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8 results on '"Nielsen, Susan Mary"'

1. M-ficolin : a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis

Author

Brix, Ninna, Glerup, Mia, Thiel, Steffen, Mistegaard, Clara Elbaek, Skals, Regitze Gyldenholm, Berntson, Lillemor, Fasth, Anders, Nielsen, Susan Mary, Nordal, Ellen, Rygg, Marite, Hasle, Henrik, Albertsen, Birgitte Klug, Herlin, Troels, Brix, Ninna, Glerup, Mia, Thiel, Steffen, Mistegaard, Clara Elbaek, Skals, Regitze Gyldenholm, Berntson, Lillemor, Fasth, Anders, Nielsen, Susan Mary, Nordal, Ellen, Rygg, Marite, Hasle, Henrik, Albertsen, Birgitte Klug, and Herlin, Troels

Abstract

Objective: Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALL arthropathy) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of leukaemia may be vague. The primary aim was to examine the use of lectin complement pathway proteins as markers to differentiate ALL arthropathy from JIA. The secondary aims were to compare the protein levels at baseline and follow-up in a paired number of children with ALL and to examine the correlation with haematology counts, erythrocyte sedimentation reaction (ESR), C-reactive protein (CRP), blasts, relapse and death. Study design: In this observational study, we measured M-ficolin, CL-K1 and MASP-3 in serum from children with ALL (n=151) and JIA (n=238) by time-resolved immunofluorometric assays. Logistic regression was used for predictions of ALL risk, considering the markers as the respective exposures. We performed internal validation using repeated '10-fold cross-validation' with 100 repetitions computing the area under the curve (AUC) as well as positive and negative predictive values in order to evaluate the predictive performance. Results: The level of M-ficolin was higher in JIA than ALL total and the ALL arthropathy subgroup. The M-ficolin level normalised after remission of ALL. M-ficolin could differentiate ALL from JIA with an AUC of 94% and positive predictive value (PPV) of 95%, exceeding CRP and haemoglobin. In a dichotomised predictive model with optimal cut-offs for M-ficolin, platelets and haemoglobin, AUC was 99% and PPV 98% in detecting ALL from JIA. Conclusion: M-ficolin is a valuable marker to differentiate the child with ALL from JIA.

Published
2022
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2. M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis

Author

Brix, Ninna, primary, Glerup, Mia, additional, Thiel, Steffen, additional, Mistegaard, Clara Elbæk, additional, Skals, Regitze Gyldenholm, additional, Berntson, Lillemor, additional, Fasth, Anders, additional, Nielsen, Susan Mary, additional, Nordal, Ellen, additional, Rygg, Marite, additional, Hasle, Henrik, additional, Albertsen, Birgitte Klug, additional, and Herlin, Troels, additional

Published
2021
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3. Update from the Juvenile Scleroderma Inception Cohort

Author

Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Torok, Kathryn S., Stanevicha, Valda, Sztajnbok, Flavio, Terreri, Maria Teresa, Alexeeva, Ekaterina, Anton, Jordi, Katsicas, Maria M., Smith, Vanessa, Avcin, Tadey, Cimaz, Rolando, Kostik, Mikhail, Lehman, Thomas J. A., Sifuentes-Giraldo, Walter A., Appenzeller, Simone, Janarthanan, Mahesh, Nemkova, Dana, Santos, Maria Jose, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Brunner, Juergen, Reis, Patricia Costa, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Kallinich, Tilmann, Lazarevic, Dragana, Minden, Kirsten, Nielsen, Susan Mary, Uziel, Yosef, Helmus, Nicola, Foeldvari, Ivan, Klotsche, Jens, Kasapcopur, Ozgur, Adrovic, Amra, Torok, Kathryn S., Stanevicha, Valda, Sztajnbok, Flavio, Terreri, Maria Teresa, Alexeeva, Ekaterina, Anton, Jordi, Katsicas, Maria M., Smith, Vanessa, Avcin, Tadey, Cimaz, Rolando, Kostik, Mikhail, Lehman, Thomas J. A., Sifuentes-Giraldo, Walter A., Appenzeller, Simone, Janarthanan, Mahesh, Nemkova, Dana, Santos, Maria Jose, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Brunner, Juergen, Reis, Patricia Costa, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Kallinich, Tilmann, Lazarevic, Dragana, Minden, Kirsten, Nielsen, Susan Mary, Uziel, Yosef, and Helmus, Nicola

Published
2018

4. The Paediatric Rheumatology International Trials Organisation provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis

Author

Ruperto, Nicolino, Pistorio, Angela, Ravelli, Angelo, Rider, Lisa G, Pilkington, Clarissa, Oliveira, Sheila, Wulffraat, Nico, Espada, Graciela, Garay, Stella, Cuttica, Ruben, Hofer, Michael, Quartier, Pierre, Melo-Gomes, Jose, Reed, Ann M, Wierzbowska, Malgorzata, Feldman, Brian M, Harjacek, Miroslav, Huppertz, Hans-Iko, Nielsen, Susan Mary, Flato, Berit, Lahdenne, Pekka, Michels, Harmut, Murray, Kevin J, Punaro, Lynn, Rennebohm, Robert, Russo, Ricardo, Balogh, Zsolt, Rooney, Madeleine, Pachman, Lauren M, Wallace, Carol, Hashkes, Philip, Lovell, Daniel J, Giannini, Edward H, Gare, Boel Andersson, Martini, Alberto, Ruperto, Nicolino, Pistorio, Angela, Ravelli, Angelo, Rider, Lisa G, Pilkington, Clarissa, Oliveira, Sheila, Wulffraat, Nico, Espada, Graciela, Garay, Stella, Cuttica, Ruben, Hofer, Michael, Quartier, Pierre, Melo-Gomes, Jose, Reed, Ann M, Wierzbowska, Malgorzata, Feldman, Brian M, Harjacek, Miroslav, Huppertz, Hans-Iko, Nielsen, Susan Mary, Flato, Berit, Lahdenne, Pekka, Michels, Harmut, Murray, Kevin J, Punaro, Lynn, Rennebohm, Robert, Russo, Ricardo, Balogh, Zsolt, Rooney, Madeleine, Pachman, Lauren M, Wallace, Carol, Hashkes, Philip, Lovell, Daniel J, Giannini, Edward H, Gare, Boel Andersson, and Martini, Alberto

Abstract

To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables.

Published
2010

5. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria

Author

Ozen, Seza, Pistorio, Angela, Iusan, Silvia M, Bakkaloglu, Aysin, Herlin, Troels, Brik, Riva, Buoncompagni, Antonella, Lazar, Calin, Bilge, Ilmay, Uziel, Yosef, Rigante, Donato, Cantarini, Luca, Hilario, Maria Odete, Silva, Clovis A, Alegria, Mauricio, Norambuena, Ximena, Belot, Alexandre, Berkun, Yackov, Estrella, Amparo Ibanez, Olivieri, Alma Nunzia, Alpigiani, Maria Giannina, Rumba, Ingrida, Sztajnbok, Flavio, Tambic-Bukovac, Lana, Breda, Luciana, Al-Mayouf, Sulaiman, Mihaylova, Dimitrina, Chasnyk, Vyacheslav, Sengler, Claudia, Klein-Gitelman, Maria, Djeddi, Djamal, Nuno, Laura, Pruunsild, Chris, Brunner, Jurgen, Kondi, Anuela, Pagava, Karaman, Pederzoli, Silvia, Martini, Alberto, Ruperto, Nicolino, Nielsen, Susan Mary, Ozen, Seza, Pistorio, Angela, Iusan, Silvia M, Bakkaloglu, Aysin, Herlin, Troels, Brik, Riva, Buoncompagni, Antonella, Lazar, Calin, Bilge, Ilmay, Uziel, Yosef, Rigante, Donato, Cantarini, Luca, Hilario, Maria Odete, Silva, Clovis A, Alegria, Mauricio, Norambuena, Ximena, Belot, Alexandre, Berkun, Yackov, Estrella, Amparo Ibanez, Olivieri, Alma Nunzia, Alpigiani, Maria Giannina, Rumba, Ingrida, Sztajnbok, Flavio, Tambic-Bukovac, Lana, Breda, Luciana, Al-Mayouf, Sulaiman, Mihaylova, Dimitrina, Chasnyk, Vyacheslav, Sengler, Claudia, Klein-Gitelman, Maria, Djeddi, Djamal, Nuno, Laura, Pruunsild, Chris, Brunner, Jurgen, Kondi, Anuela, Pagava, Karaman, Pederzoli, Silvia, Martini, Alberto, Ruperto, Nicolino, and Nielsen, Susan Mary

Abstract

To validate the previously proposed classification criteria for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA).

Published
2010

6. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation

Author

Ruperto, Nicolino, Ozen, Seza, Pistorio, Angela, Dolezalova, Pavla, Brogan, Paul, Cabral, David A, Cuttica, Ruben, Khubchandani, Raju, Lovell, Daniel J, O'Neil, Kathleen M, Quartier, Pierre, Ravelli, Angelo, Iusan, Silvia M, Filocamo, Giovanni, Magalhães, Claudia Saad, Unsal, Erbil, Oliveira, Sheila, Bracaglia, Claudia, Bagga, Arvind, Stanevicha, Valda, Manzoni, Silvia Magni, Pratsidou, Polyxeni, Lepore, Loredana, Espada, Graciela, Kone-Paut, Isabella, Paut, Isabelle Kone, Zulian, Francesco, Barone, Patrizia, Bircan, Zelal, Maldonado, Maria del Rocio, Russo, Ricardo, Vilca, Iris, Tullus, Kjell, Cimaz, Rolando, Horneff, Gerd, Anton, Jordi, Garay, Stella, Nielsen, Susan Mary, Barbano, Giancarlo, Martini, Alberto, Ruperto, Nicolino, Ozen, Seza, Pistorio, Angela, Dolezalova, Pavla, Brogan, Paul, Cabral, David A, Cuttica, Ruben, Khubchandani, Raju, Lovell, Daniel J, O'Neil, Kathleen M, Quartier, Pierre, Ravelli, Angelo, Iusan, Silvia M, Filocamo, Giovanni, Magalhães, Claudia Saad, Unsal, Erbil, Oliveira, Sheila, Bracaglia, Claudia, Bagga, Arvind, Stanevicha, Valda, Manzoni, Silvia Magni, Pratsidou, Polyxeni, Lepore, Loredana, Espada, Graciela, Kone-Paut, Isabella, Paut, Isabelle Kone, Zulian, Francesco, Barone, Patrizia, Bircan, Zelal, Maldonado, Maria del Rocio, Russo, Ricardo, Vilca, Iris, Tullus, Kjell, Cimaz, Rolando, Horneff, Gerd, Anton, Jordi, Garay, Stella, Nielsen, Susan Mary, Barbano, Giancarlo, and Martini, Alberto

Abstract

To report methodology and overall clinical, laboratory and radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) classification criteria.

Published
2010

8. M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis.

Author

Brix N, Glerup M, Thiel S, Mistegaard CE, Skals RG, Berntson L, Fasth A, Nielsen SM, Nordal E, Rygg M, Hasle H, Albertsen BK, and Herlin T

Subjects
Biomarkers, C-Reactive Protein metabolism, Child, Humans, Lectins, Neoplasm Recurrence, Local, Ficolins, Arthritis, Juvenile diagnosis, Leukemia
Abstract

Objective: Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALL arthropathy ) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of leukaemia may be vague. The primary aim was to examine the use of lectin complement pathway proteins as markers to differentiate ALL arthropathy from JIA. The secondary aims were to compare the protein levels at baseline and follow-up in a paired number of children with ALL and to examine the correlation with haematology counts, erythrocyte sedimentation reaction (ESR), C-reactive protein (CRP), blasts, relapse and death., Study Design: In this observational study, we measured M-ficolin, CL-K1 and MASP-3 in serum from children with ALL (n=151) and JIA (n=238) by time-resolved immunofluorometric assays. Logistic regression was used for predictions of ALL risk, considering the markers as the respective exposures. We performed internal validation using repeated '10-fold cross-validation' with 100 repetitions computing the area under the curve (AUC) as well as positive and negative predictive values in order to evaluate the predictive performance., Results: The level of M-ficolin was higher in JIA than ALL total and the ALL arthropathy subgroup. The M-ficolin level normalised after remission of ALL. M-ficolin could differentiate ALL from JIA with an AUC of 94% and positive predictive value (PPV) of 95%, exceeding CRP and haemoglobin. In a dichotomised predictive model with optimal cut-offs for M-ficolin, platelets and haemoglobin, AUC was 99% and PPV 98% in detecting ALL from JIA., Conclusion: M-ficolin is a valuable marker to differentiate the child with ALL from JIA., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2022
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