25 results on '"Nieuwendaal C"'
Search Results
2. A successful alternative: Repair of a penetrating limbal wound by lamellar keratoplasty
- Author
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VAN DER MEULEN, I. J.E., DE BUY WENNIGER-PRICK, MAILLETTE L.J.J.M., LAPID-GORTZAK, R., and NIEUWENDAAL, C. P.
- Published
- 2007
3. Seven-year follow-up of unilateral multifocal pseudophakia in a child
- Author
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Lapid-Gortzak, Ruth, primary, van der Meulen, I. J., additional, Jellema, H. M., additional, Mourits, M. P., additional, and Nieuwendaal, C. P., additional
- Published
- 2016
- Full Text
- View/download PDF
4. Treatment of bandkeratopthy
- Author
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Lapid-Gortzak, R., van der Linden, Jan Willem, van der Meulen, I. J. E., Nieuwendaal, C. P., Becker, Matthias D., Davis, Janet L., Other Research, Ophthalmology, and Other departments
- Published
- 2008
5. De standaard 'Het rode oog' (eerste herziening) van het Nederlands Huisartsen Genootschap; reactie vanuit de oogheelkunde
- Author
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Schlingemann, R. O., van der Meulen, I. J. E., Nieuwendaal, C. P., Amsterdam Cardiovascular Sciences, Amsterdam Neuroscience, Ophthalmology, and Other Research
- Subjects
genetic structures ,sense organs ,eye diseases - Abstract
The revised guideline 'The red eye' of the Dutch College of General Practitioners contains adequate and scientifically well-supported recommendations for the diagnosis and management of patients with minor ocular trauma and red eyes. Unfortunately the guideline lacks a roadmap for implementation of these recommendations, as well as a definition of indicators for the measurement of implementation. This is important in the light of the limited implementation of the previous guideline 'The red eye' published in 1996
- Published
- 2007
6. Oogproblemen door contactlenzen: een advies van de Gezondheidsraad
- Author
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Schlingemann, R. O., Nieuwendaal, C. P., and Ophthalmology
- Subjects
eye diseases - Abstract
In a recent report, the Committee on Health Risks of Contact Lenses from the Health Council of the Netherlands evaluated the health risks of contact lens wear in the Netherlands. Contact lens-related eye disease appears to be common, with an incidence of approximately 80,000 persons per year, who suffer from self-limiting or mild conditions. Such conditions are multifactorial, caused for example by chronic hypoxia, tear-film dysfunction or inadequate fit of the lens. They can range from ocular irritation to giant papillary conjunctivitis, a common cause of permanent lens intolerance. A very serious complication of contact lens wear is infectious keratitis, caused by bacteria or fungi. This is most common in users of permanent-wear soft lenses (20 per 10,000 persons per year) and can lead to a severe loss of vision. Therefore, the Committee has recommended that permanent-wear lenses should not be used. Moreover, lens fitting and follow-up of contact lens wearers should be a prerequisite for optometrists and ophthalmologists. However, the Dutch government has not taken action with respect to this last recommendation
- Published
- 2002
7. Case report: aanpassing van een 12 mm RGP-contactlens na een hoornvliestranplantatie
- Author
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Koster, R., Nieuwendaal, C. P., and Ophthalmology
- Published
- 2002
8. Comparison of a new-generation sectorial addition multifocal intraocular lens and a diffractive apodized multifocal intraocular lens.
- Author
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Linden, J.W.M. van der, Velthoven, M. van, Meulen, I. van der, Nieuwendaal, C., Mourits, M., Lapid-Gortzak, R., Linden, J.W.M. van der, Velthoven, M. van, Meulen, I. van der, Nieuwendaal, C., Mourits, M., and Lapid-Gortzak, R.
- Abstract
1 januari 2012, Item does not contain fulltext, PURPOSE: To compare visual, refractive, and satisfactory outcomes between a new-generation sectorial addition multifocal intraocular lens (IOL) (Lentis Mplus LS-312; study group) and a diffractive apodized multifocal IOL (Restor SN6AD1; control group). SETTING: Private practice, Driebergen, and Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands. DESIGN: Comparative case series. METHODS: Refractive and visual outcomes at near and distance, patient satisfaction, and dysphotopsia scores were recorded 3, 6, and 12 months postoperatively. RESULTS: The study group comprised 90 eyes and the control group, 143 eyes. Three months postoperatively, the mean uncorrected distance visual acuity (UDVA) was not statistically significantly different between the study group and the control group (0.04 +/- 0.15 logMAR [SD] versus 0.06 +/- 0.25 logMAR). The control group had significantly better uncorrected near visual acuity than the study group at 30 cm (0.05 +/- 0.14 logMAR versus 0.15 +/- 0.08 logMAR) and 40 cm (0.05 +/- 0.14 versus 0.16 +/- 0.21) (P<.01 and P<.03, respectively). Patients in the control group were more satisfied with their vision (P<.001). Dissatisfaction was related to younger age at surgery and male sex (P<.0001 and P<.033 respectively). Dysphotopsia occurred in approximately 18% of cases in both groups. CONCLUSIONS: The new sectorial addition multifocal IOL performed comparably to the diffractive apodized multifocal IOL in terms of UDVA and the presence of dysphotopsia. The diffractive apodized multifocal IOL performed better at 30 cm and 40 cm reading distances and had higher patient satisfaction.
- Published
- 2012
9. Kanker van de oog en oogkas. [Cancer of the eye and orbit]
- Author
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Baldeschi, Lelio and Nieuwendaal, C.
- Published
- 2000
10. Morphology and function of the corneal endothelium after long-term contact lens wear
- Author
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Nieuwendaal, C. P., Odenthal, M. T., Kok, J. H., Venema, H. W., Oosting, J., Riemslag, F. C., Kijlstra, A., and Other departments
- Subjects
genetic structures ,sense organs ,eye diseases - Abstract
To examine whether corneal hydration control is impaired in corneas with endothelial morphologic changes (increased variation in cell size and cell angularity) due to long-term low gas-permeable contact lens wear. Twenty-one long-term wearers of low gas-permeable contact lenses (mean age, 41 years +/- 8 SD) and 18 age-matched controls (mean age, 42 years +/- 8 SD) were studied. To assess endothelial morphology, endothelial photographs were taken, enlarged 400X, scanned into a computer, and evaluated. Hydration control was assessed by a corneal stress test. Corneal swelling was induced by applying low gas-permeable soft contact lenses for 2 hours during eye closure. After the lenses were removed, the rate of deswelling was determined using optic pachometry. Morphologic analysis of the endothelial photographs showed a significant increase of polymegethism (P < 0.01) and pleomorphism (P < 0.01) in the group wearing contact lenses compared with the control group. The percentage of recovery of corneal thickness per hour (PRPH) from induced swelling proved to be significantly lower (P = 0.03) and the induced swelling proved to be significantly lower (P < 0.01) in the group wearing contact lenses than in the control group. Multiple regression analysis showed that the PRPH decreased as the morphologic alterations increased. However, this trend appeared not to be significant at the 5% level. A significant relationship was found between morphologic parameters and induced swelling, indicating that induced swelling decreased as the morphologic alterations increased. The results of this study indicate that increased endothelial polymegethism and pleomorphism may be accompanied by a decreased corneal hydration control in people who wear contact lenses
- Published
- 1994
11. Polymegethism of the corneal endothelium in an eye with long-standing ptosis
- Author
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Kok, J. H. C., Dunnebier, E. A., Nieuwendaal, C. P., Kijlstra, A., and Other departments
- Published
- 1992
12. Allogeneic Serum Eye Drops: A Randomized Clinical Trial to Evaluate the Clinical Effectiveness of Two Drop Sizes.
- Author
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Vermeulen C, van der Burg LLJ, van Geloven N, Eggink CA, Cheng YYY, Nuijts RMMA, Wisse RPL, van Luijk CM, Nieuwendaal C, Remeijer L, van der Meer PF, de Korte D, and Klei TRL
- Abstract
Introduction: Allogeneic serum from blood donors is starting to be used to treat patients with dry eye disease (DED). However, the optimal dose is not known. We therefore aimed to evaluate the clinical efficaciousness and user-friendliness of micro-sized versus conventional-sized allogeneic serum eye drops (SEDs)., Methods: In a randomized trial, patients with DED first receive micro-sized SEDs (7 µl/unit) for 1 month, followed by a 1-month washout, before receiving conventional-sized SEDs (50 µl/unit) for 1 month; or vice versa. The primary endpoint was the Ocular Surface Disease Index (OSDI) score. Secondary endpoints were tear break-up time (TBT), tear production (TP), and presence of corneal punctate lesions (CP). The user-friendliness of both application systems was also compared. A linear mixed model for cross-over design was applied to compare both treatments., Results: Forty-nine patients completed the trial. The mean OSDI score significantly improved from 52 ± 3 to 41 ± 3 for micro-sized SEDs, and from 54 ± 3 to 45 ± 3 for conventional-sized SEDs. Non-inferiority (margin = 6) of micro-sized SEDs was established. We demonstrate a significant improvement for TBT in case of conventional-sized SEDs and for CP in both treatment groups. TP trended towards an improvement in both treatment groups. The user-friendliness of the conventional drop system was significantly higher., Conclusions: For the first time, non-inferiority of micro-sized allogeneic SEDs was established. The beneficial effect of both SED volumes was similar as measured by the OSDI score. Although user-friendliness of the micro drop system was significantly lower, it is an attractive alternative as it saves valuable donor serum., Trial Registration: ClinicalTrials.gov (NCT03539159)., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
13. Grey Filter Contact Lens as Therapeutic Option for Acquired Reduced Binocular Visual Performance.
- Author
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van Vliet H, Jellema HM, Nieuwendaal C, Lapid-Gortzak R, Riemslag F, and van der Meulen I
- Abstract
Disturbing binocular problems can be too complex to be treated in such a way that comfortable binocular single vision is restored. The grey filter contact lens could offer a safe and clinically useful way to help these patients., Background: In unilateral acquired reduced visual performance or intractable diplopia the binocular performance often is less than the performance of the better eye, possibly leading to complaints of binocular visual functioning. The hypothesis is to use a grey filter contact lens on the affected eye to obtain more binocular visual comfort. The grey filter changes the binocular central visual image in the brain through delaying the image of the affected eye and has minimal effect on the peripheral vision. The purpose of this study was to evaluate the effect of the grey filter contact lens on the reduction of patients' binocular complaints in daily life., Methods: In 19 consecutive patients with unilateral acquired reduced visual performance or intractable diplopia a grey filter contact lens was fitted. The contact lens was chosen from six available filters with different transmissions, based on patient preference. The chosen filter contact lens was fitted according to the normal practice of contact lens fitting., Results: The results of 18 patients are reported, one patient was lost to follow-up. Twelve patients (67%) reported good results when wearing the grey filter contact lens. Five patients (28%) discontinued wear of the grey filter contact lens because their binocular visual complaints disappeared during filter contact lens wear and remained absent after contact lens wear was terminated., Conclusion: The grey filter contact lens is a clinically useful, safe, and easily reversible treatment option for patients with binocular visual complaints due to an acquired monocular reduction in visual quality., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2021 The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
14. Deep Lamellar Endothelial Keratoplasty Clinical Outcome: The 13- to 18-year Follow-up.
- Author
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Hooijmaijers HCM, Rodriguez-Calvo-de-Mora M, van Dijk K, Ham L, Nieuwendaal C, and Melles GRJ
- Subjects
- Adult, Aged, Aged, 80 and over, Cell Count, Corneal Pachymetry, Female, Follow-Up Studies, Humans, Male, Middle Aged, Slit Lamp, Treatment Outcome, Visual Acuity physiology, Corneal Diseases surgery, Descemet Stripping Endothelial Keratoplasty
- Published
- 2017
- Full Text
- View/download PDF
15. Comparison of a new-generation sectorial addition multifocal intraocular lens and a diffractive apodized multifocal intraocular lens.
- Author
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van der Linden JW, van Velthoven M, van der Meulen I, Nieuwendaal C, Mourits M, and Lapid-Gortzak R
- Subjects
- Female, Humans, Male, Middle Aged, Patient Satisfaction, Prosthesis Design, Pseudophakia physiopathology, Refraction, Ocular physiology, Treatment Outcome, Visual Acuity physiology, Lens Implantation, Intraocular, Lenses, Intraocular, Phacoemulsification
- Abstract
Purpose: To compare visual, refractive, and satisfactory outcomes between a new-generation sectorial addition multifocal intraocular lens (IOL) (Lentis Mplus LS-312; study group) and a diffractive apodized multifocal IOL (Restor SN6AD1; control group)., Setting: Private practice, Driebergen, and Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands., Design: Comparative case series., Methods: Refractive and visual outcomes at near and distance, patient satisfaction, and dysphotopsia scores were recorded 3, 6, and 12 months postoperatively., Results: The study group comprised 90 eyes and the control group, 143 eyes. Three months postoperatively, the mean uncorrected distance visual acuity (UDVA) was not statistically significantly different between the study group and the control group (0.04 ± 0.15 logMAR [SD] versus 0.06 ± 0.25 logMAR). The control group had significantly better uncorrected near visual acuity than the study group at 30 cm (0.05 ± 0.14 logMAR versus 0.15 ± 0.08 logMAR) and 40 cm (0.05 ± 0.14 versus 0.16 ± 0.21) (P<.01 and P<.03, respectively). Patients in the control group were more satisfied with their vision (P<.001). Dissatisfaction was related to younger age at surgery and male sex (P<.0001 and P<.033 respectively). Dysphotopsia occurred in approximately 18% of cases in both groups., Conclusions: The new sectorial addition multifocal IOL performed comparably to the diffractive apodized multifocal IOL in terms of UDVA and the presence of dysphotopsia. The diffractive apodized multifocal IOL performed better at 30 cm and 40 cm reading distances and had higher patient satisfaction., (Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
16. First DLEK series: 10-year follow-up.
- Author
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van Dijk K, Dapena I, Moutsouris K, Ham L, Nieuwendaal C, and Melles GR
- Subjects
- Adult, Aged, Aged, 80 and over, Cell Count, Female, Follow-Up Studies, Graft Survival physiology, Humans, Male, Microscopy, Confocal, Middle Aged, Prognosis, Tomography, Optical Coherence, Visual Acuity physiology, Corneal Transplantation, Endothelium, Corneal transplantation
- Published
- 2011
- Full Text
- View/download PDF
17. Straylight measurements in laser in situ keratomileusis and laser-assisted subepithelial keratectomy for myopia.
- Author
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Lapid-Gortzak R, van der Linden JW, van der Meulen I, Nieuwendaal C, and van den Berg T
- Subjects
- Adult, Female, Humans, Light, Male, Middle Aged, Postoperative Period, Preoperative Period, Prospective Studies, Refraction, Ocular physiology, Visual Acuity physiology, Young Adult, Glare, Keratectomy, Subepithelial, Laser-Assisted, Keratomileusis, Laser In Situ, Lasers, Excimer therapeutic use, Myopia surgery, Scattering, Radiation
- Abstract
Purpose: To compare straylight values before and 3 months after laser in situ keratomileusis (LASIK) and laser-assisted subepithelial keratectomy (LASEK) and to analyze the causes of any change., Setting: Private refractive surgery clinic, Driebergen, The Netherlands., Methods: Straylight was measured before and after LASIK or LASEK with a C-Quant straylight meter; values were recorded as the straylight parameter log(s). Main outcome measures were the difference between postoperative and preoperative straylight values and factors causing a difference between the values., Results: The study evaluated 102 eyes having LASIK and 137 eyes having LASEK. On average, there was significant improvement in straylight values postoperatively in both groups. The mean decrease was -0.016 log(s) in the LASIK group and -0.026 log(s) in the LASEK group. Nonparametric testing (sign test) showed that the improvement in straylight was statistically significant in more than 50% of eyes in both groups. Straylight improved in 62 eyes in the LASIK group (P<.001) and 78 eyes in the LASEK group (P<.02) and deteriorated in 35 eyes and 58 eyes, respectively. There was an increase in straylight in 17 eyes (7.1%). Clinical correlations were found in some eyes that had increased postoperative straylight values., Conclusion: On average, straylight values 3 months after LASIK and LASEK were slightly decreased from baseline values., (Copyright 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
18. Straylight measurements before and after removal of epithelial ingrowth.
- Author
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Lapid-Gortzak R, van der Meulen I, van der Linden JW, Nieuwendaal C, Mourits M, and van den Berg T
- Subjects
- Corneal Diseases etiology, Corneal Stroma pathology, Female, Humans, Light, Middle Aged, Myopia surgery, Prospective Studies, Surgical Flaps pathology, Vision Disorders physiopathology, Visual Acuity physiology, Corneal Diseases surgery, Epithelium, Corneal pathology, Glare, Keratomileusis, Laser In Situ adverse effects, Postoperative Complications, Scattering, Radiation
- Abstract
In 3 eyes with epithelial ingrowth after laser in situ keratomileusis, straylight was measured before and after the ingrowth was removed. In 2 eyes of 1 patient, epithelial ingrowth reached the pupillary axis. Straylight decreased (improved) significantly after ingrowth removal: a 3.6-fold decrease in the right eye and a 10-fold decrease in the left eye. The uncorrected distance visual acuity (UDVA) improved from 0.25 (20/80) in both eyes to 1.0 (20/20) and 0.8 (20/25), respectively. In 1 eye of another patient, from which epithelial ingrowth was removed to prevent flap melting and distortion, the pupillary opening was not obscured and no significant change in straylight was found. The UDVA improved from 0.32 (20/60) to 1.0 (20/20) after the ingrowth was removed. An increase in straylight can be a significant complication of epithelial ingrowth. After the interlamellar space is cleared, the improvement in straylight is several factors larger than the gain in UDVA.
- Published
- 2009
- Full Text
- View/download PDF
19. [The practice guideline 'The red eye' (first revision) of the Dutch College of General Practitioners; a response from the perspective ofthe ophthalmologist].
- Author
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Schlingemann RO, van der Meulen IJ, and Nieuwendaal CP
- Subjects
- Diagnosis, Differential, Humans, Netherlands, Societies, Medical, Eye Diseases diagnosis, Eye Diseases therapy, Ophthalmology standards, Practice Guidelines as Topic, Practice Patterns, Physicians'
- Abstract
The revised guideline 'The red eye' of the Dutch College of General Practitioners contains adequate and scientifically well-supported recommendations for the diagnosis and management of patients with minor ocular trauma and red eyes. Unfortunately the guideline lacks a roadmap for implementation of these recommendations, as well as a definition of indicators for the measurement of implementation. This is important in the light of the limited implementation of the previous guideline 'The red eye' published in 1996.
- Published
- 2007
20. [Eye problems due to contact lenses; an advisory report from the Health Council of the Netherlands].
- Author
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Schlingemann RO and Nieuwendaal CP
- Subjects
- Contact Lenses, Extended-Wear adverse effects, Eye Diseases epidemiology, Humans, Hypoxia etiology, Incidence, Keratitis etiology, Keratitis microbiology, Netherlands epidemiology, Risk Factors, Contact Lenses adverse effects, Eye Diseases etiology
- Abstract
In a recent report, the Committee on Health Risks of Contact Lenses from the Health Council of the Netherlands evaluated the health risks of contact lens wear in the Netherlands. Contact lens-related eye disease appears to be common, with an incidence of approximately 80,000 persons per year, who suffer from self-limiting or mild conditions. Such conditions are multifactorial, caused for example by chronic hypoxia, tear-film dysfunction or inadequate fit of the lens. They can range from ocular irritation to giant papillary conjunctivitis, a common cause of permanent lens intolerance. A very serious complication of contact lens wear is infectious keratitis, caused by bacteria or fungi. This is most common in users of permanent-wear soft lenses (20 per 10,000 persons per year) and can lead to a severe loss of vision. Therefore, the Committee has recommended that permanent-wear lenses should not be used. Moreover, lens fitting and follow-up of contact lens wearers should be a prerequisite for optometrists and ophthalmologists. However, the Dutch government has not taken action with respect to this last recommendation.
- Published
- 2002
21. Sutureless, posterior lamellar keratoplasty: a case report of a modified technique.
- Author
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Melles GR, Lander F, and Nieuwendaal C
- Subjects
- Corneal Diseases surgery, Corneal Topography, Humans, Male, Middle Aged, Minimally Invasive Surgical Procedures, Surgical Flaps, Visual Acuity, Corneal Transplantation methods, Suture Techniques
- Abstract
Purpose: To describe a technique for sutureless, posterior lamellar keratoplasty., Methods: The procedure was performed for a case of pseudophakic bullous keratopathy. Through a 5.0-mm, self-sealing scleral tunnel incision, a stromal pocket was dissected across the cornea, just above Descemet's membrane. An 8.5-mm diameter posterior lamellar disc, consisting of posterior stroma, Descemet's membrane, and endothelium, was transplanted without suture fixation., Results: One week after surgery, the best spectacle corrected visual acuity (BSCVA) was 0.8 (20/25), with S -1.5 and C -1.0 x 85 degrees. After 1 year, the posterior transplant was clear and in position, and the BSCVA was 0.8 with S -1.5 and C -1.75 x 80 degrees. Pachymetry measured 0.60 mm. Endothelial cell counts averaged 1390 cells/mm2., Conclusion: Sutureless, posterior lamellar keratoplasty may be an effective new surgical approach for managing corneal endothelial disorders.
- Published
- 2002
- Full Text
- View/download PDF
22. In vivo human corneal hydration control dynamics: a new model.
- Author
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Odenthal MT, Nieuwendaal CP, Venema HW, Oosting J, Kok JH, and Kijlstra A
- Subjects
- Adult, Circadian Rhythm physiology, Contact Lenses, Cornea anatomy & histology, Female, Humans, Humidity, Hypoxia metabolism, Male, Models, Biological, Vision Tests instrumentation, Body Water metabolism, Cornea metabolism
- Abstract
Purpose: To introduce a new model describing human in vivo corneal deswelling after hypoxic contact lens wear, based on a damped harmonic oscillator, which can describe an overshoot in corneal deswelling, to compare this new model with the currently used exponential model, and also to test whether a diurnal variation in baseline corneal thickness exists that would have to be taken into consideration when calculating corneal deswelling curves., Methods: In nine healthy young adults, corneal thickness was measured every 30 minutes for 11.5 hours on average using modified optical pachometry (natural test). On another day, corneal deswelling was monitored for 11.1 hours on average after 2 hours of hypoxic contact lens wear (stress test). The damped harmonic oscillator model and the exponential model were used to calculate best-fitting deswelling curves. Natural test data were analyzed for the presence of a trend. Goodness of fit of the curves to the experimental data was analyzed using the F test., Results: In 82% of the deswelling curves the new damped harmonic oscillator model provided a better fit to the data than the exponential model (P < 0.05). An average overshoot in corneal thickness recovery of 5 microm (range, 0-11 microm) was found. In 50% of the natural tests significant trends were found, without any consistent similarities. The overshoot could not be explained by these trends., Conclusions: The new damped harmonic oscillator model describes corneal deswelling after hypoxic contact lens wear more accurately than the exponential model. No consistent diurnal variation could be demonstrated.
- Published
- 1999
23. Morphology and function of the corneal endothelium after long-term contact lens wear.
- Author
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Nieuwendaal CP, Odenthal MT, Kok JH, Venema HW, Oosting J, Riemslag FC, and Kijlstra A
- Subjects
- Adult, Body Water metabolism, Contact Lenses, Hydrophilic statistics & numerical data, Cornea pathology, Female, Humans, Longitudinal Studies, Male, Middle Aged, Photography, Contact Lenses, Hydrophilic adverse effects, Endothelium, Corneal pathology, Endothelium, Corneal physiopathology
- Abstract
Purpose: To examine whether corneal hydration control is impaired in corneas with endothelial morphologic changes (increased variation in cell size and cell angularity) due to long-term low gas-permeable contact lens wear., Methods: Twenty-one long-term wearers of low gas-permeable contact lenses (mean age, 41 years +/- 8 SD) and 18 age-matched controls (mean age, 42 years +/- 8 SD) were studied. To assess endothelial morphology, endothelial photographs were taken, enlarged 400X, scanned into a computer, and evaluated. Hydration control was assessed by a corneal stress test. Corneal swelling was induced by applying low gas-permeable soft contact lenses for 2 hours during eye closure. After the lenses were removed, the rate of deswelling was determined using optic pachometry., Results: Morphologic analysis of the endothelial photographs showed a significant increase of polymegethism (P < 0.01) and pleomorphism (P < 0.01) in the group wearing contact lenses compared with the control group. The percentage of recovery of corneal thickness per hour (PRPH) from induced swelling proved to be significantly lower (P = 0.03) and the induced swelling proved to be significantly lower (P < 0.01) in the group wearing contact lenses than in the control group. Multiple regression analysis showed that the PRPH decreased as the morphologic alterations increased. However, this trend appeared not to be significant at the 5% level. A significant relationship was found between morphologic parameters and induced swelling, indicating that induced swelling decreased as the morphologic alterations increased., Conclusion: The results of this study indicate that increased endothelial polymegethism and pleomorphism may be accompanied by a decreased corneal hydration control in people who wear contact lenses.
- Published
- 1994
24. Polymegethism of the corneal endothelium in an eye with long-standing ptosis.
- Author
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Kok JH, Dunnebier EA, Nieuwendaal CP, and Kijlstra A
- Subjects
- Adult, Aged, Aged, 80 and over, Cell Count, Endothelium, Corneal pathology, Female, Humans, Image Processing, Computer-Assisted, Ulcer, Blepharoptosis complications, Corneal Diseases etiology
- Published
- 1992
- Full Text
- View/download PDF
25. Corneal endothelial cell morphology under permanent wear of rigid contact lenses.
- Author
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Nieuwendaal CP, Kok JH, de Moor EA, Oosting J, and Venema HW
- Subjects
- Adolescent, Adult, Cell Count, Humans, Image Processing, Computer-Assisted, Methylmethacrylates, Microscopy, Photography, Prosthesis Design, Contact Lenses, Endothelium, Corneal cytology
- Abstract
The influence of the permanent wear of rigid high Dk-lenses (nominal Dk 71 or 92) with elliptical geometry on the corneal endothelium was assessed. For this purpose the endothelium of 16 patients was compared by specular microscopy before and after the permanent wear. The wearing time of the lenses varied between 7 and 24 months. Computerized morphometric analysis of the photographs revealed that the variability in cell size (polymegathism) and in cell shape (pleomorphism) did not change during the wearing period. It is suggested that this is due to the high gas-permeability and the elliptical geometry of the contact lenses.
- Published
- 1991
- Full Text
- View/download PDF
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