolds.

Author

Nizamov, Ilyas S., Shumatbaev, Georgiy G., Nizamov, Ilnar D., Nikitin, Yevgeniy N., Belov, Timur G., Shulaeva, Marina P., Pozdeev, Oscar K., Batyeva, Elvira S., and Cherkasov, Rafael A.

Subjects
SALTS, ACIDS, GLYCOLIC acid, CARBOHYDRATES
Abstract

New chiral methylbenzylammonium salts of aryldithiophosphonic acids containing glucofuranose, allofuranose, and galactopyranose diacetonide substituents were obtained using (S)-(–)-α-methylbenzylamine, (R)-(+)-α-methylbenzylamine, and (R,S)-(±)-α-methylbenzylamine. Salts obtained possess antimicrobial activity. [ABSTRACT FROM AUTHOR]

Published
2021
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12. Pyridinium salts of dithiophosphoric acids on the basis of nicotinic acids and their isomers, 3-hydroxypyridine, and 3-pyridinemethanol.

Author

Nizamov, Ilyas S., Salikhov, Ramazan Z., Timushev, Ildus D., Nikitin, Yevgeniy N., Nizamov, Ilnar D., Yakimov, Vladimir Yu., Shulaeva, Marina P., Pozdeev, Oscar K., Batyeva, Elvira S., Cherkasov, Rafael A., and Ponomareva, Anna S.

Subjects
NIACIN, PICOLINIC acid, ISOMERS, SALTS, CANDIDA albicans
Abstract

A new series of chiral carboxypyridinium dithiophosphates were synthesized by the reactions of nicotinic, isonicotinic, and picolinic acids with dithiophosphoric acid on the basis (1S)-endo-(–)-borneol in benzene or ethanol. 5,5-Dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane reacted with 3-hydroxypyridine or 3-pyridinemethanol in EtOH to afford the 3-hydroxypyridinium and 3-hydroxymethylpyridinium 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinanes which possessed antifungal activity against Candida albicans. [ABSTRACT FROM AUTHOR]

Published
2020
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