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20 results on '"Nieddu, Valentina"'

1. Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness

Author

Battistini, Chiara, Kenny, Hilary A., Zambuto, Melissa, Nieddu, Valentina, Melocchi, Valentina, Decio, Alessandra, Lo Riso, Pietro, Villa, Carlo Emanuele, Gatto, Alessia, Ghioni, Mariacristina, Porta, Francesca M., Testa, Giuseppe, Giavazzi, Raffaella, Colombo, Nicoletta, Bianchi, Fabrizio, Lengyel, Ernst, and Cavallaro, Ugo

Published
2024
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5. Supplementary table 4 from A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma

Author

Dvorkina, Maria, primary, Nieddu, Valentina, primary, Chakelam, Shalini, primary, Pezzolo, Annalisa, primary, Cantilena, Sandra, primary, Leite, Ana Paula, primary, Chayka, Olesya, primary, Regad, Tarik, primary, Pistorio, Angela, primary, Sementa, Angela Rita, primary, Virasami, Alex, primary, Barton, Jack, primary, Montano, Ximena, primary, Lechertier, Tanguy, primary, Brindle, Nicola, primary, Morgenstern, Daniel, primary, Lebras, Morgane, primary, Burns, Alan J., primary, Saunders, Nigel J., primary, Hodivala-Dilke, Kairbaan, primary, Bagella, Luigi, primary, De The, Hugues, primary, Anderson, John, primary, Sebire, Neil, primary, Pistoia, Vito, primary, Sala, Arturo, primary, and Salomoni, Paolo, primary

Published
2023
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6. Data from A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma

Author

Dvorkina, Maria, primary, Nieddu, Valentina, primary, Chakelam, Shalini, primary, Pezzolo, Annalisa, primary, Cantilena, Sandra, primary, Leite, Ana Paula, primary, Chayka, Olesya, primary, Regad, Tarik, primary, Pistorio, Angela, primary, Sementa, Angela Rita, primary, Virasami, Alex, primary, Barton, Jack, primary, Montano, Ximena, primary, Lechertier, Tanguy, primary, Brindle, Nicola, primary, Morgenstern, Daniel, primary, Lebras, Morgane, primary, Burns, Alan J., primary, Saunders, Nigel J., primary, Hodivala-Dilke, Kairbaan, primary, Bagella, Luigi, primary, De The, Hugues, primary, Anderson, John, primary, Sebire, Neil, primary, Pistoia, Vito, primary, Sala, Arturo, primary, and Salomoni, Paolo, primary

Published
2023
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7. Supplementary table 2 from A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma

Author

Dvorkina, Maria, primary, Nieddu, Valentina, primary, Chakelam, Shalini, primary, Pezzolo, Annalisa, primary, Cantilena, Sandra, primary, Leite, Ana Paula, primary, Chayka, Olesya, primary, Regad, Tarik, primary, Pistorio, Angela, primary, Sementa, Angela Rita, primary, Virasami, Alex, primary, Barton, Jack, primary, Montano, Ximena, primary, Lechertier, Tanguy, primary, Brindle, Nicola, primary, Morgenstern, Daniel, primary, Lebras, Morgane, primary, Burns, Alan J., primary, Saunders, Nigel J., primary, Hodivala-Dilke, Kairbaan, primary, Bagella, Luigi, primary, De The, Hugues, primary, Anderson, John, primary, Sebire, Neil, primary, Pistoia, Vito, primary, Sala, Arturo, primary, and Salomoni, Paolo, primary

Published
2023
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8. Supplementary Table 1 from A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma

Author

Dvorkina, Maria, primary, Nieddu, Valentina, primary, Chakelam, Shalini, primary, Pezzolo, Annalisa, primary, Cantilena, Sandra, primary, Leite, Ana Paula, primary, Chayka, Olesya, primary, Regad, Tarik, primary, Pistorio, Angela, primary, Sementa, Angela Rita, primary, Virasami, Alex, primary, Barton, Jack, primary, Montano, Ximena, primary, Lechertier, Tanguy, primary, Brindle, Nicola, primary, Morgenstern, Daniel, primary, Lebras, Morgane, primary, Burns, Alan J., primary, Saunders, Nigel J., primary, Hodivala-Dilke, Kairbaan, primary, Bagella, Luigi, primary, De The, Hugues, primary, Anderson, John, primary, Sebire, Neil, primary, Pistoia, Vito, primary, Sala, Arturo, primary, and Salomoni, Paolo, primary

Published
2023
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12. Biological evaluation of 1,3,4-oxadiazoles bis-substitute derivatives as potential anticancer agents

Author

Nieddu, Valentina and Bagella, Luigi Marco

Subjects
BIO/10 Biochimica
Abstract

Cancer is a major health problem and causes substantial morbidity and mortality worldwide. In order to identify new potent antitumor agents with good specificity and low toxicity, a series of 12 new 1,3,4-oxadiazole bis-substitute molecules were tested on different cancer cell lines as potential antitumor candidates. All the compounds were tested in order to select the molecules with stronger and more selective cell growth inhibitory activity. The cytotoxic effects were evaluated in vitro and it was found that Molecule 10 had the greatest antitumor activity on cancer cells and it exerted an antiproliferative behavior in a dose-dependent manner. Clonogenic assay revealed a visible reduction of colony formation in all cell lines. To investigate the effects of the molecule on the cell cycle progression, flow cytometry analysis were performed identifying cell cycle arrest in G2/M phases, therefore immunofluorescence analyses were realized using β-tubulin antibody and abnormal effects were showed on tubulin organization. To understand molecular mechanism involved in cell cycle arrest, western blot analysis were executed identifying a deregulation of p53 levels. Same experiments were repeated in human fibroblast cells as normal control versus the respective immortalized cell lines. All the fibroblasts were less sensitive and showed a higher IC50 than cancer and immortalized cells, validating that Molecule 10 has low systemic toxicity and a specific activity to cancer cells.

Published
2015

15. A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma

Author

Dvorkina, Maria, primary, Nieddu, Valentina, additional, Chakelam, Shalini, additional, Pezzolo, Annalisa, additional, Cantilena, Sandra, additional, Leite, Ana Paula, additional, Chayka, Olesya, additional, Regad, Tarik, additional, Pistorio, Angela, additional, Sementa, Angela Rita, additional, Virasami, Alex, additional, Barton, Jack, additional, Montano, Ximena, additional, Lechertier, Tanguy, additional, Brindle, Nicola, additional, Morgenstern, Daniel, additional, Lebras, Morgane, additional, Burns, Alan J., additional, Saunders, Nigel J., additional, Hodivala-Dilke, Kairbaan, additional, Bagella, Luigi, additional, De The, Hugues, additional, Anderson, John, additional, Sebire, Neil, additional, Pistoia, Vito, additional, Sala, Arturo, additional, and Salomoni, Paolo, additional

Published
2016
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16. In vitro activity of the avb3 integrin antagonist RGDechi-hCit on malignant melanoma cells

Author

Pisano, Marina, De Paola, Ivan, Nieddu, Valentina, Sassu, Ilaria, Cossu, Sara, Galleri, Grazia, Del Gatto, Annarita, Budroni, Mario, Cossu, Antonio, Saviano, Michele, Palmieri, Giuseppe, Zaccaro, Laura, and Rozzo, Carla

Subjects
genetic structures, Malignant melanoma, Cell adhesion, Cell migration, [object Object], RGD peptide
Abstract

[object Object]

Published
2013

18. Molecular changes induced by the curcumin analogue D6 in human melanoma cells

Author

Rozzo, Carla, primary, Fanciulli, Manuela, additional, Fraumene, Cristina, additional, Corrias, Antonio, additional, Cubeddu, Tiziana, additional, Sassu, Ilaria, additional, Cossu, Sara, additional, Nieddu, Valentina, additional, Galleri, Grazia, additional, Azara, Emanuela, additional, Dettori, Maria Antonietta, additional, Fabbri, Davide, additional, Palmieri, Giuseppe, additional, and Pisano, Marina, additional

Published
2013
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19. Abstract 3804: Molecular changes induced by the curcumin biphenyl analogue D6 in melanoma cells

Author

Pisano, Marina, primary, Sassu, Ilaria, additional, Cossu, Sara, additional, Corrias, Antonio, additional, Nieddu, Valentina, additional, Pescatori, Mario, additional, Galleri, Grazia, additional, Azara, Emanuela, additional, Fabbri, Davide, additional, Dettori, Maria Antonietta, additional, Palmieri, Giuseppe, additional, and Rozzo, Carla, additional

Published
2012
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20. In vitro activity of the αvβ3 integrin antagonist RGDechi-hCit on malignant melanoma cells.

Author

Pisano M, DE Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, and Rozzo C

Subjects
Cell Adhesion drug effects, Cell Line, Tumor, Cell Movement drug effects, Humans, Integrin alphaVbeta3 analysis, Melanoma pathology, Melanoma secondary, Angiogenesis Inhibitors pharmacology, Integrin alphaVbeta3 antagonists & inhibitors, Melanoma drug therapy, Peptides pharmacology
Abstract

Background: In malignant melanoma (MM), overexpression of αvβ3 integrin is linked to a more metastatic phenotype. Development of anti-αvβ3 agents able to counteract melanoma progression would be helpful for disease treatment. A new selective ligand of αvβ3, RGDechi-hCit, has anti-angiogenic properties against endothelial cells in animal angiogenesis models. The aim of this study was to evaluate the in vitro effects of the RGDechi-hCit peptide on MM cell lines., Materials and Methods: Cytofluorimetric analysis characterized the cell surface expression of αvβ3 integrin on seven MM cell lines: A375, WM266-4, SK-Mel-28, Sbcl2, LB24Dagi, PR-Mel and PNP-Mel. Cell proliferation, adhesion, and migration assays were carried out using the αvβ3-antagonist RGDechi-hCit., Results: Proliferation was not significantly inhibited by RGDechi-hCit, although striking morphological changes were detected in MM cell lines highly expressing αvβ3. Conversely, assays on fibronectin-coated plates showed a significant RGDechi-hCit dose-dependent inhibitory effect on both adhesion and migration., Conclusion: The data demonstrate anti-adhesion and anti-migration, but not antiproliferative, activities of RGDechi-hCit against MM cells.

Published
2013

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