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2. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
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Pham, T, Heunks, L, Bellani, G, Madotto, F, Aragao, I, Beduneau, G, Goligher, E, Grasselli, G, Laake, J, Mancebo, J, Penuelas, O, Piquilloud, L, Pesenti, A, Wunsch, H, van Haren, F, Brochard, L, Laffey, J, Abrough, F, Acharya, S, Amin, P, Arabi, Y, Bauer, P, Beitler, J, Berkius, J, Bugedo, G, Camporota, L, Cerny, V, Cho, Y, Clarkson, K, Estenssoro, E, Gritsan, A, Hashemian, S, Hermans, G, Jovanovic, B, Kurahashi, K, Matamis, D, Moerer, O, Molnar, Z, Ozyilmaz, E, Panka, B, Papali, A, Perbet, S, Qiu, H, Razek, A, Rittayamai, N, Roldan, R, Serpa Neto, A, Szuldrzynski, K, Talmor, D, Tomescu, D, Villagomez, A, Zeggwagh, A, Abe, T, Aboshady, A, Acampo-de Jong, M, Adderley, J, Adiguzel, N, Agrawal, V, Aguilar, G, Aguirre, G, Aguirre-Bermeo, H, Ahlstrom, B, Akbas, T, Akker, M, Al Sadeh, G, Alamri, S, Algaba, A, Ali, M, Aliberti, A, Allegue, J, Alvarez, D, Amador, J, Andersen, F, Ansari, S, Apichatbutr, Y, Apostolopoulou, O, Arellano, D, Arica, M, Arikan, H, Arinaga, K, Arnal, J, Asano, K, Asin-Corrochano, M, Avalos Cabrera, J, Avila Fuentes, S, Aydemir, S, Aygencel, G, Azevedo, L, Bacakoglu, F, Badie, J, Baedorf Kassis, E, Bai, G, Balaraj, G, Ballico, B, Banner-Goodspeed, V, Banwarie, P, Barbieri, R, Baronia, A, Barrett, J, Barrot, L, Barrueco-Francioni, J, Barry, J, Bawangade, H, Beavis, S, Beck, E, Beehre, N, Belenguer Muncharaz, A, Belliato, M, Bellissima, A, Beltramelli, R, Ben Souissi, A, Benitez-Cano, A, Benlamin, M, Benslama, A, Bento, L, Benvenuti, D, Bernabe, L, Bersten, A, Berta, G, Bertini, P, Bertram-Ralph, E, Besbes, M, Bettini, L, Beuret, P, Bewley, J, Bezzi, M, Bhakhtiani, L, Bhandary, R, Bhowmick, K, Bihari, S, Bissett, B, Blythe, D, Bocher, S, Boedjawan, N, Bojanowski, C, Boni, E, Boraso, S, Borelli, M, Borello, S, Borislavova, M, Bosma, K, Bottiroli, M, Boyd, O, Bozbay, S, Briva, A, Bruel, C, Bruni, A, Buehner, U, Bulpa, P, Burt, K, Buscot, M, Buttera, S, Cabrera, J, Caccese, R, Caironi, P, Canchos Gutierrez, I, Canedo, N, Cani, A, Cappellini, I, Carazo, J, Cardonnet, L, Carpio, D, Carriedo, D, Carrillo, R, Carvalho, J, Caser, E, Castelli, A, Castillo Quintero, M, Castro, H, Catorze, N, Cengiz, M, Cereijo, E, Ceunen, H, Chaintoutis, C, Chang, Y, Chaparro, G, Chapman, C, Chau, S, Chavez, C, Chelazzi, C, Chelly, J, Chemouni, F, Chen, K, Chena, A, Chiarandini, P, Chilton, P, Chiumello, D, Chou-Lie, Y, Chudeau, N, Cinel, I, Cinnella, G, Clark, M, Clark, T, Clementi, S, Coaguila, L, Codecido, A, Collins, A, Colombo, R, Conde, J, Consales, G, Cook, T, Coppadoro, A, Cornejo, R, Cortegiani, A, Coxo, C, Cracchiolo, A, Crespo Ramirez, M, Crova, P, Cruz, J, Cubattoli, L, Cukurova, Z, Curto, F, Czempik, P, D'Andrea, R, da Silva Ramos, F, Dangers, L, Danguy des Deserts, M, Danin, P, Dantas, F, Daubin, C, Dawei, W, de Haro, C, de Jesus Montelongo, F, De Mendoza, D, de Pablo, R, De Pascale, G, De Rosa, S, Decavele, M, Declercq, P, Deicas, A, del Carmen Campos Moreno, M, Dellamonica, J, Delmas, B, Demirkiran, O, Demirkiran, H, Dendane, T, di Mussi, R, Diakaki, C, Diaz, A, Diaz, W, Dikmen, Y, Dimoula, A, Doble, P, Doha, N, Domingos, G, Dres, M, Dries, D, Duggal, A, Duke, G, Dunts, P, Dybwik, K, Dykyy, M, Eckert, P, Efe, S, Elatrous, S, Elay, G, Elmaryul, A, Elsaadany, M, Elsayed, H, Elsayed, S, Emery, M, Ena, S, Eng, K, Englert, J, Erdogan, E, Ergin Ozcan, P, Eroglu, E, Escobar, M, Esen, F, Esen Tekeli, A, Esquivel, A, Esquivel Gallegos, H, Ezzouine, H, Facchini, A, Faheem, M, Fanelli, V, Farina, M, Fartoukh, M, Fehrle, L, Feng, F, Feng, Y, Fernandez, I, Fernandez, B, Fernandez-Rodriguez, M, Ferrando, C, Ferreira da Silva, M, Ferreruela, M, Ferrier, J, Flamm Zamorano, M, Flood, L, Floris, L, Fluckiger, M, Forteza, C, Fortunato, A, Frans, E, Frattari, A, Fredes, S, Frenzel, T, Fumagalli, R, Furche, M, Fusari, M, Fysh, E, Galeas-Lopez, J, Galerneau, L, Garcia, A, Garcia, M, Garcia, E, Garcia Olivares, P, Garlicki, J, Garnero, A, Garofalo, E, Gautam, P, Gazenkampf, A, Gelinotte, S, Gelormini, D, Ghrenassia, E, Giacomucci, A, Giannoni, R, Gigante, A, Glober, N, Gnesin, P, Gollo, Y, Gomaa, D, Gomero Paredes, R, Gomes, R, Gomez, R, Gomez, O, Gomez, A, Gondim, L, Gonzalez, M, Gonzalez, I, Gonzalez-Castro, A, Gordillo Romero, O, Gordo, F, Gouin, P, Graf Santos, J, Grainne, R, Grando, M, Granov Grabovica, S, Grasso, S, Grasso, R, Grimmer, L, Grissom, C, Gu, Q, Guan, X, Guarracino, F, Guasch, N, Guatteri, L, Gueret, R, Guerin, C, Guerot, E, Guitard, P, Gul, F, Gumus, A, Gurjar, M, Gutierrez, P, Hachimi, A, Hadzibegovic, A, Hagan, S, Hammel, C, Han Song, J, Hanlon, G, Heines, S, Henriksson, J, Herbrecht, J, Heredia Orbegoso, G, Hermon, A, Hernandez, R, Hernandez, C, Herrera, L, Herrera-Gutierrez, M, Hidalgo, J, Hill, D, Holmquist, D, Homez, M, Hongtao, X, Hormis, A, Horner, D, Hornos, M, Hou, M, House, S, Housni, B, Hugill, K, Humphreys, S, Humbert, L, Hunter, S, Hwa Young, L, Iezzi, N, Ilutovich, S, Inal, V, Innes, R, Ioannides, P, Iotti, G, Ippolito, M, Irie, H, Iriyama, H, Itagaki, T, Izura, J, Izza, S, Jabeen, R, Jamaati, H, Jamadarkhana, S, Jamoussi, A, Jankowski, M, Jaramillo, L, Jeon, K, Jeong Lee, S, Jeswani, D, Jha, S, Jiang, L, Jing, C, Jochmans, S, Johnstad, B, Jongmin, L, Joret, A, Junhasavasdikul, D, Jurado, M, Kam, E, Kamohara, H, Kane, C, Kara, I, Karakurt, S, Karnjanarachata, C, Kataoka, J, Katayama, S, Kaushik, S, Kelebek Girgin, N, Kerr, K, Kerslake, I, Khairnar, P, Khalid, A, Khan, A, Khanna, A, Khorasanee, R, Kienhorst, D, Kirakli, C, Knafelj, R, Kol, M, Kongpolprom, N, Kopitko, C, Korkmaz Ekren, P, Kubisz-Pudelko, A, Kulcsar, Z, Kumasawa, J, Kuriyama, A, Kutchak, F, Labarca, E, Labat, F, Laborda, C, Laca Barrera, M, Lagache, L, Landaverde Lopez, A, Lanspa, M, Lascari, V, Le Meur, M, Lee, S, Lee, Y, Lee, J, Lee, W, Legernaes, T, Leiner, T, Lemiale, V, Leonor, T, Lepper, P, Li, D, Li, H, Li, O, Lima, A, Lind, D, Litton, E, Liu, N, Liu, L, Liu, J, Llitjos, J, Llorente, B, Lopez, R, Lopez, C, Lopez Nava, C, Lovazzano, P, Lu, M, Lucchese, F, Lugano, M, Lugo Goytia, G, Luo, H, Lynch, C, Macheda, S, Madrigal Robles, V, Maggiore, S, Magret Iglesias, M, Malaga, P, Mallapura Maheswarappa, H, Malpartida, G, Malyarchikov, A, Mansson, H, Manzano, A, Marey, I, Marin, N, Marin, M, Markman, E, Martin, F, Martin, A, Martin Dal Gesso, C, Martinez, F, Martinez-Fidalgo, C, Martin-Loeches, I, Mas, A, Masaaki, S, Maseda, E, Massa, E, Mattsson, A, Maugeri, J, Mccredie, V, Mccullough, J, Mcguinness, S, Mckown, A, Medve, L, Mei, C, Mellado Artigas, R, Mendes, V, Mervat, M, Michaux, I, Mikhaeil, M, Milagros, O, Milet, I, Millan, M, Minwei, Z, Mirabella, L, Mishra, S, Mistraletti, G, Mochizuki, K, Moghal, A, Mojoli, F, Molin, A, Montiel, R, Montini, L, Monza, G, Mora Aznar, M, Morakul, S, Morales, M, Moreno Torres, D, Morocho Tutillo, D, Motherway, C, Mouhssine, D, Mouloudi, E, Munoz, T, Munoz de Cabo, C, Mustafa, M, Muthuchellappan, R, Muthukrishnan, M, Muttini, S, Nagata, I, Nahar, D, Nakanishi, M, Nakayama, I, Namendys-Silva, S, Nanchal, R, Nandakumar, S, Nasi, A, Nasir, K, Navalesi, P, Naz Aslam, T, Nga Phan, T, Nichol, A, Niiyama, S, Nikolakopoulou, S, Nikolic, E, Nitta, K, Noc, M, Nonas, S, Nseir, S, Nur Soyturk, A, Obata, Y, Oeckler, R, Oguchi, M, Ohshimo, S, Oikonomou, M, Ojados, A, Oliveira, M, Oliveira Filho, W, Oliveri, C, Olmos, A, Omura, K, Orlandi, M, Orsenigo, F, Ortiz-Ruiz De Gordoa, L, Ota, K, Ovalle Olmos, R, Oveges, N, Oziemski, P, Ozkan Kuscu, O, Pachas Alvarado, F, Pagella, G, Palaniswamy, V, Palazon Sanchez, E, Palmese, S, Pan, G, Pan, W, Papanikolaou, M, Papavasilopoulou, T, Parekh, A, Parke, R, Parrilla, F, Parrilla, D, Pasha, T, Pasin, L, Patao, L, Patel, M, Patel, G, Pati, B, Patil, J, Pattnaik, S, Paul, D, Pavesi, M, Pavlotsky, V, Paz, G, Paz, E, Pecci, E, Pellegrini, C, Pena Padilla, A, Perchiazzi, G, Pereira, T, Pereira, V, Perez, M, Perez Calvo, C, Perez Cheng, M, Perez Maita, R, Perez-Araos, R, Perez-Teran, P, Perez-Torres, D, Perkins, G, Persona, P, Petnak, T, Petrova, M, Philippart, F, Picetti, E, Pierucci, E, Piervincenzi, E, Pinciroli, R, Pintado, M, Piraino, T, Piras, S, Piras, C, Pirompanich, P, Pisani, L, Platas, E, Plotnikow, G, Porras, W, Porta, V, Portilla, M, Portugal, J, Povoa, P, Prat, G, Pratto, R, Preda, G, Prieto, I, Prol-Silva, E, Pugh, R, Qi, Y, Qian, C, Qin, T, Qu, H, Quintana, T, Quispe Sierra, R, Quispe Soto, R, Rabbani, R, Rabee, M, Rabie, A, Rahe Pereira, M, Rai, A, Raj Ashok, S, Rajab, M, Ramdhani, N, Ramey, E, Ranieri, M, Rathod, D, Ray, B, Redwanul Huq, S, Regli, A, Reina, R, Resano Sarmiento, N, Reynaud, F, Rialp, G, Ricart, P, Rice, T, Richardson, A, Rieder, M, Rinket, M, Rios, F, Risso Vazquez, A, Riva, I, Rivette, M, Roca, O, Roche-Campo, F, Rodriguez, C, Rodriguez, G, Rodriguez Gonzalez, D, Rodriguez Tucto, X, Rogers, A, Romano, M, Rortveit, L, Rose, A, Roux, D, Rouze, A, Rubatto Birri, P, Ruilan, W, Ruiz Robledo, A, Ruiz-Aguilar, A, Sadahiro, T, Saez, I, Sagardia, J, Saha, R, Saiphoklang, N, Saito, S, Salem, M, Sales, G, Salgado, P, Samavedam, S, Sami Mebazaa, M, Samuelsson, L, San Juan Roman, N, Sanchez, P, Sanchez-Ballesteros, J, Sandoval, Y, Sani, E, Santos, M, Santos, C, Sanui, M, Saravanabavan, L, Sari, S, Sarkany, A, Sauneuf, B, Savioli, M, Sazak, H, Scano, R, Schneider, F, Schortgen, F, Schultz, M, Schwarz, G, Seckin Yucesoy, F, Seely, A, Seiler, F, Seker Tekdos, Y, Seok Chan, K, Serano, L, Serednicki, W, Setten, M, Shah, A, Shah, B, Shang, Y, Shanmugasundaram, P, Shapovalov, K, Shebl, E, Shiga, T, Shime, N, Shin, P, Short, J, Shuhua, C, Siddiqui, S, Silesky Jimenez, J, Silva, D, Silva Sales, B, Simons, K, Sjobo, B, Slessor, D, Smiechowicz, J, Smischney, N, Smith, P, Smith, T, Smith, M, Snape, S, Snyman, L, Soetens, F, Sook Hong, K, Sosa Medellin, M, Soto, G, Souloy, X, Sousa, E, Sovatzis, S, Sozutek, D, Spadaro, S, Spagnoli, M, Spangfors, M, Spittle, N, Spivey, M, Stapleton, A, Stefanovic, B, Stephenson, L, Stevenson, E, Strand, K, Strano, M, Straus, S, Sun, C, Sun, R, Sundaram, V, Sunpark, T, Surlemont, E, Sutherasan, Y, Szabo, Z, Tainter, C, Takaba, A, Tallott, M, Tamasato, T, Tang, Z, Tangsujaritvijit, V, Taniguchi, L, Taniguchi, D, Tarantino, F, Teerapuncharoen, K, Temprano, S, Terragni, P, Terzi, N, Thakur, A, Theerawit, P, Thille, A, Thomas, M, Thungtitigul, P, Thyrault, M, Tilouch, N, Timenetsky, K, Tirapu, J, Todeschini, M, Tomas, R, Tomaszewski, C, Tonetti, T, Tonnelier, A, Trinder, J, Trongtrakul, K, Truwit, J, Tsuei, B, Tulaimat, A, Turan, S, Turkoglu, M, Tyagi, S, Ubeda, A, Vagginelli, F, Valenti, M, Vallverdu, I, Van Axel, A, van den Hul, I, van der Hoeven, H, Van Der Meer, N, Vanhoof, M, Vargas-Ordonez, M, Vaschetto, R, Vascotto, E, Vatsik, M, Vaz, A, Vazquez-Sanchez, A, Ventura, S, Vermeijden, J, Vidal, A, Vieira, J, Vilela Costa Pinto, B, Villagra, A, Villegas Succar, C, Vinorum, O, Vitale, G, Vj, R, Vochin, A, Voiriot, G, Volta, C, von Seth, M, Wajdi, M, Walsh, D, Wang, S, Wardi, G, Ween-Velken, N, Wei, B, Weller, D, Welsh, D, Welters, I, Wert, M, Whiteley, S, Wilby, E, Williams, E, Williams, K, Wilson, A, Wojtas, J, Won Huh, J, Wrathall, D, Wright, C, Wu, J, Xi, G, Xing, Z, Xu, H, Yamamoto, K, Yan, J, Yanez, J, Yang, X, Yates, E, Yazicioglu Mocin, O, Ye, Z, Yildirim, F, Yoshida, N, Yoshido, H, Young Lee, B, Yu, R, Yu, G, Yu, T, Yuan, B, Yuangtrakul, N, Yumoto, T, Yun, X, Zakalik, G, Zaki, A, Zalba-Etayo, B, Zambon, M, Zang, B, Zani, G, Zarka, J, Zerbi, S, Zerman, A, Zetterquist, H, Zhang, J, Zhang, H, Zhang, W, Zhang, G, Zhao, H, Zheng, J, Zhu, B, Zumaran, R, Pham T., Heunks L., Bellani G., Madotto F., Aragao I., Beduneau G., Goligher E. C., Grasselli G., Laake J. H., Mancebo J., Penuelas O., Piquilloud L., Pesenti A., Wunsch H., van Haren F., Brochard L., Laffey J. G., Abrough F., Acharya S. P., Amin P., Arabi Y., Bauer P., Beitler J., Berkius J., Bugedo G., Camporota L., Cerny V., Cho Y. -J., Clarkson K., Estenssoro E., Goligher E., Gritsan A., Hashemian S. M., Hermans G., Heunks L. M., Jovanovic B., Kurahashi K., Matamis D., Moerer O., Molnar Z., Ozyilmaz E., Panka B., Papali A., Perbet S., Qiu H., Razek A. A., Rittayamai N., Roldan R., Serpa Neto A., Szuldrzynski K., Talmor D., Tomescu D., Villagomez A., Zeggwagh A. A., Abe T., Aboshady A., Acampo-de Jong M., Acharya S., Adderley J., Adiguzel N., Agrawal V. K., Aguilar G., Aguirre G., Aguirre-Bermeo H., Ahlstrom B., Akbas T., Akker M., Al Sadeh G., Alamri S., Algaba A., Ali M., Aliberti A., Allegue J. M., Alvarez D., Amador J., Andersen F. H., Ansari S., Apichatbutr Y., Apostolopoulou O., Arellano D., Arica M., Arikan H., Arinaga K., Arnal J. -M., Asano K., Asin-Corrochano M., Avalos Cabrera J. M., Avila Fuentes S., Aydemir S., Aygencel G., Azevedo L., Bacakoglu F., Badie J., Baedorf Kassis E., Bai G., Balaraj G., Ballico B., Banner-Goodspeed V., Banwarie P., Barbieri R., Baronia A., Barrett J., Barrot L., Barrueco-Francioni J. E., Barry J., Bawangade H., Beavis S., Beck E., Beehre N., Belenguer Muncharaz A., Belliato M., Bellissima A., Beltramelli R., Ben Souissi A., Benitez-Cano A., Benlamin M., Benslama A., Bento L., Benvenuti D., Bernabe L., Bersten A., Berta G., Bertini P., Bertram-Ralph E., Besbes M., Bettini L. R., Beuret P., Bewley J., Bezzi M., Bhakhtiani L., Bhandary R., Bhowmick K., Bihari S., Bissett B., Blythe D., Bocher S., Boedjawan N., Bojanowski C. M., Boni E., Boraso S., Borelli M., Borello S., Borislavova M., Bosma K. J., Bottiroli M., Boyd O., Bozbay S., Briva A., Bruel C., Bruni A., Buehner U., Bulpa P., Burt K., Buscot M., Buttera S., Cabrera J., Caccese R., Caironi P., Canchos Gutierrez I., Canedo N., Cani A., Cappellini I., Carazo J., Cardonnet L. P., Carpio D., Carriedo D., Carrillo R., Carvalho J., Caser E., Castelli A., Castillo Quintero M., Castro H., Catorze N., Cengiz M., Cereijo E., Ceunen H., Chaintoutis C., Chang Y., Chaparro G., Chapman C., Chau S., Chavez C. E., Chelazzi C., Chelly J., Chemouni F., Chen K., Chena A., Chiarandini P., Chilton P., Chiumello D., Chou-Lie Y., Chudeau N., Cinel I., Cinnella G., Clark M., Clark T., Clementi S., Coaguila L., Codecido A. J., Collins A., Colombo R., Conde J., Consales G., Cook T., Coppadoro A., Cornejo R., Cortegiani A., Coxo C., Cracchiolo A. N., Crespo Ramirez M., Crova P., Cruz J., Cubattoli L., Cukurova Z., Curto F., Czempik P., D'Andrea R., da Silva Ramos F., Dangers L., Danguy des Deserts M., Danin P. -E., Dantas F., Daubin C., Dawei W., de Haro C., de Jesus Montelongo F., De Mendoza D., de Pablo R., De Pascale G., De Rosa S., Decavele M., Declercq P. -L., Deicas A., del Carmen Campos Moreno M., Dellamonica J., Delmas B., Demirkiran O., Demirkiran H., Dendane T., di Mussi R., Diakaki C., Diaz A., Diaz W., Dikmen Y., Dimoula A., Doble P., Doha N., Domingos G., Dres M., Dries D., Duggal A., Duke G., Dunts P., Dybwik K., Dykyy M., Eckert P., Efe S., Elatrous S., Elay G., Elmaryul A. S., Elsaadany M., Elsayed H., Elsayed S., Emery M., Ena S., Eng K., Englert J. A., Erdogan E., Ergin Ozcan P., Eroglu E., Escobar M., Esen F., Esen Tekeli A., Esquivel A., Esquivel Gallegos H., Ezzouine H., Facchini A., Faheem M., Fanelli V., Farina M. F., Fartoukh M., Fehrle L., Feng F., Feng Y., Fernandez I., Fernandez B., Fernandez-Rodriguez M. L., Ferrando C., Ferreira da Silva M. J., Ferreruela M., Ferrier J., Flamm Zamorano M. J., Flood L., Floris L., Fluckiger M., Forteza C., Fortunato A., Frans E., Frattari A., Fredes S., Frenzel T., Fumagalli R., Furche M. A., Fusari M., Fysh E., Galeas-Lopez J. L., Galerneau L. -M., Garcia A., Garcia M. F., Garcia E., Garcia Olivares P., Garlicki J., Garnero A., Garofalo E., Gautam P., Gazenkampf A., Gelinotte S., Gelormini D., Ghrenassia E., Giacomucci A., Giannoni R., Gigante A., Glober N., Gnesin P., Gollo Y., Gomaa D., Gomero Paredes R., Gomes R., Gomez R. A., Gomez O., Gomez A., Gondim L., Gonzalez M., Gonzalez I., Gonzalez-Castro A., Gordillo Romero O., Gordo F., Gouin P., Graf Santos J., Grainne R., Grando M., Granov Grabovica S., Grasso S., Grasso R., Grimmer L., Grissom C., Gu Q., Guan X. -D., Guarracino F., Guasch N., Guatteri L., Gueret R., Guerin C., Guerot E., Guitard P. -G., Gul F., Gumus A., Gurjar M., Gutierrez P., Hachimi A., Hadzibegovic A., Hagan S., Hammel C., Han Song J., Hanlon G., Heines S., Henriksson J., Herbrecht J. -E., Heredia Orbegoso G. O., Hermon A., Hernandez R., Hernandez C., Herrera L., Herrera-Gutierrez M., Hidalgo J., Hill D., Holmquist D., Homez M., Hongtao X., Hormis A., Horner D., Hornos M. C., Hou M., House S., Housni B., Hugill K., Humphreys S., Humbert L., Hunter S., Hwa Young L., Iezzi N., Ilutovich S., Inal V., Innes R., Ioannides P., Iotti G. A., Ippolito M., Irie H., Iriyama H., Itagaki T., Izura J., Izza S., Jabeen R., Jamaati H., Jamadarkhana S., Jamoussi A., Jankowski M., Jaramillo L. A., Jeon K., Jeong Lee S., Jeswani D., Jha S., Jiang L., Jing C., Jochmans S., Johnstad B. A., Jongmin L., Joret A., Junhasavasdikul D., Jurado M. T., Kam E., Kamohara H., Kane C., Kara I., Karakurt S., Karnjanarachata C., Kataoka J., Katayama S., Kaushik S., Kelebek Girgin N., Kerr K., Kerslake I., Khairnar P., Khalid A., Khan A., Khanna A. K., Khorasanee R., Kienhorst D., Kirakli C., Knafelj R., Kol M. K., Kongpolprom N., Kopitko C., Korkmaz Ekren P., Kubisz-Pudelko A., Kulcsar Z., Kumasawa J., Kuriyama A., Kutchak F., Labarca E., Labat F., Laborda C., Laca Barrera M. A., Lagache L., Landaverde Lopez A., Lanspa M., Lascari V., Le Meur M., Lee S. H., Lee Y. J., Lee J., Lee W. -Y., Legernaes T., Leiner T., Lemiale V., Leonor T., Lepper P. M., Li D., Li H., Li O., Lima A. R., Lind D., Litton E., Liu N., Liu L., Liu J., Llitjos J. -F., Llorente B., Lopez R., Lopez C. E., Lopez Nava C., Lovazzano P., Lu M., Lucchese F., Lugano M., Lugo Goytia G., Luo H., Lynch C., Macheda S., Madrigal Robles V. H., Maggiore S. M., Magret Iglesias M., Malaga P., Mallapura Maheswarappa H., Malpartida G., Malyarchikov A., Mansson H., Manzano A., Marey I., Marin N., Marin M. D. C., Markman E., Martin F., Martin A., Martin Dal Gesso C., Martinez F., Martinez-Fidalgo C., Martin-Loeches I., Mas A., Masaaki S., Maseda E., Massa E., Mattsson A., Maugeri J., McCredie V., McCullough J., McGuinness S., McKown A., Medve L., Mei C., Mellado Artigas R., Mendes V., Mervat M. K. E., Michaux I., Mikhaeil M., Milagros O., Milet I., Millan M. T., Minwei Z., Mirabella L., Mishra S., Mistraletti G., Mochizuki K., Moghal A., Mojoli F., Molin A., Montiel R., Montini L., Monza G., Mora Aznar M., Morakul S., Morales M., Moreno Torres D., Morocho Tutillo D. R., Motherway C., Mouhssine D., Mouloudi E., Munoz T., Munoz de Cabo C., Mustafa M., Muthuchellappan R., Muthukrishnan M., Muttini S., Nagata I., Nahar D., Nakanishi M., Nakayama I., Namendys-Silva S. A., Nanchal R., Nandakumar S., Nasi A., Nasir K., Navalesi P., Naz Aslam T., Nga Phan T., Nichol A., Niiyama S., Nikolakopoulou S., Nikolic E., Nitta K., Noc M., Nonas S., Nseir S., Nur Soyturk A., Obata Y., Oeckler R., Oguchi M., Ohshimo S., Oikonomou M., Ojados A., Oliveira M. T., Oliveira Filho W., Oliveri C., Olmos A., Omura K., Orlandi M. C., Orsenigo F., Ortiz-Ruiz De Gordoa L., Ota K., Ovalle Olmos R., Oveges N., Oziemski P., Ozkan Kuscu O., Pachas Alvarado F., Pagella G., Palaniswamy V., Palazon Sanchez E. L., Palmese S., Pan G., Pan W., Papanikolaou M., Papavasilopoulou T., Parekh A., Parke R., Parrilla F. J., Parrilla D., Pasha T., Pasin L., Patao L., Patel M., Patel G., Pati B. K., Patil J., Pattnaik S., Paul D., Pavesi M., Pavlotsky V. 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M., Regli A., Reina R., Resano Sarmiento N., Reynaud F., Rialp G., Ricart P., Rice T., Richardson A., Rieder M., Rinket M., Rios F., Risso Vazquez A., Riva I., Rivette M., Roca O., Roche-Campo F., Rodriguez C., Rodriguez G., Rodriguez Gonzalez D., Rodriguez Tucto X. Y., Rogers A., Romano M. E., Rortveit L., Rose A., Roux D., Rouze A., Rubatto Birri P. N., Ruilan W., Ruiz Robledo A., Ruiz-Aguilar A. L., Sadahiro T., Saez I., Sagardia J., Saha R., Saiphoklang N., Saito S., Salem M., Sales G., Salgado P., Samavedam S., Sami Mebazaa M., Samuelsson L., San Juan Roman N., Sanchez P., Sanchez-Ballesteros J., Sandoval Y., Sani E., Santos M., Santos C., Sanui M., Saravanabavan L., Sari S., Sarkany A., Sauneuf B., Savioli M., Sazak H., Scano R., Schneider F., Schortgen F., Schultz M. J., Schwarz G. 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W., Thomas M., Thungtitigul P., Thyrault M., Tilouch N., Timenetsky K., Tirapu J., Todeschini M., Tomas R., Tomaszewski C., Tonetti T., Tonnelier A., Trinder J., Trongtrakul K., Truwit J., Tsuei B., Tulaimat A., Turan S., Turkoglu M., Tyagi S., Ubeda A., Vagginelli F., Valenti M. F., Vallverdu I., Van Axel A., van den Hul I., van der Hoeven H., Van Der Meer N., Vanhoof M., Vargas-Ordonez M., Vaschetto R., Vascotto E., Vatsik M., Vaz A., Vazquez-Sanchez A., Ventura S., Vermeijden J. W., Vidal A., Vieira J., Vilela Costa Pinto B., Villagra A., Villegas Succar C., Vinorum O. G., Vitale G., Vj R., Vochin A., Voiriot G., Volta C. A., von Seth M., Wajdi M., Walsh D., Wang S., Wardi G., Ween-Velken N. 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C., Grasselli G., Laake J. H., Mancebo J., Penuelas O., Piquilloud L., Pesenti A., Wunsch H., van Haren F., Brochard L., Laffey J. G., Abrough F., Acharya S. P., Amin P., Arabi Y., Bauer P., Beitler J., Berkius J., Bugedo G., Camporota L., Cerny V., Cho Y. -J., Clarkson K., Estenssoro E., Goligher E., Gritsan A., Hashemian S. M., Hermans G., Heunks L. M., Jovanovic B., Kurahashi K., Matamis D., Moerer O., Molnar Z., Ozyilmaz E., Panka B., Papali A., Perbet S., Qiu H., Razek A. A., Rittayamai N., Roldan R., Serpa Neto A., Szuldrzynski K., Talmor D., Tomescu D., Villagomez A., Zeggwagh A. A., Abe T., Aboshady A., Acampo-de Jong M., Acharya S., Adderley J., Adiguzel N., Agrawal V. K., Aguilar G., Aguirre G., Aguirre-Bermeo H., Ahlstrom B., Akbas T., Akker M., Al Sadeh G., Alamri S., Algaba A., Ali M., Aliberti A., Allegue J. M., Alvarez D., Amador J., Andersen F. H., Ansari S., Apichatbutr Y., Apostolopoulou O., Arellano D., Arica M., Arikan H., Arinaga K., Arnal J. -M., Asano K., Asin-Corrochano M., Avalos Cabrera J. M., Avila Fuentes S., Aydemir S., Aygencel G., Azevedo L., Bacakoglu F., Badie J., Baedorf Kassis E., Bai G., Balaraj G., Ballico B., Banner-Goodspeed V., Banwarie P., Barbieri R., Baronia A., Barrett J., Barrot L., Barrueco-Francioni J. E., Barry J., Bawangade H., Beavis S., Beck E., Beehre N., Belenguer Muncharaz A., Belliato M., Bellissima A., Beltramelli R., Ben Souissi A., Benitez-Cano A., Benlamin M., Benslama A., Bento L., Benvenuti D., Bernabe L., Bersten A., Berta G., Bertini P., Bertram-Ralph E., Besbes M., Bettini L. R., Beuret P., Bewley J., Bezzi M., Bhakhtiani L., Bhandary R., Bhowmick K., Bihari S., Bissett B., Blythe D., Bocher S., Boedjawan N., Bojanowski C. M., Boni E., Boraso S., Borelli M., Borello S., Borislavova M., Bosma K. J., Bottiroli M., Boyd O., Bozbay S., Briva A., Bruel C., Bruni A., Buehner U., Bulpa P., Burt K., Buscot M., Buttera S., Cabrera J., Caccese R., Caironi P., Canchos Gutierrez I., Canedo N., Cani A., Cappellini I., Carazo J., Cardonnet L. P., Carpio D., Carriedo D., Carrillo R., Carvalho J., Caser E., Castelli A., Castillo Quintero M., Castro H., Catorze N., Cengiz M., Cereijo E., Ceunen H., Chaintoutis C., Chang Y., Chaparro G., Chapman C., Chau S., Chavez C. E., Chelazzi C., Chelly J., Chemouni F., Chen K., Chena A., Chiarandini P., Chilton P., Chiumello D., Chou-Lie Y., Chudeau N., Cinel I., Cinnella G., Clark M., Clark T., Clementi S., Coaguila L., Codecido A. J., Collins A., Colombo R., Conde J., Consales G., Cook T., Coppadoro A., Cornejo R., Cortegiani A., Coxo C., Cracchiolo A. N., Crespo Ramirez M., Crova P., Cruz J., Cubattoli L., Cukurova Z., Curto F., Czempik P., D'Andrea R., da Silva Ramos F., Dangers L., Danguy des Deserts M., Danin P. -E., Dantas F., Daubin C., Dawei W., de Haro C., de Jesus Montelongo F., De Mendoza D., de Pablo R., De Pascale G., De Rosa S., Decavele M., Declercq P. -L., Deicas A., del Carmen Campos Moreno M., Dellamonica J., Delmas B., Demirkiran O., Demirkiran H., Dendane T., di Mussi R., Diakaki C., Diaz A., Diaz W., Dikmen Y., Dimoula A., Doble P., Doha N., Domingos G., Dres M., Dries D., Duggal A., Duke G., Dunts P., Dybwik K., Dykyy M., Eckert P., Efe S., Elatrous S., Elay G., Elmaryul A. S., Elsaadany M., Elsayed H., Elsayed S., Emery M., Ena S., Eng K., Englert J. A., Erdogan E., Ergin Ozcan P., Eroglu E., Escobar M., Esen F., Esen Tekeli A., Esquivel A., Esquivel Gallegos H., Ezzouine H., Facchini A., Faheem M., Fanelli V., Farina M. F., Fartoukh M., Fehrle L., Feng F., Feng Y., Fernandez I., Fernandez B., Fernandez-Rodriguez M. L., Ferrando C., Ferreira da Silva M. J., Ferreruela M., Ferrier J., Flamm Zamorano M. J., Flood L., Floris L., Fluckiger M., Forteza C., Fortunato A., Frans E., Frattari A., Fredes S., Frenzel T., Fumagalli R., Furche M. A., Fusari M., Fysh E., Galeas-Lopez J. L., Galerneau L. -M., Garcia A., Garcia M. F., Garcia E., Garcia Olivares P., Garlicki J., Garnero A., Garofalo E., Gautam P., Gazenkampf A., Gelinotte S., Gelormini D., Ghrenassia E., Giacomucci A., Giannoni R., Gigante A., Glober N., Gnesin P., Gollo Y., Gomaa D., Gomero Paredes R., Gomes R., Gomez R. A., Gomez O., Gomez A., Gondim L., Gonzalez M., Gonzalez I., Gonzalez-Castro A., Gordillo Romero O., Gordo F., Gouin P., Graf Santos J., Grainne R., Grando M., Granov Grabovica S., Grasso S., Grasso R., Grimmer L., Grissom C., Gu Q., Guan X. -D., Guarracino F., Guasch N., Guatteri L., Gueret R., Guerin C., Guerot E., Guitard P. -G., Gul F., Gumus A., Gurjar M., Gutierrez P., Hachimi A., Hadzibegovic A., Hagan S., Hammel C., Han Song J., Hanlon G., Heines S., Henriksson J., Herbrecht J. -E., Heredia Orbegoso G. O., Hermon A., Hernandez R., Hernandez C., Herrera L., Herrera-Gutierrez M., Hidalgo J., Hill D., Holmquist D., Homez M., Hongtao X., Hormis A., Horner D., Hornos M. C., Hou M., House S., Housni B., Hugill K., Humphreys S., Humbert L., Hunter S., Hwa Young L., Iezzi N., Ilutovich S., Inal V., Innes R., Ioannides P., Iotti G. A., Ippolito M., Irie H., Iriyama H., Itagaki T., Izura J., Izza S., Jabeen R., Jamaati H., Jamadarkhana S., Jamoussi A., Jankowski M., Jaramillo L. A., Jeon K., Jeong Lee S., Jeswani D., Jha S., Jiang L., Jing C., Jochmans S., Johnstad B. A., Jongmin L., Joret A., Junhasavasdikul D., Jurado M. T., Kam E., Kamohara H., Kane C., Kara I., Karakurt S., Karnjanarachata C., Kataoka J., Katayama S., Kaushik S., Kelebek Girgin N., Kerr K., Kerslake I., Khairnar P., Khalid A., Khan A., Khanna A. K., Khorasanee R., Kienhorst D., Kirakli C., Knafelj R., Kol M. K., Kongpolprom N., Kopitko C., Korkmaz Ekren P., Kubisz-Pudelko A., Kulcsar Z., Kumasawa J., Kuriyama A., Kutchak F., Labarca E., Labat F., Laborda C., Laca Barrera M. A., Lagache L., Landaverde Lopez A., Lanspa M., Lascari V., Le Meur M., Lee S. H., Lee Y. J., Lee J., Lee W. -Y., Legernaes T., Leiner T., Lemiale V., Leonor T., Lepper P. M., Li D., Li H., Li O., Lima A. R., Lind D., Litton E., Liu N., Liu L., Liu J., Llitjos J. -F., Llorente B., Lopez R., Lopez C. E., Lopez Nava C., Lovazzano P., Lu M., Lucchese F., Lugano M., Lugo Goytia G., Luo H., Lynch C., Macheda S., Madrigal Robles V. H., Maggiore S. M., Magret Iglesias M., Malaga P., Mallapura Maheswarappa H., Malpartida G., Malyarchikov A., Mansson H., Manzano A., Marey I., Marin N., Marin M. D. C., Markman E., Martin F., Martin A., Martin Dal Gesso C., Martinez F., Martinez-Fidalgo C., Martin-Loeches I., Mas A., Masaaki S., Maseda E., Massa E., Mattsson A., Maugeri J., McCredie V., McCullough J., McGuinness S., McKown A., Medve L., Mei C., Mellado Artigas R., Mendes V., Mervat M. K. E., Michaux I., Mikhaeil M., Milagros O., Milet I., Millan M. T., Minwei Z., Mirabella L., Mishra S., Mistraletti G., Mochizuki K., Moghal A., Mojoli F., Molin A., Montiel R., Montini L., Monza G., Mora Aznar M., Morakul S., Morales M., Moreno Torres D., Morocho Tutillo D. R., Motherway C., Mouhssine D., Mouloudi E., Munoz T., Munoz de Cabo C., Mustafa M., Muthuchellappan R., Muthukrishnan M., Muttini S., Nagata I., Nahar D., Nakanishi M., Nakayama I., Namendys-Silva S. A., Nanchal R., Nandakumar S., Nasi A., Nasir K., Navalesi P., Naz Aslam T., Nga Phan T., Nichol A., Niiyama S., Nikolakopoulou S., Nikolic E., Nitta K., Noc M., Nonas S., Nseir S., Nur Soyturk A., Obata Y., Oeckler R., Oguchi M., Ohshimo S., Oikonomou M., Ojados A., Oliveira M. T., Oliveira Filho W., Oliveri C., Olmos A., Omura K., Orlandi M. C., Orsenigo F., Ortiz-Ruiz De Gordoa L., Ota K., Ovalle Olmos R., Oveges N., Oziemski P., Ozkan Kuscu O., Pachas Alvarado F., Pagella G., Palaniswamy V., Palazon Sanchez E. L., Palmese S., Pan G., Pan W., Papanikolaou M., Papavasilopoulou T., Parekh A., Parke R., Parrilla F. J., Parrilla D., Pasha T., Pasin L., Patao L., Patel M., Patel G., Pati B. K., Patil J., Pattnaik S., Paul D., Pavesi M., Pavlotsky V. A., Paz G., Paz E., Pecci E., Pellegrini C., Pena Padilla A. G., Perchiazzi G., Pereira T., Pereira V., Perez M., Perez Calvo C., Perez Cheng M., Perez Maita R., Perez-Araos R., Perez-Teran P., Perez-Torres D., Perkins G., Persona P., Petnak T., Petrova M., Philippart F., Picetti E., Pierucci E., Piervincenzi E., Pinciroli R., Pintado M. -C., Piraino T., Piras S., Piras C., Pirompanich P., Pisani L., Platas E., Plotnikow G., Porras W., Porta V., Portilla M., Portugal J., Povoa P., Prat G., Pratto R., Preda G., Prieto I., Prol-Silva E., Pugh R., Qi Y., Qian C., Qin T., Qu H., Quintana T., Quispe Sierra R., Quispe Soto R., Rabbani R., Rabee M., Rabie A., Rahe Pereira M. A., Rai A., Raj Ashok S., Rajab M., Ramdhani N., Ramey E., Ranieri M., Rathod D., Ray B., Redwanul Huq S. M., Regli A., Reina R., Resano Sarmiento N., Reynaud F., Rialp G., Ricart P., Rice T., Richardson A., Rieder M., Rinket M., Rios F., Risso Vazquez A., Riva I., Rivette M., Roca O., Roche-Campo F., Rodriguez C., Rodriguez G., Rodriguez Gonzalez D., Rodriguez Tucto X. Y., Rogers A., Romano M. E., Rortveit L., Rose A., Roux D., Rouze A., Rubatto Birri P. N., Ruilan W., Ruiz Robledo A., Ruiz-Aguilar A. L., Sadahiro T., Saez I., Sagardia J., Saha R., Saiphoklang N., Saito S., Salem M., Sales G., Salgado P., Samavedam S., Sami Mebazaa M., Samuelsson L., San Juan Roman N., Sanchez P., Sanchez-Ballesteros J., Sandoval Y., Sani E., Santos M., Santos C., Sanui M., Saravanabavan L., Sari S., Sarkany A., Sauneuf B., Savioli M., Sazak H., Scano R., Schneider F., Schortgen F., Schultz M. J., Schwarz G. L., Seckin Yucesoy F., Seely A., Seiler F., Seker Tekdos Y., Seok Chan K., Serano L., Serednicki W., Setten M., Shah A., Shah B., Shang Y., Shanmugasundaram P., Shapovalov K., Shebl E., Shiga T., Shime N., Shin P., Short J., Shuhua C., Siddiqui S., Silesky Jimenez J. I., Silva D., Silva Sales B., Simons K., Sjobo B. A., Slessor D., Smiechowicz J., Smischney N., Smith P., Smith T., Smith M., Snape S., Snyman L., Soetens F., Sook Hong K., Sosa Medellin M. A., Soto G., Souloy X., Sousa E., Sovatzis S., Sozutek D., Spadaro S., Spagnoli M., Spangfors M., Spittle N., Spivey M., Stapleton A., Stefanovic B., Stephenson L., Stevenson E., Strand K., Strano M. T., Straus S., Sun C., Sun R., Sundaram V., SunPark T., Surlemont E., Sutherasan Y., Szabo Z., Tainter C., Takaba A., Tallott M., Tamasato T., Tang Z., Tangsujaritvijit V., Taniguchi L., Taniguchi D., Tarantino F., Teerapuncharoen K., Temprano S., Terragni P., Terzi N., Thakur A., Theerawit P., Thille A. W., Thomas M., Thungtitigul P., Thyrault M., Tilouch N., Timenetsky K., Tirapu J., Todeschini M., Tomas R., Tomaszewski C., Tonetti T., Tonnelier A., Trinder J., Trongtrakul K., Truwit J., Tsuei B., Tulaimat A., Turan S., Turkoglu M., Tyagi S., Ubeda A., Vagginelli F., Valenti M. F., Vallverdu I., Van Axel A., van den Hul I., van der Hoeven H., Van Der Meer N., Vanhoof M., Vargas-Ordonez M., Vaschetto R., Vascotto E., Vatsik M., Vaz A., Vazquez-Sanchez A., Ventura S., Vermeijden J. W., Vidal A., Vieira J., Vilela Costa Pinto B., Villagra A., Villegas Succar C., Vinorum O. G., Vitale G., Vj R., Vochin A., Voiriot G., Volta C. A., von Seth M., Wajdi M., Walsh D., Wang S., Wardi G., Ween-Velken N. C., Wei B. -L., Weller D., Welsh D., Welters I., Wert M., Whiteley S., Wilby E., Williams E., Williams K., Wilson A., Wojtas J., Won Huh J., Wrathall D., Wright C., Wu J. -F., Xi G., Xing Z. -J., Xu H., Yamamoto K., Yan J., Yanez J., Yang X., Yates E., Yazicioglu Mocin O., Ye Z., Yildirim F., Yoshida N., Yoshido H. H. L., Young Lee B., Yu R., Yu G., Yu T., Yuan B., Yuangtrakul N., Yumoto T., Yun X., Zakalik G., Zaki A., Zalba-Etayo B., Zambon M., Zang B., Zani G., Zarka J., Zerbi S. M., Zerman A., Zetterquist H., Zhang J., Zhang H., Zhang W., Zhang G., Zhao H., Zheng J., Zhu B., and Zumaran R.
- Abstract
Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 d
- Published
- 2023
3. 602 Efficacy of autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A single arm, multi-center, confirmatory clinical study
- Author
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Harada, K., primary, Ohyama, M., additional, Niiyama, S., additional, Irisawa, R., additional, Mae, K., additional, Mori, M., additional, Wakimoto, H., additional, Kinoshita-Ise, M., additional, Fukuyama, M., additional, Hayakawa, R., additional, Takagi, M., additional, Yamazaki, M., additional, Miyoshi, M., additional, Nishikawa, S., additional, Sato, S., additional, Nakazawa, Y., additional, Sugimoto, T., additional, Ogo, M., additional, and Tsuboi, R., additional
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- 2023
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4. Characterization of Cu(In,Ga)Se 2 thin films prepared by evaporationfrom ternary compounds
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Yamaguchi, T., Naka, M., Niiyama, S., and Imanishi, T.
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- 2005
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5. Twenty-nail dystrophy (trachyonychia) caused by lichen planus in a patient with gold allergy
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YOKOZEKI, H., NIIYAMA, S., and NISHIOKA, K.
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- 2005
6. Mutational spectrum of NSDHL in CHILD syndrome
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Bornholdt, D, König, A, Happle, R, Leveleki, L, Bittar, M, Danarti, R, Vahlquist, A, Tilgen, W, Reinhold, U, Baptista, A Poiares, Grosshans, É, Vabres, P, Niiyama, S, Sasaoka, K, Tanaka, T, Meiss, A L, Treadwell, P A, Lambert, D, Camacho, F, and Grzeschik, K-H
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- 2005
7. Dietary soy oil content and soy-derived phytoestrogen genistein increase resistance to alopecia areata onset in C3H/HeJ mice
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McElwee, K. J., Niiyama, S., Freyschmidt-Paul, P., Wenzel, E., Kissling, S., Sundberg, J. P., and Hoffmann, R.
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- 2003
8. 17α-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo
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Hoffmann, R., Niiyama, S., Huth, A., Kissling, S., and Happle, R.
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- 2002
9. The feasibility of quantitative analysis of androgen metabolism by use of single dermal papillae from human hair follicles
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Niiyama, S., Happle, R., and Hoffmann, R.
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- 2001
10. Preparation of CuIn(S,Se) 2 thin films by thermal crystallization in sulfur and selenium atmosphere
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Yamaguchi, T., Naoyama, T., Lee, H.S., Yoshida, A., Kobata, T., Niiyama, S., and Nakamura, T.
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- 2003
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11. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles
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Niiyama, S, primary, Ishimatsu-Tsuji, Y, additional, Nakazawa, Y, additional, Yoshida, Y, additional, Soma, T, additional, Ideta, R, additional, Mukai, H, additional, and Kishimoto, J, additional
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- 2018
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12. Galectin-7 in the stratum corneum: a biomarker of the skin barrier function
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Niiyama, S., primary, Yoshino, T., additional, Yasuda, C., additional, Yu, X., additional, Izumi, R., additional, Ishiwatari, S., additional, Matsukuma, S., additional, and Mukai, H., additional
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- 2016
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13. Heat Shock Protein 27 kDa Content in Stratum Corneum Correlates with Severity of Atopic Dermatitis
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Niiyama, S, primary, Yoshino, T, additional, Matsukuma, S, additional, and Mukai, H, additional
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- 2016
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14. Multiple Perianal Nodules in an HIV-positive Man: A Quiz
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Suzuki, R, primary, Niiyama, S, additional, Yokouchi, Y, additional, and Mukai, H, additional
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- 2015
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15. A Syndrome of Leukonychia, Koilonychia and Multiple Pilar Cysts
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Mutoh, M, primary, Niiyama, S, additional, Nishikawa, S, additional, Oharaseki, T, additional, and Mukai, H, additional
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- 2015
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16. Preparation of Cu2ZnSnSe4thin films by selenization of precursor evaporated from Cu2ZnSnSe4compound
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Yamaguchi, T., primary, Kawamoto, K., additional, Oura, S., additional, Niiyama, S., additional, and Imanishi, T., additional
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- 2013
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17. Cu2ZnSn(S,Se)4 thin films prepared by thermal crystallization in S/Se atmosphere and their photovoltaic applications
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Yamaguchi, T., primary, Oka, Y., additional, Niiyama, S., additional, and Imanishi, T., additional
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- 2013
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18. Cutaneous Myeloid Sarcoma Presenting as Grey Pigmented Macules
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Niiyama, S, primary, Amoh, Y, additional, Watarai, A, additional, Katsuoka, K, additional, and Mukai, H, additional
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- 2012
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19. Mutational spectrum of NSDHL in CHILD syndrome.
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Bornholdt, D, König, A, Happle, R, Leveleki, L, Bittar, M, Danarti, R, Vahlquist, Anders, Tilgen, W, Reinhold, U, Baptista, A, Grosshans, E, Vabres, P, Niiyama, S, Sasaoka, K, Tanaka, T, Meiss, AL, Treadwell, PA, Lambert, D, Camacho, F, Grzeschik, K-H, Bornholdt, D, König, A, Happle, R, Leveleki, L, Bittar, M, Danarti, R, Vahlquist, Anders, Tilgen, W, Reinhold, U, Baptista, A, Grosshans, E, Vabres, P, Niiyama, S, Sasaoka, K, Tanaka, T, Meiss, AL, Treadwell, PA, Lambert, D, Camacho, F, and Grzeschik, K-H
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- 2004
20. Chlamydophila pneumoniae Infection Induced Nodular Vasculitis
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Sakuma, H., primary, Niiyama, S., additional, Amoh, Y., additional, and Katsuoka, K., additional
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- 2011
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21. Cu(In,Ga)(S,Se)2 thin films prepared by thermal crystallization from CuInGaSe/CuGaSe precursor in S/Se atmosphere
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Yamaguchi, T., primary, Hirao, T., additional, Niiyama, S., additional, and Miyake, Y., additional
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- 2006
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22. Characterization of Cu(In,Ga) (S,Se)2thin films prepared by sequential evaporation from ternary compounds
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Yamaguchi, T., primary, Hatori, M., additional, Niiyama, S., additional, and Miyake, Y., additional
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- 2006
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23. Treatment of Osmidrosis Using the Ultrasonic Surgical Aspirator: A Case Report
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Niiyama, S, primary, Aiba, S, additional, Katsuoka, K, additional, Ito, Y, additional, and Sumiya, N, additional
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- 2006
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24. 1. The experience of the practice to decrease the numbers of the mental disorders in our company(The Risk Management by Occupational Health Nurse-Prevention of Accidents and Diseases due to Work-,Forum of Bureau of Occupational Health Nursing,Occupational Health in the Age of Decentralization Reform in Japan,The 79th Annual Meeting of Japan Society for Occupational Health)
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Niiyama, S., primary
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- 2006
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25. Characterization of Cu(In,Ga)Se2 thin films prepared by evaporationfrom ternary compounds
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Yamaguchi, T., primary, Naka, M., additional, Niiyama, S., additional, and Imanishi, T., additional
- Published
- 2005
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26. Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons
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Niiyama, S., primary, Tanaka, E., additional, Tsuji, S., additional, Murai, Y., additional, Satani, M., additional, Sakamoto, H., additional, Takahashi, K., additional, Kuroiwa, M., additional, Yamada, A., additional, Noguchi, M., additional, and Higashi, H., additional
- Published
- 2005
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27. Preparation of CuIn(S,Se)2 thin films by thermal crystallization in sulfur and selenium atmosphere
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Yamaguchi, T., primary, Naoyama, T., additional, Lee, H.S., additional, Yoshida, A., additional, Kobata, T., additional, Niiyama, S., additional, and Nakamura, T., additional
- Published
- 2003
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28. Thin films of Cu(In,Ga)Se and ordered vacancy compound prepared by thermal crystallization and their photovoltaic applications
- Author
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YAMAGUCHI, T, primary, KOBATA, T, additional, NIIYAMA, S, additional, NAKAMURA, T, additional, and YOSHIDA, A, additional
- Published
- 2003
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29. The presynaptic modulation of glutamate release and the membrane dysfunction induced by in vitro ischemia in rat hippocampal CA1 neurons
- Author
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Tanaka, E, primary, Niiyama, S, additional, Uematsu, K, additional, Yokomizo, Y, additional, and Higashi, H, additional
- Published
- 2002
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30. Extrusion of Intracellular Calcium Ion After In Vitro Ischemia in the Rat Hippocampal CA1 Region
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Tanaka, E., primary, Uchikado, H., additional, Niiyama, S., additional, Uematsu, K., additional, and Higashi, H., additional
- Published
- 2002
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31. Mechanisms Underlying the Depression of Evoked Fast EPSCs Following In Vitro Ischemia in Rat Hippocampal CA1 Neurons
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Tanaka, E., primary, Yasumoto, S., additional, Hattori, G., additional, Niiyama, S., additional, Matsuyama, S., additional, and Higashi, H., additional
- Published
- 2001
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32. Protective actions of local anesthetics against the membrane dysfunction induced by in vitro ischemia in rat hippocampal CA1 neurons
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Niiyama, S, primary
- Published
- 2000
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33. Preparation of Cu2ZnSnSe4 thin films by selenization of precursor evaporated from Cu2ZnSnSe4 compound.
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Yamaguchi, T., Kawamoto, K., Oura, S., Niiyama, S., and Imanishi, T.
- Subjects
THIN films ,INGOTS ,ELECTRON probe microanalysis ,X-ray diffraction ,SOLAR cells - Abstract
Cu
2 ZnSnSe4 ingot was synthesized and then used as a precursor for selenization process in order to fabricate Cu2 ZnSnSe4 thin films. The thin films were prepared at each point A-F in our selenization process and their properties were investigated. Cu2 ZnSnSe4 ingot and thin films had a kesterite Cu2 ZnSnSe4 structure. From EPMA analysis and XRD studies, the mechanism of Cu2 ZnSnSe4 formation was discussed. Cu-Se phases were related to Cu2 ZnSnSe4 formation. Cu2 ZnSnSe4 may decompose to Sn-Se compound during the annealing process at 550o C. Cu2 ZnSnSe4 thin film solar cells demonstrated Voc =300 mV, Isc =7.25 mA/cm2 . The band gap energy of Cu2 ZnSnSe4 thin film determined from the QE spectra estimated to be approximately 1.04 eV. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [ABSTRACT FROM AUTHOR]- Published
- 2013
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34. Cu2ZnSn(S,Se)4 thin films prepared by thermal crystallization in S/Se atmosphere and their photovoltaic applications.
- Author
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Yamaguchi, T., Oka, Y., Niiyama, S., and Imanishi, T.
- Subjects
THIN film research ,CRYSTALLIZATION ,PHOTOVOLTAIC effect ,ELECTRON probe microanalysis ,X-ray diffraction ,KESTERITE - Abstract
Cu
2 ZnSn(S,Se)4 thin films were prepared by annealing the Cu/Sn/Zn precursors in sulfur/selenium mixing atmosphere. From EPMA analysis, the S/(S+Se) mole ratio in the thin films increased with increasing the S/(S+Se) mole ratio in the sealed ampoule. XRD study showed that the thin films had a kesterite phase in Cu2 ZnSn(S,Se)4 and the a- and c-axis constants decreased with increasing the S/(S+Se) mole ratio in the thin films, following the usual linear Vegard behavior. Cu2 ZnSn(S,Se)4 thin film solar cells annealed in S/Se atmosphere with an addition of Sn demonstrated Voc =460 mV, Isc =6.99 mA/cm2 and Voc =605 mV, Isc =5.53 mA/cm2 . (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [ABSTRACT FROM AUTHOR]- Published
- 2013
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35. Clinical features and prognosis of liver cirrhosis which were found in drinker
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Ishihara, K., Nozawa, A., Niiyama, S., Yamamoto, S., and Hosoda, T.
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- 1969
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36. Cu(In,Ga)(S,Se)2 thin films prepared by thermal crystallization from CuInGaSe/CuGaSe precursor in S/Se atmosphere.
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Yamaguchi, T., Hirao, T., Niiyama, S., and Miyake, Y.
- Published
- 2006
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37. Arachidonic Acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia.
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Tanaka E, Niiyama S, Sato S, Yamada A, and Higashi H
- Subjects
- *
HIPPOCAMPUS (Brain) , *NEURONS , *OXYGEN , *ISCHEMIA , *GLUCOSE - Abstract
Intracellular recordings were made from hippocampal CA1 neurons in rat slice preparations. Superfusion with oxygen- and glucose-deprived medium (in vitro ischemia) produced a rapid depolarization approximately 5 min after the onset of the superfusion. Even when oxygen and glucose were reintroduced immediately after rapid depolarization, the membrane depolarized further (persistent depolarization) and reached 0 mV (irreversible depolarization) after 5 min from the reintroduction. The pretreatment of the slice preparation with a phospholipase A2 (PLA2) inhibitor, para-bromophenacyl bromide, or a cytochrome P-450 inhibitor, 17-octadecynoic acid, significantly restored the membrane to the preexposure potential level after the reintroduction of oxygen and glucose. The administration of 14,15-epoxyeicosatrienoic acid or 20-hydroxyeicosatetraenoic acid did not change the latency of the rapid depolarization and did not allow the membrane potential to recover after the ischemic exposure. In contrast, after pretreatment with cyclooxygenase or lipoxygenase inhibitors, such as indomethacin, resveratrol, Dup-697, nordihydroguaiaretic acid, and 3,4-dihydrophenyl ethanol, a minority of neurons tested showed postischemic recovery from the persistent depolarization. Improved recovery was also seen after treatment with the free radical scavengers, edaravone and alpha-tocopherol. These results suggest that the activation of the arachidonic acid cascade via PLA2 and the free radicals produced by arachidonic acid metabolism contribute to the irreversible depolarization produced by in vitro ischemia. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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38. Characterization of Cu(In,Ga) (S,Se)2 thin films prepared by sequential evaporation from ternary compounds
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Yamaguchi, T., Hatori, M., Niiyama, S., and Miyake, Y.
- Abstract
Cu(In,Ga) (S,Se)2 thin films were fabricated by sequential evaporation from CuGaSe2, CuInSe2 and In2S3 compounds for photovoltaic device applications. From XRF analysis, the Cu:(In + Ga):(S + Se) atomic ratio in all thin films was approximately 1:1:2. As the [In2S3]/([CuGaSe2] + [CuInSe2]) mole ratio in the evaporating materials increased, the S/(S + Se) atomic ratio in the thin films increased from 0 to 0.16 determined by XRF and to 0.43 by EPMA. XRD studies demonstrated that the prepared thin films had a chalcopyrite Cu(In,Ga) (S,Se)2 structure and the preferred orientation to the 112 plane. The SEM images demonstrated that Cu(In,Ga) (S,Se)2 thin films had large and columnar grains. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
- Published
- 2006
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39. CHARACTERIZATION OF THE BLACK SURFACE LAYER ON A COPPER ALLOY COLOURED BY TRADITIONAL JAPANESE SURFACE TREATMENT
- Author
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Murakami, R., primary, Niiyama, S., additional, and Kitada, M., additional
- Published
- 1988
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40. Characterization of Cu(In,Ga)Se2 thin films prepared by evaporationfrom ternary compounds
- Author
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Yamaguchi, T., Naka, M., Niiyama, S., and Imanishi, T.
- Subjects
- *
THIN films , *SURFACE coatings , *ELECTRIC conductivity , *EVAPORITES - Abstract
Abstract: Thin films of Cu(In,Ga)Se2 were fabricated by evaporation from ternary CuGaSe2 and CuInSe2 compounds for photovoltaic device applications and their properties were investigated. From XRF analysis, the Cu:(In+Ga):Se atomic ratio in all thin films was approximately 1:1:2. The Ga/(In+Ga) atomic ratio in the thin films changed linearly from 0 to 1.0 with increasing the [CGS]/([CGS]+[CIS]) mole ratio in the evaporating materials. However, for thin films prepared at the [CGS]/([CGS]+[CIS]) mole ratio above 0.4, the composition by EPMA analysis was not consistent with that by XRF analysis. The result of EPMA analysis showed that the surface of a thin film was Cu-rich. XRD studies demonstrated that the thin films prepared at the [CGS]/([CGS]+[CIS]) mole ratio under 0.2 had a chalcopyrite Cu(In,Ga)Se2 structure and the preferred orientation to the 112 plane. On the other hand, XRD patterns of the thin films produced at the [CGS]/([CGS]+[CIS]) mole ratio above 0.6 showed the diffraction lines from a chalcopyrite Cu(In,Ga)Se2 and a foreign phase. The separation of a peak was observed near 2θ=27°, indicative the graded Ga concentration in Cu(In,Ga)Se2 thin film. [Copyright &y& Elsevier]
- Published
- 2005
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41. Preparation of CuIn(S,Se)2 thin films by thermal crystallization in sulfur and selenium atmosphere
- Author
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Yamaguchi, T., Naoyama, T., Lee, H.S., Yoshida, A., Kobata, T., Niiyama, S., and Nakamura, T.
- Subjects
- *
THIN films , *CRYSTALLIZATION , *SULFUR , *SELENIUM - Abstract
Thin films of CuIn(S,Se)2 were prepared by thermal crystallization process for photovoltaic device applications and their properties were investigated. From EPMA analysis, S/(S+Se) atomic ratio in the thin films was changed from 0.18 to 1.0 with increasing the S/(S+Se) vapor ratio in the quartz ampoule. X-ray diffraction studies revealed that the thin films had a chalcopyrite CuIn(S,Se)2 structure and the preferred orientation to the 112 plane. The SEM images showed that the grain sizes in CuIn(S,Se)2 thin films decreased with the increase in the S/(S+Se) atomic ratio. [Copyright &y& Elsevier]
- Published
- 2003
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42. White matter lesions as a prognostic marker of recurrence in cryptogenic stroke with high-risk patent foramen ovale.
- Author
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Niiyama S, Ueno Y, Kurita N, Nakajima S, Kijima C, Hira K, Miyamoto N, Watanabe M, Yamashiro K, Urabe T, and Hattori N
- Subjects
- Humans, Female, Male, Middle Aged, Aged, Risk Factors, Risk Assessment, Time Factors, Leukoencephalopathies diagnostic imaging, Leukoencephalopathies etiology, White Matter diagnostic imaging, Aged, 80 and over, Magnetic Resonance Imaging, Prognosis, Retrospective Studies, Foramen Ovale, Patent diagnostic imaging, Foramen Ovale, Patent complications, Recurrence, Registries, Ischemic Stroke etiology, Ischemic Stroke diagnostic imaging, Ischemic Stroke diagnosis, Echocardiography, Transesophageal, Predictive Value of Tests
- Abstract
Purpose: A high-risk patent foramen ovale (PFO) could be the cause of cryptogenic stroke, and an atrial septal aneurysm (ASA) increases the risk of stroke recurrence in cryptogenic stroke patients with a patent foramen ovale (PFO). Factors related to stroke recurrence according to PFO characteristics have not been fully evaluated., Methods: Data from a multicenter, observational registry of ischemic stroke patients undergoing transesophageal echocardiography were used for this study. Patients were classified into three groups: high-risk PFO, PFO with large shunt (≥20 microbubbles) or ASA; right-to-left shunt (RLS), RLS including PFO with <20 microbubbles or without ASA, or pulmonary arteriovenous fistula; and negative RLS. Cox proportional hazards regression analysis was used to explore the factors related to stroke recurrence in these three groups., Results: In total, 586 patients (185 females; 65.5±13.2 years) were analyzed. In cryptogenic stroke (329 patients) with median follow-up of 4.2 (interquartile range, 1.0-6.1) years, 55 patients had stroke recurrence. The negative RLS, RLS, and high-risk PFO groups included 179, 90, and 60 patients, in which stroke recurrence occurred in 5.3%, 2.5%, and 4.6% per person-year, respectively. In patients with high-risk PFO, the National Institutes of Health stroke scale score (hazard ratio [HR] 1.257 [1.034-1.530]) and periventricular hyperintensity (HR 3.369 [1.103-10.294]) were predictors of stroke recurrence on multivariable Cox hazards analysis, but no factors were related to stroke recurrence in the RLS and negative RLS groups., Conclusion: Periventricular hyperintensity was shown to predict recurrent stroke in patients with a high-risk PFO., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yuji Ueno reports financial support was provided by Bristol-Myers Squibb. Yuji Ueno reports a relationship with Ohara Pharmaceutical Co Ltd that includes: speaking and lecture fees. Nobukazu Miyamoto reports a relationship with Ohara Pharmaceutical Co Ltd that includes: speaking and lecture fees. Kazuo Yamashiro reports a relationship with Nestle Japan Ltd Tokyo Commercial Office that includes: funding grants. Takao Urabe reports a relationship with Daiichi Sankyo Inc that includes: speaking and lecture fees. Takao Urabe reports a relationship with Boehringer Ingelheim Ltd that includes: speaking and lecture fees. Takao Urabe reports a relationship with Otsuka Pharmaceutical Co Ltd that includes: speaking and lecture fees. Takao Urabe reports a relationship with Bayshore Pharmaceuticals LLC that includes: speaking and lecture fees. Takao Urabe reports a relationship with AstraZeneca that includes: speaking and lecture fees. Takao Urabe reports a relationship with Otsuka Pharmaceutical Co Ltd that includes: funding grants. Takao Urabe reports a relationship with AbbVie Ltd. that includes: funding grants. Nobutaka Hattori reports a relationship with Asahi Kasei Medical Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with Shin Nippon Biomedical Laboratories Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with FP Pharmaceutical Corporation that includes: funding grants. Nobutaka Hattori reports a relationship with Eisai Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with CellSource that includes: funding grants. Nobutaka Hattori reports a relationship with MJFF that includes: funding grants. Nobutaka Hattori reports a relationship with Mds Pharma Services that includes: funding grants. Nobutaka Hattori reports a relationship with Meiji Seika Pharma Co Ltd that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Sumitomo Pharma Co Ltd that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Ono Pharmaceutical Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with Otsuka Pharmaceutical Co Ltd that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Takeda Pharmaceutical Co Ltd Tokyo Headquarters that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Kyowa Kirin Co Ltd that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with FP Pharmaceutical Corporation that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Eisai Co Ltd that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Nihon Medi-Physics Co Ltd that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Novartis Pharma that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Biogen Japan Ltd that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Abbvie GK that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Teijin Pharma Limited that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Alexion Pharmaceuticals Inc that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Daiichi Sankyo Inc that includes: speaking and lecture fees. Nobutaka Hattori reports a relationship with Sumitomo Pharma Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with Otsuka Pharmaceutical Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with Takeda Pharmaceutical Co Ltd Tokyo Headquarters that includes: funding grants. Nobutaka Hattori reports a relationship with Kyowa Kirin Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with SUNWELS that includes: funding grants. Nobutaka Hattori reports a relationship with Eisai Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with Nihon Medi-Physics Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with Abbott Japan Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with Abbvie GK that includes: funding grants. Nobutaka Hattori reports a relationship with Medtronic that includes: funding grants. Nobutaka Hattori reports a relationship with Boston Scientific Japan that includes: funding grants. Nobutaka Hattori reports a relationship with Ono Pharmaceutical Co Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with Mitsubishi Tanabe Pharma Corporation that includes: funding grants. Nobutaka Hattori reports a relationship with Kowa Co Ltd Tokyo Office that includes: funding grants. Nobutaka Hattori reports a relationship with PARKINSON Laboratories Co., Ltd that includes: funding grants. Nobutaka Hattori reports a relationship with Ohara Pharmaceutical Co Ltd that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
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43. Prehospital emergency care family satisfaction scale for care provided by emergency medical technicians: Scale development and validation.
- Author
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Haruna J, Uemura S, Hayasaka N, Taguchi Y, Muranaka S, Niiyama S, Inamura H, Sawamoto K, Mizuno H, Himuro N, and Narimatsu E
- Subjects
- Humans, Male, Female, Middle Aged, Adult, Reproducibility of Results, Japan, Surveys and Questionnaires standards, Psychometrics, Patient Satisfaction, Aged, Factor Analysis, Statistical, Emergency Medical Technicians psychology, Emergency Medical Services standards, Family psychology
- Abstract
Rationale: To date, family satisfaction with emergency medical technicians (EMTs) has only been reported through narrative statements in subjective evaluations. Although a quantitative assessment of healthcare professional satisfaction is desirable, no specific measures have been devised to assess family satisfaction with the healthcare and care provided by EMTs., Aims and Objectives: This study aimed to develop and validate an EMT care family satisfaction scale to measure patient satisfaction with prehospital emergency care., Methods: The study population comprised 216 family members (N = 216) of patients who used ambulances between November 2020 and May 2021 in a single region in Japan. Questionnaires were distributed to the participants who provided informed consent. An exploratory factor analysis of construct validity was performed to validate the Family Satisfaction Scale. The Cronbach's alpha was used to validate the internal consistency reliability of the scale., Results: The exploratory factor analysis results revealed a four-factor structure: 'explanation and communication,' 'physical treatment,' 'psychological support,' and 'environment in the ambulance.' The Cronbach's range (0.80-0.93) for the total score for each of these four factors and the overall total score confirmed favorable internal reliability of this study., Conclusions: The family satisfaction scale developed in this study was constructed and validated to highlight the role of EMTs and needs of the families in the prehospital care settings. Moreover, this scale can be applied in the evaluation and consideration of interventions to improve family satisfaction with EMTs., (© 2024 John Wiley & Sons Ltd.)
- Published
- 2024
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44. A clinical case of anaphylaxis after eating oatmeal contaminated with booklice (Liposcelis bostrychophila).
- Author
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Matsumoto C, Kawakami Y, Ishibashi O, Sagara I, Sakaguchi M, Harada Y, Takahashi M, Niiyama S, Inui T, and Fukuda H
- Abstract
A 52-year-old man presented to our department with generalized erythema, watery stools, and vomiting 30 min after ingesting coconut, oatmeal, and vegetable juice. On arrival, his blood pressure was 120/79 mm Hg, heart rate was 126 beats per min, blood oxygen saturation was 96%, and lip cyanosis was observed. The patient experienced diffuse redness throughout the body and was diagnosed as having severe anaphylaxis. A skin prick test for the leftover coconut, oatmeal, and vegetable juice, which the patient had consumed immediately before the onset of symptoms, showed a positive reaction only to the leftover oatmeal. Direct microscopic examination of the leftover oatmeal revealed numerous insect bodies that appeared as booklice. Using Western blot analysis and quantitative polymerase chain reaction, Lip b 1, a specific antigen for Liposcelis bostrychophila (badonnel), an indoor pest that inhabits various places and feeds on various indoor materials, including stored foods, was detected only in the extract of the leftover oatmeal. Based on these results, we identified an insect body infesting oatmeal, L. bostrychophila. The serum level of L. bostrychophila-specific immunoglobulin antibodies was higher than the cutoff value; therefore, we identified the disease as anaphylaxis caused by accidental ingestion of L. bostrychophila that infested the oatmeal stored in the container. We report the first case of L. bostrychophila-infested oatmeal as an orally ingested allergen in Japan., (© 2024 Japanese Dermatological Association.)
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- 2024
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45. Machine Learning Analysis of Predictors for Inhaled Nitric Oxide Therapy Administration Time Post Congenital Heart Disease Surgery: A Single-Center Observational Study.
- Author
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Niiyama S, Nakashima T, Ueno K, Hirahara D, Nakajo M, Madokoro Y, Sato M, Shimono K, Futatsuki T, and Kakihana Y
- Abstract
Background Congenital heart disease (CHD) is a structural deformity of the heart present at birth. Pulmonary hypertension (PH) may arise from increased blood flow to the lungs, persistent pulmonary arterial pressure elevation, or the use of cardiopulmonary bypass (CPB) during surgical repair. Inhaled nitric oxide (iNO) selectively reduces high blood pressure in the pulmonary vessels without lowering systemic blood pressure, making it useful for treating children with postoperative PH due to heart disease. However, reducing or stopping iNO can exacerbate postoperative PH and hypoxemia, necessitating long-term administration and careful tapering. This study aimed to evaluate, using machine learning (ML), factors that predict the need for long-term iNO administration after open heart surgery in CHD patients in the postoperative ICU, primarily for PH management. Methods We used an ML approach to establish an algorithm to predict 'patients with long-term use of iNO' and validate its accuracy in 34 pediatric postoperative open heart surgery patients who survived and were discharged from the ICU at Kagoshima University Hospital between April 2016 and March 2019. All patients were started on iNO therapy upon ICU admission. Overall, 16 features reflecting patient and surgical characteristics were utilized to predict the patients who needed iNO for over 168 hours using ML analysis with AutoGluon. The dataset was randomly classified into training and test cohorts, comprising 80% and 20% of the data, respectively. In the training cohort, the ML model was constructed using the important features selected by the decrease in Gini impurity and a synthetic oversampling technique. In the testing cohort, the prediction performance of the ML model was evaluated by calculating the area under the receiver operating characteristics curve (AUC) and accuracy. Results Among 28 patients in the training cohort, five needed iNO for over 168 hours; among six patients in the testing cohort, one needed iNO for over 168 hours. CPB, aortic clamp time, in-out balance, and lactate were the four most important features for predicting the need for iNO for over 168 hours. In the training cohorts, the ML model achieved perfect classification with an AUC of 1.00. In the testing cohort, the ML model also achieved perfect classification with an AUC of 1.00 and an accuracy of 1.00. Conclusion The ML approach identified that four factors (CPB, in-out balance, aortic cross-clamp time, and lactate) are strongly associated with the need for long-term iNO administration after open heart surgery in CHD patients. By understanding the outcomes of this study, we can more effectively manage iNO administration in postoperative open heart surgery in CHD patients with PH, potentially preventing the recurrence of postoperative PH and hypoxemia, thereby contributing to safer patient management., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Kagoshima University's Ethics Committee for Epidemiological Research issued approval 190250epi. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Niiyama et al.)
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- 2024
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46. Comparative Study of Blood Neopterin and Biopterins in Patients with COVID-19 and Secondary Bacterial Infection.
- Author
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Eguchi T, Niiyama S, Kamikokuryo C, Madokoro Y, Shimono K, Hara S, Ichinose H, and Kakihana Y
- Abstract
Background/Objectives : As COVID-19 can be severe, early predictive markers of both severity and onset of secondary bacterial infections are needed. This study first examined changes over time in the levels of plasma neopterin (NP) and biopterins (BPs), among others, in patients with COVID-19 and then in those with secondary bacterial infection complications. Methods : Fifty-two patients with COVID-19 admitted to two tertiary care centers were included. They were divided into a severe group (intubated + mechanical ventilation) ( n = 10) and a moderate group (non-intubated + oxygen administration) ( n = 42), and changes over time in plasma NP, plasma BPs, IFN-γ, lymphocyte count, CRP, and IL-6 were investigated. Four of the patients in the severe group ( n = 10) developed secondary bacterial infections during treatment. Plasma NP and plasma BPs of patients with bacterial sepsis (no viral infection) ( n = 25) were also examined. Results : The plasma NP, IL-6, CRP, and SOFA levels were significantly higher in the severe group, while the IFN-γ level and lymphocyte count were significantly lower. The higher plasma NP in the severe group persisted only up to 1 week after symptom onset. The plasma BPs were higher in complications of bacterial infection. Conclusions : The timing of sample collection is important for assessing severity through plasma NP, while plasma BPs may be a useful diagnostic tool for identifying the development of secondary bacterial infection in patients with COVID-19. Further investigation is needed to clarify the mechanism by which NP and BPs, which are involved in the same biosynthetic pathway, are differentially activated depending on the type of pathogen.
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- 2024
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47. Inhibition of QDPR synergistically modulates intracellular tetrahydrobiopterin profiles in cooperation with methotrexate.
- Author
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Hara S, Kono H, Suto N, Kojima H, Kishimoto K, Yoshino H, Niiyama S, Kakihana Y, and Ichinose H
- Subjects
- Humans, Enzyme Inhibitors pharmacology, Oxidation-Reduction drug effects, Animals, Molecular Dynamics Simulation, Methotrexate pharmacology, Biopterins analogs & derivatives, Biopterins metabolism, Drug Synergism, Dihydropteridine Reductase metabolism
- Abstract
Tetrahydrobiopterin (BH4) is an essential cofactor for dopamine and serotonin synthesis in monoaminergic neurons, phenylalanine metabolism in hepatocytes, and nitric oxide synthesis in endothelial and immune cells. BH4 is consumed as a cofactor or is readily oxidized by autooxidation. Quinonoid dihydropteridine reductase (QDPR) is an enzyme that reduces quinonoid dihydrobiopterin (qBH2) back to BH4, and we have previously demonstrated the significance of QDPR in maintaining BH4 in vivo using Qdpr-KO mice. In addition to the levels of BH4 in the cells, the ratios of oxidized to reduced forms of BH4 are supposed to be important for regulating nitric oxide synthase (NOS) via the so-called uncoupling of NOS. However, previous studies were limited due to the absence of specific and high-affinity inhibitors against QDPR. Here, we performed a high-throughput screening for a QDPR inhibitor and identified Compound 9b with an IC
50 of 0.72 μM. To understand the inhibition mechanism, we performed kinetic analyses and molecular dynamics simulations. Treatment with 9b combined with methotrexate (MTX), an inhibitor of another BH4-reducing enzyme, dihydrofolate reductase (DHFR), significantly oxidized intracellular redox states in HepG2, Jurkat, SH-SY5Y, and PC12D cells. Collectively, these findings suggest that 9b may enhance the anticancer and anti-autoimmune effects of MTX., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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48. Intractable pemphigus foliaceus after COVID-19 mRNA vaccination.
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Matsumoto C, Terada N, Harada Y, Takahashi M, Niiyama S, and Fukuda H
- Subjects
- Humans, BNT162 Vaccine adverse effects, COVID-19 Vaccines adverse effects, SARS-CoV-2 immunology, COVID-19 prevention & control, COVID-19 immunology, Pemphigus immunology, Pemphigus drug therapy, Pemphigus etiology
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- 2024
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49. Microbial diversity in shallow-sea sediment from Tsukumo Bay, Japan, determined by 16S rRNA gene amplicon sequencing.
- Author
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Kato M, Sugitani R, Niiyama S, Kamiya T, and Matsuura N
- Abstract
Information about the microbiota in marine sediments is important because the microbiota and their activities in sediments affect the surrounding marine environment. To evaluate the microbial diversity, we performed 16S rRNA gene amplicon sequencing on sediment samples from 19 stations in Tsukumo Bay, the northern area of Noto Peninsula, Japan., Competing Interests: The authors declare no conflict of interest.
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- 2024
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50. Influence of Personal and Work Environments on Work-Life Balance Among Emergency Medical Technicians.
- Author
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Haruna J, Uemura S, Niiyama S, Taguchi Y, Muranaka S, Inamura H, Sawamoto K, Mizuno H, and Narimatsu E
- Abstract
Introduction Work-life balance (WLB) is a critical concern for emergency medical technicians (EMTs) because it significantly affects the provision of comprehensive emergency medical services (EMS). This study investigated personal and work-related factors influencing work-to-family negative spillover (WFNS), a key element of WLB, among EMTs. Methods A web-based survey was conducted from July 26 to September 13, 2021, among EMTs in Hokkaido, Japan. The study included 21 facilities that were randomly selected from 42 fire stations. The Japanese version of the Survey Work-Home Interaction-NijmeGen (SWING-J) was used to measure WFNS. Personal background factors, such as age, sex, years of work experience, and education, were surveyed. We also evaluated work environment factors, such as weekly working hours, monthly night shifts, monthly overtime hours, and yearly paid vacation days. Unpaired Student's t-tests, one-way analysis of variance (ANOVA), and multilevel generalized linear model (MGLM) analyses were used to explore the relationships between WFNS and personal and work-related factors. Results A total of 912 respondents were included in our analysis. They were predominantly male (98.2%), with an average EMT work experience of 12.7 years and a mean WFNS score of 1.16 (standard deviation (SD) = 1.67). MGLM analysis, adjusting for covariates, identified years of work experience (β = -0.129, p = 0.001), monthly overtime hours (β = 0.184, p < 0.001), and yearly paid vacation days (β = -0.170, p < 0.001) as independent factors associated with WFNS. Conclusion This study suggested that adjusting WFNS among EMTs could be achieved by reducing overtime hours and fostering an organized approach to paid leave within the work environment., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Haruna et al.)
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- 2024
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