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The Himalayan leucogranites are important for deciphering the role of crustal thickening and anatexis during the tectono-thermal evolution of the Himalayas. The Higher Himalayan Sequences (HHS) in Sikkim are intruded by Miocene leucogranites which comprise two-mica-bearing (2mg) and tourmaline-bearing leucogranites (Tg) both of which are peraluminous in nature, and are characterized by high 87Sr/86Sr ratios and low 143Nd/144Nd ratios, typical of crustal values. In the case of 2mg, the average (87Sr/86Sr) ratio is 0.792020, and the average (143Nd/144Nd) ratio is 0.511764 whilst for Tg, the average (87Sr/86Sr) and (143Nd/144Nd) ratios are 0.772874 and 0.511912 respectively. In comparison to 2mg, Tg has lower average ratios of (87Sr/86Sr) and slightly elevated average ratios of (143Nd/144Nd). The Sr-Nd isotope compositions for the granitic gneisses from the HHS have an average (87Sr/86Sr) ratio of 0.764026 and an average (143Nd/144Nd) ratio of 0. 511959. The present day average εNd values for 2mg, Tg, and granite gneiss are -17.1, -14.2, and -13.2 respectively. The granite gneiss samples all lie within the field defined by the HHS across the Himalayan orogen as do the Tg samples suggesting a source from pelitic rocks within the HHS. The 2mg samples are somewhat evolved towards more radiogenic Sr isotope ratios and slightly lower neodymium ratios suggesting either a source in metagreywacke rocks of the HHC or, alternatively, reflect minor melt contributions from anatexis of the Lesser Himalayan formations.Keywords: Sr-Nd isotopes, Source magma, Sikkim Himalayas, Leucogranites

The distribution of Oligo−Miocene magmatic rocks from southern Tibet in space and time yields critical information on the geometry and deformation of the subducted Indian lithosphere which impacts on plateau growth following the India and Eurasia collision. A growing body of geophysical evidence has shown that the subducted Indian lithosphere beneath the Tibetan Plateau has been torn apart. However, the spatiotemporal distribution and cause of the tearing remain enigmatic. Timing of the post-collisional magmatic rocks in southern Tibet exhibits four patterns of decreasing ages; magmatism began earlier in the west and east Himalayan syntaxis and evolved to two age undulations in the central southern Tibet. Seismic images show that regions of slab window (both 90°E and 84°E) and flattened subducted lithosphere (both 86°E and 81°E) are present at depth of 135 km. Correspondingly, increasing mineral crystallization temperatures (absolute value of 50 °C) were recorded in the Oligo−Miocene ultrapotassic-potassic rocks at 90°E and 84°E, while opposing trends were shown by coeval ultrapotassic-potassic rocks at 86°E and 81°E. Besides, the melting depth of the Oligo−Miocene ultrapotassic-potassic primitive melts decreases from nearly 100 km to 70 km between 81°E and 90°E, probably indicating progressive rising of the lithosphere-asthenosphere boundary. Such variations were possibly the results of the focused flow and upwelling of asthenosphere, which advanced rapidly but diachronously through weakened and torn sectors within the overlying Indian slab. The upwellings probably induced diachronously upward bending of the residual Indian slab and its flattening, which accelerated the tearing of the Indian lithosphere during continental subduction.

The timing of high-pressure (HP) metamorphism in the eastern Himalayan syntaxis is important for understanding the India-Asia collisional processes, but it remains elusive. To reveal the metamorphic history of the eastern Himalayan syntaxis, we performed a study of geochronology, trace elements, and mineral inclusions of detrital zircon and monazite from modern stream sediments in the eastern Himalayan syntaxis. Detrital zircon comprise magmatic and metamorphic domains with different zoning. Inherited magmatic zircon domains have high Th/U, low (Dy/Yb)N, and retain ages of 1798−360 Ma. Metamorphic zircon domains with low Th/U, high (Dy/Yb)N, and inclusions of garnet, kyanite, and/or clinopyroxene probably formed under HP conditions. They yield age groups of 49−35 Ma, 33−17 Ma, and 12−7 Ma. The low Th/U and low (Dy/Yb)N metamorphic zircon domains probably formed during retrogression and yield age groups of 27−16 Ma and 10−6 Ma. Detrital monazite yield age distributions similar to those of the low (Dy/Yb)N metamorphic zircon except for the 821−402 Ma inherited cores. The (Dy/Yb)N of 31.6−5.7 Ma monazite decreases with increasing Y content, which indicates that it likely formed under the retrograde stage during garnet breakdown. Based on the oldest metamorphic ages, the initial India-Asia collision occurred no later than 50−44 Ma in the eastern Himalayan syntaxis. The multimodal age patterns of the metamorphic zircon and monazite indicate that the Indian continent underwent multistage HP and retrograde metamorphism in the eastern Himalayan syntaxis. The nearly contemporaneous HP and retrograde metamorphism indicate that the Indian continent continued subducting while the earlier HP metamorphic slices detached and exhumed.

Several scholars have studied meanings attributed to the lion in the western European Middle Ages, but their accounts have tended to be partial and fragmentary. A balanced, coherent interpretive history of the medieval lion has yet to be written. This article seeks to promote and initiate the process of composing such a history by briefly reviewing previous research, by proposing a thematic and chronological framework on which work on the lion might reliably be based, and by itself discussing numerous textual examples, not least from German, Latin, and French literature. The five categories of lion symbolism covered are, respectively, the threatening lion, the Christian lion, the noble lion, the sinful lion, and the clement lion. These meanings are shown successively to have constituted regnant fashions that at various times profoundly shaped people's understanding of the lion; but it is demonstrated also that they existed alongside, and in a state of creative tension with, a “ground bass” of lion meanings that changed relatively little. Lions nearly always, for example, represented important, imposing things and people (for example, kings); and the New Testament's polarized presentation of the lion as either Christ or the devil proved enormously influential both throughout and beyond the Middle Ages. As such any cultural history of the lion — and indeed of many other natural phenomena — must be continually sensitive to the co-existence and interaction of tradition and innovation, stability and dynamism.

The purpose of this study was to assess the feasibility and preliminary efficacy of a high-intensity interval training (HIIT) intervention integrated into the workplace on physical and mental health outcomes in a sample of adults. The Work-HIIT intervention was evaluated at the University of Newcastle (March-July 2019). University employees (18+ years) who self-identified as predominantly sedentary at work (n = 47, 43.0 ± 10.7 years; 41 female) were recruited, screened, and randomized after baseline assessments into Work-HIIT (n = 24) or wait-list control (n = 23) conditions. Participants were asked to attend 2-3 researcher-facilitated HIIT sessions/week (weeks 1-8). Sessions included a 2-minute gross-motor warm-up, followed by various combinations of aerobic and muscular fitness exercises lasting 8 minutes (using 30:30 second work: rest intervals). Program feasibility was assessed using measures of satisfaction, compliance, adherence, fidelity, and retention. Physiological and psychological outcomes were measured at baseline and 9 weeks. Feasibility data were investigated using descriptive statistics and efficacy outcomes determined using linear mixed models and Cohen's d effect sizes. Participant ratings showed high levels of satisfaction (4.6/5); 71% of participants attended ≥2 sessions/wk and averaged 85.9% HRmax across all sessions (including rest and work intervals). Small-to-medium positive effects resulted for cardiorespiratory fitness [+2.9 laps, 95% CI (-4.19-10.14); d = 0.34] and work productivity [+0.26, d = 0.47]. Large positive effects resulted for muscular fitness [push-ups +3.5, d = 0.95; standing jump +10.1 cm, d = 1.12]; HIIT self-efficacy [+16.53, d = 1.57]; sleep [weekday +0.76 hours, d = 1.05]; and autonomous motivation [+0.23, d = 0.76]. This study supports the feasibility and preliminary efficacy of facilitator-led Work-HIIT as a time-efficient, enjoyable, and convenient workplace exercise option for adults.

The petrogenesis of Himalayan leucogranites remains crucial for understanding the thermal and tectonic evolution of the Himalayan orogen. To understand whether they are largely pristine melts of crustal anatexis or have experienced a high degree of fractional crystallization (FC), we present Fe isotopic data of 30 representative Himalayan leucogranites and 9 local metasedimentary rocks. Excepting three garnet leucogranites with low δ56Fe (−0.04‰–0.06‰) that are likely affected by garnet accumulation, tourmaline, and two-mica leucogranites have largely homogeneous δ56Fe from 0.13‰ to 0.24‰ irrespective of their highly variable SiO2, MgO, and FeOt contents. Combined with observed mineral assemblages and available fractionation factors, this does not support a high degree of FC (with or without assimilation) in their petrogenesis. The elevated δ56Fe relative to the supposed source rocks, represented by metasedimentary rocks and/or metabasite with a δ56Fe value of 0.10‰, by ∼0.07‰, may reflect Fe isotope fractionation during crustal anatexis. This study indicates most leucogranites can provide robust constraints on the conditions of crustal anatexis and thus the thermal and tectonic evolution of the Himalayan orogen.

Aluminosilicates (kyanite, sillimanite and andalusite) are useful pressure-temperature (P-T)indicators that can form in a range of rock types through different mineral reactions, including thosethat involve partial melting. Their involvement in melting reactions means that the presence ofaluminosilicates in migmatite mineral assemblages can help to (broadly) constrain the P-T conditionsof melt formation, which then has implications for evaluating models of orogenic tectonics.Xenocrystic grains could lead to spurious tectonic interpretations, so being able to distinguishbetween different petrogenetic sources is important. Petrological and geochemical investigation ofmigmatite-hosted kyanite from Eastern Bhutan shows that kyanite petrogenesis may be constrainedby combining information from morphology, cathodoluminescence response, microtextural positionand geochemical zoning patterns. Mg, Ti, Ca, Fe, Cr and Ge concentrations provide diagnostic cluesthat distinguish sub-solidus kyanite from kyanite that crystallised directly from melt, or grewperitectically during muscovite dehydration reactions. The abundance of these elements in kyanite isalso strongly controlled by protolith composition, with considerable inter-sample variation observedin this sample set. LA-ICP-MS maps, especially of Cr/V, provide additional information aboutchanging geochemical environments during kyanite growth. These data and observations show thatmost kyanite is of xenocrystic origin in the analysed samples, and therefore that its presence does notnecessarily constrain the P-T conditions of the melt reaction(s). This finding has significantimplications for the interpretation of kyanite-bearing migmatites as representing early stages ofmelting during Himalayan evolution.

This study involved the design and evaluation of the High-Intensity Interval Training Self-Efficacy Questionnaire (HIIT-SQ). Phase 1: Questionnaire items were developed. Phase 2: Australian adolescents (N = 389, 16.0 ± 0.4 years, 41.10% female) completed the HIIT-SQ, and factorial validity of the measurement model was explored. Phase 3: Adolescents (N = 100, age 12–14 years, 44% female) completed the HIIT-SQ twice (1 week apart) to evaluate test–retest reliability. Confirmatory factor analysis of the final six items (mean = 3.43–6.73, SD = 0.99–25.30) revealed adequate fit, χ2(21) = 21, p = .01, comparative fit index = .99, Tucker–Lewis index = .99, root mean square of approximation = .07, 90% confidence interval [.04, .11]. Factor loading estimates showed that all items were highly related to the factor (estimates range: 0.81–0.90). Intraclass coefficients and typical error values were .99 (95% confidence interval [.99, 1.00]) and .22, respectively. This study provides preliminary evidence for the validity and reliability of scores derived from the HIIT-SQ in adolescents.

Recovery time in the rail industry is the additional time that is included in train timetables over and above the minimum journey time necessary often with the explicit aim of improving punctuality. Recovery time is widely used in railways in a number of countries but prior to this study there has been no investigation of the rail users’ point of view. Perceived recovery time, such as being held outside stations and prolonged stops at stations, might have some premium valuation due to the frustration caused. If perceived recovery time in train timetables does carry a premium, then the benefits of improved punctuality achieved by it will be reduced. This paper is the first to investigate passengers’ views and preferences on the use of recovery time. We summarise the findings of a large study and provide estimates of passengers’ valuations of recovery time, both relative to in-vehicle time and late time, that can be used for economic appraisal purposes. Overall, we find most passengers support the use of recovery time but the context is important. Only 13% of users disapprove of its use as a tool to reduce lateness. The estimated premia vary by demand characteristics and are significant in some contexts, although on average are of a small magnitude. The applicability of the estimates is demonstrated through the appraisal of an actual scheme in the UK. We observe that the introduction of more recovery time along with the subsequent improvement in reliability can lead to significant reductions in generalised journey time, even when recovery time carries a valuation premium. We must however strike a word of caution since we note that there were higher than expected proportions of non-traders in the survey which may have affected the results; future studies into the topic should look to minimise the proportion of non-traders. This study provides valuable and necessary first steps in this challenging topic.

This study sought to examine time course changes in maximal oxygen consumption (VO2max) confirmed with verification testing following 12 weeks of standardized vs. individualized exercise training. Participants (N=39) were randomly allocated to differing exercise intensity prescription groups: ventilatory threshold (individualized) or % heart rate reserve (standardized). At baseline, 4, 8, and 12 weeks, participants completed maximal exercise testing with a verification protocol to confirm ‘true VO2max.’ VO2max in the standardized group changed from 24.3±4.6 ml·kg−1·min−1 at baseline to 24.7±4.6, 25.9±4.7, and 26.0±4.2 ml·kg−1·min−1 at week 4, 8, and 12, respectively, with a significant difference (p

INTRODUCTION Despite knowledge of cardiorespiratory fitness (CRF) training responders and nonresponders, it is not well understood how the exercise intensity prescription affects the incidence of response. The purpose of this study was to determine CRF training responsiveness based on cohort-specific technical error after 12 wk of standardized or individually prescribed exercise and the use of a verification protocol to confirm maximal oxygen uptake (V˙O2max). METHODS Sedentary adult participants (9 men, 30 women; 48.2 ± 12.2 yr) completed exercise training on 3 d·wk for 12 wk, with exercise intensity prescribed based on standardized methods using heart rate reserve or an individualized approach using ventilatory thresholds. A verification protocol was used at baseline and 12 wk to confirm the identification of a true V˙O2max and subsequent relative percent changes to quantify CRF training responsiveness. A cohort-specific technical error (4.7%) was used as a threshold to identify incidence of response. RESULTS Relative V˙O2max significantly increased (P < 0.05) from 24.3 ± 4.6 to 26.0 ± 4.2 and 29.2 ± 7.5 to 32.8 ± 8.6 mL·kg·min for the standardized and individualized groups, respectively. Absolute V˙O2max significantly increased (P < 0.05) from 2.0 ± 0.6 to 2.2 ± 0.6 and 2.4 ± 0.8 to 2.6 ± 0.9 L·min for the standardized and individualized groups, respectively. A significant difference in responsiveness was found between the individualized and standardized groups with 100% and 60% of participants categorized as responders, respectively. CONCLUSIONS A threshold model for exercise intensity prescription had a greater effect on the incidence of CRF training response compared with a standardized approach using heart rate reserve. The use of thresholds for intensity markers accounts for individual metabolic characteristics and should be considered as a viable and practical method to prescribe exercise intensity.

Background : Despite being a very common complication, the aetiology and potential risk factors of diabetic neuropathy (DN) have not been clearly determined in a prospective study. Aims: The aim of Sheffield Prospective Diabetes Study was to identify the abnormalities of physiological, biochemical, haemorrhelogical and cellular function for complications of diabetes in type 1 diabetes. Materials and Methods: 66 newly diagnosed type 1 diabetic subjects (mean age 31 ± 9 (SD) duration (3 years ± 2) were identified and followed for 9 years. They had detailed neurological assessment (symptoms and signs score, nerve conduction, vibration perception threshold, warm thermal discrimination threshold and autonomic function tests) and blood samples taken for detail biochemical and haemorrheological analysis at base line and at follow up. Results: At the 9 years follow up, 51 subjects were studied of whom 18 were found to have DN using Dyck’s criteria. As expected subjects with DN had significantly higher (p

Objectives Technology-based prompting has the potential to support people with dementia to complete multistep tasks in the home. However, these devices can be complex to use. This paper reports a feasibility trial of a personalised touchscreen digital prompter designed for home use. Methodology: A tablet-based prompter suitable for people living with dementia was developed, along with a detailed guidance manual. Carers loaded instructions for completing the task onto the prompter, and the person with dementia then used the tablet independently to complete a task. Eleven couples used the prompter ‘out-of-the-box’ with no support other than a guidance manual. Results The majority of participants with dementia could follow the steps on the prompter, and carers were able to breakdown and load tasks onto the prompter. Eight couples used the prompter successfully to complete goals that they had identified in advance. These included preparing simple snacks and using a TV remote control. Successfully achieving goals was associated with more frequent use of the prompting screen on more days, but not higher levels of editing or previewing of tasks. Conclusion The study provides the preliminary evidence that family caregivers can use a touchscreen tablet, software and manual package to identify specific tasks and break these down into steps and that people living with dementia can then follow the prompts to complete the tasks. This potentially represents an important advance in dementia care. Further testing is required to establish efficacy and to identify any factors that impact on outcomes.

ObjectivesLittle is known of socioeconomic and gender disparities in tobacco use in the Caribbean. We evaluated education and occupation disparities in tobacco smoking prevalence in Jamaica.MethodsData on tobacco smoking, education attainment and usual occupation in adults 25-74 years in a national survey collected between 2007 and 2008 was analyzed. Using post stratification survey weights, Poisson regression models estimated sex-specific, age-adjusted prevalence estimates, prevalence differences and prevalence ratios.ResultsAnalyses included 2299 participants (696 men, 1603 women), mean age 43 years. Current smoking prevalence was 26% in men and 8% in women (pConclusionIn Jamaica, there are socioeconomic disparities in current tobacco smoking among men, where it is inversely associated with education attainment and occupation but in women is less clear. These findings suggest interventions to reduce smoking should consider these disparities.

Purpose: The aim of this study was to determine the feasibility of generalist school teachers delivering curriculum connected high-intensity interval training in a school’s physical education class time. Method: Two schools volunteered to participate. A total of 84 students (11.9 [0.5] y, M = 64 and F = 19) volunteered to participate. Four classes from 2 schools were randomized to either intervention (n = 53) or control (n = 31) for one school term (8 wk). Intervention class teachers participated in a 1-day workshop instructing them how to deliver twice weekly, high-intensity interval training sessions. The control classes continued with their usual physical education curriculum. Recruitment, intervention fidelity, and program satisfaction were assessed. Preliminary efficacy (primary outcome cardiorespiratory fitness) was quantified using generalized linear mixed models, expressed as effect size. A range of secondary outcomes was also assessed. Results: The recruitment rate was 88%. About 84% of the sessions were delivered. The heart rate peak over all sessions was 89.6% (13%) of the predicted maximum. The intervention teachers reported high levels of satisfaction. Almost all student participants were positive about participating. No adverse events occurred. The adjusted between-group difference for cardiorespiratory fitness was trivial (effect size 0.02). Conclusions: This teacher-delivered high-intensity interval training program was feasible and acceptable to both teachers and student participants. It is therefore potentially scalable.

SECTION I: PHOSPHOLIPIDS AND CLOTTING. Structures and Properties of Self-Assembled Phospholipids in Excess Water (Ching-Hsien Huang). Phospholipids and the Clotting Process (Robert F.A. Zwaall, Edouard M. Bevers, Jan Rosing). SECTION II: THE IMMUNOLOGY OF PHOSPHOLIPID BINDING AUTOANTIBODIES. Autoantibodies: Their Nature and Significance (Keith B. Elkon). Antibodies to Lipids and Lipid Membranes: Reactions with Phosphatidyl-Choline, Cholesterol, Liposomes, and Bromolin-Treated Erythromytes (Carl R. Alving). Phospholipid Binding Antibodies in Natural and Experimental Syphilis (Konrad Wicher, Victoria Wicher). Role of Monoclonal Antibodies in Understanding the Interactions Between Anti-Phospholipid Antibodies and Phospholipids (Joyce Rauch, Andrew S. Janoff). The Immunology of Phospholipid Binding Antibodies in the Anti-Phospholipid Syndrome and Related Disorders (E. Nigel Harris, Genesio Balestrieri, Angela Tincani, Azzudin E. Gharavi). SECTION III: MEASUREMENT OF PHOSPHOLIPID BINDING ANTIBODIES. Lupus Anticoagulants: Characteristics, Methods of Laboratory Detection and Some Clinical Associations (Thomas Exner, Douglas Triplett). Acquired Circulating Anticoagulants Other Than Lupus Anticoagulants (Thomas Exner, David Green). The Anti-Cardiolipin Assay (E. Nigel Harris, Azzudin E. Gharavi, Graham R.V. Hughes). SECTION IV: PHOSPHOLIPID BINDING ANTIBODIES AND THROMBOSIS. Arterial Thrombosis: Diagnosis and Management (H. Patrick McNeil, Steven A. Krilis, Colin Chesterman). Spontaneous (Unexplained) Thrombosis: The Inherited Basis for the Thrombohemorrhagic Balance (Helge Stormorken). The Pathogenic Role of Anti-Phospholipid Antibodies in Thrombosis (Ronald H. Derksen, Paula Hasselaar, Ph.G. DeGroot). Anti-Phospholipid Antibodies and Impairment of Prostacyclin Synthesis by Endothelium (Luis O. Carreras, Jos Vermylen). Anti-Phospholipid Autoantibodies in Thrombosis: Cause and/or Consequence of the Rupture of the Protein C-Dependent Hemostatic Balance (Jean-Marie Freyssinet, Catherine Ravanat, Lelia Grunebaum, Marie Louise Wiesel, Jean Pierre Cazenave). SECTION V: PHOSPHOLIPID BINDING ANTIBODIES AND PREGNANCY LOSS. Habitual Abortion (Dwight D. Pridham, Christine L. Cook). Pregnancy in SLE (Michael D. Lockshin). Treatment of Anti-Phospholipid Antibody Mediated Fetal Loss: The Case for Corticosteroid Therapy (Neil S. Pattison, Wilhelm F. Lubbe). Clinical Implication of Anti-Phospholipid Antibodies: The Utah Experience (Ware D. Branch, James R. Scott). Alternative Approaches to Treatment of Women with Anti-Phospholipid Antibodies and Fetal Loss (Susan F. Cowchock). Anti-Phospholipid Antibodies and Fetal Loss-Proposed Mechanism (Neil A. MacLachland, Murdo G. Elder). SECTION VI: THE ANTI-PHOSPHOLIPID SYNDROME. The "Anti-Phospholipid Syndrome" - An Introduction (E.Nigel Harris). The "PRIMARY" Anti-Phospholipid Syndrome (Ronald A. Asherson). Anti-Phospholipid Antibodies: Clinical Complications Reported in the Literature (Ronald A. Asherson). Hematological Immune Cytopenias and Anti-Phospholipid Antibodies (Munther A. Khamashta, Samuel J. Machin). Anti-Phospholipid Syndrome in Murine Lupus (Azzudin E. Gharavi). Anti-Phospholipid Antibodies: A Personal History (Graham R.V. Hughes).

This chapter aims to provide an overview of the research literature regarding exercise for children and adolescents. It outlines seminal and contemporary research evidence of the benefits of aerobic, resistance, and flexibility training, as well as recommendations for exercise prescription in this population. The chapter focuses on the ways in which various forms of exercise can be utilized to improve health-related fitness in young people. It also provides detail regarding the application of the principles to aerobic, resistance, and flexibility training, and examine an overview of prior research related to each of the specific forms of exercise conducted with children and adolescents. Children and adolescents have a greater capacity than adults to recover when performing resistance training, and it has been suggested that a 1-minute rest period between sets is sufficient for most youth. There is growing recognition of the importance of structured exercise programs for children and adolescents, which is reflected in national and international physical activity guidelines.

Objectives: People who are living with dementia typically experience difficulties in completing multi-step, everyday tasks. However, digital technology such as touchscreen tablets provide a means of delivering concise personalised prompts that combine audio, text and pictures. This study was one component of a broader, mixed methods study that tested how an application (app) –based prompter running on a touchscreen tablet computer could support everyday activities in individuals with mild to moderate dementia. In this study we set out to understand the experiences of people living with dementia and their primary carer in using the prompter over a four-week period. Method: We collected qualitative data using semi-structured interviews from 26 dyads, composed of a person living with dementia and their carer. Dyads were interviewed at the start and end of this period. Transcripts were then analysed using thematic analysis. Results: The study identified three overarching themes related to: participants’ attitudes towards the technology; their judgements about how useful the prompter would be; and the emotional impact of using it. Conclusion: Consistent with the Technology Acceptance Model, carers and participants were influenced by their approaches to technology and determined the usefulness of the prompter according to whether it worked for them and fitted into their routines. In addition, participants’ decisions about using the prompter were also determined by the extent to which doing so would impact on their self-identity.

The most significant consequence of prograde metamorphism for orogenic evolution is the melting of high-grade metamorphic rocks, resulting in a dramatic decrease in their mechanical strength, the activation of shear zones and consequent exhumation. Granitic bodies emplaced within the highest metamorphic grades of the Himalayan orogen form by the melting of amphibolite-grade pelitic rocks, either due to the presence of aqueous fluid or through the dehydration of hydrous phases such as muscovite. Across the Himalayas, these granites, and partially melted source migmatites, are found in the Greater Himalayan Sequence (GHS), bounded by the Main Central Thrust (MCT) and the South Tibetan Detachment (STD). Many of these granites formed during the Miocene when decompression of the unit during rapid exhumation triggered melting; however, exact timings and reaction pathways appear to vary laterally across the orogen. The timescales of anatexis, amalgamation, migration, and emplacement are the focus of active research and have implications for orogenic tectonic development. Recent studies of granite pluton formation suggest a series of pulsed melting events with protracted periods of crystallisation under low melt-fraction conditions. These studies show that grain-scale variations in age can be linked with trace element data in both monazite and zircon, spanning millions of years of crystallisation. It is, therefore, important to recognise the geochemical signatures that these processes leave in granites, migmatites, and melt-extracted restite and to delineate more precisely the relevant processes and timescales leading to magma genesis. We present a preliminary dataset that aims to constrain the source, melt reactions, and timescales of melting episodes that form the migmatites and leucogranites of the upper GHS. We sampled leucogranites, migmatites, and their host metasediments along the Rishi Ganga (Badrinath) and Alaknanda valleys in the Garhwal region of the Indian Himalaya. Zircon from these samples were analysed for their crystallisation age (U-Pb), Hf-isotopic ratios, oxygen isotope and trace element composition using LA-ICPMS. Rim domains identified using cathodoluminescence (CL) imaging were preferentially targeted, with the aim of collecting data that related to Himalayan melting processes. Preliminary findings suggest that the leucogranites crystallised from 22 Ma to ~13 Ma, with punctuated zircon crystallisation occurring throughout this timespan. Zircon rim ages from migmatites are generally older, ranging from 34 Ma to ~15 Ma. Integration of Hf-isotopic and trace elemental data, combined with petrographic observations allow mineral age data to be linked to changes in geological processes.