14 results on '"Nietsch, Rouven"'
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2. Genomic structural variations lead to dysregulation of important coding and non‐coding RNA species in dilated cardiomyopathy
- Author
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Haas, Jan, Mester, Stefan, Lai, Alan, Frese, Karen S, Sedaghat‐Hamedani, Farbod, Kayvanpour, Elham, Rausch, Tobias, Nietsch, Rouven, Boeckel, Jes‐Niels, Carstensen, Avisha, Völkers, Mirko, Dietrich, Carsten, Pils, Dietmar, Amr, Ali, Holzer, Daniel B, Martins Bordalo, Diana, Oehler, Daniel, Weis, Tanja, Mereles, Derliz, Buss, Sebastian, Riechert, Eva, Wirsz, Emil, Wuerstle, Maximilian, Korbel, Jan O, Keller, Andreas, Katus, Hugo A, Posch, Andreas E, and Meder, Benjamin
- Published
- 2018
- Full Text
- View/download PDF
3. Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure
- Author
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Meder, Benjamin, Haas, Jan, Sedaghat-Hamedani, Farbod, Kayvanpour, Elham, Frese, Karen, Lai, Alan, Nietsch, Rouven, Scheiner, Christina, Mester, Stefan, Bordalo, Diana Martins, Amr, Ali, Dietrich, Carsten, Pils, Dietmar, Siede, Dominik, Hund, Hauke, Bauer, Andrea, Holzer, Daniel Benjamin, Ruhparwar, Arjang, Mueller-Hennessen, Matthias, Weichenhan, Dieter, Plass, Christoph, Weis, Tanja, Backs, Johannes, Wuerstle, Maximilian, Keller, Andreas, Katus, Hugo A., and Posch, Andreas E.
- Published
- 2017
- Full Text
- View/download PDF
4. Marathon-Induced Cardiac Strain as Model for the Evaluation of Diagnostic microRNAs for Acute Myocardial Infarction
- Author
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Shirvani Samani, Omid, primary, Scherr, Johannes, additional, Kayvanpour, Elham, additional, Haas, Jan, additional, Lehmann, David H., additional, Gi, Weng-Tein, additional, Frese, Karen S., additional, Nietsch, Rouven, additional, Fehlmann, Tobias, additional, Sandke, Steffi, additional, Weis, Tanja, additional, Keller, Andreas, additional, Katus, Hugo A., additional, Halle, Martin, additional, Frey, Norbert, additional, Meder, Benjamin, additional, and Sedaghat-Hamedani, Farbod, additional
- Published
- 2021
- Full Text
- View/download PDF
5. Atlas of the clinical genetics of human dilated cardiomyopathy
- Author
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Haas, Jan, Frese, Karen S., Peil, Barbara, Kloos, Wanda, Keller, Andreas, Nietsch, Rouven, Feng, Zhu, Müller, Sabine, Kayvanpour, Elham, Vogel, Britta, Sedaghat-Hamedani, Farbod, Lim, Wei-Keat, Zhao, Xiaohong, Fradkin, Dmitriy, Köhler, Doreen, Fischer, Simon, Franke, Jennifer, Marquart, Sabine, Barb, Ioana, Li, Daniel Tian, Amr, Ali, Ehlermann, Philipp, Mereles, Derliz, Weis, Tanja, Hassel, Sarah, Kremer, Andreas, King, Vanessa, Wirsz, Emil, Isnard, Richard, Komajda, Michel, Serio, Alessandra, Grasso, Maurizia, Syrris, Petros, Wicks, Eleanor, Plagnol, Vincent, Lopes, Luis, Gadgaard, Tenna, Eiskjær, Hans, Jørgensen, Mads, Garcia-Giustiniani, Diego, Ortiz-Genga, Martin, Crespo-Leiro, Maria G., Deprez, Rondal H. Lekanne Dit, Christiaans, Imke, van Rijsingen, Ingrid A., Wilde, Arthur A., Waldenstrom, Anders, Bolognesi, Martino, Bellazzi, Riccardo, Mörner, Stellan, Bermejo, Justo Lorenzo, Monserrat, Lorenzo, Villard, Eric, Mogensen, Jens, Pinto, Yigal M., Charron, Philippe, Elliott, Perry, Arbustini, Eloisa, Katus, Hugo A., and Meder, Benjamin
- Published
- 2015
- Full Text
- View/download PDF
6. Alterations in cardiac DNA methylation in human dilated cardiomyopathy
- Author
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Haas, Jan, Frese, Karen S., Park, Yoon Jung, Keller, Andreas, Vogel, Britta, Lindroth, Anders M., Weichenhan, Dieter, Franke, Jennifer, Fischer, Simon, Bauer, Andrea, Marquart, Sabine, Sedaghat‐Hamedani, Farbod, Kayvanpour, Elham, Köhler, Doreen, Wolf, Nadine M., Hassel, Sarah, Nietsch, Rouven, Wieland, Thomas, Ehlermann, Philipp, Schultz, Jobst‐Hendrik, Dösch, Andreas, Mereles, Derliz, Hardt, Stefan, Backs, Johannes, Hoheisel, Jörg D., Plass, Christoph, Katus, Hugo A., and Meder, Benjamin
- Published
- 2013
- Full Text
- View/download PDF
7. Marathon-Induced Cardiac Strain as Model for the Evaluation of Diagnostic microRNAs for Acute Myocardial Infarction
- Author
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Shirvani Samani, Omid, Scherr, Johannes; https://orcid.org/0000-0001-9948-1024, Kayvanpour, Elham; https://orcid.org/0000-0001-7285-2825, Haas, Jan, Lehmann, David H, Gi, Weng-Tein, Frese, Karen S; https://orcid.org/0000-0003-1822-8559, Nietsch, Rouven, Fehlmann, Tobias, Sandke, Steffi, Weis, Tanja, Keller, Andreas; https://orcid.org/0000-0002-5361-0895, Katus, Hugo A, Halle, Martin, Frey, Norbert, Meder, Benjamin, Sedaghat-Hamedani, Farbod; https://orcid.org/0000-0002-3266-0527, Shirvani Samani, Omid, Scherr, Johannes; https://orcid.org/0000-0001-9948-1024, Kayvanpour, Elham; https://orcid.org/0000-0001-7285-2825, Haas, Jan, Lehmann, David H, Gi, Weng-Tein, Frese, Karen S; https://orcid.org/0000-0003-1822-8559, Nietsch, Rouven, Fehlmann, Tobias, Sandke, Steffi, Weis, Tanja, Keller, Andreas; https://orcid.org/0000-0002-5361-0895, Katus, Hugo A, Halle, Martin, Frey, Norbert, Meder, Benjamin, and Sedaghat-Hamedani, Farbod; https://orcid.org/0000-0002-3266-0527
- Abstract
Background: The current gold standard biomarker for myocardial infarction (MI), cardiac troponin (cTn), is recognized for its high sensitivity and organ specificity; however, it lacks diagnostic specificity. Numerous studies have introduced circulating microRNAs as potential biomarkers for MI. This study investigates the MI-specificity of these serum microRNAs by investigating myocardial stress/injury due to strenuous exercise. Methods: MicroRNA biomarkers were retrieved by comprehensive review of 109 publications on diagnostic serum microRNAs for MI. MicroRNA levels were first measured by next-generation sequencing in pooled sera from runners (n = 46) before and after conducting a full competitive marathon. Hereafter, reverse transcription quantitative real-time PCR (qPCR) of 10 selected serum microRNAs in 210 marathon runners was performed (>10,000 qPCR measurements). Results: 27 potential diagnostic microRNA for MI were retrieved by the literature review. Eight microRNAs (miR-1-3p, miR-21-5p, miR-26a-5p, miR-122-5p, miR-133a-3p, miR-142-5p, miR-191-5p, miR-486-3p) showed positive correlations with cTnT in marathon runners, whereas two miRNAs (miR-134-5p and miR-499a-5p) showed no correlations. Upregulation of miR-133a-3p (p = 0.03) and miR-142-5p (p = 0.01) went along with elevated cTnT after marathon. Conclusion: Some MI-associated microRNAs (e.g., miR-133a-3p and miR-142-5p) have similar kinetics under strenuous exercise and MI as compared to cTnT, which suggests that their diagnostic specificity could be limited. In contrast, several MI-associated microRNAs (miR-26a-5p, miR-134-5p, miR-191-5p) showed different release behavior; hence, combining cTnT with these microRNAs within a multi-marker strategy may add diagnostic accuracy in MI.
- Published
- 2021
8. Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy
- Author
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Haas, Jan, primary, Frese, Karen S., additional, Sedaghat-Hamedani, Farbod, additional, Kayvanpour, Elham, additional, Tappu, Rewati, additional, Nietsch, Rouven, additional, Tugrul, Oguz Firat, additional, Wisdom, Michael, additional, Dietrich, Carsten, additional, Amr, Ali, additional, Weis, Tanja, additional, Niederdränk, Torsten, additional, Murphy, Michael P., additional, Krieg, Thomas, additional, Dörr, Marcus, additional, Völker, Uwe, additional, Fielitz, Jens, additional, Frey, Norbert, additional, Felix, Stephan B., additional, Keller, Andreas, additional, Katus, Hugo A., additional, and Meder, Benjamin, additional
- Published
- 2021
- Full Text
- View/download PDF
9. Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue
- Author
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Jakobi, Tobias, primary, Siede, Dominik, additional, Eschenbach, Jessica, additional, Heumüller, Andreas W., additional, Busch, Martin, additional, Nietsch, Rouven, additional, Meder, Benjamin, additional, Most, Patrick, additional, Dimmeler, Stefanie, additional, Backs, Johannes, additional, Katus, Hugo A., additional, and Dieterich, Christoph, additional
- Published
- 2020
- Full Text
- View/download PDF
10. Genomic structural variations lead to dysregulation of important coding and non‐coding RNA species in dilated cardiomyopathy
- Author
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Haas, Jan, primary, Mester, Stefan, additional, Lai, Alan, additional, Frese, Karen S, additional, Sedaghat‐Hamedani, Farbod, additional, Kayvanpour, Elham, additional, Rausch, Tobias, additional, Nietsch, Rouven, additional, Boeckel, Jes‐Niels, additional, Carstensen, Avisha, additional, Völkers, Mirko, additional, Dietrich, Carsten, additional, Pils, Dietmar, additional, Amr, Ali, additional, Holzer, Daniel B, additional, Martins Bordalo, Diana, additional, Oehler, Daniel, additional, Weis, Tanja, additional, Mereles, Derliz, additional, Buss, Sebastian, additional, Riechert, Eva, additional, Wirsz, Emil, additional, Wuerstle, Maximilian, additional, Korbel, Jan O, additional, Keller, Andreas, additional, Katus, Hugo A, additional, Posch, Andreas E, additional, and Meder, Benjamin, additional
- Published
- 2017
- Full Text
- View/download PDF
11. The Role of Quality Control in Targeted Next-generation Sequencing Library Preparation
- Author
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Nietsch, Rouven, primary, Haas, Jan, additional, Lai, Alan, additional, Oehler, Daniel, additional, Mester, Stefan, additional, Frese, Karen S., additional, Sedaghat-Hamedani, Farbod, additional, Kayvanpour, Elham, additional, Keller, Andreas, additional, and Meder, Benjamin, additional
- Published
- 2016
- Full Text
- View/download PDF
12. Atlas of the clinical genetics of human dilated cardiomyopathy
- Author
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Haas, Jan, Frese, Karen S., Peil, Barbara, Kloos, Wanda, Keller, Andreas, Nietsch, Rouven, Feng, Zhu, Müller, Sabine, Kayvanpour, Elham, Vogel, Britta, Sedaghat-Hamedani, Farbod, Lim, Wie-Keat, Zhao, Xiaohong, Fradkin, Dmitriy, Köhler, Doreen, Fischer, Simon, Franke, Jennifer, Marquart, Sabine, Barb, Ioana, Li, Daniel Tian, Amr, Ali, Ehlermann, Philipp, Mereles, Derliz, Weis, Tanja, Hassel, Sarah, Kremer, Andreas, King, Vanessa, Wirsz, Emil, Isnard, Richard, Komajda, Michel, Serio, Alessandra, Grasso, Maurizia, Syrris, Petros, Wicks, Eleanor, Plagnol, Vincent, Lopes, Luis, Gadgaard, Tenna, Eiskjaer, Hans, Jorgensen, Mads, García-Giustiniani, Diego, Ortiz-Genga, Martín, Crespo-Leiro, María Generosa, Deprez, Rondal H. Lekanne Dit, Christiaans, Imke, Rijsingen, Ingrid A. van, Wilde, Arthur A., Waldenstrom, Anders, Bolognesi, Martino, Bellazzi, Riccardo, Mörner, Stellan, Lorenzo Bermejo, Justo, Monserrat, Lorenzo, Villard, Eric, Mogensen, Jens, Pinto, Yigal M., Charron, Philippe, Elliott, Perry, Arbustini, Eloisa, Katus, Hugo A., Meder, Benjamin, Haas, Jan, Frese, Karen S., Peil, Barbara, Kloos, Wanda, Keller, Andreas, Nietsch, Rouven, Feng, Zhu, Müller, Sabine, Kayvanpour, Elham, Vogel, Britta, Sedaghat-Hamedani, Farbod, Lim, Wie-Keat, Zhao, Xiaohong, Fradkin, Dmitriy, Köhler, Doreen, Fischer, Simon, Franke, Jennifer, Marquart, Sabine, Barb, Ioana, Li, Daniel Tian, Amr, Ali, Ehlermann, Philipp, Mereles, Derliz, Weis, Tanja, Hassel, Sarah, Kremer, Andreas, King, Vanessa, Wirsz, Emil, Isnard, Richard, Komajda, Michel, Serio, Alessandra, Grasso, Maurizia, Syrris, Petros, Wicks, Eleanor, Plagnol, Vincent, Lopes, Luis, Gadgaard, Tenna, Eiskjaer, Hans, Jorgensen, Mads, García-Giustiniani, Diego, Ortiz-Genga, Martín, Crespo-Leiro, María Generosa, Deprez, Rondal H. Lekanne Dit, Christiaans, Imke, Rijsingen, Ingrid A. van, Wilde, Arthur A., Waldenstrom, Anders, Bolognesi, Martino, Bellazzi, Riccardo, Mörner, Stellan, Lorenzo Bermejo, Justo, Monserrat, Lorenzo, Villard, Eric, Mogensen, Jens, Pinto, Yigal M., Charron, Philippe, Elliott, Perry, Arbustini, Eloisa, Katus, Hugo A., and Meder, Benjamin
- Abstract
[Abstract] Aim. Numerous genes are known to cause dilated cardiomyopathy (DCM). However, until now technological limitations have hindered elucidation of the contribution of all clinically relevant disease genes to DCM phenotypes in larger cohorts. We now utilized next-generation sequencing to overcome these limitations and screened all DCM disease genes in a large cohort. Methods and results. In this multi-centre, multi-national study, we have enrolled 639 patients with sporadic or familial DCM. To all samples, we applied a standardized protocol for ultra-high coverage next-generation sequencing of 84 genes, leading to 99.1% coverage of the target region with at least 50-fold and a mean read depth of 2415. In this well characterized cohort, we find the highest number of known cardiomyopathy mutations in plakophilin-2, myosin-binding protein C-3, and desmoplakin. When we include yet unknown but predicted disease variants, we find titin, plakophilin-2, myosin-binding protein-C 3, desmoplakin, ryanodine receptor 2, desmocollin-2, desmoglein-2, and SCN5A variants among the most commonly mutated genes. The overlap between DCM, hypertrophic cardiomyopathy (HCM), and channelopathy causing mutations is considerably high. Of note, we find that >38% of patients have compound or combined mutations and 12.8% have three or even more mutations. When comparing patients recruited in the eight participating European countries we find remarkably little differences in mutation frequencies and affected genes. Conclusion. This is to our knowledge, the first study that comprehensively investigated the genetics of DCM in a large-scale cohort and across a broad gene panel of the known DCM genes. Our results underline the high analytical quality and feasibility of Next-Generation Sequencing in clinical genetic diagnostics and provide a sound database of the genetic causes of DCM.
- Published
- 2014
13. Atlas of the clinical genetics of human dilated cardiomyopathy
- Author
-
Haas, Jan, primary, Frese, Karen S., additional, Peil, Barbara, additional, Kloos, Wanda, additional, Keller, Andreas, additional, Nietsch, Rouven, additional, Feng, Zhu, additional, Müller, Sabine, additional, Kayvanpour, Elham, additional, Vogel, Britta, additional, Sedaghat-Hamedani, Farbod, additional, Lim, Wei-Keat, additional, Zhao, Xiaohong, additional, Fradkin, Dmitriy, additional, Köhler, Doreen, additional, Fischer, Simon, additional, Franke, Jennifer, additional, Marquart, Sabine, additional, Barb, Ioana, additional, Li, Daniel Tian, additional, Amr, Ali, additional, Ehlermann, Philipp, additional, Mereles, Derliz, additional, Weis, Tanja, additional, Hassel, Sarah, additional, Kremer, Andreas, additional, King, Vanessa, additional, Wirsz, Emil, additional, Isnard, Richard, additional, Komajda, Michel, additional, Serio, Alessandra, additional, Grasso, Maurizia, additional, Syrris, Petros, additional, Wicks, Eleanor, additional, Plagnol, Vincent, additional, Lopes, Luis, additional, Gadgaard, Tenna, additional, Eiskjær, Hans, additional, Jørgensen, Mads, additional, Garcia-Giustiniani, Diego, additional, Ortiz-Genga, Martin, additional, Crespo-Leiro, Maria G., additional, Deprez, Rondal H. Lekanne Dit, additional, Christiaans, Imke, additional, van Rijsingen, Ingrid A., additional, Wilde, Arthur A., additional, Waldenstrom, Anders, additional, Bolognesi, Martino, additional, Bellazzi, Riccardo, additional, Mörner, Stellan, additional, Bermejo, Justo Lorenzo, additional, Monserrat, Lorenzo, additional, Villard, Eric, additional, Mogensen, Jens, additional, Pinto, Yigal M., additional, Charron, Philippe, additional, Elliott, Perry, additional, Arbustini, Eloisa, additional, Katus, Hugo A., additional, and Meder, Benjamin, additional
- Published
- 2014
- Full Text
- View/download PDF
14. Marathon-Induced Cardiac Strain as Model for the Evaluation of Diagnostic microRNAs for Acute Myocardial Infarction.
- Author
-
Shirvani Samani, Omid, Scherr, Johannes, Kayvanpour, Elham, Haas, Jan, Lehmann, David H., Gi, Weng-Tein, Frese, Karen S., Nietsch, Rouven, Fehlmann, Tobias, Sandke, Steffi, Weis, Tanja, Keller, Andreas, Katus, Hugo A., Halle, Martin, Frey, Norbert, Meder, Benjamin, and Sedaghat-Hamedani, Farbod
- Subjects
MYOCARDIAL infarction ,MICRORNA ,NUCLEOTIDE sequencing - Abstract
Background: The current gold standard biomarker for myocardial infarction (MI), cardiac troponin (cTn), is recognized for its high sensitivity and organ specificity; however, it lacks diagnostic specificity. Numerous studies have introduced circulating microRNAs as potential biomarkers for MI. This study investigates the MI-specificity of these serum microRNAs by investigating myocardial stress/injury due to strenuous exercise. Methods: MicroRNA biomarkers were retrieved by comprehensive review of 109 publications on diagnostic serum microRNAs for MI. MicroRNA levels were first measured by next-generation sequencing in pooled sera from runners (n = 46) before and after conducting a full competitive marathon. Hereafter, reverse transcription quantitative real-time PCR (qPCR) of 10 selected serum microRNAs in 210 marathon runners was performed (>10,000 qPCR measurements). Results: 27 potential diagnostic microRNA for MI were retrieved by the literature review. Eight microRNAs (miR-1-3p, miR-21-5p, miR-26a-5p, miR-122-5p, miR-133a-3p, miR-142-5p, miR-191-5p, miR-486-3p) showed positive correlations with cTnT in marathon runners, whereas two miRNAs (miR-134-5p and miR-499a-5p) showed no correlations. Upregulation of miR-133a-3p (p = 0.03) and miR-142-5p (p = 0.01) went along with elevated cTnT after marathon. Conclusion: Some MI-associated microRNAs (e.g., miR-133a-3p and miR-142-5p) have similar kinetics under strenuous exercise and MI as compared to cTnT, which suggests that their diagnostic specificity could be limited. In contrast, several MI-associated microRNAs (miR-26a-5p, miR-134-5p, miR-191-5p) showed different release behavior; hence, combining cTnT with these microRNAs within a multi-marker strategy may add diagnostic accuracy in MI. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
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