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260 results on '"Nikiforov, Mikhail A."'

1. Booster Transformers Energy Performance Assessment in the Traction Power Supply System of Railway Transport

Author

Komyakov, Aleksandr, Nikiforov, Mikhail, Tarasevich, Viktor, Bartel, Lyubov, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, and S. Shmaliy, Yuriy, editor

Published
2024
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2. Improving the Efficiency of Static Reactive Power Generators in Traction Power Supply Systems of Railways

Author

Nezevak, Vladislav L., Nikiforov, Mikhail M., Kondratiev, Yuri V., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, and S. Shmaliy, Yuriy, editor

Published
2024
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4. Methodology for Forecasting the Electricity Losses for Train Traction

Author

Ushakov, Sergey, Nikiforov, Mikhail, Komyakov, Aleksandr, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, S. Shmaliy, Yuriy, editor, and Nayyar, Anand, editor

Published
2023
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5. Energy Intensity and Energy Efficiency of Energy Saving Policy of Railway Transport

Author

Rozhitsky, Dmitry, Rybak, Alexey, Krasnova, Irina, Komyakov, Aleksandr, Nikiforov, Mikhail, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Guda, Alexander, editor

Published
2023
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8. Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4

Author

Wolff, David W., Deng, Zhiyong, Bianchi-Smiraglia, Anna, Foley, Colleen E., Han, Zhannan, Wang, Xingyou, Shen, Shichen, Rosenberg, Masha M., Moparthy, Sudha, Yun, Dong Hyun, Chen, Jialin, Baker, Brian K., Roll, Matthew V., Magiera, Andrew J., Li, Jun, Hurley, Edward, Feltri, Maria Laura, Cox, Anderson O., Lee, Jingyun, Furdui, Cristina M., Liu, Liang, Bshara, Wiam, LaConte, Leslie E.W., Kandel, Eugene S., Pasquale, Elena B., Qu, Jun, Hedstrom, Lizbeth, and Nikiforov, Mikhail A.

Published
2022
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11. Author Correction: Regulation of local GTP availability controls RAC1 activity and cell invasion

Author

Bianchi-Smiraglia, Anna, Wolff, David W., Marston, Daniel J., Deng, Zhiyong, Han, Zhannan, Moparthy, Sudha, Wombacher, Rebecca M., Mussell, Ashley L., Shen, Shichen, Chen, Jialin, Yun, Dong-Hyun, O’Brien Cox, Anderson, Furdui, Cristina M., Hurley, Edward, Feltri, Maria Laura, Qu, Jun, Hollis, Thomas, Kengne, Jules Berlin Nde, Fongang, Bernard, Sousa, Rui J., Kandel, Mikhail E., Kandel, Eugene S., Hahn, Klaus M., and Nikiforov, Mikhail A.

Published
2021
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12. Regulation of local GTP availability controls RAC1 activity and cell invasion

Author

Bianchi-Smiraglia, Anna, Wolff, David W., Marston, Daniel J., Deng, Zhiyong, Han, Zhannan, Moparthy, Sudha, Wombacher, Rebecca M., Mussell, Ashley L., Shen, Shichen, Chen, Jialin, Yun, Dong-Hyun, O’Brien Cox, Anderson, Furdui, Cristina M., Hurley, Edward, Feltri, Maria Laura, Qu, Jun, Hollis, Thomas, Kengne, Jules Berlin Nde, Fongang, Bernard, Sousa, Rui J., Kandel, Mikhail E., Kandel, Eugene S., Hahn, Klaus M., and Nikiforov, Mikhail A.

Published
2021
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14. Intelligent Automated System for the Monitoring of Railway Areas with a Low Transport Process Energy Efficiency

Author

Cheremisin, Vasily, Nikiforov, Mikhail, Kashtanov, Alexey, Ushakov, Sergey, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio S., Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Murgul, Vera, editor, and Popovic, Zdenka, editor

Published
2018
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16. KLF9-dependent ROS regulate melanoma progression in stage-specific manner

Author

Bagati, Archis, Moparthy, Sudha, Fink, Emily E., Bianchi-Smiraglia, Anna, Yun, Dong Hyun, Kolesnikova, Masha, Udartseva, Olga O., Wolff, David W., Roll, Matthew V., Lipchick, Brittany C., Han, Zhannan, Kozlova, Nadezhda I., Jowdy, Peter, Berman, Albert E., Box, Neil F., Rodriguez, Cesar, Bshara, Wiam, Kandel, Eugene S., Soengas, Maria S., Paragh, Gyorgy, and Nikiforov, Mikhail A.

Published
2019
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20. Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1

Author

Bagati, Archis, Bianchi-Smiraglia, Anna, Moparthy, Sudha, Kolesnikova, Kateryna, Fink, Emily E., Lipchick, Brittany C., Kolesnikova, Masha, Jowdy, Peter, Polechetti, Anthony, Mahpour, Amin, Ross, Jason, Wawrzyniak, Joseph A., Yun, Dong Hyun, Paragh, Gyorgy, Kozlova, Nadezhda I., Berman, Albert E., Wang, Jianmin, Liu, Song, Nemeth, Michael J., and Nikiforov, Mikhail A.

Published
2017
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23. Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma

Author

Bianchi-Smiraglia, Anna, Bagati, Archis, Fink, Emily E., Affronti, Hayley C., Lipchick, Brittany C., Moparthy, Sudha, Long, Mark D., Rosario, Spencer R., Lightman, Shivana M., Moparthy, Kalyana, Wolff, David W., Yun, Dong Hyun, Han, Zhannan, Polechetti, Anthony, Roll, Matthew V., Gitlin, Ilya I., Leonova, Katerina I., Rowsam, Aryn M., Kandel, Eugene S., Gudkov, Andrei V., Bergsagel, P. Leif, Lee, Kelvin P., Smiraglia, Dominic J., and Nikiforov, Mikhail A.

Subjects
Cell receptors -- Health aspects, Multiple myeloma -- Genetic aspects -- Development and progression -- Care and treatment, Genetic regulation -- Health aspects, Health care industry
Abstract

Polyamine inhibition for cancer therapy is, conceptually, an attractive approach but has yet to meet success in the clinical setting. The aryl hydrocarbon receptor (AHR) is the central transcriptional regulator of the xenobiotic response. Our study revealed that AHR also positively regulates intracellular polyamine production via direct transcriptional activation of 2 genes, ODC1 and AZIN1, which are involved in polyamine biosynthesis and control, respectively. In patients with multiple myeloma (MM), AHR levels were inversely correlated with survival, suggesting that AHR inhibition may be beneficial for the treatment of this disease. We identified clofazimine (CLF), an FDA-approved anti-leprosy drug, as a potent AHR antagonist and a suppressor of polyamine biosynthesis. Experiments in a transgenic model of MM (Vk*Myc mice) and in immunocompromised mice bearing MM cell xenografts revealed high efficacy of CLF comparable to that of bortezomib, a first-in-class proteasome inhibitor used for the treatment of MM. This study identifies a previously unrecognized regulatory axis between AHR and polyamine metabolism and reveals CLF as an inhibitor of AHR and a potentially clinically relevant anti-MM agent., Introduction Polyamines are small polycationic molecules that have been implicated in virtually every aspect of eukaryotic cells, including DNA replication, transcription, translation, and proliferation (1-3). Polyamine levels are increased in [...]

Published
2018
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24. FOXQ1 controls the induced differentiation of melanocytic cells

Author

Bagati, Archis, Bianchi-Smiraglia, Anna, Moparthy, Sudha, Kolesnikova, Kateryna, Fink, Emily E., Kolesnikova, Masha, Roll, Matthew V., Jowdy, Peter, Wolff, David W., Polechetti, Anthony, Yun, Dong Hyun, Lipchick, Brittany C., Paul, Leslie M., Wrazen, Brian, Moparthy, Kalyana, Mudambi, Shaila, Morozevich, Galina E., Georgieva, Sofia G., Wang, Jianmin, Shafirstein, Gal, Liu, Song, Kandel, Eugene S., Berman, Albert E., Box, Neil F., Paragh, Gyorgy, and Nikiforov, Mikhail A.

Published
2018
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25. Distinct inflammatory Th17 subsets emerge in autoimmunity and infection

Author

Bouch, Ronald J., primary, Zhang, Jing, additional, Miller, Brandi C., additional, Robbins, Caroline J., additional, Mosher, Timothy H., additional, Li, Wencheng, additional, Krupenko, Sergey A., additional, Nagpal, Ravinder, additional, Zhao, Jun, additional, Bloomfeld, Richard S., additional, Lu, Yong, additional, Nikiforov, Mikhail A., additional, Song, Qianqian, additional, and He, Zhiheng, additional

Published
2023
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27. Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy

Author

Affronti, Hayley C., Rowsam, Aryn M., Pellerite, Anthony J., Rosario, Spencer R., Long, Mark D., Jacobi, Justine J., Bianchi-Smiraglia, Anna, Boerlin, Christoph S., Gillard, Bryan M., Karasik, Ellen, Foster, Barbara A., Moser, Michael, Wilton, John H., Attwood, Kristopher, Nikiforov, Mikhail A., Azabdaftari, Gissou, Pili, Roberto, Phillips, James G., Casero, Jr., Robert A., and Smiraglia, Dominic J.

Published
2020
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29. Nrf2 Amplifies Oxidative Stress via Induction of Klf9

Author

Zucker, Shoshanna N., Fink, Emily E., Bagati, Archis, Mannava, Sudha, Bianchi-Smiraglia, Anna, Bogner, Paul N., Wawrzyniak, Joseph A., Foley, Colleen, Leonova, Katerina I., Grimm, Melissa J., Moparthy, Kalyana, Ionov, Yurij, Wang, Jianmin, Liu, Song, Sexton, Sandra, Kandel, Eugene S., Bakin, Andrei V., Zhang, Yuesheng, Kaminski, Naftali, Segal, Brahm H., and Nikiforov, Mikhail A.

Published
2014
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32. A Purine Nucleotide Biosynthesis Enzyme Guanosine Monophosphate Reductase Is a Suppressor of Melanoma Invasion

Author

Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Bshara, Wiam, Mannava, Sudha, Ackroyd, Jeff, Bagati, Archis, Omilian, Angela R., Im, Michael, Fedtsova, Natalia, Miecznikowski, Jeffrey C., Moparthy, Kalyana C., Zucker, Shoshanna N., Zhu, Qianqian, Kozlova, Nadezhda I., Berman, Albert E., Hoek, Keith S., Gudkov, Andrei V., Shewach, Donna S., Morrison, Carl D., and Nikiforov, Mikhail A.

Published
2013
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42. Concept of intelligent system for controlling regenerative braking and using recovery energy

Author

Vilgelm Alexander, Nikiforov Mikhail, and Cheremisin Vasily

Subjects
Engineering (General). Civil engineering (General), TA1-2040
Abstract

The issue of increasing the level of electrical energy recovered by the electric rolling stock and the efficiency of its use at the electrified sections of railways of JSC “Russian Railways” is still topical at present. This issue is considered today in the context of increasing the efficiency of the use of traction rolling stock. Increasing the energy efficiency of the transportation process by increasing the efficiency of recovery can be achieved both by the implementation of organizational decisions and through the introduction of additional equipment in the traction power supply system, for example, installation of reversible converters at traction substations or power storage devices on electric rolling stock and in the system of traction power supply, as well as other technical means, changing the parameters of the operation of sections with mandatory provision of the operability of the regenerative braking systems in the electric rolling stock. To assist in the reasoned adoption of similar and other managerial decisions, it is advisable to create an intelligent system for controlling the processes of applying regenerative braking and using recovery energy. This paper briefly reviews the main results of scientific research on the efficiency of recovery, suggests a mechanism for adapting the methods developed earlier to the system for controlling energy efficiency of recovery processes at the sections of railways.

Published
2018
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44. Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition

Author

Nikiforov, Mikhail A., Riblett, MaryBeth, Tang, Wen-Hua, Gratchouck, Vladimir, Zhuang, Dazhong, Fernandez, Yolanda, Verhaegen, Monique, Varambally, Sooryanarayana, Chinnaiyan, Arul M., Jakubowiak, Andrzej J., and Soengas, Maria S.

Subjects
Apoprotein -- Health aspects, Apoprotein -- Genetic aspects, Apoprotein -- Research, Oncology, Experimental -- Methods, Ubiquitin-proteasome system -- Physiological aspects, Ubiquitin-proteasome system -- Genetic aspects, Ubiquitin-proteasome system -- Research, Cancer -- Research, Cancer -- Methods, Science and technology
Abstract

The proteasome controls a plethora of survival factors in all mammalian cells analyzed to date. Therefore, it is puzzling that proteasome inhibitors such as bortezomib can display a preferential toxicity toward malignant cells. In fact, proteasome inhibitors have the salient feature of promoting a dramatic induction of the proapoptotic protein NOXA in a tumor cell-restricted manner. However, the molecular determinants that control this specific regulation of NOXA are unknown. Here, we show that the induction of NOXA by bortezomib is directly dependent on the oncogene c-MYC. This requirement for c-MYC was found in a variety of tumor cell types, in marked contrast with dispensable roles of p53, HIF-I[alpha], and E2F-1 (classical proteasomal targets that can regulate NOXA mRNA under stress). Conserved MYC-binding sites identified at the NOXA promoter were validated by ChIP and reporter assays. Down-regulation of the endogenous levels of c-MYC abrogated the induction of NOXA in proteasome-defective tumor cells. Conversely, forced expression of c-MYC enabled normal cells to accumulate NOXA and subsequently activate cell death programs in response to proteasome blockage, c-MYC is itself a proteasomal target whose levels or function are invariably upregulated during tumor progression. Our data provide an unexpected function of c-MYC in the control of the apoptotic machinery, and reveal a long sought-after oncogenic event conferring sensitivity to proteasome inhibition. drug selectivity | melanoma | oncogenes | apoptosis | Bcl-2 family

Published
2007

48. Abstract B32: A novel combination therapy for metastatic melanoma potentiates a gap junction positive feedback mechanism

Author

Bagati, Archis, primary, Koch, Zethan, additional, Hutcherson, Timothy C., additional, Pechette, Joseph, additional, Dianat, Hossein, additional, Higley, Cory, additional, Chiu, Lisa, additional, Song, Yesul, additional, Shah, Jay, additional, Chazen, Elana, additional, Nicolais, Andrew, additional, Casey, Peter, additional, Thompson, Kyle, additional, Nikiforov, Mikhail A., additional, Zirnheld, Jennifer, additional, and Zucker, Shoshanna N., additional

Published
2020
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49. Novel combination therapy for melanoma induces apoptosis via a gap junction positive feedback mechanism

Author

Bagati, Archis, primary, Hutcherson, Timothy C., additional, Koch, Zethan, additional, Pechette, Joseph, additional, Dianat, Hossein, additional, Higley, Cory, additional, Chiu, Lisa, additional, Song, Yesul, additional, Shah, Jay, additional, Chazen, Elana, additional, Nicolais, Andrew, additional, Casey, Peter, additional, Thompson, Kyle, additional, Burke, Kevin, additional, Nikiforov, Mikhail A., additional, Zirnheld, Jennifer, additional, and Zucker, Shoshanna N., additional

Published
2020
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