Author: "Nicolotti N." - Searchworks@Jio Institute Digital Library Search Results

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195 results on '"Nicolotti N."'

1. Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (ec-SOD)

Author: Mancini, A., Silvestrini, Andrea, Marcheggiani, F., Capobianco, E., Silvestri, S., Lembo, Erminia, Orlando, P., Beccia, Flavia, Nicolotti, Nicola, Panocchia, Nicola, Tiano, L., Silvestrini A. (ORCID:0000-0002-2005-3746), Lembo E., Beccia F., Nicolotti N., Panocchia N., Mancini, A., Silvestrini, Andrea, Marcheggiani, F., Capobianco, E., Silvestri, S., Lembo, Erminia, Orlando, P., Beccia, Flavia, Nicolotti, Nicola, Panocchia, Nicola, Tiano, L., Silvestrini A. (ORCID:0000-0002-2005-3746), Lembo E., Beccia F., Nicolotti N., and Panocchia N.
Abstract: Oxidative stress (OS) is implicated in several chronic diseases. Extra-cellular superoxide dismutase (ec-SOD) catalyses the dismutation of superoxide anions with a protective role in endothelial cells. In chronic kidney disease (CKD), OS and thyroid dysfunction (low fT3 syndrome) are frequently present, but their relationship has not yet been investigated. This cohort study evaluated ec-SOD activity in CKD patients during haemodialysis, divided into "acute haemodialytic patients" (AH, 1-3 months of treatment) and "chronic haemodialytic patients" (CH, treated for a longer period). We also evaluated plasmatic total antioxidant capacity (TAC) and its relationships with thyroid hormones. Two basal samples ("basal 1", obtained 3 days after the last dialysis; and "basal 2", obtained 2 days after the last dialysis) were collected. On the same day of basal 2, a sample was collected 5 and 10 min after the standard heparin dose and at the end of the procedure. The ec-SOD values were significantly higher in CH vs. AH in all determinations. Moreover, the same patients had lower TAC values. When the CH patients were divided into two subgroups according to fT3 levels (normal or low), we found significantly lower ec-SOD values in the group with low fT3 in the basal, 5, and 10 min samples. A significant correlation was also observed between fT3 and ec-SOD in the basal 1 samples. These data, confirming OS and low fT3 syndrome in patients with CKD, suggest that low fT3 concentrations can influence ec-SOD activity and could therefore potentially contribute to endothelial oxidative damage in these patients.
Published: 2024

2. Hospital reengineering against COVID-19 outbreak: 1-month experience of an Italian tertiary care center

Author: Tosoni, A., Rizzatti, G., Nicolotti, N., Di Giambenedetto, S., Addolorato, G., Franceschi, F., Dal Verme, L. Z., Tosoni A., Rizzatti G. (ORCID:0000-0003-1876-7587), Nicolotti N., Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Tosoni, A., Rizzatti, G., Nicolotti, N., Di Giambenedetto, S., Addolorato, G., Franceschi, F., Dal Verme, L. Z., Tosoni A., Rizzatti G. (ORCID:0000-0003-1876-7587), Nicolotti N., Di Giambenedetto S. (ORCID:0000-0001-6990-5076), Addolorato G. (ORCID:0000-0002-1522-9946), and Franceschi F. (ORCID:0000-0001-6266-445X)
Abstract: Objective: The recent outbreak of SARS-CoV-2 infection in Italy has resulted in a sudden and massive flow of patients into emergency rooms, and a high number of hospitalizations with the need for respiratory isolation. Massive admission of patients to the Policlinico "Agostino Gemelli" Foundation of Rome, Italy, determined the need for reengineering the entire hospital. Materials and Methods: In this article, we consider some of the structural and organizational changes that have been necessary to deal with the emergency, with particular reference to non-intensive medicine wards, and the preventive measures aimed at limiting the spread of SARS-CoV-2 infection among hospital staff and patients themselves. Results: 577 staff members were subjected to molecular tests in 1-month period and 3.8% of the total were positive. 636 patients admitted to the COVID-19 pathway were included and analyzed: 45.4% were identified as SARS-CoV-2 positive. More SARS-CoV-2 negative patients were discharged in comparison to SARS-CoV-2 positive patients (59% vs. 41%, respectively). On the other hand, more SARS-CoV-2 positive patients were transferred to ICUs in comparison to SARSCoV-2 negative patients (16% vs. 1%, respectively). Occurrence of death was similar between the two groups, 11% vs. 7%, for SARS-CoV-2 negative and positive patients, respectively. 25% of .80 years old SARS-CoV-2 positive patients died during the hospitalization, while death rate was lower in other age groups (5% in 70-79 years old patients and 0% in remaining age groups). Conclusions: Rapid hospital reengineering has probably had an impact on the management of patients with and without SARS-CoV-2 infection, and on in-hospital mortality rates over the reporting period.
Published: 2020

3. Balancing Donor and Recipient Risk Factors in Liver Transplantation: The Value of D-MELD With Particular Reference to HCV Recipients

Author: Avolio, A.W., Cillo, U., Salizzoni, M., De Carlis, L., Colledan, M., Gerunda, G.E., Mazzaferro, V., Tisone, G., Romagnoli, R., Caccamo, L., Rossi, M., Vitale, A., Cucchetti, A., Lupo, L., Gruttadauria, S., Nicolotti, N., Burra, P., Gasbarrini, A., and Agnes, S.
Published: 2011
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4. EASE SCORE, NOVEL ALGORITHM BASED ON KINETICS OF AST, BILIRUBIN, PLATELETS AND RECIPIENT DATA TO PREDICT EARLY ALLOGRAFT FAILURE. AN ITALIAN MULTICENTER STUDY DESIGNED IN THE PERSPECTIVE OF LIVER RE-TRANSPLANTATION WITH UK VALIDATION

Author: Franco, A, De Simone, P, Schlegel, A, Lai, Q, Burra, P, Patrono, D, Meli, S, Ravaioli, M, Bassi, D, Ferla, F, Pagano, D, Violi, P, Camagni, S, Dondossola, D, Montalti, R, Alrawashdeh, W, Vitale, A, Teofili, L, Ghinolfi, D, Spoletini, G, Maroni, L, Nicolotti, N, Magistri, P, Pastena, D, Bongini, M, Rossi, M, Mazzaferro, V, Di Benedetto, F, Hammond, J, Vivarelli, M, Agnes, S, Colledan, M, Carraro, A, De Carlis, L, Cescon, M, Caccamo, L, Gruttadauria, S, Muiesan, P, Cillo, U, Romagnoli, R, Avolio, A, Franco A, De Simone P, Schlegel A, Lai Q, Burra P, Patrono D, Meli S, Ravaioli M, Bassi D, Ferla F, Pagano D, Violi P, Camagni S, Dondossola D, Montalti R, Alrawashdeh W, Vitale A, Teofili L, Ghinolfi D, Spoletini G, Maroni L, Nicolotti N, Magistri P, Pastena D, Bongini M, Rossi M, Mazzaferro V, Di Benedetto F, Hammond J, Vivarelli M, Agnes S, Colledan M, Carraro A, De Carlis L, Cescon M, Caccamo L, Gruttadauria S, Muiesan P, Cillo U, Romagnoli R, Avolio A, Franco, A, De Simone, P, Schlegel, A, Lai, Q, Burra, P, Patrono, D, Meli, S, Ravaioli, M, Bassi, D, Ferla, F, Pagano, D, Violi, P, Camagni, S, Dondossola, D, Montalti, R, Alrawashdeh, W, Vitale, A, Teofili, L, Ghinolfi, D, Spoletini, G, Maroni, L, Nicolotti, N, Magistri, P, Pastena, D, Bongini, M, Rossi, M, Mazzaferro, V, Di Benedetto, F, Hammond, J, Vivarelli, M, Agnes, S, Colledan, M, Carraro, A, De Carlis, L, Cescon, M, Caccamo, L, Gruttadauria, S, Muiesan, P, Cillo, U, Romagnoli, R, Avolio, A, Franco A, De Simone P, Schlegel A, Lai Q, Burra P, Patrono D, Meli S, Ravaioli M, Bassi D, Ferla F, Pagano D, Violi P, Camagni S, Dondossola D, Montalti R, Alrawashdeh W, Vitale A, Teofili L, Ghinolfi D, Spoletini G, Maroni L, Nicolotti N, Magistri P, Pastena D, Bongini M, Rossi M, Mazzaferro V, Di Benedetto F, Hammond J, Vivarelli M, Agnes S, Colledan M, Carraro A, De Carlis L, Cescon M, Caccamo L, Gruttadauria S, Muiesan P, Cillo U, Romagnoli R, and Avolio A
Published: 2019

5. Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis

Author: Avolio, A. W., Gaspari, R., Teofili, L., Bianco, G., Spinazzola, G., Soave, P. M., Paiano, G., Francesconi, A. G., Arcangeli, A., Nicolotti, N., Antonelli, M., Avolio A. W. (ORCID:0000-0003-2491-7625), Gaspari R. (ORCID:0000-0003-0141-3686), Teofili L. (ORCID:0000-0002-7214-1561), Soave P. M., Paiano, Gianfranco, Francesconi, Alessandra Gioia, Arcangeli A. (ORCID:0000-0001-6755-5981), Nicolotti N., Antonelli M. (ORCID:0000-0003-3007-1670), Avolio, A. W., Gaspari, R., Teofili, L., Bianco, G., Spinazzola, G., Soave, P. M., Paiano, G., Francesconi, A. G., Arcangeli, A., Nicolotti, N., Antonelli, M., Avolio A. W. (ORCID:0000-0003-2491-7625), Gaspari R. (ORCID:0000-0003-0141-3686), Teofili L. (ORCID:0000-0002-7214-1561), Soave P. M., Paiano, Gianfranco, Francesconi, Alessandra Gioia, Arcangeli A. (ORCID:0000-0001-6755-5981), Nicolotti N., and Antonelli M. (ORCID:0000-0003-3007-1670)
Abstract: Background :Postoperative respiratory failure (PRF, namely mechanical ventilation >48 hours) significantly affects morbidity and mortality in liver transplantation (LTx). Previous studies analyzed only one or two categories of PRF risk factors (preoperative, intraoperative or postoperative ones). The aims of this study were to identify PRF predictors, to assess the length of stay (LoS) in ICU and the 90-day survival according to the PRF in LTx patients. Methods: Two classification approaches were used: systematic classification (recipient-related preoperative factors; intraoperative factors; logistic factors; donor factors; postoperative ICU factors; postoperative surgical factors) and patient/organ classification (patient-related general factors; native-liver factors; new-liver factors; kidney factors; heart factors; brain factors; lung factors). Two hundred adult non-acute patients were included. Missing analysis was performed. The competitive role of each factor was assessed. Results: PRF occurred in 36.0% of cases. Among 28 significant PRF predictors at univariate analysis, 6 were excluded because of collinearity, 22 were investigated by ROC curves and by logistic regression analysis. Recipient age (OR = 1.05; p = 0.010), female sex (OR = 2.75; p = 0.018), Model for End-Stage Liver Disease (MELD, OR = 1.09; p<0.001), restrictive lung pattern (OR = 2.49; p = 0.027), intraoperative veno-venous bypass (VVBP, OR = 3.03; p = 0.008), pre-extubation PaCO 2 (OR = 1.11; p = 0.003) and Model for Early Allograft Function (MEAF, OR = 1.37; p<0.001) resulted independent PRF risk factors. As compared to patients without PRF, the PRF-group had longer LoS (10 days IQR 7-18 versus 5 days IQR 4-7, respectively; p<0.001) and lower day-90 survival (86.0% versus 97.6% respectively, p<0.001). Conclusion: In conclusion, MELD, restrictive lung pattern, surgical complexity as captured by VVBP, pre-extubation PaCO 2 and MEAF are the main predictors of PRF in non-acute LTx
Published: 2019

6. Successful Use of Extended Criteria Donor Grafts With Low to Moderate Steatosis in Patients With Model for End-Stage Liver Disease Scores Below 27

Author: Avolio, A.W., Frongillo, F., Nicolotti, N., Mulè, A., Vennarecci, G., De Simone, P., and Agnes, S.
Published: 2009
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7. Gemelli decision tree Algorithm to Predict the need for home monitoring or hospitalization of confirmed and unconfirmed COVID-19 patients (GAP-Covid19): preliminary results from a retrospective cohort study

Author: Vetrugno, Giuseppe, Laurenti, Patrizia, Franceschi, F, Foti, F, D'Ambrosio, F, Cicconi, M, La Milia, Daniele Ignazio, Di Pumpo, M, Carini, E, Pascucci, Domenico, Boccia, Stefania, Pastorino, Roberta, Damiani, Gianfranco, De-Giorgio, F, Oliva, A, Nicolotti, Nicola, Cambieri, Andrea, Ghisellini, R, Murri, Rita, Sabatelli, G, Musolino, M, Gasbarrini, Antonio, Vetrugno, G (ORCID:0000-0003-0181-2855), Laurenti, P (ORCID:0000-0002-8532-0593), LA Milia, D I, Pascucci, D (ORCID:0000-0002-5804-2284), Boccia, S (ORCID:0000-0002-1864-749X), Pastorino, R (ORCID:0000-0001-5013-0733), Damiani, G (ORCID:0000-0003-3028-6188), Nicolotti, N, Cambieri, A, Murri, R (ORCID:0000-0003-4263-7854), Gasbarrini, A (ORCID:0000-0002-7278-4823), Vetrugno, Giuseppe, Laurenti, Patrizia, Franceschi, F, Foti, F, D'Ambrosio, F, Cicconi, M, La Milia, Daniele Ignazio, Di Pumpo, M, Carini, E, Pascucci, Domenico, Boccia, Stefania, Pastorino, Roberta, Damiani, Gianfranco, De-Giorgio, F, Oliva, A, Nicolotti, Nicola, Cambieri, Andrea, Ghisellini, R, Murri, Rita, Sabatelli, G, Musolino, M, Gasbarrini, Antonio, Vetrugno, G (ORCID:0000-0003-0181-2855), Laurenti, P (ORCID:0000-0002-8532-0593), LA Milia, D I, Pascucci, D (ORCID:0000-0002-5804-2284), Boccia, S (ORCID:0000-0002-1864-749X), Pastorino, R (ORCID:0000-0001-5013-0733), Damiani, G (ORCID:0000-0003-3028-6188), Nicolotti, N, Cambieri, A, Murri, R (ORCID:0000-0003-4263-7854), and Gasbarrini, A (ORCID:0000-0002-7278-4823)
Abstract: OBJECTIVE: To develop a deep learning-based decision tree for the primary care setting, to stratify adult patients with confirmed and unconfirmed coronavirus disease 2019 (COVID-19), and to predict the need for hospitalization or home monitoring.PATIENTS AND METHODS: We performed a retrospective cohort study on data from patients admitted to a COVID hospital in Rome, Italy, between 5 March 2020 and 5 June 2020. A confirmed case was defined as a patient with a positive nasopharyngeal RT-PCR test result, while an unconfirmed case had negative results on repeated swabs. Patients' medical history and clinical, laboratory and radiological findings were collected, and the dataset was used to train a predictive model for COVID-19 severity.RESULTS: Data of 198 patients were included in the study. Twenty-eight (14.14%) had mild disease, 62 (31.31%) had moderate disease, 64 (32.32%) had severe disease, and 44 (22.22%) had critical disease. The G(2) value assessed the contribution of each collected value to decision tree building. On this basis, SpO2 (%) with a cut point at 92 was chosen for the optimal first split. Therefore, the decision tree was built using values maximizing G(2) and LogWorth. After the tree was built, the correspondence between inputs and outcomes was validated.CONCLUSIONS: We developed a machine learning-based tool that is easy to understand and apply. It provides good discrimination in stratifying confirmed and unconfirmed COVID-19 patients with different prognoses in every context. Our tool might allow general practitioners visiting patients at home to decide whether the patient needs to be hospitalized.
Published: 2021

8. A machine-learning parsimonious multivariable predictive model of mortality risk in patients with Covid-19

Author: Murri, Rita, Lenkowicz, Jacopo, Masciocchi, Carlotta, Iacomini, C., Fantoni, Massimo, Damiani, Andrea, Marchetti, A., Sergi, P. D. A., Arcuri, G., Cesario, Alfredo, Patarnello, S., Antonelli, Massimo, Bellantone, Rocco Domenico Alfonso, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria Marchiano, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, Valentini, Vincenzo, Armuzzi, Alessandro, Barba, Marta, Baroni, Silvia, Bellesi, Silvia, Bentivoglio, Anna Rita, Biasucci, Luigi Marzio, Biscetti, Federico, Candelli, Marcello, Capalbo, Gennaro, Cattani Franchi, Paola, Chiusolo, Patrizia, Cingolani, Antonella, Corbo, Giuseppe Maria, Covino, Marcello, Cozzolino, A. M., D'Alfonso, Maria Elena, De Angelis, Giulia, De Pascale, Gennaro, Frisullo, Giovanni, Gabrielli, M., Gambassi, Giovanni, Garcovich, M., Gremese, Elisa, Grieco, D. L., Iaconelli, A., Iorio, Raffaele, Landi, Francesco, Larici, Anna Rita, Liuzzo, Giovanna, Maviglia, Riccardo, Miele, Luca, Montalto, Massimo, Natale, Luigi, Nicolotti, Nicola, Ojetti, Veronica, Pompili, Maurizio, Posteraro, Brunella, Rapaccini, Gian Ludovico, Rinaldi, R., Rossi, Elena, Santoliquido, Angelo, Sica, Simona, Tamburrini, Enrica, Teofili, Luciana, Testa, Antonia Carla, Tosoni, A., Trani, Carlo, Varone, Francesco, Verme, L. Z. D., Murri R. (ORCID:0000-0003-4263-7854), Lenkowicz J., Masciocchi C., Fantoni M. (ORCID:0000-0001-6913-8460), Damiani A., Cesario A. (ORCID:0000-0003-4687-0709), Antonelli M. (ORCID:0000-0003-3007-1670), Bellantone R. (ORCID:0000-0002-0844-3469), Bernabei R. (ORCID:0000-0002-9197-004X), Boccia S. (ORCID:0000-0002-1864-749X), Calabresi P. (ORCID:0000-0003-0326-5509), Cambieri A., Cauda R. (ORCID:0000-0002-1498-4229), Colosimo C. (ORCID:0000-0003-3800-3648), Crea F. (ORCID:0000-0001-9404-8846), De Maria R. (ORCID:0000-0003-2255-0583), De Stefano V. (ORCID:0000-0002-5178-5827), Franceschi F. (ORCID:0000-0001-6266-445X), Gasbarrini A. (ORCID:0000-0002-7278-4823), Parolini O. (ORCID:0000-0002-5211-6430), Richeldi L. (ORCID:0000-0001-8594-1448), Sanguinetti M. (ORCID:0000-0002-9780-7059), Urbani A. (ORCID:0000-0001-9168-3174), Zega M. (ORCID:0000-0002-7821-2615), Scambia G. (ORCID:0000-0003-2758-1063), Valentini V. (ORCID:0000-0003-4637-6487), Armuzzi A. (ORCID:0000-0003-1572-0118), Barba M. (ORCID:0000-0001-6084-7666), Baroni S. (ORCID:0000-0002-3410-2617), Bellesi S., Bentivoglio A. (ORCID:0000-0002-9663-095X), Biasucci L. M. (ORCID:0000-0002-6921-6497), Biscetti F. (ORCID:0000-0001-7449-657X), Candelli M. (ORCID:0000-0001-8443-7880), Capalbo G., Cattani P. (ORCID:0000-0003-4678-4763), Chiusolo P. (ORCID:0000-0002-1355-1587), Cingolani A. (ORCID:0000-0002-3793-2755), Corbo G. (ORCID:0000-0002-8104-4659), Covino M. (ORCID:0000-0002-6709-2531), D'Alfonso M., De Angelis G. (ORCID:0000-0002-7087-7399), De Pascale G. (ORCID:0000-0002-8255-0676), Frisullo G., Gambassi G. (ORCID:0000-0002-7030-9359), Gremese E. (ORCID:0000-0002-2248-1058), Iorio R. (ORCID:0000-0002-6270-0956), Landi F. (ORCID:0000-0002-3472-1389), Larici A. (ORCID:0000-0002-1882-6244), Liuzzo G. (ORCID:0000-0002-5714-0907), Maviglia R., Miele L. (ORCID:0000-0003-3464-0068), Montalto M. (ORCID:0000-0001-8819-3684), Natale L. (ORCID:0000-0002-7949-5119), Nicolotti N., Ojetti V. (ORCID:0000-0002-8953-0707), Pompili M. (ORCID:0000-0001-6699-7980), Posteraro B. (ORCID:0000-0002-1663-7546), Rapaccini G. (ORCID:0000-0002-6467-857X), Rossi E. (ORCID:0000-0002-7572-9379), Santoliquido A. (ORCID:0000-0003-1539-4017), Sica S. (ORCID:0000-0003-2426-3465), Tamburrini E. (ORCID:0000-0003-4930-426X), Teofili L. (ORCID:0000-0002-7214-1561), Testa A. (ORCID:0000-0003-2217-8726), Trani C. (ORCID:0000-0001-9777-013X), Varone F., Murri, Rita, Lenkowicz, Jacopo, Masciocchi, Carlotta, Iacomini, C., Fantoni, Massimo, Damiani, Andrea, Marchetti, A., Sergi, P. D. A., Arcuri, G., Cesario, Alfredo, Patarnello, S., Antonelli, Massimo, Bellantone, Rocco Domenico Alfonso, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria Marchiano, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, Valentini, Vincenzo, Armuzzi, Alessandro, Barba, Marta, Baroni, Silvia, Bellesi, Silvia, Bentivoglio, Anna Rita, Biasucci, Luigi Marzio, Biscetti, Federico, Candelli, Marcello, Capalbo, Gennaro, Cattani Franchi, Paola, Chiusolo, Patrizia, Cingolani, Antonella, Corbo, Giuseppe Maria, Covino, Marcello, Cozzolino, A. M., D'Alfonso, Maria Elena, De Angelis, Giulia, De Pascale, Gennaro, Frisullo, Giovanni, Gabrielli, M., Gambassi, Giovanni, Garcovich, M., Gremese, Elisa, Grieco, D. L., Iaconelli, A., Iorio, Raffaele, Landi, Francesco, Larici, Anna Rita, Liuzzo, Giovanna, Maviglia, Riccardo, Miele, Luca, Montalto, Massimo, Natale, Luigi, Nicolotti, Nicola, Ojetti, Veronica, Pompili, Maurizio, Posteraro, Brunella, Rapaccini, Gian Ludovico, Rinaldi, R., Rossi, Elena, Santoliquido, Angelo, Sica, Simona, Tamburrini, Enrica, Teofili, Luciana, Testa, Antonia Carla, Tosoni, A., Trani, Carlo, Varone, Francesco, Verme, L. Z. D., Murri R. (ORCID:0000-0003-4263-7854), Lenkowicz J., Masciocchi C., Fantoni M. (ORCID:0000-0001-6913-8460), Damiani A., Cesario A. (ORCID:0000-0003-4687-0709), Antonelli M. (ORCID:0000-0003-3007-1670), Bellantone R. (ORCID:0000-0002-0844-3469), Bernabei R. (ORCID:0000-0002-9197-004X), Boccia S. (ORCID:0000-0002-1864-749X), Calabresi P. (ORCID:0000-0003-0326-5509), Cambieri A., Cauda R. (ORCID:0000-0002-1498-4229), Colosimo C. (ORCID:0000-0003-3800-3648), Crea F. (ORCID:0000-0001-9404-8846), De Maria R. (ORCID:0000-0003-2255-0583), De Stefano V. (ORCID:0000-0002-5178-5827), Franceschi F. (ORCID:0000-0001-6266-445X), Gasbarrini A. (ORCID:0000-0002-7278-4823), Parolini O. (ORCID:0000-0002-5211-6430), Richeldi L. (ORCID:0000-0001-8594-1448), Sanguinetti M. (ORCID:0000-0002-9780-7059), Urbani A. (ORCID:0000-0001-9168-3174), Zega M. (ORCID:0000-0002-7821-2615), Scambia G. (ORCID:0000-0003-2758-1063), Valentini V. (ORCID:0000-0003-4637-6487), Armuzzi A. (ORCID:0000-0003-1572-0118), Barba M. (ORCID:0000-0001-6084-7666), Baroni S. (ORCID:0000-0002-3410-2617), Bellesi S., Bentivoglio A. (ORCID:0000-0002-9663-095X), Biasucci L. M. (ORCID:0000-0002-6921-6497), Biscetti F. (ORCID:0000-0001-7449-657X), Candelli M. (ORCID:0000-0001-8443-7880), Capalbo G., Cattani P. (ORCID:0000-0003-4678-4763), Chiusolo P. (ORCID:0000-0002-1355-1587), Cingolani A. (ORCID:0000-0002-3793-2755), Corbo G. (ORCID:0000-0002-8104-4659), Covino M. (ORCID:0000-0002-6709-2531), D'Alfonso M., De Angelis G. (ORCID:0000-0002-7087-7399), De Pascale G. (ORCID:0000-0002-8255-0676), Frisullo G., Gambassi G. (ORCID:0000-0002-7030-9359), Gremese E. (ORCID:0000-0002-2248-1058), Iorio R. (ORCID:0000-0002-6270-0956), Landi F. (ORCID:0000-0002-3472-1389), Larici A. (ORCID:0000-0002-1882-6244), Liuzzo G. (ORCID:0000-0002-5714-0907), Maviglia R., Miele L. (ORCID:0000-0003-3464-0068), Montalto M. (ORCID:0000-0001-8819-3684), Natale L. (ORCID:0000-0002-7949-5119), Nicolotti N., Ojetti V. (ORCID:0000-0002-8953-0707), Pompili M. (ORCID:0000-0001-6699-7980), Posteraro B. (ORCID:0000-0002-1663-7546), Rapaccini G. (ORCID:0000-0002-6467-857X), Rossi E. (ORCID:0000-0002-7572-9379), Santoliquido A. (ORCID:0000-0003-1539-4017), Sica S. (ORCID:0000-0003-2426-3465), Tamburrini E. (ORCID:0000-0003-4930-426X), Teofili L. (ORCID:0000-0002-7214-1561), Testa A. (ORCID:0000-0003-2217-8726), Trani C. (ORCID:0000-0001-9777-013X), and Varone F.
Abstract: The COVID-19 pandemic is impressively challenging the healthcare system. Several prognostic models have been validated but few of them are implemented in daily practice. The objective of the study was to validate a machine-learning risk prediction model using easy-to-obtain parameters to help to identify patients with COVID-19 who are at higher risk of death. The training cohort included all patients admitted to Fondazione Policlinico Gemelli with COVID-19 from March 5, 2020, to November 5, 2020. Afterward, the model was tested on all patients admitted to the same hospital with COVID-19 from November 6, 2020, to February 5, 2021. The primary outcome was in-hospital case-fatality risk. The out-of-sample performance of the model was estimated from the training set in terms of Area under the Receiving Operator Curve (AUROC) and classification matrix statistics by averaging the results of fivefold cross validation repeated 3-times and comparing the results with those obtained on the test set. An explanation analysis of the model, based on the SHapley Additive exPlanations (SHAP), is also presented. To assess the subsequent time evolution, the change in paO2/FiO2 (P/F) at 48 h after the baseline measurement was plotted against its baseline value. Among the 921 patients included in the training cohort, 120 died (13%). Variables selected for the model were age, platelet count, SpO2, blood urea nitrogen (BUN), hemoglobin, C-reactive protein, neutrophil count, and sodium. The results of the fivefold cross-validation repeated 3-times gave AUROC of 0.87, and statistics of the classification matrix to the Youden index as follows: sensitivity 0.840, specificity 0.774, negative predictive value 0.971. Then, the model was tested on a new population (n = 1463) in which the case-fatality rate was 22.6%. The test model showed AUROC 0.818, sensitivity 0.813, specificity 0.650, negative predictive value 0.922. Considering the first quartile of the predicted risk score (low-risk sc
Published: 2021

9. Protective effect of SARS-CoV-2 preventive measures against ESKAPE and Escherichia coli infections

Author: Gaspari, Rita, Spinazzola, Giorgia, Teofili, Luciana, Avolio, Alfonso Wolfango, Fiori, Barbara, Maresca, G. M., Spanu Pennestri, Teresa, Nicolotti, Nicola, De Pascale, Gennaro, Antonelli, Massimo, Gaspari R. (ORCID:0000-0003-0141-3686), Spinazzola G. (ORCID:0000-0001-8055-5142), Teofili L. (ORCID:0000-0002-7214-1561), Avolio A. W. (ORCID:0000-0003-2491-7625), Fiori B. (ORCID:0000-0003-3318-5809), Spanu T. (ORCID:0000-0003-1864-5184), Nicolotti N., De Pascale G. (ORCID:0000-0002-8255-0676), Antonelli M. (ORCID:0000-0003-3007-1670), Gaspari, Rita, Spinazzola, Giorgia, Teofili, Luciana, Avolio, Alfonso Wolfango, Fiori, Barbara, Maresca, G. M., Spanu Pennestri, Teresa, Nicolotti, Nicola, De Pascale, Gennaro, Antonelli, Massimo, Gaspari R. (ORCID:0000-0003-0141-3686), Spinazzola G. (ORCID:0000-0001-8055-5142), Teofili L. (ORCID:0000-0002-7214-1561), Avolio A. W. (ORCID:0000-0003-2491-7625), Fiori B. (ORCID:0000-0003-3318-5809), Spanu T. (ORCID:0000-0003-1864-5184), Nicolotti N., De Pascale G. (ORCID:0000-0002-8255-0676), and Antonelli M. (ORCID:0000-0003-3007-1670)
Abstract: Background/Objectives: We investigated whether behavioral precautions adopted during Coronavirus disease (COVID-19) pandemic also influenced the spreading and multidrug resistance (MDR) of ESKAPEEc (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii [AB], Pseudomonas aeruginosa, Enterobacter spp and Escherichia Coli, [EC]) among Intensive Care Unit (ICU) patients. Subjects/Methods: We performed a single-center retrospective study in adult patients admitted to our COVID-19-free surgical ICU. Only patients staying in ICU for more than 48 hours were included. The ESKAPEEc infections recorded during the COVID-19 period (June 1, 2020 - February 28, 2021) and in the corresponding pre-pandemic period (June 1, 2019 - February 28, 2020) were compared. An interrupted time series analysis was performed to rule out possible confounders. Results: Overall, 173 patients in the COVID-19 period and 132 in the pre-COVID-19 period were investigated. The ESKAPEEc infections were documented in 23 (13.3%) and 35 (26.5%) patients in the pandemic and the pre-pandemic periods, respectively (p = 0.005). Demographics, diagnosis, comorbidities, type of surgery, Simplified Acute Physiology Score II, length of mechanical ventilation, hospital and ICU length of stay, ICU death rate, and 28-day hospital mortality were similar in the two groups. In comparison with the pre-pandemic period, no AB was recorded during COVID-19 period, (p = 0.017), while extended-spectrum beta-lactamase-producing EC infections significantly decreased (p = 0.017). Overall, the ESKAPEEc isolates during pandemic less frequently exhibited multidrug-resistant (p = 0.014). Conclusions: These findings suggest that a robust adherence to hygiene measures together with human contact restrictions in a COVID-19 free ICU might also restrain the transmission of ESKAPEEc pathogens.
Published: 2021

10. Let‐7a‐5p, mir‐100‐5p, mir‐101‐3p, and mir‐199a‐3p hyperexpression as potential predictive biomarkers in early breast cancer patients

Author: Fuso, Paola, Di Salvatore, Mariantonietta, Santonocito, Concetta, Guarino, Donatella, Autilio, C., Mule, A., Arciuolo, Damiano, Rinninella, A., Mignone, Flavio, Ramundo, M., Di Stefano, B., Orlandi, Armando, Capoluongo, Ettore Domenico, Nicolotti, Nicola, Franceschini, Gianluca, Sanchez, A. M., Tortora, Giampaolo, Scambia, Giovanni, Barone, C., Cassano, Alessandra, Fuso P., Di Salvatore M., Santonocito C. (ORCID:0000-0003-3624-1386), Guarino D., Arciuolo D., Mignone F., Orlandi A. (ORCID:0000-0001-5253-4678), Capoluongo E. (ORCID:0000-0001-9872-0572), Nicolotti N., Franceschini G. (ORCID:0000-0002-2950-3395), Tortora G. (ORCID:0000-0002-1378-4962), Scambia G. (ORCID:0000-0003-2758-1063), Cassano A. (ORCID:0000-0002-3311-7163), Fuso, Paola, Di Salvatore, Mariantonietta, Santonocito, Concetta, Guarino, Donatella, Autilio, C., Mule, A., Arciuolo, Damiano, Rinninella, A., Mignone, Flavio, Ramundo, M., Di Stefano, B., Orlandi, Armando, Capoluongo, Ettore Domenico, Nicolotti, Nicola, Franceschini, Gianluca, Sanchez, A. M., Tortora, Giampaolo, Scambia, Giovanni, Barone, C., Cassano, Alessandra, Fuso P., Di Salvatore M., Santonocito C. (ORCID:0000-0003-3624-1386), Guarino D., Arciuolo D., Mignone F., Orlandi A. (ORCID:0000-0001-5253-4678), Capoluongo E. (ORCID:0000-0001-9872-0572), Nicolotti N., Franceschini G. (ORCID:0000-0002-2950-3395), Tortora G. (ORCID:0000-0002-1378-4962), Scambia G. (ORCID:0000-0003-2758-1063), and Cassano A. (ORCID:0000-0002-3311-7163)
Abstract: Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC). Patients and methods: We retrospec-tively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next‐Generation‐Sequencing (NGS) system. Results: Event‐free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let‐7a‐5p (EFS p = 0.006; OS p = 0.0001), mirR‐100‐5p (EFS s p = 0.01; OS p = 0.03), miR‐ 101‐3p (EFS p = 0.05; OS p = 0.01), and miR‐199a‐3p (EFS p = 0.02; OS p = 0.01) in post‐NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let‐7a‐5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up‐regulation of the above miRNAs could represent biomarkers in breast cancer.
Published: 2021

11. Evaluation of kisspeptin levels in prepubertal obese and overweight children: Sexual dimorphism and modulation of antioxidant levels

Author: Mancini, Antonio, Curro', Diego, Cipolla, C., Barini, Angelina, Bruno, Carmine, Vergani, Edoardo, Segni, C. D. I., Guidi, Francesco, Nicolotti, Nicola, Silvestrini, Andrea, Meucci Calabrese, Elisabetta, Valentini, Piero, Rossodivita, Aurora Natalia, Mancini A. (ORCID:0000-0002-7707-4564), Curro D. (ORCID:0000-0001-6726-6872), Barini A. (ORCID:0000-0002-1440-5581), Bruno C., Vergani E., Guidi F., Nicolotti N., Silvestrini A. (ORCID:0000-0002-2005-3746), Meucci E. (ORCID:0000-0002-8821-8041), Valentini P. (ORCID:0000-0001-6095-9510), Rossodivita A. N., Mancini, Antonio, Curro', Diego, Cipolla, C., Barini, Angelina, Bruno, Carmine, Vergani, Edoardo, Segni, C. D. I., Guidi, Francesco, Nicolotti, Nicola, Silvestrini, Andrea, Meucci Calabrese, Elisabetta, Valentini, Piero, Rossodivita, Aurora Natalia, Mancini A. (ORCID:0000-0002-7707-4564), Curro D. (ORCID:0000-0001-6726-6872), Barini A. (ORCID:0000-0002-1440-5581), Bruno C., Vergani E., Guidi F., Nicolotti N., Silvestrini A. (ORCID:0000-0002-2005-3746), Meucci E. (ORCID:0000-0002-8821-8041), Valentini P. (ORCID:0000-0001-6095-9510), and Rossodivita A. N.
Abstract: OBJECTIVE: Kisspeptin, neuropeptide involved in puberty beginning and regulation of pituitary-gonadal axis, has been shown to stimulate antioxidant defenses in murine models. Its levels are greater in females than males and also in obese prepubertal girls. Therefore, our aim was to evaluate sex-related differences in prepubertal obese patients and the relationships of Kisspeptin with metabolic/ hormonal parameters. PATIENTS AND METHODS: We studied Kisspeptin concentrations in 54 children (22 males and 32 females, Tanner stage 1), 5-12 ys, classified according to Cole’s criteria into 17 overweight and 37 obese; 25 normal-weight children, aged 6-12 years, were studied as controls. We evaluated metabolic (glucose and insulin levels after oral glucose load, total- LDL- HDL-cholesterol, triglycerides, uric acid) and hormonal (fT3, fT4, TSH, IGF-1, leptin) parameters. Moreover, total antioxidant capacity (TAC) was evaluated by spectrophotometric method, using the system H202-metmyoglobin-ABTS. Kisspeptin levels were measured by RIA. RESULTS: We did not find significant differences between obese and normal-weight children, but obese males presented significantly lower levels than females. Kisspeptin did not correlate with BMI, HOMA-IR, Insulin peak levels and TAC; a significant correlation was found between Kisspeptin and fT3 (r2=0.25; p=0.003) in the obese group; leptin levels, significantly greater in obese vs. overweight and control children, significantly correlated with TAC (r2=0.39; p=0.03). CONCLUSIONS: These data suggest that both hormones could modulate antioxidants, Kisspeptin indirectly via influence on thyroid hormones, and Leptin by a direct effect. This mechanism seems to be sex-related, not attributable to peripheral steroid levels. Further studies can clarify the complex interrelationship between central and peripheral Kisspeptin secretion and oxidative stress in children obesity.
Published: 2021

12. Surgery-related complications and long-term functional morbidity after segmental colo-rectal resection for deep infiltrating endometriosis (ENDO-RESECT morb)

Author: Turco, L. C., Tortorella, L., Tuscano, A., Palumbo, M. A., Fagotti, Anna, Uccella, S., Fanfani, Francesco, Ferrandina, Maria Gabriella, Nicolotti, Nicola, Vargiu, V., Lodoli, C., Scaldaferri, Franco, Scambia, Giovanni, Cosentino, F., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), Nicolotti N., Scaldaferri F. (ORCID:0000-0001-8334-7541), Scambia G. (ORCID:0000-0003-2758-1063), Turco, L. C., Tortorella, L., Tuscano, A., Palumbo, M. A., Fagotti, Anna, Uccella, S., Fanfani, Francesco, Ferrandina, Maria Gabriella, Nicolotti, Nicola, Vargiu, V., Lodoli, C., Scaldaferri, Franco, Scambia, Giovanni, Cosentino, F., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), Nicolotti N., Scaldaferri F. (ORCID:0000-0001-8334-7541), and Scambia G. (ORCID:0000-0003-2758-1063)
Abstract: Purpose: Segmental resection has been generally associated with increased peri-operative risk of major complications. While major complications are widely acknowledged, minor complications, such as slight, to moderate infections, peripheral sensory disturbances, bladder voiding dysfunction, postoperative urinary obstruction, and sexual disorders are less reported. The aim of this study is to investigate the surgery-related complications and functional disorders, as well as to evaluate their persistence after long-term follow-up in women undergone segmental resection for deep infiltrating endometriosis. Special attention is given to evaluating impairments of bowel, bladder, and sexual function. Methods: All clinical data obtained from medical records of women who underwent segmental resection for intestinal endometriosis between October 2005, and November 2017, in Catholic University Institutions. Perioperative morbidity was classified by Extended Clavien–Dindo classification. Postoperative intestinal, voiding, and sexual morbidity was estimated by the compilation of specific questionnaires. Results: Fifty women were included in the study. Forty-three high colorectal resections (86%), 6 low resections (12%), and 1 ultra-low resection (2%) were performed, while in 3 cases (6%) multiple resections were needed. The overall complication rate was 44%. Nineteen women (38%) experienced early complications and 3 women (6%) late complications. Long-term functional postoperative complications were composed of intestinal in 30%, urinary in 50%, and sexual in 64% of the study population. Median follow-up was 55.5 months. Conclusions: Segmental resection, when indicated, offers a radical and feasible approach for bowel deep infiltrating endometriosis, resulting in an improved general quality of life. The bowel and bladder complications appear to be acceptable and often reversible. Postoperative sexual dysfunctions, such as anorgasmia and insufficient vaginal lubrication, app
Published: 2020

13. Comparison of short- and long-term effectiveness of ixekizumab and secukinumab in real-world practice

Author: Caldarola, Giacomo, Mariani, M., Pirro, Federico, Nicolotti, Nicola, Burlando, M., Calabrese, L., Parodi, A., Peris, Ketty, De Simone, Clara, Caldarola G. (ORCID:0000-0002-8837-9232), Pirro F., Nicolotti N., Peris K. (ORCID:0000-0002-5237-0463), De Simone C. (ORCID:0000-0002-0898-0045), Caldarola, Giacomo, Mariani, M., Pirro, Federico, Nicolotti, Nicola, Burlando, M., Calabrese, L., Parodi, A., Peris, Ketty, De Simone, Clara, Caldarola G. (ORCID:0000-0002-8837-9232), Pirro F., Nicolotti N., Peris K. (ORCID:0000-0002-5237-0463), and De Simone C. (ORCID:0000-0002-0898-0045)
Abstract: Background: Although secukinumab and ixekizumab both act by inhibiting IL-17A, some scientific evidence suggests that there are differences in efficacy between the two agents. Objective: The aim of this study was to compare the short- and long-term effectiveness of ixekizumab and secukinumab in clinical practice. Methods: A retrospective study was conducted on a cohort of 245 psoriatic patients receiving secukinumab or ixekizumab during the period from September 2016 to December 2019. The proportion of patients achieving PASI75, PASI90, and PASI100 at weeks 12 and 24 was calculated. We recorded the 12- and 24-month drug survival as a measure to assess long-term effectiveness. Results: A higher proportion of patients in the secukinumab group achieved PASI75, 90, and 100 at 12 weeks. The Kaplan-Meier survival curve for any reason of discontinuation showed no differences between the two groups. Instead, the multivariate analysis for ineffectiveness, adjusted for potential confounders, showed a lower drug survival rate in the secukinumab group, with an adjusted HR of 2.57 (95% CI 1.05–6.28, p 0.038). Conclusion: This real-life study demonstrated that ixekizumab and secukinumab are both highly effective in short- and long-term treatment of psoriasis, even though few differences exist concerning speed of action and long-term effectiveness.
Published: 2020

14. Long-term evaluation of quality of life and gastrointestinal well-being after segmental colo-rectal resection for deep infiltrating endometriosis (ENDO-RESECT QoL)

Author: Turco, L. C., Scaldaferri, Franco, Chiantera, V., Cianci, Stefano, Ercoli, A., Fagotti, Anna, Fanfani, Francesco, Ferrandina, Maria Gabriella, Nicolotti, N., Tamburrano, A., Vargiu, V., Scambia, Giovanni, Cosentino, Francesco, Scaldaferri F. (ORCID:0000-0001-8334-7541), Cianci S., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), Scambia G. (ORCID:0000-0003-2758-1063), Cosentino F., Turco, L. C., Scaldaferri, Franco, Chiantera, V., Cianci, Stefano, Ercoli, A., Fagotti, Anna, Fanfani, Francesco, Ferrandina, Maria Gabriella, Nicolotti, N., Tamburrano, A., Vargiu, V., Scambia, Giovanni, Cosentino, Francesco, Scaldaferri F. (ORCID:0000-0001-8334-7541), Cianci S., Fagotti A. (ORCID:0000-0001-5579-335X), Fanfani F. (ORCID:0000-0003-1991-7284), Ferrandina G. (ORCID:0000-0003-4672-4197), Scambia G. (ORCID:0000-0003-2758-1063), and Cosentino F.
Abstract: Purposes: The primary objective is to assess the long-term quality of life (QoL) and gastrointestinal well-being in patients with endometriosis (DIE) who underwent segmental resection (SR), through specific questionnaires focused on endometriosis and specific gastrointestinal evaluation. The secondary objectives are represented by the evaluation of peri-operative and post-operative outcomes of the procedure. Methods: This observational cohort study ENDO-RESECT (ClinicalTrials.gov ID: NCT03824054) reports all clinical data about women who underwent SR for DIE between October 2005 and November 2017. In the part of the study dedicated to the QoL assessment, the questionnaires adopted were the Endometriosis Health Profile (EHP30), the Psychological General Well-Being Index and the Hospital Anxiety and Depression Scale, the Gastrointestinal Well-being questionnaire and the Bristol Stool chart. Major post-surgical morbidity and obstetric outcomes were also collected. Results: 50 women (18% stage III and 82% stage IV rAFS) were considered for enrollment. EHP-30 interpretation demonstrated a significant improvement in all continuous variables, except for fertility concerns. The overall gastrointestinal QoL and most of the specific symptoms improved after surgery. Frequent bowel movements appeared in the 13% of the series not resulting in an impairment of general and gastrointestinal QoL. Constipation remained unchanged. Patients with depressive mood managed with laparoscopy, benefited the most from SR; moreover, patients with multinodular bowel localizations experienced a greater reduction in abdominal pain. Median FU after SR was 42.5 months (range 12–157 months). Only three (6%) cases of late major grade III complications were documented. The pregnancy rate was 50%. Conclusions: Improvement of general QoL and most of gastrointestinal symptoms was documented after SR.
Published: 2020

15. Allogeneic cord blood transfusions prevent fetal haemoglobin depletion in preterm neonates. Results of the CB-TrIP study

Author: Teofili, Luciana, Papacci, Patrizia, Orlando, Nicoletta, Bianchi, Maria, Molisso, Anna, Purcaro, Velia, Valentini, C. G., Giannantonio, Carmen, Serrao, Francesca, Chiusolo, Patrizia, Nicolotti, Nicola, Pellegrino, C., Carducci, Brigida, Vento, Giovanni, De Stefano, Valerio, Teofili L. (ORCID:0000-0002-7214-1561), Papacci P. (ORCID:0000-0001-8236-7460), Orlando N., Bianchi M., Molisso A., Purcaro V., Giannantonio C., Serrao F., Chiusolo P. (ORCID:0000-0002-1355-1587), Nicolotti N., Carducci B., Vento G. (ORCID:0000-0002-8132-5127), De Stefano V. (ORCID:0000-0002-5178-5827), Teofili, Luciana, Papacci, Patrizia, Orlando, Nicoletta, Bianchi, Maria, Molisso, Anna, Purcaro, Velia, Valentini, C. G., Giannantonio, Carmen, Serrao, Francesca, Chiusolo, Patrizia, Nicolotti, Nicola, Pellegrino, C., Carducci, Brigida, Vento, Giovanni, De Stefano, Valerio, Teofili L. (ORCID:0000-0002-7214-1561), Papacci P. (ORCID:0000-0001-8236-7460), Orlando N., Bianchi M., Molisso A., Purcaro V., Giannantonio C., Serrao F., Chiusolo P. (ORCID:0000-0002-1355-1587), Nicolotti N., Carducci B., Vento G. (ORCID:0000-0002-8132-5127), and De Stefano V. (ORCID:0000-0002-5178-5827)
Abstract: Repeated red blood cell (RBC) transfusions in preterm neonates are associated with poor outcome and increased risk for prematurity-associated diseases. RBC transfusions cause the progressive replacement of fetal haemoglobin (HbF) by adult haemoglobin (HbA). We monitored HbF levels in 25 preterm neonates until 36 weeks of post-menstrual age (PMA); patients received RBC units from allogeneic cord blood (cord-RBCs) or from adult donors (adult-RBCs), depending on whether cord-RBCs were available. Primary outcome was HbF level at PMA of 32 weeks. Twenty-three neonates survived until this age: 14 received no transfusions, two only cord-RBCs, three only adult-RBCs and four both RBC types. HbF levels in neonates transfused with cord-RBCs were significantly higher than in neonates receiving adult-RBCs (P < 0·0001) or both RBC types (P < 0·0001). Superimposable results were obtained at PMA of 36 weeks. Every adult-RBCs transfusion increased the risk for an HbF in the lowest quartile by about 10-fold, whereas this effect was not evident if combined adult- and cord-RBCs were evaluated. Overall, these data show that transfusing cord-RBCs can limit the HbF depletion caused by conventional RBC transfusions. Transfusing cord blood warrants investigation in randomised trials as a strategy to mitigate the severity of retinopathy of prematurity (NCT03764813).
Published: 2020

16. Assessment of neurological manifestations in hospitalized patients with COVID-19

Author: Luigetti, Marco, Iorio, Raffaele, Bentivoglio, Anna Rita, Tricoli, Luca, Riso, Vittorio, Marotta, Jessica, Piano, Carla, Primiano, Guido Alessandro, Zileri Del Verme, L., Lo Monaco, Maria Rita, Calabresi, Paolo, Abbate, V., Acampora, N., Addolorato, G., Agostini, F., Ainora, M. E., Akacha, K., Amato, E., Andreani, F., Andriollo, G., Annetta, Maria Giuseppina, Annicchiarico, B. E., Antonelli, Massimo, Antonucci, G., Anzellotti, G. M., Armuzzi, A., Baldi, F., Barattucci, I., Barillaro, C., Barone, F., Bellantone, R. D. A., Bellieni, A., Bello, G., Benicchi, A., Benvenuto, F., Berardini, L., Berloco, F., Bernabei, R., Bianchi, A., Biasucci, D. G., Biasucci, L. M., Bibbo, S., Bini, A., Bisanti, A., Biscetti, F., Bocci, M. G., Bonadia, N., Bongiovanni, F., Borghetti, A., Bosco, G., Bosello, Silvia Laura, Bove, V., Bramato, G., Brandi, V., Bruni, T., Bruno, C., Bruno, D., Bungaro, M. C., Buonomo, A., Burzo, L., Calabrese, A., Calvello, M. R., Cambieri, A., Cambise, C., Camma, G., Candelli, M., Canistro, G., Cantanale, A., Capalbo, G., Capaldi, L., Capone, E., Capristo, E., Carbone, L., Cardone, S., Carelli, S., Carfi, A., Carnicelli, A., Caruso, C., Casciaro, F. A., Catalano, L., Cauda, R., Cecchini, A. L., Cerrito, L., Cesarano, M., Chiarito, A., Cianci, Rossella, Cicchinelli, S., Ciccullo, A., Cicetti, M., Ciciarello, F., Cingolani, A., Cipriani, M. C., Consalvo, M. L., Coppola, G., Corbo, G. M., Corsello, A., Costante, F., Costanzi, M., Covino, M., Crupi, D., Cutuli, S. L., D'Addio, S., D'Alessandro, A., D'Alfonso, M. E., D'Angelo, E., D'Aversa, F., Damiano, F., De Berardinis, G. M., De Cunzo, T., De Gaetano, D. K., De Luca, G., De Matteis, G., De Pascale, G., De Santis, P., De Siena, M., De Vito, F., Del Gatto, V., Del Giacomo, P., Del Zompo, F., Dell'Anna, A. M., Della, P. D., Di Gialleonardo, L., Di Giambenedetto, S., Di Luca, R., Di Maurizio, L., Di Muro, M., Dusina, A., Eleuteri, D., Esperide, A., Fachechi, D., Faliero, D., Falsiroli, C., Fantoni, M., Fedele, A., Feliciani, D., Ferrante, C., Ferrone, G., Festa, R., Fiore, M. C., Flex, A., Forte, E., Franceschi, Francesco, Francesconi, A., Franza, L., Funaro, B., Fuorlo, M., Fusco, D., Gabrielli, M., Gaetani, E., Galletta, C., Gallo, A., Gambassi, G., Garcovich, M., Gasbarrini, A., Gasparrini, I., Gelli, S., Giampietro, A., Gigante, L., Giuliano, G., Giupponi, B., Gremese, E., Grieco, Domenico Luca, Guerrera, M., Guglielmi, V., Guidone, C., Gulli, A., Iaconelli, A., Iafrati, A., Ianiro, Gianluca, Iaquinta, A., Impagnatiello, M., Inchingolo, R., Intini, E., Iorio, R., Izzi, I. M., Jovanovic, T., Kadhim, C., La Macchia, R., La Milia, D. I., Landi, F., Landi, G., Landi, R., Landolfi, R., Leo, M., Leone, P. M., Levantesi, L., Liguori, A., Liperoti, R., Lizzio, M. M., Lo Monaco Maria, R., Locantore, P., Lombardi, F., Lombardi, G., Lopetuso, L., Loria, V., Losito, A. R., Lucia, M. B. P., Macagno, F., Macerola, N., Maggi, G., Maiuro, G., Mancarella, F., Mangiola, F., Manno, A., Marchesini, D., Maresca, G. M., Marrone, G., Martis, I., Martone, A. M., Marzetti, Emanuele, Mattana, C., Matteo, M. V., Maviglia, R., Mazzarella, A., Memoli, C., Miele, Luca, Migneco, A., Mignini, I., Milani, A., Milardi, D., Montalto, M., Montemurro, G., Monti, F., Montini, Luca, Morena, T. C., Morra, V., Morretta, C., Moschese, D., Murace, C. A., Murdolo, M., Murri, Rita, Napoli, M., Nardella, E., Natalello, G., Natalini, D., Navarra, S. M., Nesci, A., Nicoletti, A., Nicoletti, R., Nicoletti, T. F., Nicolo, R., Nicolotti, N., Nista, E. C., Nuzzo, E., Oggiano, M., Ojetti, V., Pagano, F. C., Paiano, G., Pais, C., Pallavicini, F., Palombo, A., Paolillo, F., Papa, Alfredo, Papanice, D., Papparella, L. G., Paratore, M., Parrinello, G., Pasciuto, G., Pasculli, P., Pecorini, G., Perniola, S., Pero, E., Petricca, L., Petrucci, M., Picarelli, C., Piccioni, A., Piccolo, A., Piervincenzi, E., Pignataro, G., Pignataro, R., Pintaudi, G., Pisapia, L., Pizzoferrato, M., Pizzolante, F., Pola, R., Policola, C., Pompili, M., Pontecorvi, F., Pontecorvi, V., Ponziani, F., Popolla, V., Porceddu, E., Porfidia, A., Porro, L. M., Potenza, A., Pozzana, F., Privitera, G., Pugliese, D., Pulcini, G., Racco, S., Raffaelli, F., Ramunno, V., Rapaccini, G. L., Richeldi, Luca, Rinninella, Emanuele, Rocchi, S., Romano, B., Romano, S., Rosa, F., Rossi, L., Rossi, R., Rossini, E., Rota, E., Rovedi, F., Rubino, C., Rumi, G., Russo, A., Sabia, L., Salerno, A., Salini, S., Salvatore, L., Samori, D., Sandroni, Claudio, Sanguinetti, M., Santarelli, L., Santini, P., Santolamazza, D., Santoliquido, A., Santopaolo, F., Santoro, M. C., Sardeo, F., Sarnari, C., Saviano, A., Saviano, L., Scaldaferri, Franco, Scarascia, R., Schepis, T., Schiavello, F., Scoppettuolo, G., Sedda, D., Sessa, F., Sestito, L., Settanni, C., Siciliano, M., Siciliano, V., Sicuranza, R., Simeoni, B., Simonetti, J., Smargiassi, A., Soave, P. M., Sonnino, C., Staiti, D., Stella, C., Stella, L., Stival, E., Taddei, E., Talerico, R., Tamburello, E., Tamburrini, E., Tanzarella, E. S., Tarascio, E., Tarli, C., Tersali, A., Tilli, P., Timpano, J., Torelli, E., Torrini, F., Tosato, M., Tosoni, A., Tricoli, L., Tritto, M., Tumbarello, M., Tummolo, A. M., Vallecoccia, M. S., Valletta, F., Varone, F., Vassalli, F., Ventura, G., Verardi, L., Vetrone, L., Vetrugno, G., Visconti, E., Visconti, F., Viviani, A., Zaccaria, R., Zaccone, C., Zelano, L., Zileri Dal Verme, L., Zuccala, G., Luigetti M. (ORCID:0000-0001-7539-505X), Iorio R. (ORCID:0000-0002-6270-0956), Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Tricoli L., Riso V., Marotta J., Piano C., Primiano G., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Calabresi P. (ORCID:0000-0003-0326-5509), Annetta M. G. (ORCID:0000-0001-7574-1311), Antonelli M. (ORCID:0000-0003-3007-1670), Bosello S. (ORCID:0000-0002-4837-447X), Cianci R. (ORCID:0000-0001-5378-8442), Franceschi F. (ORCID:0000-0001-6266-445X), Grieco D. L. (ORCID:0000-0002-4557-6308), Ianiro G. (ORCID:0000-0002-8318-0515), Marzetti E. (ORCID:0000-0001-9567-6983), Miele L. (ORCID:0000-0003-3464-0068), Montini L. (ORCID:0000-0003-4602-5134), Murri R. (ORCID:0000-0003-4263-7854), Papa A. (ORCID:0000-0002-4186-7298), Richeldi L. (ORCID:0000-0001-8594-1448), Rinninella E. (ORCID:0000-0002-9165-2367), Sandroni C. (ORCID:0000-0002-8878-2611), Scaldaferri F. (ORCID:0000-0001-8334-7541), Luigetti, Marco, Iorio, Raffaele, Bentivoglio, Anna Rita, Tricoli, Luca, Riso, Vittorio, Marotta, Jessica, Piano, Carla, Primiano, Guido Alessandro, Zileri Del Verme, L., Lo Monaco, Maria Rita, Calabresi, Paolo, Abbate, V., Acampora, N., Addolorato, G., Agostini, F., Ainora, M. E., Akacha, K., Amato, E., Andreani, F., Andriollo, G., Annetta, Maria Giuseppina, Annicchiarico, B. E., Antonelli, Massimo, Antonucci, G., Anzellotti, G. M., Armuzzi, A., Baldi, F., Barattucci, I., Barillaro, C., Barone, F., Bellantone, R. D. A., Bellieni, A., Bello, G., Benicchi, A., Benvenuto, F., Berardini, L., Berloco, F., Bernabei, R., Bianchi, A., Biasucci, D. G., Biasucci, L. M., Bibbo, S., Bini, A., Bisanti, A., Biscetti, F., Bocci, M. G., Bonadia, N., Bongiovanni, F., Borghetti, A., Bosco, G., Bosello, Silvia Laura, Bove, V., Bramato, G., Brandi, V., Bruni, T., Bruno, C., Bruno, D., Bungaro, M. C., Buonomo, A., Burzo, L., Calabrese, A., Calvello, M. R., Cambieri, A., Cambise, C., Camma, G., Candelli, M., Canistro, G., Cantanale, A., Capalbo, G., Capaldi, L., Capone, E., Capristo, E., Carbone, L., Cardone, S., Carelli, S., Carfi, A., Carnicelli, A., Caruso, C., Casciaro, F. A., Catalano, L., Cauda, R., Cecchini, A. L., Cerrito, L., Cesarano, M., Chiarito, A., Cianci, Rossella, Cicchinelli, S., Ciccullo, A., Cicetti, M., Ciciarello, F., Cingolani, A., Cipriani, M. C., Consalvo, M. L., Coppola, G., Corbo, G. M., Corsello, A., Costante, F., Costanzi, M., Covino, M., Crupi, D., Cutuli, S. L., D'Addio, S., D'Alessandro, A., D'Alfonso, M. E., D'Angelo, E., D'Aversa, F., Damiano, F., De Berardinis, G. M., De Cunzo, T., De Gaetano, D. K., De Luca, G., De Matteis, G., De Pascale, G., De Santis, P., De Siena, M., De Vito, F., Del Gatto, V., Del Giacomo, P., Del Zompo, F., Dell'Anna, A. M., Della, P. D., Di Gialleonardo, L., Di Giambenedetto, S., Di Luca, R., Di Maurizio, L., Di Muro, M., Dusina, A., Eleuteri, D., Esperide, A., Fachechi, D., Faliero, D., Falsiroli, C., Fantoni, M., Fedele, A., Feliciani, D., Ferrante, C., Ferrone, G., Festa, R., Fiore, M. C., Flex, A., Forte, E., Franceschi, Francesco, Francesconi, A., Franza, L., Funaro, B., Fuorlo, M., Fusco, D., Gabrielli, M., Gaetani, E., Galletta, C., Gallo, A., Gambassi, G., Garcovich, M., Gasbarrini, A., Gasparrini, I., Gelli, S., Giampietro, A., Gigante, L., Giuliano, G., Giupponi, B., Gremese, E., Grieco, Domenico Luca, Guerrera, M., Guglielmi, V., Guidone, C., Gulli, A., Iaconelli, A., Iafrati, A., Ianiro, Gianluca, Iaquinta, A., Impagnatiello, M., Inchingolo, R., Intini, E., Iorio, R., Izzi, I. M., Jovanovic, T., Kadhim, C., La Macchia, R., La Milia, D. I., Landi, F., Landi, G., Landi, R., Landolfi, R., Leo, M., Leone, P. M., Levantesi, L., Liguori, A., Liperoti, R., Lizzio, M. M., Lo Monaco Maria, R., Locantore, P., Lombardi, F., Lombardi, G., Lopetuso, L., Loria, V., Losito, A. R., Lucia, M. B. P., Macagno, F., Macerola, N., Maggi, G., Maiuro, G., Mancarella, F., Mangiola, F., Manno, A., Marchesini, D., Maresca, G. M., Marrone, G., Martis, I., Martone, A. M., Marzetti, Emanuele, Mattana, C., Matteo, M. V., Maviglia, R., Mazzarella, A., Memoli, C., Miele, Luca, Migneco, A., Mignini, I., Milani, A., Milardi, D., Montalto, M., Montemurro, G., Monti, F., Montini, Luca, Morena, T. C., Morra, V., Morretta, C., Moschese, D., Murace, C. A., Murdolo, M., Murri, Rita, Napoli, M., Nardella, E., Natalello, G., Natalini, D., Navarra, S. M., Nesci, A., Nicoletti, A., Nicoletti, R., Nicoletti, T. F., Nicolo, R., Nicolotti, N., Nista, E. C., Nuzzo, E., Oggiano, M., Ojetti, V., Pagano, F. C., Paiano, G., Pais, C., Pallavicini, F., Palombo, A., Paolillo, F., Papa, Alfredo, Papanice, D., Papparella, L. G., Paratore, M., Parrinello, G., Pasciuto, G., Pasculli, P., Pecorini, G., Perniola, S., Pero, E., Petricca, L., Petrucci, M., Picarelli, C., Piccioni, A., Piccolo, A., Piervincenzi, E., Pignataro, G., Pignataro, R., Pintaudi, G., Pisapia, L., Pizzoferrato, M., Pizzolante, F., Pola, R., Policola, C., Pompili, M., Pontecorvi, F., Pontecorvi, V., Ponziani, F., Popolla, V., Porceddu, E., Porfidia, A., Porro, L. M., Potenza, A., Pozzana, F., Privitera, G., Pugliese, D., Pulcini, G., Racco, S., Raffaelli, F., Ramunno, V., Rapaccini, G. L., Richeldi, Luca, Rinninella, Emanuele, Rocchi, S., Romano, B., Romano, S., Rosa, F., Rossi, L., Rossi, R., Rossini, E., Rota, E., Rovedi, F., Rubino, C., Rumi, G., Russo, A., Sabia, L., Salerno, A., Salini, S., Salvatore, L., Samori, D., Sandroni, Claudio, Sanguinetti, M., Santarelli, L., Santini, P., Santolamazza, D., Santoliquido, A., Santopaolo, F., Santoro, M. C., Sardeo, F., Sarnari, C., Saviano, A., Saviano, L., Scaldaferri, Franco, Scarascia, R., Schepis, T., Schiavello, F., Scoppettuolo, G., Sedda, D., Sessa, F., Sestito, L., Settanni, C., Siciliano, M., Siciliano, V., Sicuranza, R., Simeoni, B., Simonetti, J., Smargiassi, A., Soave, P. M., Sonnino, C., Staiti, D., Stella, C., Stella, L., Stival, E., Taddei, E., Talerico, R., Tamburello, E., Tamburrini, E., Tanzarella, E. S., Tarascio, E., Tarli, C., Tersali, A., Tilli, P., Timpano, J., Torelli, E., Torrini, F., Tosato, M., Tosoni, A., Tricoli, L., Tritto, M., Tumbarello, M., Tummolo, A. M., Vallecoccia, M. S., Valletta, F., Varone, F., Vassalli, F., Ventura, G., Verardi, L., Vetrone, L., Vetrugno, G., Visconti, E., Visconti, F., Viviani, A., Zaccaria, R., Zaccone, C., Zelano, L., Zileri Dal Verme, L., Zuccala, G., Luigetti M. (ORCID:0000-0001-7539-505X), Iorio R. (ORCID:0000-0002-6270-0956), Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Tricoli L., Riso V., Marotta J., Piano C., Primiano G., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Calabresi P. (ORCID:0000-0003-0326-5509), Annetta M. G. (ORCID:0000-0001-7574-1311), Antonelli M. (ORCID:0000-0003-3007-1670), Bosello S. (ORCID:0000-0002-4837-447X), Cianci R. (ORCID:0000-0001-5378-8442), Franceschi F. (ORCID:0000-0001-6266-445X), Grieco D. L. (ORCID:0000-0002-4557-6308), Ianiro G. (ORCID:0000-0002-8318-0515), Marzetti E. (ORCID:0000-0001-9567-6983), Miele L. (ORCID:0000-0003-3464-0068), Montini L. (ORCID:0000-0003-4602-5134), Murri R. (ORCID:0000-0003-4263-7854), Papa A. (ORCID:0000-0002-4186-7298), Richeldi L. (ORCID:0000-0001-8594-1448), Rinninella E. (ORCID:0000-0002-9165-2367), Sandroni C. (ORCID:0000-0002-8878-2611), and Scaldaferri F. (ORCID:0000-0001-8334-7541)
Abstract: Background and purpose: The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods: Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results: In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions: Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.
Published: 2020

17. Cost of Illness Analysis of Hemophilia A: Resources Use and Direct Costs in Italy: PO-MO-053

Author: CADEDDU, C., CAPIZZI, S., CAPRI, S., DE WAURE, C., DI PIETRO, M. L., GUALANO, M. R., KHEIRAOUI, F., LA TORRE, G., NICOLOTTI, N., SFERRAZZA, A., SPECCHIA, M. L., VENEZIANO, M. S., GRINGERI, A., MORFINI, M., RICCIARDI, W., and ROCINO, A.
Published: 2012

18. The UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factors.: Abstract# O-162

Author: Avolio, A. W., Agnes, S., Lirosi, M., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Romagnoli, R., Vitale, A., Cucchetti, A., Gruttadauria, S., Baccarani, U., Caccamo, L., Mangoni, I., Pinelli, D., Montalti, R., Morelli, N., Vennarecci, G., Nicolini, D., Regalia, E., Lai, Q., Anselmo, A., Tondolo, E., Perrella, A., Burra, P., and Cillo, U.
Published: 2012

19. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants.: Abstract# 1672: Poster Board #-Session: P234-IV

Author: Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Valente, U., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Nicolotti, N., Vitale, A., Romagnoli, R., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Burra, P., Gasbarrini, A., and Cillo, U.
Published: 2012

20. www.D-MELD.com. THE ONLINE PROGNOSTIC CALCULATOR TO OPTIMIZE DONOR-RECIPIENT MATCH: O-123

Author: Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R, Lupo, F., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R, Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T, Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., de Waure, C., De Feo, T, Burra, P., Gasbarrini, A., and Cillo, U.
Published: 2011

21. Evaluation and cost estimation of laboratory tests overuse through a CCDSS in a university hospital

Author: Vallone, D, primary, Tamburrano, A, additional, Carrozza, C, additional, Urbani, A, additional, Cambieri, A, additional, Nicolotti, N, additional, Sanguinetti, M, additional, and Laurenti, P, additional
Published: 2020
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22. Hospital Hygiene and Infection Prevention and Control in Italy: state of the art and perspectives

Author: Brusaferro, S, Arnoldo, L, Finzi, G, Mura, I, Auxilia, F, Pasquarella, C, Agodi, A and the GISIO Group (Agodi A, Arrigoni, C, Barchitta, M, Calella, G, Casini, B, Cristina, Ml, D'Errico, M, Laurenti, P, Masia, Md, Montagna, Mt, Olivieri, G, Orsi, A, Orsi, Gb, Pesapane, L, Ripabelli, G, Sodano, L, Squeri, R, Teti, V, Torregrossa, Mv, Torri, E, Zarrilli, R, Are, Bm, Brighenti, A, Mascipinto, S, Iannazzo, S, D'Ancona, Fp, Sessa, G, Motta, A, Appignanesi, R, Argiolas, F, Baldovin, T, Bargellini, A, Berdini, S, Boccia, G, Calagreti, G, Caldarulo, T, Campanella, F, Chiesa, R, Ciorba, V, Contrisciani, R, D'Alessandro, D, De Giglio, O, Fabiani, L, Fara, Gm, Giuliani, G, Laganà, P, Marani, A, Mattaliano, Ar, Molino, A, Montesano, M, Moretti, F, Moro, M, Moscato, U, Napoli, C, Nicolotti, N, Nobile, M, Novati, R, Palumbo, F, Piana, A, Privitera, G, Prospero, E, Quattrocchi, A, Righi, E, Romano Spica, V, Rossi, F, Rossini, A, Schieppati, S, Sotgiu, G, Tardivo, S, Torre, I, Valeriani, F, Veronesi, L, Zotti, C), Brusaferro, S., Arnoldo, L., Finzi, G., Mura, I., Auxilia, F., Pasquarella, C., Agodi, A., Pitzurra, M., Arrigoni, C., Barchitta, M., Calella, G., Casini, B., Cristina, M. L., D'Errico, M., Laurenti, P., Masia, M. D., Montagna, M. T., Olivieri, G., Orsi, A., Orsi, G. B., Pesapane, L., Ripabelli, G., Sodano, L., Squeri, R., Teti, V., Torregrossa, M. V., Torri, E., Zarrilli, R., Are, B. M., Brighenti, A., Mascipinto, S., Iannazzo, S., D'Ancona, F. P., Sessa, G., Motta, A., Appignanesi, R., Argiolas, F., Baldovin, T., Bargellini, A., Berdini, S., Boccia, G., Calagreti, G., Caldarulo, T., Campanella, F., Chiesa, R., Ciorba, V., Contrisciani, R., D'Alessandro, D., De Giglio, O., Fabiani, L., Fara, G. M., Giuliani, G., Lagana, P., Marani, A., Mattaliano, A. R., Molino, A., Montesano, M., Moretti, F., Moro, M., Moscato, U., Napoli, C., Nicolotti, N., Nobile, M., Novati, R., Palumbo, F., Piana, A., Privitera, G., Prospero, E., Quattrocchi, A., Righi, E., Romano Spica, V., Rossi, F., Rossini, A., Schieppati, S., Sotgiu, G., Tardivo, S., Torre, I., Valeriani, F., Veronesi, L., and Zotti, C.
Subjects: Adult, Male, Healthcare organisation Igiene ospedaliera, National Health Programs, Infection Prevention and Control, hospital hygiene, infection prevention and control, public health, environmental and occupational health, infectious diseases, igiene ospedaliera, organizzazione sanitaria, prevenzione e controllo delle infezioni, Attitude of Health Personnel, Health Promotion, Healthcare organisation, Iran, Nursing Staff, Hospital, Hospital Hygiene, Igiene ospedaliera, Hospital Hygiene, Infection Prevention and Control, Healthcare organisation Igiene ospedaliera, prevenzione e controllo delle infezioni, organizzazione sanitaria, Hospital Administration, Patient Education as Topic, Terminology as Topic, Medical Staff, Hospital, Humans, Igiene ospedaliera, prevenzione e controllo delle infezioni, organizzazione sanitaria, European Union, Hospitals, Teaching, Workplace, Occupational Health, Cross-Sectional Studie, Cross Infection, Infection Control, Healthcare organisation Parole chiave: Igiene ospedaliera, Analysis of Variance, Organizzazione sanitaria, Prevenzione e controllo delle infezioni, Europe, Italy, Health Facilities, Hygiene, Healthcare organisation, Igiene ospedaliera, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, Infectious Diseases, Healthcare organisation, Hospital Hygiene, Infection Prevention and Control, Public Health, Environmental and Occupational Health, Infectious Diseases, Hospital Administrator, Female, Public Health, Patient Participation, Hospital Hygiene, Infection Prevention and Control, Healthcare organisation, Human
Abstract: Although hospital hygiene has a long history in Italy it is necessary to reflect about it because of the innovation in healthcare systems and because of the evolution due to European Union related activities. Different traditions exist in European countries about hospital hygiene and European Centre for Disease Prevention and Control (ECDC) adopted the term of "infection control and hospital hygiene" which includes all the engaged European healthcare professionals. We propose to modify hospital hygiene as "healthcare organisation hygiene" in order to focalise the attention to all care settings not only hospitals and to adopt the following definition: "all activities aimed to guarantee, in an appropriate, scientifically sound and efficient way, that structures and processes support healthcare practices in a safe comfortable and healthy environment both for patients, caregivers and healthcare workers". Hospital hygiene and its professionals, besides the long tradition, still remain a relevant pillar in guaranteeing quality and safety of healthcare in Italy.
Published: 2018

23. Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis

Author: Avolio, Alfonso Wolfango, Gaspari, Rita, Teofili, Luciana, Bianco, G., Spinazzola, G., Soave, Paolo Maurizio, Paiano, Gianfranco, Francesconi, Alessandra Gioia, Arcangeli, A., Nicolotti, Nicola, Antonelli, Massimo, Avolio A. W. (ORCID:0000-0003-2491-7625), Gaspari R. (ORCID:0000-0003-0141-3686), Teofili L. (ORCID:0000-0002-7214-1561), Soave P. M., Paiano G., Francesconi A. G., Nicolotti N., Antonelli M. (ORCID:0000-0003-3007-1670), Avolio, Alfonso Wolfango, Gaspari, Rita, Teofili, Luciana, Bianco, G., Spinazzola, G., Soave, Paolo Maurizio, Paiano, Gianfranco, Francesconi, Alessandra Gioia, Arcangeli, A., Nicolotti, Nicola, Antonelli, Massimo, Avolio A. W. (ORCID:0000-0003-2491-7625), Gaspari R. (ORCID:0000-0003-0141-3686), Teofili L. (ORCID:0000-0002-7214-1561), Soave P. M., Paiano G., Francesconi A. G., Nicolotti N., and Antonelli M. (ORCID:0000-0003-3007-1670)
Abstract: Background :Postoperative respiratory failure (PRF, namely mechanical ventilation >48 hours) significantly affects morbidity and mortality in liver transplantation (LTx). Previous studies analyzed only one or two categories of PRF risk factors (preoperative, intraoperative or postoperative ones). The aims of this study were to identify PRF predictors, to assess the length of stay (LoS) in ICU and the 90-day survival according to the PRF in LTx patients. Methods: Two classification approaches were used: systematic classification (recipient-related preoperative factors; intraoperative factors; logistic factors; donor factors; postoperative ICU factors; postoperative surgical factors) and patient/organ classification (patient-related general factors; native-liver factors; new-liver factors; kidney factors; heart factors; brain factors; lung factors). Two hundred adult non-acute patients were included. Missing analysis was performed. The competitive role of each factor was assessed. Results: PRF occurred in 36.0% of cases. Among 28 significant PRF predictors at univariate analysis, 6 were excluded because of collinearity, 22 were investigated by ROC curves and by logistic regression analysis. Recipient age (OR = 1.05; p = 0.010), female sex (OR = 2.75; p = 0.018), Model for End-Stage Liver Disease (MELD, OR = 1.09; p<0.001), restrictive lung pattern (OR = 2.49; p = 0.027), intraoperative veno-venous bypass (VVBP, OR = 3.03; p = 0.008), pre-extubation PaCO 2 (OR = 1.11; p = 0.003) and Model for Early Allograft Function (MEAF, OR = 1.37; p<0.001) resulted independent PRF risk factors. As compared to patients without PRF, the PRF-group had longer LoS (10 days IQR 7-18 versus 5 days IQR 4-7, respectively; p<0.001) and lower day-90 survival (86.0% versus 97.6% respectively, p<0.001). Conclusion: In conclusion, MELD, restrictive lung pattern, surgical complexity as captured by VVBP, pre-extubation PaCO 2 and MEAF are the main predictors of PRF in non-acute LTx
Published: 2019

24. Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study

Author: Silvestrini, Andrea, Bruno, Carmine, Vergani, E, Venuti, A, Favuzzi, Angela Maria Rita, Guidi, F, Nicolotti, Nicola, Meucci Calabrese, Elisabetta, Mordente, Alvaro, Mancini, Antonio, Silvestrini A (ORCID:0000-0002-2005-3746), Bruno C, Favuzzi AMR, Nicolotti N, Meucci E (ORCID:0000-0002-8821-8041), Mordente A (ORCID:0000-0003-3260-9796), Mancini A (ORCID:0000-0002-7707-4564), Silvestrini, Andrea, Bruno, Carmine, Vergani, E, Venuti, A, Favuzzi, Angela Maria Rita, Guidi, F, Nicolotti, Nicola, Meucci Calabrese, Elisabetta, Mordente, Alvaro, Mancini, Antonio, Silvestrini A (ORCID:0000-0002-2005-3746), Bruno C, Favuzzi AMR, Nicolotti N, Meucci E (ORCID:0000-0002-8821-8041), Mordente A (ORCID:0000-0003-3260-9796), and Mancini A (ORCID:0000-0002-7707-4564)
Abstract: Irisin, a recently discovered myokine, has been considered a prognostic factor in several cardiovascular diseases. Nevertheless, no data are available on the role of irisin in patients with heart failure (HF), both with preserved (HFpEF) or reduced (HFrEF) ejection fraction. We have therefore evaluated the circulating irisin levels in HFpEF and HFrEF patients, correlating them with metabolic parameters and total antioxidant capacity (TAC), as index of oxidative stress. Irisin was significantly higher in HFpEF than in HFrEF patients (7.72 ± 0.76 vs 2.77 ± 0.77 ng/ml, respectively). An inverse correlation between irisin and TAC was found in HFpEF, but not in HFrEF. Conversely, no correlation was present with HOMA index. These data support the hypothesis that a different pathophysiological mechanism is involved in the two HF subtypes, and oxidative stress modulates irisin secretion.
Published: 2019

25. Gemelli decision tree Algorithm to Predict the need for home monitoring or hospitalization of confirmed and unconfirmed COVID-19 patients (GAP-Covid19): preliminary results from a retrospective cohort study.

Author: VETRUGNO, G., LAURENTI, P., FRANCESCHI, F., FOTI, F., D'AMBROSIO, F., CICCONI, M., LA MILIA, D. I., DI PUMPO, M., CARINI, E., PASCUCCI, D., BOCCIA, S., PASTORINO, R., DAMIANI, G., DE-GIORGIO, F., OLIVA, A., NICOLOTTI, N., CAMBIERI, A., GHISELLINI, R., MURRI, R., and SABATELLI, G.
Abstract: OBJECTIVE: To develop a deep learning-based decision tree for the primary care setting, to stratify adult patients with confirmed and unconfirmed coronavirus disease 2019 (COVID-19), and to predict the need for hospitalization or home monitoring. PATIENTS AND METHODS: We performed a retrospective cohort study on data from patients admitted to a COVID hospital in Rome, Italy, between 5 March 2020 and 5 June 2020. A confirmed case was defined as a patient with a positive nasopharyngeal RT-PCR test result, while an unconfirmed case had negative results on repeated swabs. Patients' medical history and clinical, laboratory and radiological findings were collected, and the dataset was used to train a predictive model for COVID-19 severity. RESULTS: Data of 198 patients were included in the study. Twenty-eight (14.14%) had mild disease, 62 (31.31%) had moderate disease, 64 (32.32%) had severe disease, and 44 (22.22%) had critical disease. The G2 value assessed the contribution of each collected value to decision tree building. On this basis, SpO2 (%) with a cut point at 92 was chosen for the optimal first split. Therefore, the decision tree was built using values maximizing G2 and LogWorth. After the tree was built, the correspondence between inputs and outcomes was validated. CONCLUSIONS: We developed a machine learning-based tool that is easy to understand and apply. It provides good discrimination in stratifying confirmed and unconfirmed COVID-19 patients with different prognoses in every context. Our tool might allow general practitioners visiting patients at home to decide whether the patient needs to be hospitalized. [ABSTRACT FROM AUTHOR]
Published: 2021

26. Evaluation of kisspeptin levels in prepubertal obese and overweight children: sexual dimorphism and modulation of antioxidant levels.

Author: MANCINI, A., CURRÒ, D., CIPOLLA, C., BARINI, A., BRUNO, C., VERGANI, E., DI SEGNI, C., GUIDI, F., NICOLOTTI, N., SILVESTRINI, A., MEUCCI, E., VALENTINI, P., and ROSSODIVITA, A. N.
Abstract: OBJECTIVE: Kisspeptin, neuropeptide involved in puberty beginning and regulation of pituitary-gonadal axis, has been shown to stimulate antioxidant defenses in murine models. Its levels are greater in females than males and also in obese prepubertal girls. Therefore, our aim was to evaluate sex-related differences in prepubertal obese patients and the relationships of Kisspeptin with metabolic/hormonal parameters. PATIENTS AND METHODS: We studied Kisspeptin concentrations in 54 children (22 males and 32 females, Tanner stage 1), 5-12 ys, classified according to Cole's criteria into 17 overweight and 37 obese; 25 normal-weight children, aged 6-12 years, were studied as controls. We evaluated metabolic (glucose and insulin levels after oral glucose load, total- LDL- HDL-cholesterol, triglycerides, uric acid) and hormonal (fT3, fT4, TSH, IGF-1, leptin) parameters. Moreover, total antioxidant capacity (TAC) was evaluated by spectrophotometric method, using the system H202-metmyoglobin-ABTS. Kisspeptin levels were measured by RIA. RESULTS: We did not find significant differences between obese and normal-weight children, but obese males presented significantly lower levels than females. Kisspeptin did not correlate with BMI, HOMA-IR, Insulin peak levels and TAC; a significant correlation was found between Kisspeptin and fT3 (r2=0.25; p=0.003) in the obese group; leptin levels, significantly greater in obese vs. overweight and control children, significantly correlated with TAC (r2=0.39; p=0.03). CONCLUSIONS: These data suggest that both hormones could modulate antioxidants, Kisspeptin indirectly via influence on thyroid hormones, and Leptin by a direct effect. This mechanism seems to be sex-related, not attributable to peripheral steroid levels. Further studies can clarify the complex interrelationship between central and peripheral Kisspeptin secretion and oxidative stress in children obesity. [ABSTRACT FROM AUTHOR]
Published: 2021

27. Continuity of Care Unit (CCU): an organizational model based on Lean Management principles.

Author: Tamburrano, A, primary, Nicolotti, N, additional, D'Alfonso, ME, additional, Cambieri, A, additional, Turriziani, A, additional, Barillaro, C, additional, Sganga, F, additional, Bernabei, R, additional, and Laurenti, P, additional
Published: 2018
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28. Donor Risk Index and MELD Score Interactions in Graft Survival Prediction after Liver Transplantation. An Analysis of the OPTN-UNOS Database

Author: Nicolotti N., Avolio A.W., Annicchiarico E., Barone M., Francesca Romana Ponziani, Grieco A., Agnes S., Siciliano M., and Boscarino G.
Subjects: Transplantation, Database, business.industry, medicine.medical_treatment, Liver transplantation, medicine.disease, computer.software_genre, Medium term, body regions, Organ procurement, Liver disease, Risk index, Medicine, Graft survival, business, computer
Abstract: Donor Risk Index (DRI) has been introduced to predict post-transplant graft survival (GS) using donor data. The MELD score, which is the gold-standard in scoring liver disease in liver transplant candidates, has a low prognostic significance. The present analysis is aimed to assess the role of DRI and of MELD score in predicting the outcome after liver transplantation, in short (180 days) and medium term (1460 days). The Organ Procurement Transplantation Network (OPTN) database relevant to 23.392 consecutive cases in the MELD era was used. Cases were stratified in classes according to DRI (4 classes), MELD (6 classes), and DRI-MELD match (24 classes). GS was assessed by Kaplan Meier method at 0-1460 days. Differences were tested by Log-rank test. All three parameters allow an effective stratification. Using the DRI, the gaps between the highest and lowest GS were 7.8% and 14.9%, at 180 and 1460 days, respectively. Using the MELD score, the gaps were 10.2% and 9.5%, respectively. Using DRI-MELD, the gaps were 25.5% and 35.4%, respectively. Both the DRI and the MELD can predict the outcome, although the predictive power of the DRI is the highest of the two, and the predictive power of the donor- recipient match, is even higher.
Published: 2011

29. D-MELD, a Powerful Instrument To Optimize Donor-2-Recipient Match. Differences between US and Italy

Author: Avolio, A, Halldorson, J, Lirosi, M, Agnes, S, Salizzoni, M, Pinna, A, Spada, M, De Carlis, L, Colledan, M, Gerunda, G, Andorno, E, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Vivarelli, M, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Bonsignore, P, Mangoni, I, Pinelli, D, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Santaniello, W, Bottino, G, Spagnoletti, G, Mariano, G, Gasbarrini, A, Burra, P, Cillo, U, Avolio A, Halldorson J, Lirosi M, Agnes S, Salizzoni M, Pinna A, Spada M, De Carlis L, Colledan M, Gerunda G, Andorno E, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Vivarelli M, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Bonsignore P, Mangoni I, Pinelli D, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Santaniello W, Bottino G, Spagnoletti G, Mariano G, Gasbarrini A, Burra P, Cillo U, Avolio, A, Halldorson, J, Lirosi, M, Agnes, S, Salizzoni, M, Pinna, A, Spada, M, De Carlis, L, Colledan, M, Gerunda, G, Andorno, E, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Vivarelli, M, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Bonsignore, P, Mangoni, I, Pinelli, D, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Santaniello, W, Bottino, G, Spagnoletti, G, Mariano, G, Gasbarrini, A, Burra, P, Cillo, U, Avolio A, Halldorson J, Lirosi M, Agnes S, Salizzoni M, Pinna A, Spada M, De Carlis L, Colledan M, Gerunda G, Andorno E, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Vivarelli M, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Bonsignore P, Mangoni I, Pinelli D, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Santaniello W, Bottino G, Spagnoletti G, Mariano G, Gasbarrini A, Burra P, and Cillo U
Published: 2013

30. THE UN-SUSTAINABLE MATCH IN HCV LIVER TRANSPLANT PATIENTS

Author: Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, Angelico M, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, Angelico M, Burra P, Gasbarrini A, and Cillo U
Published: 2012

31. The UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factors

Author: Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Romagnoli, R, Vitale, A, Cucchetti, A, Gruttadauria, S, Baccarani, U, Caccamo, L, Mangoni, I, Pinelli, D, Montalti, R, Morelli, N, Vennarecci, G, Nicolini, D, Regalia, E, Lai, Q, Anselmo, A, Tondolo, E, Perrella, A, Burra, P, Cillo, U, Avolio AW, Agnes S, Lirosi M, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Romagnoli R, Vitale A, Cucchetti A, Gruttadauria S, Baccarani U, Caccamo L, Mangoni I, Pinelli D, Montalti R, Morelli N, Vennarecci G, Nicolini D, Regalia E, Lai Q, Anselmo A, Tondolo E, Perrella A, Burra P, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Romagnoli, R, Vitale, A, Cucchetti, A, Gruttadauria, S, Baccarani, U, Caccamo, L, Mangoni, I, Pinelli, D, Montalti, R, Morelli, N, Vennarecci, G, Nicolini, D, Regalia, E, Lai, Q, Anselmo, A, Tondolo, E, Perrella, A, Burra, P, Cillo, U, Avolio AW, Agnes S, Lirosi M, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Romagnoli R, Vitale A, Cucchetti A, Gruttadauria S, Baccarani U, Caccamo L, Mangoni I, Pinelli D, Montalti R, Morelli N, Vennarecci G, Nicolini D, Regalia E, Lai Q, Anselmo A, Tondolo E, Perrella A, Burra P, and Cillo U
Published: 2012

32. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants

Author: Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Burra P, Gasbarrini A, and Cillo U
Published: 2012

33. D-MELD, a Powerful Instrument To Optimize Donor-2-Recipient Match. Differences between US and Italy

Author: Avolio A, Halldorson J, Lirosi M, Agnes S, Salizzoni M, Pinna A, Spada M, De Carlis L, Colledan M, Gerunda G, Andorno E, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Vivarelli M, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Bonsignore P, Mangoni I, Pinelli D, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Santaniello W, Bottino G, Spagnoletti G, Mariano G, Gasbarrini A, Burra P, Cillo U, Avolio, A, Halldorson, J, Lirosi, M, Agnes, S, Salizzoni, M, Pinna, A, Spada, M, De Carlis, L, Colledan, M, Gerunda, G, Andorno, E, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Vivarelli, M, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Bonsignore, P, Mangoni, I, Pinelli, D, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Santaniello, W, Bottino, G, Spagnoletti, G, Mariano, G, Gasbarrini, A, Burra, P, and Cillo, U
Subjects: Transplantation, Surgery
Published: 2013

34. From directive to practice: are pictorial warnings and plain packaging effective in combating tobacco use?

Author: Mipatrini, D, Mannocci, A, Colamesta, V, Messina, G, Gualano, Mr, Langiano, E, De Vito, E, Gianfagna, Francesco, Boccia, G, Nicolotti, N, and La Torre, G.
Subjects: prevention, public health, cancer, smoking, cardiovascular diseases
Published: 2015

35. Use of HBcAb Positive Liver Grafts. Medium Term Results According to Donor-Recipient Risk Factors

Author: Avolio, A, Agnes, S, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Lirosi, M, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scudieri, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio A, Agnes S, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Lirosi M, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scudieri E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Lirosi, M, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scudieri, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio A, Agnes S, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Lirosi M, Vitale A, Nicolotti N, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scudieri E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, and Cillo U
Published: 2011

36. www.D-MELD.com. The online prognostic calculator to optimize donor-recipient match

Author: Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Antonelli B, de Waure C, De Feo T, Burra P, Gasbarrini A, and Cillo U
Published: 2011

37. OPTIMIZATION OF DONOR-RECIPIENT MATCH AND IDENTIFICATION OF THE FUTILE MATCH CUTOFF. A NATIONAL ITALIAN STUDY ON LIVER TRANSPLANTATION

Author: Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Barone, M, Perrella, A, Romano, M, de Waure, C, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Barone M, Perrella A, Romano M, de Waure C, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Barone, M, Perrella, A, Romano, M, de Waure, C, Burra, P, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Bresadola F, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Donataccio M, Nicolotti N, Vitale A, Romagnoli R, Lupo F, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Barone M, Perrella A, Romano M, de Waure C, Burra P, Gasbarrini A, and Cillo U
Published: 2011

38. WWW.D-MELD.COM THE PROGNOSTIC CALCULATOR TO BALANCE DONOR AND RECIPIENT LIVER TRANSPLANT FACTORS USING D-MELD AND COVARIATES

Author: Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Baccarani, U, Lai, Q, Manzia, T, Tondolo, V, Rendina, M, Scuderi, V, Perrella, A, Angelico, M, Burra, P, Fagiuoli, S, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Baccarani U, Lai Q, Manzia TM, Tondolo V, Rendina M, Scuderi V, Perrella A, Angelico M, Burra P, Fagiuoli S, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Baccarani, U, Lai, Q, Manzia, T, Tondolo, V, Rendina, M, Scuderi, V, Perrella, A, Angelico, M, Burra, P, Fagiuoli, S, Gasbarrini, A, Cillo, U, Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna AD, Gridelli B, De Carlis L, Colledan M, Gerunda GE, Valente U, Rossi G, Ettorre GM, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Montalti R, Caccamo L, Vennarecci G, Nicolini D, Baccarani U, Lai Q, Manzia TM, Tondolo V, Rendina M, Scuderi V, Perrella A, Angelico M, Burra P, Fagiuoli S, Gasbarrini A, and Cillo U
Published: 2011

39. Erratum: Recreational physical activity and risk of head and neck cancer: A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium (European Journal of Epidemiology DOI: 10.1007/s10654-011- 9612-3)

Author: Nicolotti, N., Chuang, S. -C., Cadoni, G., Arzani, D., Petrelli, L., Bosetti, C., Brenner, H., Hosono, S., La Vecchia, C., Talamini, R., Matsuo, K., Muller, H., Muscat, J., Paludetti, G., Ricciardi, G., Boffetta, P., Hashibe, M., Boccia, S., Nicolotti N., Cadoni G. (ORCID:0000-0001-8244-784X), Petrelli L., Paludetti G. (ORCID:0000-0003-2480-1243), Ricciardi G. (ORCID:0000-0002-5655-688X), Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Nicolotti, N., Chuang, S. -C., Cadoni, G., Arzani, D., Petrelli, L., Bosetti, C., Brenner, H., Hosono, S., La Vecchia, C., Talamini, R., Matsuo, K., Muller, H., Muscat, J., Paludetti, G., Ricciardi, G., Boffetta, P., Hashibe, M., Boccia, S., Nicolotti N., Cadoni G. (ORCID:0000-0001-8244-784X), Petrelli L., Paludetti G. (ORCID:0000-0003-2480-1243), Ricciardi G. (ORCID:0000-0002-5655-688X), Boffetta P., and Boccia S. (ORCID:0000-0002-1864-749X)
Published: 2011

40. Prediction of Outcome after Liver Transplantation by D-MELD. Stratification of Graft Survival According to Donor Recipient Match in the Italian Multicenter Study

Author: Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Risaliti, A, Bresadola, V, Gridelli, B, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Boscarino, G, Nicolotti, N, Nicolini, D, Baccarani, U, Gruttadauria, S, Regalia, E, Angelico, M, Gasbarrini, A, Agnes, S, Avolio AW, Cillo U, Rossi M, Colledan M, Tisone G, Rossi G, Gerunda G, Valente U, Lupo L, Ettorre G, Risaliti A, Bresadola V, Gridelli B, Vitale A, Lai Q, Pinelli D, Anselmo A, Caccamo L, Montalti R, Morelli N, Rendina M, Vennarecci G, Boscarino G, Nicolotti N, Nicolini D, Baccarani U, Gruttadauria S, Regalia E, Angelico M, Gasbarrini A, Agnes S, Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Risaliti, A, Bresadola, V, Gridelli, B, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Boscarino, G, Nicolotti, N, Nicolini, D, Baccarani, U, Gruttadauria, S, Regalia, E, Angelico, M, Gasbarrini, A, Agnes, S, Avolio AW, Cillo U, Rossi M, Colledan M, Tisone G, Rossi G, Gerunda G, Valente U, Lupo L, Ettorre G, Risaliti A, Bresadola V, Gridelli B, Vitale A, Lai Q, Pinelli D, Anselmo A, Caccamo L, Montalti R, Morelli N, Rendina M, Vennarecci G, Boscarino G, Nicolotti N, Nicolini D, Baccarani U, Gruttadauria S, Regalia E, Angelico M, Gasbarrini A, and Agnes S
Published: 2010

41. D-MELD, a Powerful Predictor of Graft Survival after Liver Transplantation. Long-Term Results of a Multicenter Italian Study

Author: Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Grieco, A, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Angeli, P, Corno, V, Antonelli, B, Gaspari, R, Gelli, M, Boscarino, G, Nicolotti, N, Costa, R, Angelico, M, Corradini, S, Gasbarrini, A, Di Leo, A, Agnes, S, Avolio AW, Cillo U, Rossi M, Colledan M, Tisone G, Rossi G, Gerunda G, Valente U, Lupo L, Ettorre G, Grieco A, Vitale A, Lai Q, Pinelli D, Anselmo A, Caccamo L, Montalti R, Morelli N, Rendina M, Vennarecci G, Angeli P, Corno V, Antonelli B, Gaspari R, Gelli M, Boscarino G, Nicolotti N, Costa R, Angelico M, Corradini SG, Gasbarrini A, Di Leo A, Agnes S, Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Grieco, A, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Angeli, P, Corno, V, Antonelli, B, Gaspari, R, Gelli, M, Boscarino, G, Nicolotti, N, Costa, R, Angelico, M, Corradini, S, Gasbarrini, A, Di Leo, A, Agnes, S, Avolio AW, Cillo U, Rossi M, Colledan M, Tisone G, Rossi G, Gerunda G, Valente U, Lupo L, Ettorre G, Grieco A, Vitale A, Lai Q, Pinelli D, Anselmo A, Caccamo L, Montalti R, Morelli N, Rendina M, Vennarecci G, Angeli P, Corno V, Antonelli B, Gaspari R, Gelli M, Boscarino G, Nicolotti N, Costa R, Angelico M, Corradini SG, Gasbarrini A, Di Leo A, and Agnes S
Published: 2010

42. The Un-sustainable Match In Hcv Liver Transplant Patients

Author: Avolio, Aw, Agnes, S, Lirosi, Mc, Salizzoni, Mauro, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, Renato, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, Cillo, U., Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, Angelico, M, Burra, P, Gasbarrini, A, and Cillo, U
Subjects: Liver transplantation, donor-recipient match, liver transplantation
Published: 2012

43. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants

Author: Avolio AW, Agnes S, Lirosi MC, Salizzoni M, Pinna A, Gridelli B, De Carlis L, Colledan M, Gerunda G, Valente U, Rossi G, Ettorre G, Risaliti A, Mazzaferro V, Rossi M, Tisone G, Zamboni F, Lupo L, Cuomo O, Calise F, Nicolotti N, Vitale A, Romagnoli R, Cucchetti A, Gruttadauria S, Mangoni I, Pinelli D, Montalti R, Gelli M, Caccamo L, Vennarecci G, Nicolini D, Regalia E, Baccarani U, Lai Q, Manzia T, Tondolo E, Rendina M, Perrella A, Scuderi E, Burra P, Gasbarrini A, Cillo U, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Burra, P, Gasbarrini, A, and Cillo, U
Subjects: liver transplantation, D-MELD
Published: 2012

44. The UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factors

Author: Avolio, A. W., Agnes, S., Lirosi, M., Salizzoni, M., Pinna, A., Gridelli, B., Carlis, L., Colledan, M., Gerunda, G., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Romagnoli, R., Vitale, A., Cucchetti, A., Gruttadauria, S., Baccarani, U., Caccamo, L., Mangoni, I., Pinelli, D., Montalti, R., Morelli, N., Vennarecci, G., Nicolini, D., Regalia, E., Lai, Q., Alessandro Anselmo, Tondolo, E., Perrella, A., Burra, P., Cillo, U., Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Romagnoli, R, Vitale, A, Cucchetti, A, Gruttadauria, S, Baccarani, U, Caccamo, L, Mangoni, I, Pinelli, D, Montalti, R, Morelli, N, Vennarecci, G, Nicolini, D, Regalia, E, Lai, Q, Anselmo, A, Tondolo, E, Perrella, A, Burra, P, and Cillo, U
Subjects: Transplantation, D-MELD, donor-recipient match, liver transplantation, Hepatology, Gastroenterology, Surgery
Published: 2012

45. Use of HBcAb Positive Liver Grafts. Medium Term Results According to Donor-Recipient Risk Factors

Author: Avolio, A., Agnes, S., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Valente, U., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, Massimo, Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Lirosi, M., Vitale, A., Nicolotti, N., Romagnoli, R., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scudieri, E., Antonelli, B., de Waure, C., De Feo, T., Burra, P., Gasbarrini, A., Cillo, U., Avolio, A, Agnes, S, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Lirosi, M, Vitale, A, Nicolotti, N, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scudieri, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, and Cillo, U
Subjects: liver transplantation, HBcAb positive donor
Published: 2011

46. Www.d-meld.com the Prognostic Calculator To Balance Donor and Recipient Liver Transplant Factors Using D-meld and Covariates

Author: Avolio, Aw, Agnes, S, Lirosi, Mc, Salizzoni, Mauro, Pinna, Ad, Gridelli, B, Decarlis, L, Colledan, M, Gerunda, Ge, Valente, U, Rossi, G, Ettorre, Gm, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, Renato, Cucchetti, A, Gruttadauria, S, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Baccarani, U, Lai, Q, Manzia, Tm, Tondolo, V, Rendina, M, Scuderi, V, Perrella, A, Angelico, M, Burra, P, Fagiuoli, S, Gasbarrini, A, Cillo, U., Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Rossi, M, Tisone, G, Zamboni, F, Cuomo, O, Calise, F, Nicolotti, N, Vitale, A, Romagnoli, R, Cucchetti, A, Gruttadauria, S, Montalti, R, Caccamo, L, Vennarecci, G, Nicolini, D, Baccarani, U, Lai, Q, Manzia, T, Tondolo, V, Rendina, M, Scuderi, V, Perrella, A, Angelico, M, Burra, P, Fagiuoli, S, Gasbarrini, A, and Cillo, U
Subjects: liver transplantation, WWW.D-MELD.COM, D-MELD, LIVER TRANSPLANT
Published: 2011

47. www.D-MELD.com. THE ONLINE PROGNOSTIC CALCULATOR TO OPTIMIZE DONOR-RECIPIENT MATCH

Author: Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., Carlis, L. D., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R., Lupo, F., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., Waure, C. d., Feo, T. D., Burra, Patrizia, Gasbarrini, A., Cillo, Umberto, Avolio, A, Agnes, S, Lirosi, M, Salizzoni, M, Pinna, A, Gridelli, B, De Carlis, L, Colledan, M, Gerunda, G, Valente, U, Rossi, G, Ettorre, G, Risaliti, A, Mazzaferro, V, Bresadola, F, Rossi, M, Tisone, G, Zamboni, F, Lupo, L, Cuomo, O, Calise, F, Donataccio, M, Nicolotti, N, Vitale, A, Romagnoli, R, Lupo, F, Cucchetti, A, Gruttadauria, S, Mangoni, I, Pinelli, D, Montalti, R, Gelli, M, Caccamo, L, Vennarecci, G, Nicolini, D, Regalia, E, Baccarani, U, Lai, Q, Manzia, T, Tondolo, E, Rendina, M, Perrella, A, Scuderi, E, Antonelli, B, de Waure, C, De Feo, T, Burra, P, Gasbarrini, A, and Cillo, U
Subjects: Transplantation, liver transplantation, Surgery, D-MELD
Published: 2011

48. Prediction of Outcome after Liver Transplantation by D-MELD. Stratification of Graft Survival According to Donor Recipient Match in the Italian Multicenter Study

Author: Avolio AW, Cillo U, Rossi M, Colledan M, Tisone G, Rossi G, Gerunda G, Valente U, Lupo L, Ettorre G, Risaliti A, Bresadola V, Gridelli B, Vitale A, Lai Q, Pinelli D, Anselmo A, Caccamo L, Montalti R, Morelli N, Rendina M, Vennarecci G, Boscarino G, Nicolotti N, Nicolini D, Baccarani U, Gruttadauria S, Regalia E, Angelico M, Gasbarrini A, Agnes S, Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Risaliti, A, Bresadola, V, Gridelli, B, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Boscarino, G, Nicolotti, N, Nicolini, D, Baccarani, U, Gruttadauria, S, Regalia, E, Angelico, M, Gasbarrini, A, and Agnes, S
Subjects: Transplantation, Donor Recipient Match in the Italian Multicenter Study, D-MELD, Surgery
Published: 2010

49. D-MELD, a Powerful Predictor of Graft Survival after Liver Transplantation. Long-Term Results of a Multicenter Italian Study

Author: Avolio, A. W., Cillo, U., Rossi, M., Colledan, M., Tisone, G., Rossi, G., Gerunda, G., Valente, U., Lupo, L., Ettorre, G., Grieco, A., Vitale, A., Lai, Q., Pinelli, D., Alessandro Anselmo, Caccamo, L., Montalti, R., Morelli, N., Rendina, M., Vennarecci, G., Angeli, P., Corno, V., Antonelli, B., Gaspari, R., Gelli, M., Boscarino, G., Nicolotti, N., Costa, R., Angelico, M., Corradini, S. Ginanni, Gasbarrini, A., Di Leo, A., Agnes, S., Avolio, A, Cillo, U, Rossi, M, Colledan, M, Tisone, G, Rossi, G, Gerunda, G, Valente, U, Lupo, L, Ettorre, G, Grieco, A, Vitale, A, Lai, Q, Pinelli, D, Anselmo, A, Caccamo, L, Montalti, R, Morelli, N, Rendina, M, Vennarecci, G, Angeli, P, Corno, V, Antonelli, B, Gaspari, R, Gelli, M, Boscarino, G, Nicolotti, N, Costa, R, Angelico, M, Corradini, S, Gasbarrini, A, Di Leo, A, and Agnes, S
Subjects: Transplantation, Hepatology, Gastroenterology, Surgery
Published: 2010

50. A new drug responding an unmet need: belimumab in the treatment of systemic lupus erythematosus

Author: De Waure, Chiara, Specchia, Maria Lucia, Doria, A, Turchetti, G, Capizzi, Silvio, Iaccarino, L, Pierotti, F, Kheiraoui, F, Cadeddu, Chiara, Palla, I, Di Nardo, Francesco, Gliubizzi, Maria Daniela, Sferrazza, Antonella, Nicolotti, N, Gualano, Mr, La Torre, G, Di Pietro, Maria Luisa, and Ricciardi, Walter
Subjects: Health Technology Assessment, Systemic Lupus Erythematosus, Settore MED/42 - IGIENE GENERALE E APPLICATA, Belimumab
Published: 2013

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