11 results on '"Nicolosi K"'
Search Results
2. SAT0107 Simple Predictors of Abnormal 2h Postload Glucose in RA Patients with Normal Fasting Glucose
- Author
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Ursini, F., primary, D'Angelo, S., additional, Tripolino, C., additional, Bruno, C., additional, D'Antona, L., additional, Nicolosi, K., additional, Naty, S., additional, Olivieri, I., additional, and Grembiale, R.D., additional
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- 2016
- Full Text
- View/download PDF
3. AB0264 Fatty Liver Index Predicts Glucose Metabolism Disturbance in Inflammatory Arthritis Patients
- Author
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Tripolino, C., primary, Ursini, F., additional, Bruno, C., additional, Nicolosi, K., additional, Naty, S., additional, and Grembiale, R.D., additional
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- 2016
- Full Text
- View/download PDF
4. FRI0076 What Inflammatory Marker Best Reflects Insulin Resistance in Rheumatoid Arthritis?
- Author
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Ursini, F., primary, Naty, S., additional, Bruno, C., additional, D'Antona, L., additional, Tripolino, C., additional, Nicolosi, K., additional, Rubino, M., additional, Savarino, F., additional, and Grembiale, R.D., additional
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- 2015
- Full Text
- View/download PDF
5. Solving inverse initial-value, boundary-value problems via genetic algorithm
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Karr, C. L., Yakushin, I., and Nicolosi, K.
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- 2000
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- View/download PDF
6. High Prevalence of Achilles Tendon Enthesopathic Changes in Patients with Type 2 Diabetes Without Peripheral Neuropathy
- Author
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Lewa Amara, Saverio Naty, Caterina Bruno, Ignazio Olivieri, Salvatore D'Angelo, Franco Arturi, Giovambattista De Sarro, Rosa Daniela Grembiale, Emilio Russo, Kassandra Nicolosi, Francesco Ursini, Ursini F., Arturi F., D'Angelo S., Amara L., Nicolosi K., Russo E., Naty S., Bruno C., De Sarro G., Olivieri I., and Grembiale R.D.
- Subjects
Adult ,Male ,medicine.medical_specialty ,030209 endocrinology & metabolism ,Type 2 diabetes ,Comorbidity ,Enthesopathy ,Asymptomatic ,Achilles Tendon ,Risk Assessment ,Severity of Illness Index ,NO ,03 medical and health sciences ,0302 clinical medicine ,Diabetic Neuropathies ,Reference Values ,Diabetes mellitus ,Severity of illness ,medicine ,Prevalence ,Humans ,Aged ,030203 arthritis & rheumatology ,Observer Variation ,Achilles tendon ,business.industry ,enthesopathy diabetes ultrasonography achilles tendon ,Peripheral Nervous System Diseases ,Ultrasonography, Doppler ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Surgery ,Peripheral neuropathy ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,Italy ,diabete ,Case-Control Studies ,Disease Progression ,Female ,medicine.symptom ,business - Abstract
Background: Metabolic disorders are known to alter the mechanical properties of tendons. We sought to evaluate the prevalence of asymptomatic Achilles tendon enthesopathic changes in patients with type 2 diabetes mellitus (T2DM) without peripheral neuropathy. Methods: We recruited 43 patients with T2DM and 40 controls. Neuropathy was excluded with the Michigan Neuropathy Scoring Instrument. Bilateral ultrasonography of the Achilles tendon enthesis was performed. Results: Patients with T2DM had a higher prevalence of hypoechogenicity (26.7% versus 2.5%; P = .0001), entheseal thickening (24.4% versus 8.7%; P = .007), and enthesophytes (74.4% versus 57.5%; P = .02). No differences were found in the number of patients with erosions (1.2% versus 0%; P > .99), cortical irregularities (11.6% versus 3.7%; P = .09), bursitis (5.8% versus 3.7%; P = .72), or tears (2.3% versus 1.2%; P > .99). The mean ± SD sum of abnormalities was higher in patients with T2DM (1.5 ± 1.1 versus 0.7 ± 0.6; P < .0001), as was the percentage of bilateral involvement (72.1% versus 45.0%; P = .01). Mean ± SD thickness did not differ between patients and controls (4.4 ± 1.1 mm versus 4.2 ± 0.8 mm; P = .07). Conclusions: According to our data, there is an elevated prevalence of asymptomatic Achilles tendon enthesopathic changes in patients with T2DM independent of peripheral neuropathy.
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- 2016
7. Complement C3 is the strongest predictor of whole-body insulin sensitivity in psoriatic arthritis
- Author
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Caterina Bruno, Ignazio Olivieri, Kassandra Nicolosi, Rosa Daniela Grembiale, Francesco Ursini, Giovambattista De Sarro, Emilio Russo, Salvatore D'Angelo, Saverio Naty, Agostino Chiaravalloti, Antonio Gallucci, Ursini F., D'Angelo S., Russo E., Nicolosi K., Gallucci A., Chiaravalloti A., Bruno C., Naty S., De Sarro G., Olivieri I., and Grembiale R.D.
- Subjects
0301 basic medicine ,Physiology ,medicine.medical_treatment ,Oral Glucose Suppression Test ,lcsh:Medicine ,Blood Pressure ,Pathology and Laboratory Medicine ,Biochemistry ,Vascular Medicine ,0302 clinical medicine ,Endocrinology ,C reactive protein ,complement component C3 ,Blood plasma ,Medicine and Health Sciences ,Insulin ,lcsh:Science ,Immune Response ,Multidisciplinary ,Hematology ,Body Fluids ,Blood ,Population study ,Anatomy ,Research Article ,medicine.medical_specialty ,Psoriatic Arthritis ,Immunology ,Blood Plasma ,NO ,03 medical and health sciences ,Psoriatic arthritis ,Insulin resistance ,Signs and Symptoms ,Settore MED/36 ,Psoriatic arthritis, insulin resistance ,Rheumatology ,Diagnostic Medicine ,Internal medicine ,medicine ,030203 arthritis & rheumatology ,Diabetic Endocrinology ,Pharmacology ,Inflammation ,Receiver operating characteristic ,Endocrine Physiology ,business.industry ,Arthritis ,lcsh:R ,Biology and Life Sciences ,Stepwise regression ,medicine.disease ,Hormones ,Pharmacologic-Based Diagnostics ,030104 developmental biology ,Blood pressure ,Glucose Tolerance Tests ,lcsh:Q ,Insulin Resistance ,business - Abstract
Objectives To evaluate the correlation between inflammatory measures and whole-body insulin sensitivity in psoriatic arthritis (PsA) patients. Methods For the present study, 40 nondiabetic PsA patients were recruited. A standard oral glucose tolerance test (OGTT) was performed. The insulin sensitivity index (ISI), insulinogenic index (IGI) and oral disposition index (ODI) were calculated from dynamic values of glucose and insulin obtained during OGTT. Results In our study population, mean ISI was 3.5 ± 2.5, median IGI was 1.2 (0.7–1.8), mean ODI 4.5 ± 4.5. In univariate correlation analysis, ISI correlated inversely with systolic blood pressure (sBP) (R = -0.52, p = 0.001), diastolic blood pressure (dBP) (R = -0.45, p = 0.004) and complement C3 (R = -0.43, p = 0.006) and ODI correlated inversely with sBP (R = -0.38, p = 0.02), dBP (R = -0.35, p = 0.03) and complement C3 (R = -0.37, p = 0.02). No significant correlations were found between analyzed variables and IGI. In a stepwise multiple regression, only complement C3 entered in the regression equation and accounted for approximately 50% of the variance of ISI. Using a receiver operating characteristic (ROC) curve we identified the best cut-off for complement C3 of 1.32 g/L that yielded a sensitivity of 56% and a specificity of 96% for classification of insulin resistant patients. Conclusions In conclusion, our data suggest that serum complement C3 could represent a useful marker of whole-body insulin sensitivity in PsA patients.
- Published
- 2016
8. Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function
- Author
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Kassandra Nicolosi, Francesco Ursini, Saverio Naty, Ignazio Olivieri, Salvatore D'Angelo, Franco Arturi, Antonio Ammendolia, Emilio Russo, Giovambattista De Sarro, Rosa Daniela Grembiale, Caterina Bruno, Ursini F., Arturi F., Nicolosi K., Ammendolia A., D'Angelo S., Russo E., Naty S., Bruno C., De Sarro G., Olivieri I., and Grembiale R.D.
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Male ,Physiology ,lcsh:Medicine ,Kidney ,Biochemistry ,Gastroenterology ,Body Mass Index ,Tendons ,Endocrinology ,0302 clinical medicine ,Diabetic Neuropathies ,Medicine and Health Sciences ,Fascia ,lcsh:Science ,enthesopathy, plantar fascia ,Multidisciplinary ,Pharmaceutics ,Enthesopathy ,Drugs ,Diabetic retinopathy ,Middle Aged ,Lipids ,Type 2 Diabetes ,Cholesterol ,medicine.anatomical_structure ,Physiological Parameters ,Connective Tissue ,Adult ,Aged ,Diabetes Mellitus, Type 2 ,Diabetic Retinopathy ,Female ,Humans ,Anatomy ,Type 2 ,Research Article ,Retinopathy ,medicine.medical_specialty ,Endocrine Disorders ,Lipoproteins ,030209 endocrinology & metabolism ,NO ,03 medical and health sciences ,Drug Therapy ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,medicine ,Pharmacology ,030203 arthritis & rheumatology ,business.industry ,lcsh:R ,Body Weight ,Statins ,Biology and Life Sciences ,Proteins ,medicine.disease ,Surgery ,Biological Tissue ,Peripheral neuropathy ,Metabolic Disorders ,lcsh:Q ,Plantar fascia ,business ,Body mass index - Abstract
Background Aim of this study was to evaluate the prevalence of plantar fascia (PF) enthesopathy in Type 2 diabetes mellitus (T2DM) patients without distal peripheral neuropathy (DPN). Methods We recruited 50 T2DM patients without DPN and 50 healthy controls. DPN was excluded using the Michigan Neuropathy Screening Instrument (MNSI). All patients underwent a bilateral sonographicevaluation of the enthesealportion of the PF. Results PF thickness was significantly higher in T2DM patients (p
- Published
- 2017
9. Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function.
- Author
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Ursini F, Arturi F, Nicolosi K, Ammendolia A, D'Angelo S, Russo E, Naty S, Bruno C, De Sarro G, Olivieri I, and Grembiale RD
- Subjects
- Adult, Aged, Body Mass Index, Diabetes Mellitus, Type 2 complications, Diabetic Neuropathies physiopathology, Diabetic Retinopathy complications, Enthesopathy complications, Female, Humans, Kidney physiopathology, Male, Middle Aged, Tendons physiopathology, Diabetes Mellitus, Type 2 physiopathology, Diabetic Retinopathy physiopathology, Enthesopathy physiopathology, Fascia physiopathology
- Abstract
Background: Aim of this study was to evaluate the prevalence of plantar fascia (PF) enthesopathy in Type 2 diabetes mellitus (T2DM) patients without distal peripheral neuropathy (DPN)., Methods: We recruited 50 T2DM patients without DPN and 50 healthy controls. DPN was excluded using the Michigan Neuropathy Screening Instrument (MNSI). All patients underwent a bilateral sonographicevaluation of the enthesealportion of the PF., Results: PF thickness was significantly higher in T2DM patients (p<0.0001). T2DM patients presented a higher prevalence of entheseal thickening (p = 0.002), enthesophyte (p = 0.02) and cortical irregularity (p = 0.02). The overall sum of abnormalities was higher in T2DM patients (p<0.0001), as was the percentage of bilateral involvement (p = 0.005). In a logistic regression analysis, retinopathy predicted entheseal thickening (OR 3.5, p = 0.05) and enthesophytes (OR 5.13, p = 0.001); reduced eGFR predicted enthesophytes (OR 2.93, p = 0.04); body mass index (BMI) predicted cortical irregularity (OR 0.87, p = 0.05); mean glucose predicted enthesophyte (OR 1.01, p = 0.03); LDL cholesterol predicted cortical irregularity (OR 0.98, p = 0.02)., Conclusions: Our data suggest that T2DM is associated with PF enthesopathyindependently of DPN.
- Published
- 2017
- Full Text
- View/download PDF
10. High Prevalence of Achilles Tendon Enthesopathic Changes in Patients with Type 2 Diabetes Without Peripheral Neuropathy.
- Author
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Ursini F, Arturi F, D'Angelo S, Amara L, Nicolosi K, Russo E, Naty S, Bruno C, De Sarro G, Olivieri I, and Grembiale RD
- Subjects
- Achilles Tendon diagnostic imaging, Adult, Aged, Case-Control Studies, Comorbidity, Diabetes Mellitus, Type 2 physiopathology, Diabetic Neuropathies diagnostic imaging, Diabetic Neuropathies epidemiology, Disease Progression, Enthesopathy diagnostic imaging, Female, Humans, Italy, Male, Middle Aged, Observer Variation, Peripheral Nervous System Diseases epidemiology, Peripheral Nervous System Diseases physiopathology, Prevalence, Prognosis, Reference Values, Risk Assessment, Severity of Illness Index, Achilles Tendon pathology, Diabetes Mellitus, Type 2 epidemiology, Enthesopathy epidemiology, Ultrasonography, Doppler
- Abstract
Background: Metabolic disorders are known to alter the mechanical properties of tendons. We sought to evaluate the prevalence of asymptomatic Achilles tendon enthesopathic changes in patients with type 2 diabetes mellitus (T2DM) without peripheral neuropathy., Methods: We recruited 43 patients with T2DM and 40 controls. Neuropathy was excluded with the Michigan Neuropathy Scoring Instrument. Bilateral ultrasonography of the Achilles tendon enthesis was performed., Results: Patients with T2DM had a higher prevalence of hypoechogenicity (26.7% versus 2.5%; P = .0001), entheseal thickening (24.4% versus 8.7%; P = .007), and enthesophytes (74.4% versus 57.5%; P = .02). No differences were found in the number of patients with erosions (1.2% versus 0%; P > .99), cortical irregularities (11.6% versus 3.7%; P = .09), bursitis (5.8% versus 3.7%; P = .72), or tears (2.3% versus 1.2%; P > .99). The mean ± SD sum of abnormalities was higher in patients with T2DM (1.5 ± 1.1 versus 0.7 ± 0.6; P < .0001), as was the percentage of bilateral involvement (72.1% versus 45.0%; P = .01). Mean ± SD thickness did not differ between patients and controls (4.4 ± 1.1 mm versus 4.2 ± 0.8 mm; P = .07)., Conclusions: According to our data, there is an elevated prevalence of asymptomatic Achilles tendon enthesopathic changes in patients with T2DM independent of peripheral neuropathy.
- Published
- 2017
- Full Text
- View/download PDF
11. Complement C3 Is the Strongest Predictor of Whole-Body Insulin Sensitivity in Psoriatic Arthritis.
- Author
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Ursini F, D'Angelo S, Russo E, Nicolosi K, Gallucci A, Chiaravalloti A, Bruno C, Naty S, De Sarro G, Olivieri I, and Grembiale RD
- Abstract
Objectives: To evaluate the correlation between inflammatory measures and whole-body insulin sensitivity in psoriatic arthritis (PsA) patients., Methods: For the present study, 40 nondiabetic PsA patients were recruited. A standard oral glucose tolerance test (OGTT) was performed. The insulin sensitivity index (ISI), insulinogenic index (IGI) and oral disposition index (ODI) were calculated from dynamic values of glucose and insulin obtained during OGTT., Results: In our study population, mean ISI was 3.5 ± 2.5, median IGI was 1.2 (0.7-1.8), mean ODI 4.5 ± 4.5. In univariate correlation analysis, ISI correlated inversely with systolic blood pressure (sBP) (R = -0.52, p = 0.001), diastolic blood pressure (dBP) (R = -0.45, p = 0.004) and complement C3 (R = -0.43, p = 0.006) and ODI correlated inversely with sBP (R = -0.38, p = 0.02), dBP (R = -0.35, p = 0.03) and complement C3 (R = -0.37, p = 0.02). No significant correlations were found between analyzed variables and IGI. In a stepwise multiple regression, only complement C3 entered in the regression equation and accounted for approximately 50% of the variance of ISI. Using a receiver operating characteristic (ROC) curve we identified the best cut-off for complement C3 of 1.32 g/L that yielded a sensitivity of 56% and a specificity of 96% for classification of insulin resistant patients., Conclusions: In conclusion, our data suggest that serum complement C3 could represent a useful marker of whole-body insulin sensitivity in PsA patients., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2016
- Full Text
- View/download PDF
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