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This study has been undertaken with a view to note the incidence of skin diseases in renal allograft recipients, to study the clinical spectrum of skin disorders and correlation between dose, duration, regimen of immunosuppressive protocol and incidence of skin infections, inflammatory diseases and malignancies. Fifty consecutive unselected kidney transplant recipients attending transplant clinic at a tertiary health care centre between September 2005 and August 2006 were evaluated for presence of skin diseases. Detailed dermatological history was obtained and examination of skin lesions including their morphology, number, size, shape, surface, distribution, pigmentation and configuration was carried out in all fifty patients. We concluded that skin diseases are common in renal transplant recipients due to side effects of immunosuppressive drugs as well as prolonged immunosuppressed state. Cushingoid features due to steroid therapy are the most common cutaneous manifestations. They are common in early post -- transplant period, are dose related and tend to improve when steroids are reduced to maintenance dosages. Gingival hyperplasia and hypertrichosis are common in patients on cyclosporine. Hypectrichosis is cosmetically troublesome in female patients, it is reversible with gradual dose reduction. There is high incidence of skin infections; superficial fungal infections are the most common and the incidence is higher in patients on maintenance immunosuppression as compared to patients who are in first post transplant year, and those who receive Mycophenolate mofetyl and triple immunosuppression. Both dose as well as duration of steroid treatment contribute to skin infections. There is no correlation between absolute neutrophil count and skin infections. Diabetes mellitus, MMF based or triple drug regimen and lymphopenia contribute to dissemination and refractoriness of fungal infections. HPV induced warts are the most common viral infections ; the frequency and number of warts increase with duration of transplant. [ABSTRACT FROM AUTHOR]

Primary renal involvement by T lymphoblasts is rare among adults with T acute lymphoblastic leukaemia. We report a 28-year-old man presenting with acute renal failure due to infiltration by T lymphoblasts and his response to paediatric-inspired modified BFM-90 protocol. The patient achieved an initial complete remission (CR) but developed central nervous system relapse. He achieved CR2 with cranial irradiation and intrathecal chemotherapy. He underwent a haploidentical transplant in CR2 and remains in remission post-transplant day 330. An early kidney biopsy helped confirm the diagnosis. Such presentations remain responsive to modified BFM-90. An early allotransplant in CR2 remains the standard of care., Competing Interests: The authors declare no conflict of interest., (© 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)

Rosuvastatin is a recently approved statin and used widely across the globe for primary and secondary prevention of atherosclerotic cardiovascular heart disease. It has the highest lipid-lowering property among all statins and relatively well tolerated. Rhabdomyolysis is a rare but potentially serious adverse effect. The present report highlights the case of a patient admitted with proximal myopathy with severe rhabdomyolysis and acute kidney injury associated with life-threatening hyperkalemia. The symptoms appeared within 1 month of starting rosuvastatin. He required temporary dialysis to overcome the crisis. His myopathy and kidney injury were completely reversible after a few months of stopping the drug. In this report, we have also discussed the various risk factors for developing myopathy with statins and the importance of strict pharmacovigilance, and a greater caution among physicians while using this drug., Competing Interests: There are no conflicts of interest., (Copyright: © 2021 Indian Journal of Nephrology.)

There are multiple causes of lung abscess, but the differential rarely includes pyelonephritis as a primary cause leading to lung abscess resulting from the development of a nephrobronchial fistula. The patient had no urinary symptoms or abdominal pain and the etiology of lung abscess was only incidentally discovered after chest CT revealed extension of pleural fluid below the diaphragm.