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Your search keyword '"Nicolini, Simona"' showing total 27 results
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27 results on '"Nicolini, Simona"'

1. A Multiple Case Study on Blended and Online Educational Strategies

Author

Panciroli, Chiara, Corazza, Laura, Macauda, Anita, Nicolini, Simona, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Agrati, Laura Sara, editor, Burgos, Daniel, editor, Ducange, Pietro, editor, Limone, Pierpaolo, editor, Perla, Loredana, editor, Picerno, Pietro, editor, Raviolo, Paolo, editor, and Stracke, Christian M., editor

Published
2021
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15. Phospha-Michael-Type Reactions between 1,2-Diaza-1,3-dienes and Bidentate Nucleophiles: Formation of New Mono- and Diylides and their Elaboration to Heterocycles

Author

Boga, Carla, primary, Zanna, Nicola, additional, Attanasi, Orazio A., additional, Baccolini, Graziano, additional, De Crescentini, Lucia, additional, Forlani, Luciano, additional, Mantellini, Fabio, additional, Nicolini, Simona, additional, Micheletti, Gabriele, additional, and Tozzi, Silvia, additional

Published
2011
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23. Regioselective Formation of 5-Methylene-6-methoxy-1,4,5,6-tetrahydropyridazines from the [4+2]-Cycloaddition Reaction of In Situ Generated 1,2-Diaza-1,3-dienes with Methoxyallene.

Author

Attanasi, Orazio A., Favi, Gianfranco, Mantellini, Fabio, Mantenuto, Serena, Moscatelli, Giada, and Nicolini, Simona

Subjects
REGIOSELECTIVITY (Chemistry), DIELS-Alder reaction, RING formation (Chemistry), METHYLENE group, PYRIDAZINES
Abstract

A regioselective inverse-electron-demand hetero-Diels-Alder reaction of in situ generated 1,2-diaza-1,3-dienes with methoxyallene is reported. These Lewis and Brønsted acid free reactions benefit from operational simplicity and allow access to synthetically valuable 5-methylene-6-methoxy-1,4,5,6-tetrahydropyridazines in high yields. [ABSTRACT FROM AUTHOR]

Published
2015
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25. Reaction of 1,2Diaza1,3butadienes with Aminophosphorus Nucleophiles: A Practical Access to New Phosphorylated Pyrazolones

Author

Attanasi, Orazio A., Baccolini, Graziano, Boga, Carla, De Crescentini, Lucia, Giorgi, Gianluca, Mantellini, Fabio, and Nicolini, Simona

Abstract

The reaction of 1,2diaza1,3butadienes with dibenzyl diisopropylphosphoramidite, methyl tetraisopropylphosphorodiamidite or trisdimethylaminophosphane under solventfree conditions gave stable αphosphoranylidenehydrazones that, in turn, were transformed into the corresponding 5oxo4phosphoranylidene4,5dihydro1Hpyrazoles. Xray diffraction analysis of one of these derivatives is reported. αPhosphoranylidenehydrazones, derived from the reaction between 1,2diaza1,3butadienes with dibenzyl diisopropylphosphoramidite, were converted by hydrolytic cleavage into Ehydrazonophosphonates, which are useful for the preparation of the corresponding 3oxo2,3dihydro1Hpyrazol4ylphosphonamidates.© WileyVCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009

Published
2008
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26. 1,3,5-Trisubstituted and 5-acyl-1,3-disubstituted hydantoin derivatives via novel sequential three-component reaction.

Author

Attanasi OA, De Crescentini L, Favi G, Nicolini S, Perrulli FR, and Santeusanio S

Subjects
Catalysis, Combinatorial Chemistry Techniques, Hydantoins chemistry, Molecular Structure, Alkenes chemistry, Amines chemistry, Aza Compounds chemistry, Hydantoins chemical synthesis
Abstract

1,2-Diaza-1,3-dienes (DDs) react as Michael acceptors with primary amines to afford α-aminohydrazone derivatives that were in situ coupled with isocyanates. Intramolecular ring closure of the asymmetric urea derivatives so formed allows for a selectively substituted hydantoin ring to be obtained. The hydrazone side chain introduced by the conjugated heterodiene system at the 5-position of the heterocycle represents a valuable functionality for accessing novel 5-acyl derivatives difficult to obtain by other methods.

Published
2011
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27. Electrophilic reactivities of 1,2-diaza-1,3-dienes.

Author

Kanzian T, Nicolini S, De Crescentini L, Attanasi OA, Ofial AR, and Mayr H

Abstract

The kinetics of the reactions of 1,2-diaza-1,3-dienes 1 with acceptor-substituted carbanions 2 have been studied at 20 °C. The reactions follow a second-order rate law, and can be described by the linear free energy relationship log k(20 °C)=s(N+E) [Eq. (1)]. With Equation (1) and the known nucleophile-specific parameters N and s for the carbanions, the electrophilicity parameters E of the 1,2-diaza-1,3-dienes 1 were determined. With E parameters in the range of -13.3 to -15.4, the electrophilic reactivities of 1a-d are comparable to those of benzylidenemalononitriles, 2-benzylideneindan-1,3-diones, and benzylidenebarbituric acids. The experimental second-order rate constants for the reactions of 1a-d with amines 3 and triarylphosphines 4 agreed with those calculated from E, N, and s, indicating the applicability of the linear free energy relationship [Eq. (1)] for predicting potential nucleophilic reaction partners of 1,2-diaza-1,3-dienes 1. Enamines 5 react up to 10(2) to 10(3) times faster with compounds 1 than predicted by Equation (1), indicating a change of mechanism, which becomes obvious in the reactions of 1 with enol ethers.

Published
2010
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