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OBJECTIVE: To investigate the diagnostic value of CEUS in atypical-enhanced PTC. METHODS: The clinical data, qualitative and quantitative parameters of CEUS in 177 Iso/hyper-enhanced thyroid nodules with definite pathological results were retrospectively analyzed in the Lanzhou University Second Hospital from June 2019 to January 2021. And the clinical value of CEUS in the diagnosis of atypical-enhanced PTC was assessed using univariate and multivariate analysis. RESULTS: Among the 177 thyroid nodules, 59 were benign and 118 were PTC. There were significant differences in age, enhancement border, ring enhancement, speed of wash in, speed of wash out, enhancement pattern, capsule interruption, time to peak, time to wash out, RT, TPH, and TTP (P < 0.05). Multivariate analysis showed unclear enhancement border and concentric enhancement were independent risk factors for the diagnosis of atypical-enhanced PTC by CEUS. The sensitivity, specificity, PPV, NPV, and accuracy of the model in diagnosing atypical-enhanced PTC were 88.1%, 71.2%, 86.0%, 75.0%, and 82.5%, respectively. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was 0.910. CONCLUSION: The diagnosis of atypical-enhanced PTC can be better performed by enhancement characteristics and time intensity curve (TIC) of CEUS, which have a good clinical application value. [ABSTRACT FROM AUTHOR]

Asthma is a common chronic respiratory diseases, and the relationship between pulmonary ventilation function and the prognosis of patients with suspected asthma is not well understood. This study aims to explore the impact of pulmonary ventilation functions on the prognosis of patients with suspected asthma. This retrospective observational study included patients with suspected asthma who were diagnosed and treated at the Guangdong Provincial Hospital of Traditional Chinese Medicine between August 2015 and January 2020. The primary outcome of interest was improvement in asthma symptoms, as measured by bronchial provocation test (BPT) results within one year after diagnosis. The impact of pulmonary ventilation functions on prognosis was explored by multivariable logistic regression analysis. Seventy-two patients were included in the study. Patients with normal (OR = 0.123, p =.004) or generally normal (OR = 0.075, p =.039) pulmonary ventilation function were more likely to achieve improvement in asthma symptoms compared with patients with mild obstruction. There were no significant differences between the improvement and non-improvement groups in baseline characteristics. These results suggest that suspected asthma patients with normal or generally normal pulmonary ventilation function are more likely to achieve improvement in asthma symptoms within one year compared to patients with mild obstruction. [ABSTRACT FROM AUTHOR]

The engineering of ferroic orders, which involves the evolution of atomic structure and local ferroic configuration in the development of next‐generation electronic devices. Until now, diverse polarization structures and topological domains are obtained in ferroelectric thin films or heterostructures, and the polarization switching and subsequent domain nucleation are found to be more conducive to building energy‐efficient and multifunctional polarization structures. In this work, a continuous and periodic strain in a flexible freestanding BaTiO3 membrane to achieve a zigzag morphology is introduced. The polar head/tail boundaries and vortex/anti‐vortex domains are constructed by a compressive strain as low as ≈0.5%, which is extremely lower than that used in epitaxial rigid ferroelectrics. Overall, this study c efficient polarization structures, which is of both theoretical value and practical significance for the development of next‐generation flexible multifunctional devices. [ABSTRACT FROM AUTHOR]

Background: Microcirculatory perfusion disorder and inflammatory response are critical links in acute kidney injury (AKI). We aim to construct anti‐vascular cell adhesion molecule‐1(VCAM‐1) targeted microbubbles (TM) to monitor renal microcirculatory perfusion and inflammatory response. Methods: TM carrying VCAM‐1 polypeptide was constructed by biological coupling. The binding ability of TM to human umbilical vein endothelial cells (HUVECs) was detected. Bilateral renal ischemia–reperfusion injury (IRI) models of mice were established to evaluate microcirculatory perfusion and inflammatory response using TM. Thirty‐six mice were randomly divided into six groups according to the different reperfusion time (0.5, 2, 6, 12, and 24 h) and sham‐operated group (Sham group). The correlation of TM imaging with serum and histopathological biomarkers was investigated. Results: TM has advantages such as uniform distribution, regular shape, high stability, and good biosafety. TM could bind specifically to VCAM‐1 molecule expressed by tumor necrosis factor‐alpha (TNF‐α)‐treated HUVECs. In the renal IRI‐AKI model, the area under the curve (AUC) of TM significantly decreased both in the renal cortical and medullary after 2 h of reperfusion compared with the Sham group (p < 0.05). Normalized intensity difference (NID) of TM at different reperfusion time was all higher than that of blank microbubbles (BM) and the Sham group (p < 0.05). Ultrasound molecular imaging of TM could detect AKI early before commonly used renal function markers, histopathological biomarkers, and BM imaging. AUC of TM was negatively correlated with serum creatinine (Scr), blood urea nitrogen (BUN), and Cystatin C (Cys‐C) levels, and NID of TM was linearly correlated with VCAM‐1, TNF‐α, and interleukin‐6 (IL‐6) expression (p < 0.05). Conclusions: Ultrasound molecular imaging based on TM carrying VCAM‐1 polypeptide can accurately evaluate the changes in renal microcirculatory perfusion and inflammatory response, which might be a promising modality for early diagnosis of AKI. [ABSTRACT FROM AUTHOR]

Objective To investigate the application value of quality control circle (QCC)with health education pathway and teach-back method in reducing the incidence of constipation after transurethral resection of the prostate (TURP). Methods A QCC group was set up and theme of QCC activity was to reduce the incidence of constipation after TURP. Influencing factors were analysis based on literature review and cross-sectional study, and key issues and related countermeasures to process improvement were established. The health education pathway and teach-back method were adopted in the QCC, and incidence of constipation before and after implementation of QCC was compared. Results The incidence of constipation dropped from 68. 75%(33/48)before QCC to 18. 75%(9/48)after QCC, with a significant difference(P＜0. 05). Conclusion Based on the education pathway of preventing constipation after TURP, the health education using the teach-back method is effective to reduce the incidence of constipation after TURP and relieve postoperative pain of patients. (目的 探讨健康宣教路径联合回授法在降低前列腺电切术后患者便秘发生率的应用效果。方法 成立品管圈小组, 确定“降低前列腺电切术后患者便秘发生率”主题, 查阅文献并开展现况调查, 分析原因, 确立改善重点, 设定目标值, 制定对策, 构建预防前列腺电切术后便秘宣教路径并采用回授法实施, 对比实施前后前列腺电切术后便秘发生率。结果 前列腺电切术后便秘发生率由实施前的68. 75%(33/48)降低至实施后的18. 75%(9/48), 差异有统计学意义(P＜0. 05)。结论 通过构建预防前列腺电切术后患者便秘宣教路径, 采用回授法进行健康宣教, 能够有效降低前列腺电切术后便秘的发生风险, 减少患者痛苦。)

Objective To explore the application value of the standardized training model for newly recruited nurses based on demand and post competence. Methods Totally 70 nurses recruited in 2017 were selected as control group by convenient sampling method, and their training, examination and management were organized by using a traditional training mode. The same method was adopted to select 69 nurses in 2018 as observation group, and a standardized training model based on demand orientation and post competence was established. Primary indicators were professional knowledge, nursing skills, bedside comprehensive ability, score of Competency Inventory for Registered Nurse, turnover rate, ward satisfaction with newly recruited nurses. Results The scores in assessment of nurses' professional knowledge, professional skills, bedside comprehensive ability and post competence in the observation group were higher than those in the control group (P＜0. 01). The ward satisfaction with newly recruited nurses and nurse hospital training satisfaction in the observation group were higher than those in the control group (P＜0. 01). The turnover rate in the observation group was lower than that in the control group (P＜0. 01). Conclusion The standardized training model based on demand orientation and post competence can effectively improve the post competence of newly recruited nurses. (目的 探讨基于教育需求评估和核心能力的新入职护士规范化培训的应用效果。方法 采用便利抽样法选择2017届70名新入职护士作为对照组, 用传统培训模式组织培训、考核、管理。同样方法选择2018届69名新入职护士为观察组, 建立以教育需求评估和核心能力为理论框架的护士规范化培训模式, 组织培训、考核、管理、反馈等。比较2组新入职护士培训期间专业知识、护理技能、床边综合能力、护士岗位胜任力量表自评得分、新入职护士对培训满意度、病区对新入职护士满意度、离职率、等指标。结果 观察组新入职护士专业知识、专业技能、床边综合能力、岗位胜任力自评分均高于对照组, 差异有统计学意义(P＜0. 01)。观察组病区对新入职护士满意度、新入职护士对培训满意度均高于对照组, 差异有统计学意义(P＜0. 01)。观察组新入职护士离职率低于对照组, 差异有统计学意义(P＜0. 01)。结论 以教育需求评估和核心能力为理论框架的新入职护士规范化培训模式能有效提升新入职护士岗位胜任力。)