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Physical work reduce insulinmia after glucose load, plasma cholesterol and triglycerides by intact rat at normal diet or diet enriched with sucrose, or beef fat, or both. By the male rat at normal diet or enriched with sucrose + beef fat castration increase insulin secretion. -1) Glycemia by those at work with diet rich in sucrose with or without beef fat, -2) Oestrogens increase triglyceridemia by castrated at diet rich in sucrose or beef fat but physical work suppress those increase. By the female at normal diet or enriched with sucrose and at recastration increase insulinemia after glucose load; castration increase insulinemia by female at work with diet enriched with beef fat or beef fat + sucrose. Castration increase the fall of triglyceridemia at work except by those at diet enriched with sucrose and those receiving testosterone and at diet enriched with sucrose + beef fat.

Neo natal androgenisation of the female rat provoke at 3 months : 1) an accentuation of the insulin secretion at the glucose loading with the diet rich in saturated fat an a reduction with the diet rich in sucrose or rapesced oil; 2) Hypercholesterolemia with all the diets and 3) hypertriglyceridemia with diet rich in saturated fat or sucrose. Neo natal oestrogenisation of the male rata provoke at 3 months : 1) a reduction of the insulin secretion at the glucose loading with all the diets 2) hypercholesterolemia with the diet rich in saturated fats 3) hypertriglyceridemia with diets rich in M.C.T. or sucrose.

In the male rat a diet rich in beef fat facilitates the occurrence of hyperinsulinemia after a glucose load whereas fats rich in linoleic acid produce no such effect. The combination of saturated fat and saccharose facilitates the occurrence of hypertriglyceridemia in the male rat, no such effect is produced by the combination of fats rich in linoleic acid and saccharose. Linoleic acid prevents natrium chloride from provoking hypertriglyceridemia in male and in female rats subjected to a diet enriched in saccharose and fat. Estrogen-induced hypertriglyceridemia in castrated animals is strongly inhibited if the diet is rich in linoleic acid. Physical effort can prevent saccharose combined with saturated fats from inducing hypertriglyceridemia.

In the male rat, sorbitol, beef fat nor M.C.T. in the diet provoke hypertriglyceridemia but the association sorbitol-beef fat and sorbitol-M.C.T. significantly rise the triglyceridemia and the cholesterolemia. In the castrated male rat estrogens provoke a considerable rise of the triglyceridemia and the cholesterolemia with the diet enriched in M.C.T. but not modify the hypertriglyceridemia and the hypercholesterolemia provoked with the diet enriched with the association sorbitol-T.C.M.

Rats are fed during one month with normal diet or diet enriched with 25% of many fats. It is no change of the hyperglycemia curve with the addition of 25% sucrose to these diets but 1 degree by male on the normal diet or on the diet enriched with corn oil the insulin discharge is higher; it is no change with the diet enriched with beef fat or with M.C.T. 2 degrees by the female the insulin discharge is higher with all the diets.