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Background and Objective: Head and neck carcinoma of unknown primary is a diagnostic dilemma. The clinical and imaging workup remains ineffective in two-thirds of patients. Transoral robotic surgery has shown an advantage in the primary detection over the previous standard panendoscopy. Methods: This is an observational cohort study that took place at a large healthcare centre with robotic surgery experience in head and neck over six-years. All included carcinoma of unknown primary patients followed the standard recommendation for primary identification. Final diagnostic step of robotic tongue base mucosectomy with or without tonsillectomy was introduced. The cancer detection rate in tongue base only, the functional outcome and the effect on the cancer pathway were evaluated. Results: Carcinoma of unknown primary was reported in 44 per cent of patients. All identified specimens were human papillomavirus positive. There was no significant effect on functional outcome of swallowing and the national 62-day cancer pathway. Robotic surgery allowed optimum treatment of carcinoma of unknown primary in early nodal disease. Conclusion: Robotic surgery is a useful paradigm in the management of carcinoma of unknown primary. It is safe with minimal morbidity and good functional outcome after the surgery. [ABSTRACT FROM AUTHOR]

Design and Setting. A retrospective study was conducted on all 2WW referrals made to our tertiary head and neck centre in a 12-month period. Methods. Sensitivity, specificity, and PPV of presenting complaints in H&N cancer diagnosis using Excel® and the statistical package SPSS®. Results. The sensitivity and specificity of 2005 NICE guidelines in detecting H&N cancers were 91.2% and 59%, respectively; their PPV was 9%. The sensitivity and specificity of 2015 NICE guidelines were 75.4% and 71%, respectively; their PPV was 10.3%. Eight out of 85 patients who presented with unilateral sore throat for more than 4 weeks, with or without otalgia and normal otoscopy, had H&N cancer (PPV 9.5%). Conclusions. Although the 2015 NICE guidelines have a high rate in detecting H&N cancers, consideration of reincluding unilateral sore throat in the referral criteria might be necessary. [ABSTRACT FROM AUTHOR]

Ductal carcinoma of the salivary glands is a very rare tumor that primarily affects the parotid gland. It is characterized by its locoregional and metastatic aggressiveness and by its poor prognosis. We report the case of a 68-year-old man with right parotid tumor and with a final diagnosis of salivary ductal adenocarcinoma. We review the specific characteristics of this tumor, the treatment options and the clinical evolution. [ABSTRACT FROM AUTHOR]

Uvula primary carcinomas are rare tumors, and they are, even in early stages, very aggressive because of the high incidence of cervical metastasis. We report a case of primary carcinoma of the uvula diagnosed by positron emission tomography-computed tomography (PET-CT) during the study of cervical metastasis of occult primary. The PET-CT has become a useful test in patients with cervical metastasis from primary carcinomas of the head and neck of unknown origin, combining metabolic information from positron emission tomography and anatomic information of computed tomography. [ABSTRACT FROM AUTHOR]