193 results on '"Nigsch, Florian"'
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2. Small molecule induced STING degradation facilitated by the HECT ligase HERC4
3. Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin Deficiency
4. Convergence of multiple RNA-silencing pathways on GW182/TNRC6
5. Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease
6. Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis
7. Genome-wide CRISPR-Cas9 screens identify mechanisms of BET bromodomain inhibitor sensitivity
8. Systematic Chemogenetic Library Assembly
9. Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution
10. BET bromodomain inhibitors regulate keratinocyte plasticity
11. Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis
12. YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury
13. Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy
14. Computational prediction of molecular properties for drug discovery
15. Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology
16. Convergence of multiple RNA-silencing pathways on GW182/TNRC6
17. IRF2 is a master regulator of human keratinocyte stem cell fate
18. CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data
19. A novel HERC4-dependent glue degrader targeting STING
20. Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer
21. High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions
22. Non‐invasive candidate protein signature predicts hepatic venous pressure gradient reduction in cirrhotic patients after sustained virologic response.
23. The Multidimensional Perturbation Value: A Single Metric to Measure Similarity and Activity of Treatments in High-Throughput Multidimensional Screens
24. De-novo generation of novel phenotypically active molecules for Chagas disease from biological signatures using AI-driven generative chemistry
25. Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease
26. Determination of minimal transcriptional signatures of compounds for target prediction
27. Predicting the mechanism of phospholipidosis
28. Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information
29. Toxicological relationships between proteins obtained from protein target predictions of large toxicity databases
30. Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction
31. A novel hybrid ultrafast shape descriptor method for use in virtual screening
32. Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesis
33. The Role of Data Mining in the Identification of Bioactive Compounds via High-Throughput Screening
34. Total synthesis of (+)-crocacin D
35. Using Chemical Structure as Probes for Biological Networks
36. Recent trends and observations in the design of high-quality screening collections
37. Proteomic identification of serum factors that correlate with reduction of HVPG following curative treatment for hepatitis C virus infection
38. Systematic Chemogenetic Library Assembly
39. Additional file 1: of CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data
40. Additional file 3: of CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data
41. Farnesoid X Receptor Agonism, Acetyl‐Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model
42. Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease map
43. CellSIUS provides sensitive and specific detection of rare cell populations from complex single cell RNA-seq data
44. Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction
45. A novel hybrid ultrafast shape descriptor method for use in virtual screening
46. Farnesoid X Receptor Agonism, Acetyl‐Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model.
47. Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy
48. Author response: Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy
49. SAT268 - Proteomic identification of serum factors that correlate with reduction of HVPG following curative treatment for hepatitis C virus infection
50. Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy
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