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Purpose: Reduced slow wave sleep (SWS) has been linked to hypertension in some studies. The aim of the study is to investigate the association between SWS and office blood pressure (BP) in non-hypertensive obstructive sleep apnea (OSA). Methods: This is a retrospective study of 3350 patients who underwent polysomnography (PSG) in our hospital. Based on quartiles of percent SWS, participants were classified into four groups. BP was measured manually on the randomly chosen arm in a seated position with sphygmomanometer after PSG in the morning, and the average of the second and third measurements was used for this analysis. Elevated office BP was defined as a systolic BP≥140 mmHg or diastolic BP≥90 mmHg. Results: There were 1365 patients with OSA and 597 primary snorers included in our study. In OSA group, OSA patients with SWS <13.5% had a significant elevated risk with elevated office BP (OR,1.49[95%CI 1.05-2.10], P=0.025), compared to the highest quartile (percent SWS >39.2%). However, no significant relationship between decreased SWS and elevated office BP was found in primary snorers group. Conclusion: In non-hypertensive OSA patients, decreased SWS is associated with elevated office BP. This is the first study to investigate the association between decreased SWS and incident elevated office BP in non-hypertensive OSA patients. Our results found that in non-hypertensive OSA patients, decreased SWS is associated with elevated office BP. The relationship between decreased SWS and elevated office BP in OSA patients was evident especially in men and in those <60 years old. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the asthma control and insights of asthmatic outpatients in Beijing urban districts and to provide the basis for drawing up a work plan for Beijing Asthma Alliance., Methods: We performed a investigation by a questionnaire in a face-to-face method in asthmatic outpatients. A total of 6 teaching hospitals distributed in the 6 different Urban districts participated in this study., Results: A total of 527 asthmatic patients completed the questionnaire. The percentage of asthmatic patients who had various social insurance was 87.1% (459/527). According to the GINA standards the disease classification was 19.2% (101/527), 26.0% (137/527), 36.8% (194/527) and 18.0% (95/527) respectively in intermittent, mild persistent, moderate persistent and severe persistent asthma. The results showed that 19.5% (103/527) of respondents had been admitted to hospital and 29.2% (154/527) had visited a hospital emergency because of exacerbation during the past year. The percentage of adults with lost workdays was 33.8% (76/225) and 4 students of 22 school-aged asthmatic patients (4/22, 18.2%) had lost school days. The rates of complete control and well control were 25.2% (133/527) and 27.7% (146/527) respectively. Only 46.1% (243/527) of respondents had undergone lung function tests during the past year. Approximately one fourth of respondents 23.1% (122/527) had owned peak flowmeter. Only 6.1% (32/527) reported regular use of peak flowmeter. The percentage of regular inhaled corticosteroids was 59.6% (314/527). The level of knowledge for asthma management had improved significantly., Conclusion: With the implementation of patient education program and asthma guideline, the asthma control level improved further and the knowledge for disease management also improved obviously.

Objective: To explore the relationship of interleukin-8 (IL-8), adherence function of neutrophil (PMN) and acute lung injury (ALI)., Methods: Eighteen male New Zealand rabbits were divided into two groups randomly: the control group (n=8) and the ALI group (n=10). The model of ALI was replicated by using intravenous lipopolysaccharide (LPS) in the rabbits of group ALI. Blood pressure, heart rate, blood gas analysis, hemogram, CD11b expression intensity on the surface of PMN, concentration of serum IL-8 and malondialdehyde (MDA) were measured at each time point. Specimens for pathology were obtained at the end of experiment., Results: In group ALI, blood pressure, heart rate and pH declined obviously. PMN count was lowered obviously at 3 hours and increased at 6 hours to some extent. CD11b expression intensity on the surface of PMN, the concentration of serum IL-8 and MDA were increased progressively (all P<0.05). The main changes in the microscopic examination were inflammatory granulocyte infiltration, disseminated thickening of alveolar septa and focal hemorrhages. There were significant correlations between CD11b and IL-8 (r2=0.813, Y=26.729X), and between CD11b and the grades of pathological changes at 6 hours after intravenous LPS (r2=0.771, Y=0.011 02X+5.292)., Conclusion: LPS could induce the release of large amount of IL-8, and it activates the expression of CD11b on the surface of PMN, which shows high degree of correlation with IL-8 and the degree of pathological changes in the lung. Therefore, both of them could serve as sensitive indexes for the diagnosis of ALI.