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Additional file 1: Table S1. Thelist of 114 genes by NGS.

Additional file 2: Table S2. Reference database website.

The ultra-deep gas reservoir in the Keshen gas field is characterized by complicated geological conditions, poor static data and gas reservoir description, making it a world-class challenge of exploration and development. To depict the characteristics of gas reservoir, long distance multi-well and multi-azimuth interference well testing in gas reservoir was carried out in Keshen gas field. Accurate multi-well interference data was acquired and verified by both positive and negative authentication. Approaches like extremal value analysis, investigation radius method, etc. are employed to analyze the tested data, which is also compared with numerical simulation outcomes. The results of investigation show that the interference signals in the developed area of Keshen Block 2 are strong, indicating that the reservoir is highly connected with natural fractures. Few faults or dominant fractures appear. The fracture permeability is above Darcy level; obvious interference signals have been detected between Wells in Keshen Block 5 and 11, which means that the two blocks are interconnected and proved to be the same gas reservoir. Results from numerical simulation show that connectivity in the west area is better than that in the east. This technology has made quantitative analysis of fractured gas reservoir a reality. It can serve a solid foundation of fine reservoir description, well location selection, well drilling and completion, and related development processes. An objective judgment on the contradictions of dynamic and static data can be achieved using this technology, which is of great significance for the effective exploration and development of ultra-depth, high pressure, and fractured tight sandstone gas reservoirs.