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The European Space Agency's INTErnational Gamma-Ray Astrophysics Laboratory (ESA/INTEGRAL) was launched aboard a Proton-DM2 rocket on 17 October 2002 at 06:41 CEST, from Baikonur in Kazakhstan. Since then, INTEGRAL has been providing long, uninterrupted observations (up to about 47h, or 170ksec, per satellite orbit of 2.7 days) with a large field-of-view (FOV, fully coded: 100 deg), millisecond time resolution, keV energy resolution, polarization measurements, as well as additional wavelength coverage at optical wavelengths. This is realized by two main instruments in the 15keV to 10MeV energy range, the spectrometer SPI (spectral resolution 3keV at 1.8MeV) and the imager IBIS (angular resolution: 12arcmin FWHM), complemented by X-ray (JEM-X; 3–35keV) and optical (OMC; Johnson V-band) monitor instruments. All instruments are co-aligned to simultaneously observe the target region. A particle radiation monitor (IREM) measures charged particle fluxes near the spacecraft. The Anti-coincidence subsystems of the main instruments, built to reduce the background, are also very efficient all-sky γ-ray detectors, which provide virtually omni-directional monitoring above ∼75keV. Besides the long, scheduled observations, INTEGRAL can rapidly (within a couple of hours) re-point and conduct Target of Opportunity (ToO) observations on a large variety of sources. INTEGRAL observations and their scientific results have been building an impressive legacy: The discovery of currently more than 600 new high-energy sources; the first-ever direct detection of Ni and Co radio-active decay lines from a Type Ia supernova; spectroscopy of isotopes from galactic nucleo-synthesis sources; new insights on enigmatic positron annihilation in the Galactic bulge and disk; and pioneering gamma-ray polarization studies. INTEGRAL is also a successful actor in the new multi-messenger astronomy introduced by non-electromagnetic signals from gravitational waves and from neutrinos: INTEGRAL found the first prompt electromagnetic radiation in coincidence with a binary neutron star merger. Up to now more than 1750 scientific papers based on INTEGRAL data have been published in refereed journals. In this paper, we will give a comprehensive update of the satellite status after more than 18 years of operations in a harsh space environment, and an account of the successful Ground Segment., Kuulkers, Erik, et al., he OMC team has been funded by different Spanish grants, including Spanish State Research Agency grants PID2019–107061GB–C61 and MDM–2017-0737 (Unidad de Excelencia María de Maeztu – CAB). The INTEGRAL French teams acknowledge partial funding from the French Space Agency (CNES). The Danish JEM-X gratefully acknowledges support from the Danish PRODEX delegation through contract C90057. The INTEGRAL Italian team acknowledges support form the Italian Space Agency, ASI, along these years via different agreements, last of which is 2019–35-HH.0. LH acknowledges support from SFI under grant 19/FFP/6777 and the EU AHEAD2020 project (grant agreement 871158). MH acknowledges support from Spanish MICINN grant PID2019-108709GB-I00. TS is supported by the German Research Society (DFG-Forschungsstipendium SI 2502/1-1 & SI 2502/3-1).

Laue lenses has been proposed for gamma-ray astronomy since long. But Laue lenses are seriously constrained by Braggs law. Consequently, it has proven difficult to devise convincing designs of Laue lenses covering an energy range of more than a few hundred keV. We are developing a miniature pedestal allowing to adjust the Bragg angle of individual crystals in a large Laue lens. We also develop an optical system to monitor the adjustment. These developments would eliminate two major technical obstacles for Laue lens construction: one: the precision mounting of the crystals to the support panel, and two: ensuring the necessary rigidity and stability of the gamma-ray transparent support panel. But even more importantly, these developments would open the way for retuning the Laue lens for different energy bands. We shall show, how a lens designed for the 300 to 800 keV band can be used effectively between 150 keV and 2.4 MeV.

The tunable gamma-ray lens has turned out to be a promising alternative to the classical fixed-energy Laue-lenses discussed in the past. We describe here our development work on a miniature pedestal with one-axis tilt adjustment. We also outline our design for an optical system, capable of monitoring the alignment of the many crystals needed. An added benefit of the tunable crystal pedestal is that it relieves both the demands for high precision in the crystal mounting and the stringent requirements for long-term stability of the support platform on which the crystals are mounted. Moreover, mounting the individual crystals on separate pedestals facilitates the use of double layers of crystals. Keywords: Gamma-ray astronomy, Telescope technology, Laue lenses, Submitted to Experimental Astronomy

A new concept for an astronomical telescope in the MeV energy band is presented. The concept builds on Bragg diffraction in crystals, which has been discussed in the past, but so far a design with good sensitivity over a wide energy range has seemed out of reach. In this paper we point out that if we find ways to adjust, in orbit, the individual tilt of all the crystals in the lens this would allow one single lens to cover with excellent efficiency the full range of energies from 200 keV to 2.5 MeV in a few observation steps. Secondly, we note that the use of lenses with double crystal layers will increase the photon collection significantly. In an accompanying paper we describe our overall lens design in more detail and present our first prototype tilt adjustment pedestal for use with the individual lens facets. Keyords: Gamma-ray astronomy, Telescope technology, Laue lenses, Submitted to Experimental Astronomy

We present a catalogue of long-duration bursts observed with the Joint European X-ray Monitor and IBIS/ISGRI instruments onboard the INTEGRAL satellite. The 14 bursts have e-folding times ranging from 55 s to ≈17 min, and are therefore classified as intermediate-duration bursts, caused by the ignition of an unusually thick helium layer. Though seven events have already been reported in literature, we have systematically reanalysed the whole sample. We find three new photospheric radius expansion bursts, which are not reported in the literature, allowing us to provide a new estimate of the distances to these sources. We apply the enhanced persistent emission method (also known as the fa method) on sources with detectable persistent emission prior to a burst, in order to follow the evolution of the accretion rate during the burst. Although we do not get significantly better fits, the evolution of the fa factor shows an indicative behaviour, which we discuss.

Seventeen years of hard X-ray observations with the instruments of the INTEGRAL observatory, with a focus on the Milky Way and in particular on the Galactic Centre region, have provided a unique database for exploration of the Galactic population of low-mass X-ray binaries (LMXBs). Our understanding of the diverse energetic phenomena associated with accretion of matter onto neutron stars and black holes has greatly improved. We review the large variety of INTEGRAL based results related to LMXBs. In particular, we discuss the spatial distribution of LMXBs over the Galaxy and their X-ray luminosity function as well as various physical phenomena associated with Atoll and Z sources, bursters, symbiotic X-ray binaries, ultracompact X-ray binaries and persistent black hole LMXBs. We also present an up-to-date catalogue of confirmed LMXBs detected by INTEGRAL, which comprises 166 objects. Last but not least, the long-term monitoring of the Galactic Centre with INTEGRAL has shed light on the activity of Sgr A* in the recent past, confirming previous indications that our supermassive black hole experienced a major accretion episode just ~100 years ago. This exciting topic is covered in this review too., 60 pages, 26 figures, 2 tables, accepted for publication in New Astronomy Reviews

It is rather baffling that Archbishop Adalbert of Hamburg-Bremen should have wanted to alienate Sven Estridsen, on whose cooperation he depended entirely for the pursuance of his mission in Denmark...

There is growing awareness of the impact of human activity on the climate and the need to stem this impact. Public health care decision makers from Sweden and the United Kingdom have started examining environmental impacts when assessing new technologies. This article considers the case for incorporating environmental impacts into the health technology assessment (HTA) process and discusses the associated challenges. Two arguments favor incorporating environmental impacts into HTA: 1) environmental changes could directly affect people's health and 2) policy decision makers have broad mandates and objectives extending beyond health care. Two types of challenges hinder this process. First, the nascent evidence base is insufficient to support the accurate comparison of technologies' environmental impacts. Second, cost-utility analysis, which is favored by many HTA agencies, could capture some of the value of environmental impacts, especially those generating health impacts, but might not be suitable for addressing broader concerns. Both cost-benefit and multicriteria decision analyses are potential methods for evaluating health and environmental outcomes, but are less familiar to health care decision makers. Health care is an important and sizable sector of the economy that could warrant closer policy attention to its impact on the environment. Considerable work is needed to track decision makers' demands, augment the environmental evidence base, and develop robust methods for capturing and incorporating environmental data as part of HTA.

The eXTP (enhanced X-ray Timing and Polarimetry) mission is a major project of the Chinese Academy of Sciences (CAS) and China National Space Administration (CNSA) currently performing an extended phase A study and proposed for a launch by 2025 in a low-earth orbit. The eXTP scientific payload envisages a suite of instruments (Spectroscopy Focusing Array, Polarimetry Focusing Array, Large Area Detector and Wide Field Monitor) offering unprecedented simultaneous wide-band X-ray timing and polarimetry sensitivity. A large European consortium is contributing to the eXTP study and it is expected to provide key hardware elements, including a Wide Field Monitor (WFM). The WFM instrument for eXTP is based on the design originally proposed for the LOFT mission within the ESA context. The eXTP/WFM envisages a wide field X-ray monitor system in the 2-50 keV energy range, achieved through the technology of the large-area Silicon Drift Detectors. The WFM will consist of 3 pairs of coded mask cameras with a total combined Field of View (FoV) of 90x180 degrees at zero response and a source localization accuracy of ~1 arcmin. In this paper we provide an overview of the WFM instrument design, including new elements with respect to the earlier LOFT configuration, and anticipated performance., Comment: 16 pages, 15 figures, to appear in proceedings of SPIE, Space Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray

More than half the world’s population lives in cities and two thirds of 425 million people with diabetes live in cities. That makes cities a focal point for tackling diabetes. As part of Cities Changing Diabetes (CCD) five diverse cities (Copenhagen, Houston, Mexico City, Shanghai, Tianjin) have implemented actions based on 740 individual interviews with people with type 2 diabetes or at increased risk of developing it. Based on participants’ perspectives on socio-cultural barriers to live a healthy life action plans were created relevant to the local diabetes challenge and city context and tailor-made interventions were designed. CCD is a partnership between Novo Nordisk A/S, University College London, and Steno Diabetes Center Copenhagen aiming to map the diabetes challenge, understand risk and vulnerability to type 2 diabetes, and design interventions tailor-made to the respective city context. In the cities the program is driven by local partnerships in a collaborative working approach bringing together city governments, academics, businesses, city planners, patient organizations, faith-based organizations, and other non-governmental organizations. The research insights led to four arenas for impactful interventions: Health promoting policies by incorporating awareness and understanding of type 2 diabetes into local policies to address the diabetes challenge and improve overall health. Urban planning by integrating health-promoting aspects such as walkability and bikeability in urban planning to increase the ability to live a healthy life. Community involvement by strengthening communities around citizens vulnerable to diabetes to build resilience, improve diabetes care and quality of life. Health system strengthening by building capacity into the local healthcare system to help vulnerable citizens to access it. In conclusion, insights from the research have directly guided development of city-specific tailor-made interventions within four arenas. Disclosure A. Napier: Consultant; Self; Novo Nordisk A/S. N. Lund: Employee; Self; Novo Nordisk A/S. Stock/Shareholder; Self; Novo Nordisk A/S. M. Bagger: Employee; Self; Novo Nordisk A/S. Stock/Shareholder; Self; Novo Nordisk A/S. Stock/Shareholder; Spouse/Partner; Novo Nordisk A/S. B.B. Jensen: None.

The feasibility of focusing soft gamma rays (0.1-2 MeV) using Laue diffraction in high quality metal crystals have been studied in many laboratories for over 50 years [1-4]. The manufacture of suitable crystals does not anymore appear as the primary obstacle. But the overall efficiency of Laue lenses still appears marginal, the issue of the precise and stable mounting of thousands of crystal facets has turned out to be very complex, and the design of an efficient detector to be used at the focus of the lens is still largely unproven. A method to improve the flux collection efficiency of a Laue lens by almost a factor two will be described here. This is possible using double layers of crystals and relying on the fact that the efficiency of a single crystal layer is limited by the coherent primary extinction rather than by incoherent scattering or absorption. If the energy band passes of the two crystal layers do not overlap, each layer can diffract relatively undisturbed by the other. Two construction aspects concerning the mounting and alignment of the crystals are discussed in this work. Although such very technical issues may seem hardly worth discussing in a scientific paper, the mounting of the crystals and the verification of the critical crystal tilt have turned out to be quite difficult. To get around the problems we propose here some radical departures from the currently employed techniques. The technologies proposed can be readily developed and tested on small-scale experiments. The last aspect discussed is the problem of increasing the efficiency of detecting the diffracted photons at the telescope focus. In existing wide-field gamma-ray instruments the detection efficiency in the MeV region rarely exceeds 20%. It is disheartening to invest millions in building a complex lens knowing that more than three quarters of the photons focused by the lens will be lost in the detector. Fortunately, in the focus of a Laue lens it is possible to do better, and our conclusion is that with proper design we can approach or even exceed 50% detector efficiency.

The Large Observatory For X-ray Timing (LOFT), currently in an assessment phase in the framework the ESA M3 Cosmic Vision programme, is an innovative medium-class mission specifically designed to answer fundamental questions about the behaviour of matter, in the very strong gravitational and magnetic fields around compact objects and in supranuclear density conditions. Having an effective area of ~10 m^2 at 8 keV, LOFT will be able to measure with high sensitivity very fast variability in the X-ray fluxes and spectra. A good knowledge of the in-orbit background environment is essential to assess the scientific performance of the mission and optimize the design of its main instrument, the Large Area Detector (LAD). In this paper the results of an extensive Geant-4 simulation of the instrument will be discussed, showing the main contributions to the background and the design solutions for its reduction and control. Our results show that the current LOFT/LAD design is expected to meet its scientific requirement of a background rate equivalent to 10 mCrab in 2-30 keV, achieving about 5 mCrab in the most important 2-10 keV energy band. Moreover, simulations show an anticipated modulation of the background rate as small as 10% over the orbital timescale. The intrinsic photonic origin of the largest background component also allows for an efficient modelling, supported by an in-flight active monitoring, allowing to predict systematic residuals significantly better than the requirement of 1%, and actually meeting the 0.25% science goal., 31 pages, 18 figures. Accepted for publication in Experimental Astronomy

By 1975 the hunt for GRB counterparts had been on for almost ten years without success. Gamma burst instruments of that day provided little or no directional data in themselves. Positions could be extracted only using the time delay technique – potentially accurate but very slow. Triggered by a japanese report of a balloon instrument for GRB studies based on a Rotation Modulation Collimator we at the Danish Space Research Institute started the development of an RMC detector for GRBs, the WATCH wide field monitor. Four WATCH units were flown on the Soviet Granat satellites, and one on ESA’s EURECA satellite. The design and results will be summarized. Now, 35 years later, recent detector developments may allow the construction of WATCH-type instruments able to fit weight, power and data-wise into 1 kg cubesats. This could provide the basis for a true all-sky monitor with 100 percent duty cycle for rare, bright events.

The Ultra-Fast Flash Observatory (UFFO) Pathfinder for Gamma-Ray Bursts (GRBs) consists of two telescopes. The UFFO Burst Alert & Trigger Telescope (UBAT) handles the detection and localization of GRBs, and the Slewing Mirror Telescope (SMT) conducts the measurement of the UV/optical afterglow. UBAT is equipped with an X-ray detector, analog and digital signal readout electronics that detects X-rays from GRBs and determines the location. SMT is equipped with a stepping motor and the associated electronics to rotate the slewing mirror targeting the GRBs identified by UBAT. First the slewing mirror points to a GRB, then SMT obtains the optical image of the GRB using the intensified CCD and its readout electronics. The UFFO Data Acquisition system (UDAQ) is responsible for the overall function and operation of the observatory and the communication with the satellite main processor. In this paper we present the design and implementation of the electronics of UBAT and SMT as well as the architecture and implementation of UDAQ.

LOFT (Large Observatory For X-ray Timing) is one of the four candidate missions currently under assessment study for the M3 mission in ESAs Cosmic Vision program to be launched in 2024. LOFT will carry two instruments with prime sensitivity in the 2–30 keV range: a 10 m2 class large area detector (LAD) with a

Where medieval Denmark and Scandinavia as a whole has often been seen as a cultural backwater that passively and belatedly received cultural and political impulses from Western Europe, Professor Michael H. Gelting and scholars inspired by him have shown that the intellectual, religious and political elite of Denmark actively participated in the renaissance and reformation of the central and later medieval period. This work has wide ramifications for understanding developments in medieval Europe, but so far the discussion has taken place only in Danish-language publications. This anthology brings the latest research in Danish medieval history to a wider audience and integrates it with contemporary international discussions of the making of the European middle ages. Contents: Introduction, Kerstin Hundahl and Lars Kjaer; Part I Religious Culture: The settlement of disputes by compromise according to some early Danish charters, Kim Esmark; Byzantinizing crucifixes in central medieval Denmark - how, when and why, Ebbe Nyborg; Motherhood as emotion and social practice: Mary and Anne as maternal models in medieval Iceland, Agnes S. Arnorsdottir; The Black Friars and the Black Death - effects of the plague on friars preachers in 14th-century northern Europe, Johnny Grandjean Gogsig Jokobsen. Part II Intellectual Culture: Contacts between Denmark and Flanders in the 11th and 12th centuries: the tiniest of evidence, Steffen Harpsoe; Banking on - and with - the Victorines: the strange case of Archbishop Eskil’s lost deposit, Mia Munster-Swendson; The transformation of the Danish language in the central Middle Ages - a case of Europeanization?, Niels Houlberg Hansen; Two journeys and one university: King Christian I and Queen Dorothea’s journeys to Rome and the foundation of the University of Copenhagen, Carsten Jahnke. Part III Legal Culture: The Church law of Scania on the consecration of churches and the appointment of parish priests - international canon law and that of Scania, Bertil Nilsson; Dating the laws of medieval Denmark - studies of the manuscripts of the Danish church laws, Per Andersen; Regional or central? Legislation and law in 13th-century Denmark, Helle Vogt; Border warfare between king and pope in late medieval Denmark: a case study of royal politics towards ecclesiastical benefices and papal provisions c. 1350-1525, Per Ingesman. Part IV Aristocratic and Court Culture: Apocalypse then? The First Crusade, traumas of war and Thomas de Marle, Thomas Kristian Heeboll-Holm; Rune, knives and Vikings: the Valdermarian kings and the Danish past in comparative perspective, Lars Kjaer; Placing blame and creating legitimacy: the implications of Rugish involvement in the struggle over the succession amidst the Danish Church strife c.1258-1260, Kerstin Hundahl; Index. (Less)

Mycotoxins are fungi-born metabolites that can contaminate foods through mould-infected crops. They are a significant food/feed-safety issue across the globe and represent a substantial financial burden for the world economy. Moreover, with a changing climate and fungal biota, there is now much discussion about emerging mycotoxins that are measurable at significant levels in crops world-wide. Unfortunately, we still know very little about the bioavailability and toxic potentials of many of these less characterized mycotoxins, including the large family of enniatins. In this study, we present new occurrence data for enniatin A, A1, B, B1 and beauvericin in four Danish crops: oat, wheat, and barley from the 2010 harvest, and rye from 2011 harvest. The occurrence of the four enniatins were B B1 A1 A. Enniatin B was detected in 100% of tested samples regardless of crop type. In addition to occurrence data, we report a proof-of-concept study using a human-relevant high-content hepatotoxicity, or "quadroprobe," assay to screen mycotoxins for their cytotoxic potential. The assay was sensitive for most cytotoxic compounds in the 0.009-100 µM range. Among eight tested mycotoxins (enniatin B, beauvericin, altenariol, deoxynivalenol, aflatoxin B1, andrastin A, citrinin, and penicillic acid), enniatin B and beauvericin showed significant cytotoxicity at a concentration lower than that for aflatoxin B1, which is the archetypal acute hepatotoxic and liver-carcinogenic mycotoxin. Hence, the quadroprobe hepatotoxicity assay may become a valuable assessment tool for toxicity assessment of mycotoxins in the future. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1658-1664, 2017.

There is increasing evidence that inflammation plays an important role in the progression of acute ischemic stroke (AIS). The primary aims of this study were to examine the serum levels of 13 cytokines, C-reactive protein (CRP), glucose, and hemoglobin in AIS patients, and their relationship to stroke lateralization, type, and infarct volume. Forty-five patients with AIS were evaluated. Blood samples were taken within 72 h, and volumetric analyses performed within 1–7 days after AIS onset. Cytokines were measured in serum from all patients and from 40 control subjects using Luminex Bio-Plex XMap technology. The levels of interleukin (IL)-1ra (p

Fatigue is a common but often overlooked symptom after stroke. This study investigated whether stroke type, infarct volume, and laterality, as well as the levels of various cytokines and other blood components in the acute phase of acute ischemic stroke (AIS), can predict the level of fatigue at 6, 12, and 18 months after its onset. In 45 patients with acute stroke, serum levels of C-reactive protein, hemoglobin, glucose, and 13 cytokines were measured within 72 h of stroke onset. The cytokine measurements were performed using BioPlex XMap technology (Luminex). The acute serum levels of interleukin (IL)-1β and glucose were positively correlated with the score on the Fatigue Severity Scale (FSS) at 6 months after the stroke (r = 0.37, p = 0.015, and r = 0.37, p = 0.017, respectively). The acute serum levels of IL-ra and IL-9 were negatively correlated with FSS score at 12 months after the stroke (r = −0.38, p = 0.013, and r = −0.36, p = 0.019, respectively). The FSS score at 12 months after stroke was significantly lower in patients with radiologically confirmed infarction than in those without such confirmation (p = 0.048). The FSS score at 18 months was not correlated with any of the measured variables. High acute serum levels of glucose and IL-1β, and low IL1-ra and IL-9 may predict fatigue after AIS, indicating that the development of poststroke fatigue can be accounted for by the proinflammatory response associated with AIS. These novel findings support a new cytokine theory of fatigue after stroke. However, more research is needed to validate the results of this study.

With ESA’s INTEGRAL mission gamma-ray astronomy has advanced to the point where major scientific advances must be expected from detailed studies of the many new point sources. The interest in developing focusing telescopes operating in the soft gamma-ray regime up to 1 MeV is therefore mounting rapidly. Telescopes based on Laue diffraction of gamma-rays from crystals appear as one promising route, although the practical difficulties of realizing a large scale Laue lens are certainly not small. In this paper I have attempted to develop an optimized lens design considering the size and mass constraints of a specific medium size launch vehicle. The introduction of the lens mass as a primary design driver has some surprising effects for the choice of material for the crystals and new tradeoff considerations are introduced.

SGR 1806-20 has been observed for more than 2 years with the INTEGRAL satellite. In this period the source went from a quiescent state into a very active one culminating in a giant flare on December 27 2004. Here we report on the properties of all the short bursts detected with INTEGRAL before the giant flare. We derive their number-intensity distribution and confirm the hardness-intensity correlation for the bursts found by Gotz et al. (2004a). Our sample includes a very bright outburst that occurred on October 5 2004, during which over one hundred bursts were emitted in 10 minutes, involving an energy release of 3 x 1E42 erg. We present a detailed analysis of it and discuss our results in the framework of the magnetar model., 10 pages, 8 figures, to appear in A&A main journal

We discuss INTEGRAL's capabilities to detect a high redshift population of Gamma-Ray Bursts (GRBs) in comparison to other high-energy missions. Emphasis is done on the study of the relative capabilities of IBIS on board INTEGRAL with respect to SWIFT and HETE 2 for detecting a high redshift population of GRBs. We conclude that, if the GRB rate is proportional to the star formation rate, INTEGRAL's capabilities for studying GRBs are complementary to the ones of missions like SWIFT and HETE 2, specially devoted to prompt localisations of GRBs. Whereas SWIFT and HETE 2 would detect a higher number of GRBs than INTEGRAL, IBIS might be able to detect high redshift (z>~7) GRBs, unreachable for SWIFT and HETE 2. We discuss the relevance of performing near-infrared (NIR) observations of the INTEGRAL GRBs and the strategy that large class telescopes might follow., Accepted for publication in A&A. 7 pages, 5 postscript figures

The most recent astrophysics mission of ESA is INTEGRAL, a mission dedicated to gamma-ray astronomy (Winkler et al. 2003). INTEGRAL carries two gamma-ray instruments: the imager, IBIS, and the spectrometer, SPI, and in addition an optical monitor, OMC, and an X-ray monitor, JEM-X. INTEGRAL is an observatory mission with 70% of the observation time available to the general astronomical community through a peer-reviewed selection process. This paper describes the INTEGRAL mission primarily as seen from the JEM-X perspective.

We summarize the inflight performance of JEM-X, the X-ray monitor on the INTEGRAL mission during the initial ten months of operations. The JEM-X instruments have now been tuned to stable operational conditions. The performance is found to be close to the pre-launch expectations. The ground calibrations and the inflight calibration data permit to determine the instruments characteristics to fully support the scientific data analysis. Reglero Velasco, Victor, Victor.Reglero@uv.es ; Martinez Nuñez, Silvia, Silvia.Martinez@uv.es

The science analysis of the data from JEM-X on INTEGRAL is performed through a number of levels including corrections, good time selection, imaging and source finding, spectrum and light-curve extraction. These levels consist of individual executables and the running of the complete analysis is controlled by a script where parameters for detailed settings are introduced. The end products are FITS files with a format compatible with standard analysis packages such as XSPEC. Martinez Nuñez, Silvia, Silvia.Martinez@uv.es

The ESA observatory INTEGRAL (International Gamma-Ray Astrophysics Laboratory) is dedicated to the fine spectroscopy (2.5 keV FWHM @ 1 MeV) and fine imaging (angular resolution: 12 arcmin FWHM) of celestial gamma-ray sources in the energy range 15 keV to 10 MeV with concurrent source monitoring in the X-ray ( keV) and optical (V -band, 550 nm) energy ranges. INTEGRAL carries two main gamma-ray instruments, the spectrometer SPI (Vedrenne et al. [CITE]) – optimized for the high-resolution gamma-ray line spectroscopy (20 keV–8 MeV), and the imager IBIS (Ubertini et al. [CITE]) – optimized for high-angular resolution imaging (15 keV–10 MeV). Two monitors, JEM-X (Lund et al. [CITE]) in the () keV X-ray band, and OMC (Mas-Hesse et al. [CITE]) in optical Johnson V -band complement the payload. The ground segment includes the Mission Operations Centre at ESOC, ESA and NASA ground stations, the Science Operations Centre at ESTEC and the Science Data Centre near Geneva. INTEGRAL was launched on 17 October 2002. The observing programme is well underway and sky exposure (until June 2003) reaches ~1800 ks in the Galactic plane. The prospects are excellent for the scientific community to observe the high energy sky using state-of-the-art gamma-ray imaging and spectroscopy. This paper presents a high-level overview of INTEGRAL.

We present data from the first of six monitoring Open Time observations of GRS 1915+105 undertaken with the orbiting INTEGRAL satellite. The source was clearly detected with all three X-ray and gamma-ray instruments on board. GRS 1915+105 was in a highly variable state, as demonstrated by the JEM X-2 and ISGRI lightcurves. These and simultaneous RXTE/PCA lightcurves point to a novel type of variability pattern in the source. In addition, we fit the combined JEM X-2 and ISGRI spectrum between 3-300 keV with a disk blackbody + powerlaw model leading to typical parameter values found earlier at similar luminosity levels. A new transient, IGR J19140+098, was discovered during the present observation., 5 pages, 7 figures. The original Figure 2 in color can be obtained from http://www.astro.helsinki.fi/~diana/integral.html. Accepted for publication in A&A Letters special INTEGRAL issue

The Crab pulsar is the best studied rotation powered pulsar. We report the results obtained in the 3-35 keV energy band with the X-ray monitor, JEM-X, on ESAs recently launched-ray mission, INTEGRAL.

The gamma-ray instruments on-board INTEGRAL offer an unique opportunity to perform time resolved analysis on GRBs. The imager IBIS allows accurate positioning of GRBs and broad band spectral analysis, while SPI provides high resolution spectroscopy. GRB 030501 was discovered by the INTEGRAL Burst Alert System in the ISGRI field of view. Although the burst was fairly weak (fluence F 2 0 - 2 0 0 k e V ≃ 3.5 x 10 - 6 erg cm - 2 ) it was possible to perform time resolved spectroscopy with a resolution of a few seconds. The GRB shows a spectrum in the 20-400 keV range which is consistent with a spectral index r = -1.8. No emission line or spectral break was detectable in the spectrum. Although the flux seems to be correlated with the hardness of the GRB spectrum, there is no clear soft to hard evolution seen over the duration of the burst. The INTEGRAL data have been compared with results from the Ulysses and RHESSI experiments.

We study a set of 28 GRB light-curves detected between 15 December 2002 and 9 June 2003 by the anti-coincidence shield of the spectrometer (SPI) of INTEGRAL. During this period it has detected 50 b ...

We present the result of multi-wavelength observations of the microquasar GRS 1915+105 in a plateau state with a luminosity of ~7.5x10^{38) erg s-1 (~40% L_Edd), conducted simultaneously with the INTEGRAL and RXTE satellites, the ESO/NTT, the Ryle Telescope, the NRAO VLA and VLBA, in 2003 April 2-3. For the first time were observed concurrently in GRS 1915+105 all of the following properties: a strong steady optically thick radio emission corresponding to a powerful compact jet resolved with the VLBA, bright near-IR emission, a strong QPO at 2.5 Hz in the X-rays and a power law dominated spectrum without any cutoff in the 3-400 keV range., Comment: 5 pages, 5 figures (4 colour figures), accepted by A&A Letters

We present INTEGRAL and XMM-Newton observations of the prompt gamma-ray emission and the X-ray afterglow of GRB030227, the first GRB for which the quick localization obtained with the INTEGRAL Burst Alert System (IBAS) has led to the discovery of X-ray and optical afterglows. GRB030227 had a duration of about 20 s and a peak flux of 1.1 photons cm^-2 s^-1 in the 20-200 keV energy range. The time averaged spectrum can be fit by a single power law with photon index about 2 and we find some evidence for a hard to soft spectral evolution. The X-ray afterglow has been detected starting only 8 hours after the prompt emission, with a 0.2-10 keV flux decreasing as t^-1 from 1.3x10e-12 to 5x10e-13 erg cm^-2 s^-1. The afterglow spectrum is well described by a power law with photon index 1.94+/-0.05 modified by a redshifted neutral absorber with column density of several 10e22 cm^-2. A possible emission line at 1.67 keV could be due to Fe for a redshift z=3, consistent with the value inferred from the absorption.

The small-satellites activities in the Scandinavian countries are briefly surveyed with emphasis on astrophysics research.

During the solar flare of June 10, 1990, the WATCH instrument of the GRANAT space observatory obtained 110 localizations of the X-ray source in the X-ray range 8–20 keV. Its coordinates were measured with an accuracy of ∼2 arcmin at a 3σ confidence level. The coordinates of the X-ray source do not coincide with the coordinates of the Hα-line flare. The X-ray source moved over the solar disk during the flare. This probably implies that, as the X-ray emission was generated, different parts of one loop or a system of magnetic loops dominated at different flare times.

Unmethylated cytosine-phosphate-guanine (CpG) oligodeoxynucleotides are highly frequent motifs in bacterial DNA and rare in the mammalian genome. They are potent inducers of inflammatory cytokines and act synergistically with lipopolysaccharide (LPS) for the induction of tumor necrosis factor alpha (TNF-alpha) production in vivo. It has therefore been suggested that innate immune reaction to bacterial unmethylated CpG motifs might contribute to the development of septic shock. We designed this study to assess the sensitization role of CpG motifs in LPS-induced shock using the D-galactosamine (D-GalN)-sensitized mouse model.A prospective, randomized in vivo animal laboratory study.Experimental research laboratory.We performed experiments in which CpG, LPS and D-GalN were administrated sequentially in various orders or simultaneously in 8 week-old BALB/c mice.Cytosine-phosphate-guanine treatment potentiated LPS action only if injected prior to LPS. A combination of predefined sublethal doses of CpG (1 nmol/mouse) and LPS (1 ng/mouse) not only had a synergetic effect on TNF-alpha production (20.3+/-9.2 IU/ml versus 2.5+/-1.4 IU/ml and 5.6+/-3.4 IU/ml for CpG and LPS groups, respectively, p0.05), but also led to animal death (5/5). An CpG effect requires de novo mRNA synthesis, since the sensitizing effect was inhibited by co-administration of mRNA transcription inhibitors such as D-GalN and pentoxifylline, which is a specific TNF-alpha transcription inhibitor. Furthermore, CpG treatment provoked a strong TNF-alpha mRNA production in the liver that was dramatically reduced by pre-treatment with D-GalN.Our findings indicate that CpG motifs act synergistically with LPS by initializing the synthesis of TNF-alpha and/or TNF-alpha regulating factors, thereby acting as a sensitizing agent.

A quasi-periodic component was found at the maximum of the X-ray light curve for the June 10, 1990 solar flare detected by the Granat observatory. The pulsation period was 143.2±0.8 s. The intensity of the pulsing component is not constant; the maximum amplitude of the pulsations is ∼5% of the total flare intensity. An analysis of the data showed the characteristic size of the magnetic loop responsible for these pulsations to be ∼(1–3)×1010 cm.

LOFT (Large Observatory For x-ray Timing) is one of the ESA M3 missions selected within the Cosmic Vision program in 2011 to carry out an assessment phase study and compete for a launch opportunity in 2022-2024. The phase-A studies of all M3 missions were completed at the end of 2013. LOFT is designed to carry on-board two instruments with sensitivity in the 2-50 keV range: a 10 m2 class Large Area Detector (LAD) with a

The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final down-selection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supra-nuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m 2 effective area, 2-30 keV, 240 eV spectral resolution, 1 deg collimated field of view) and a WideField Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study., Proc. SPIE 9144, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ray, 91442T

To investigate whether impaired endothelial function was related to alteration of nitric oxide (NO) formation during endotoxic shock, we studied the effects of supplementation of l-arginine (l-Arg),d-arginine (d-Arg), and NG-nitro-l-arginine methyl ester (l-NAME), on endothelial function and structure in a rabbit model. Endotoxic shock was induced by a single lipopolysaccharide bolus (0.5 mg/kg iv, Escherichia coli endotoxin). Coagulation factors and expression of monocyte tissue factor were determined by functional assays. Endothelium-dependent vascular relaxation was assessed by in vitro vascular reactivity. Immunohistochemical staining (CD31) was performed to assess damaged endothelial cell surface of the abdominal aorta. These parameters were studied 5 days after the onset of endotoxic shock and were compared under three conditions: in absence of treatment, with l-Arg or d-Arg supplementation, or with l-NAME. Bothl-Arg and d-Arg significantly improved endothelium-dependent relaxation and endothelial morphological injury.l-NAME did not alter endothelial histological injury induced by lipopolysaccharide. These data indicate that arginine supplementation nonspecifically prevents endothelial dysfunction and histological injury in rabbit endotoxic shock. Moreover,l-Arg has no effect on coagulation activation and expression of monocyte tissue factor induced by endotoxic shock.