1. RESULTS OF LONG-TERM THERAPY WITH GROWTH-HORMONE IN 2 DOSE REGIMENS IN TURNER SYNDROME
- Author
-
NIENHUIS, HE, RONGENWESTERLAKEN, C, WIT, JM, OTTEN, BJ, KEIZERSCHRAMA, SMPFD, DRAYER, NM, DELEMARREVANDEWAAL, HA, VULSMA, T, OOSTDIJK, W, and WAELKENS, JJJ
- Subjects
ADULT HEIGHT ,TURNER SYNDROME ,DEFICIENT CHILDREN ,HGH ,INJECTION FREQUENCY ,GIRLS ,HEIGHT VELOCITY ,GROWTH HORMONE DOSE ,BONE AGE ,WEEKLY IM - Abstract
Girls with Turner syndrome were divided according to age (group A 6-12 years, and group B 12-19 years) and human growth hormone (GH) dose regimen (A1 and B1, three injections/week; A2 and B2, six injections/week). All groups responded to GH, 24 IU/M2/week, with an increase in height velocity, though in the older girls, the response was comparatively poor. Therefore, the dose regimens in groups B1 and B2 were increased to 36 IU/M2/week given as six injections in both groups. This change resulted in an increase in height velocity only in group B1. During the first 2 years only, the height velocity was greater in group A2 than group A1. The conclusion is that a regimen of six injections/week is more effective than one of three injections/week in terms of initial height gain and change in predicted adult height. In girls with Turner syndrome aged over 16 years, GH therapy has no significant effect.
- Published
- 1993