Search

Your search keyword '"Nicolson, Hamish"' showing total 7 results
Start Over Author "Nicolson, Hamish"
7 results on '"Nicolson, Hamish"'

2. VEXAS syndrome: A review of bone marrow aspirate and biopsies reporting myeloid and erythroid precursor vacuolation

Author

Cherniawsky, Hannah, primary, Friedmann, Jordan, additional, Nicolson, Hamish, additional, Dehghan, Natasha, additional, Stubbins, Ryan J., additional, Foltz, Lynda M., additional, Leitch, Heather A., additional, Sreenivasan, Gayatri M., additional, Ambler, Kimberley L. S., additional, Nevill, Thomas J., additional, McGinnis, Eric, additional, Wilson, Lorena, additional, Beck, David B., additional, Chen, Luke Y. C., additional, and Marcon, Krista M., additional

Published
2023
Full Text
View/download PDF

6. Clinical care pathway for the evaluation of patients with suspected VITT after ChAdOx1 nCoV-19 vaccination

Author

Lee, Agnes Y.Y., Al Moosawi, Muntadhar, Peterson, Erica A., McCracken, Rita K., Wong, Steven K.W., Nicolson, Hamish, Chan, Vicky, Smith, Tyler, Wong, Michelle P., Lee, Lauren J., Griffiths, Cameron, Rahal, Bhavdeep, Parkin, Stephen, Afra, Kevin, Ambler, Kimberley, Chen, Luke Y.C., Field, Thalia S., Lindsay, Heather C., Lavoie, Martin, Li, Charles, Migneault, David, Naus, Monika, Piszczek, Jolanta, Rahmani, Poupak, Sreenivasan, Gayatri, Wan, Tony, Yee, Adrian, Zypchen, Leslie, and Sweet, David

Published
2022
Full Text
View/download PDF

7. Clinical Care Pathway for the Evaluation of Patients with Suspected Vaccine-Induced Immune Thrombotic Thrombocytopenia After ChAdOx1 n-CoV-19 vaccination

Author

Lee, Agnes Y Y, Al Moosawi, Muntadhar, Peterson, Erica A, McCracken, Rita K, Wong, Steven K W, Nicolson, Hamish, Chan, Vicky, Smith, Tyler, Wong, Michelle P, Lee, Lauren J, Griffiths, Cameron, Rahal, Bhavdeep, Parkin, Stephen, Afra, Kevin, Ambler, Kimberley, Chen, Luke Y C, Field, Thalia S, Lindsay, Heather C, Lavoie, Martin, Li, Charles, Migneault, David, Naus, Monika, Piszczek, Jolanta, Rahmani, Poupak, Sreenivasan, Gayatri, Wan, Tony, Yee, Adrian, Zypchen, Leslie, and Sweet, David

Abstract

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication after SARS-CoV-2 adenoviral vector vaccination. In British Columbia, a provincial clinical care pathway was developed to guide clinicians in evaluating for VITT among patients who present with thrombocytopenia or thrombosis symptoms within 4 to 28 days after adenoviral vector vaccine exposure. All patients had enzyme-linked immunosorbent assay (ELISA) testing for platelet factor 4 (PF4) antibodies and all cases with positive PF4-ELISA or D-dimer levels ≥2.0 mg/L fibrinogen equivalent units (FEU) had further testing for platelet-activating PF4 antibodies using a modified serotonin release assay (SRA). Between May 1 and June 30, 2021, 37% of 68 patients investigated for VITT had thrombosis but only 3 had VITT confirmed by PF4-ELISA and SRA. Platelet counts, D-dimer levels, and ELISA optical density values were significantly different between those with and without VITT. Three patients had thrombocytopenia and thrombosis with D-dimer levels >4.0 mg/L FEU but had negative PF4-ELISA and SRA results. Patients with VITT were treated successfully with intravenous immunoglobulin, non-heparin anticoagulants and corticosteroids. Our pathway demonstrated that thrombosis is common among patients investigated for VITT and that PF4-ELISA testing is necessary to confirm VITT in those presenting with thrombosis and thrombocytopenia.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results