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The article discusses a study on the role of CD40/CD40L interaction and the ADAM8 in regulation normal and immune-inflammatory responses. It refers to CD 40 as a type 1 trans-membrane glyco-protein receptor and member of the tumor necrosis factor (TNF) receptor family while ADAM8 is a trans-membrane protein implicated in the processing/shedding of some growth factors. Women of reproductive age having laparoscopy between January 2006 and November 2006 at the Second Department of Obstetrics and Gynecology of the University of Athens, Aretaieion Hospital, Greece were named for inclusion in the study. The study showed that neither the CD40-CD40L nor the ADAM8 levels appeared to be higher among endometriotic women.

Two aristolochic acids [2 and 3] and a flavonol glycoside 1 have been isolated from Aristolochia rigida (Aristolochiaceae). Aristolochic acid IV [2], the most abundant constituent, has shown a weak direct mutagenic activity in the Ames test: this action seems to be inhibited, at least in part, by metabolic reactions.