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167 results on '"Niewiadomski, Wiktor"'

1. Compliance of a Cardiovascular System Is Non-linear – Influence on the Relation Between Blood Pressure and an Impedance Cardiography in the Reservoir-Wave Model

Author

Żyliński, Marek, Wojciechowska, Małgorzata, Niewiadomski, Wiktor, Cybulski, Gerard, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Jarm, Tomaz, editor, Cvetkoska, Aleksandra, editor, Mahnič-Kalamiza, Samo, editor, and Miklavcic, Damijan, editor

Published
2021
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2. 'Patient Station' – Telerehabilitation System for People with Parkinson’s Disease

Author

Żyliński, Marek, Niewiadomski, Wiktor, Wacławek, Aleksandra, Budzyńska, Aleksandra, Gąsiorowska, Anna, Stępniewska, Anna, Becmer, Adam, Jagielski, Maciej, Cybulski, Gerard, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Henriques, Jorge, editor, Neves, Nuno, editor, and de Carvalho, Paulo, editor

Published
2020
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3. Short-Term Hemodynamic Variability in Supine and Tilted Position in Young Men

Author

Cybulski, Gerard, Koźluk, Edward, Piątkowska, Agnieszka, Michalak, Ewa, Stępniewska, Anna, Gąsiorowska, Anna, Niewiadomski, Wiktor, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Henriques, Jorge, editor, Neves, Nuno, editor, and de Carvalho, Paulo, editor

Published
2020
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4. Adaptive Filter Removes Variability Caused by Respiration from Impedance Cardiography Signal

Author

Żyliński, Marek, Wojciechowska, Małgorzata, Niewiadomski, Wiktor, Sadowiec, Marta, Borodzicz, Sonia, Cybulski, Gerard, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Badnjevic, Almir, editor, Škrbić, Ranko, editor, and Gurbeta Pokvić, Lejla, editor

Published
2020
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5. System for Measurement of the Mechanical Impedance of Human Body During Vibration Training

Author

Żyliński, Marek, Niewiadomski, Wiktor, Gąsiorowska, Anna, Stępniewska, Anna, Becmer, Adam, Cybulski, Gerard, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Szewczyk, Roman, editor, Krejsa, Jiří, editor, Nowicki, Michał, editor, and Ostaszewska-Liżewska, Anna, editor

Published
2020
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6. Verification of Selected Gait Parameters Derived from Inertial Sensors Using Simple Smartphone Based Optical System

Author

Budzyńska, Aleksandra, Jagielski, Maciej, Żyliński, Marek, Cybulski, Gerard, Niewiadomski, Wiktor, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Szewczyk, Roman, editor, Krejsa, Jiří, editor, Nowicki, Michał, editor, and Ostaszewska-Liżewska, Anna, editor

Published
2020
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7. Empirical Mode Decomposition in Analysis of Hemodynamic Response to Static Handgrip

Author

Olenderek, Norbert, Cybulski, Gerard, Krzemiński, Krzysztof, Niewiadomski, Wiktor, Gąsiorowska, Anna, Strasz, Anna, Magjarevic, Ratko, Editor-in-Chief, Ładyżyński, Piotr, Series Editor, Ibrahim, Fatimah, Series Editor, Lacković, Igor, Series Editor, Rock, Emilio Sacristan, Series Editor, Lhotska, Lenka, editor, Sukupova, Lucie, editor, and Ibbott, Geoffrey S., editor

Published
2019
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13. The Quality of Automatic Artifact Identification in Ambulatory Impedance Cardiography Monitoring

Author

Cybulski, Gerard, Młyńczak, Gerard, Żyliński, Marcel, Strasz, Anna, Gąsiorowska, Anna, Niewiadomski, Wiktor, Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Eskola, Hannu, editor, Väisänen, Outi, editor, Viik, Jari, editor, and Hyttinen, Jari, editor

Published
2018
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15. Graphene electrodes for long-term impedance pneumography - a feasibility study

Author

Młyńczak, Marcel, Zyliński, Marek, Janczak, Daniel, Jakubowska, Małgorzata, Niewiadomski, Wiktor, Cybulski, Gerard, Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Eskola, Hannu, editor, Väisänen, Outi, editor, Viik, Jari, editor, and Hyttinen, Jari, editor

Published
2018
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16. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model.

Author

Zadrozny, Maciej, Drapich, Patrycja, Gasiorowska-Bien, Anna, Niewiadomski, Wiktor, Harrington, Charles R., Wischik, Claude M., Riedel, Gernot, and Niewiadomska, Grazyna

Subjects
TAUOPATHIES, RIVASTIGMINE, TAU proteins, INTERNEURONS, LABORATORY mice, ALZHEIMER'S disease, SEPTUM (Brain)
Abstract

Basal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of Alzheimer's disease (AD). Recent evidence suggests that tau protein is a putative target for the treatment of dementia, and the tau aggregation inhibitor, hydromethylthionine mesylate (HMTM), has emerged as a potential disease-modifying treatment. However, its efficacy was diminished in patients already receiving approved acetylcholinesterase inhibitors. In this study, we ask whether this negative interaction can also be mimicked in experimental tau models of AD and whether the underlying mechanism can be understood. From a previous age profiling study, 6-month-old line 1 (L1) tau transgenic mice were characterized by a severe reduction in several cholinergic markers. We therefore assessed whether long-term pre-exposure with the acetylcholinesterase inhibitor rivastigmine alone and in conjunction with the tau aggregation inhibitor HMTM can reverse cholinergic deficits in L1. Rivastigmine and HMTM, and combinations of the two compounds were administered orally for 11 weeks to both L1 and wild-type mice. The brains were sectioned with a focus on the basal forebrain, motor cortex and hippocampus. Immunohistochemical staining and quantification of choline acetyltransferase (ChAT), tyrosine kinase A (TrkA)-positive neurons and relative optical intensity (ROI) for vesicular acetylcholine transporter (VAChT), and acetylcholinesterase (AChE) reactivity confirmed reversal of the diminished cholinergic phenotype of interneurons (nucleus accumbens, striatum) and projection neurons (medial septum, nucleus basalis magnocellularis) by HMTM, to a greater extent than by rivastigmine alone in L1 mice. Combined administration did not yield additivity but, in most proxies, led to antagonistic effects in which rivastigmine decreased the benefits shown with HMTM alone. Local markers (VAChT and AChE) in target structures of the basal forebrain, motor cortex and hippocampal CA3 seemed to be normalized by HMTM, but not by rivastigmine or the combination of both drugs. HMTM, which was developed as a tau aggregation inhibitor, strongly decreased the tau load in L1 mice, however, not in combination with rivastigmine. Taken together, these data confirm a cholinergic phenotype in L1 tau transgenic mice that resembles the deficits observed in AD patients. This phenotype is reversible by HMTM, but at the same time appears to be subject to a homeostatic regulation induced by chronic pre-treatment with an acetylcholinesterase inhibitor, which interferes with the efficacy of HMTM. The strongest phenotypic reversal coincided with a normalization of the tau load in the cortex and hippocampus of L1, suggesting that tau accumulation underpins the loss of cholinergic markers in the basal forebrain and its projection targets. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Impact of breathing mechanics, body posture and physique on heart rate variability

Author

Młyńczak, Marcel, Niewiadomski, Wiktor, Cybulski, Gerard, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio S., Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Jabłoński, Ryszard, editor, and Brezina, Tomas, editor

Published
2016
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39. Device for Controlling Stimulus Self-Application During Autonomic Nervous System Tests

Author

Zylinski,Marek, Niewiadomski,Wiktor, Cybulski,Gerard, GÄ…siorowska,Anna, Zylinski,Marek, Niewiadomski,Wiktor, Cybulski,Gerard, and GÄ…siorowska,Anna

Abstract

Marek Å»yliÅ„ski,1 Wiktor Niewiadomski,2 Gerard Cybulski,1 Anna GÄ…siorowska2 1Institute of Metrology and Biomedical Engineering, Faculty of Mechatronics, Warsaw University of Technology, Warsaw, Poland; 2Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, PolandCorrespondence: Marek Å»yliÅ„skiInstitute of Metrology and Biomedical Engineering, Faculty of Mechatronics, Warsaw University of Technology, ul. Å›w. Andrzeja Boboli 8, Warszawa, 02-525, PolandTel +48 22 2348387Email zylinski@mchtr.pw.edu.plAbstract: Assessment of autonomic nervous system (ANS) functioning may be performed non-invasively using autonomic tests which are based on evaluation of response of cardiovascular system to the applied stimuli, such as increased air pressure during Valsalva maneuver, skeletal muscle contraction during static handgrip or deep slow breathing. The cardiovascular response depends, besides ANS reaction and test protocol, also on the way stimulus is self-applied by the test subject. We present a versatile device for controlling stimulus self-application during three ANS tests: Valsalva maneuver, static handgrip, and deep breathing. It integrates two different gauges and a pace setter for breathing into one device. The core of the device is a linear LED display which, using green, yellow, and red diodes, informs the subject about the correctness of self-application of respective stimulus. The settings of the device can be adjusted to the needs of the protocol chosen. The device can record the duration of mouth air pressure or the force produced by the subject during ANS tests, which assures correctness of the tests, thus allowing to track individual variability changes in the response to the test. The device was verified during ANS tests and its use was intuitive for patients, reducing the time needed for training before tests and decreasing the effort of the physician.Keywords: biomedical equipment, Ewing’s battery, autonomic nervous system te

Published
2021

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