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4. Long-standing international cooperation in parasitology research: A summary of 35 years of activities in the Bolivian Chaco

Author

Gabrielli, Simona, Macchioni, Fabio, Spinicci, Michele, Strohmeyer, Marianne, Roselli, Mimmo, Nicoletti, Alessandra, Cicero, Calogero Edoardo, Poma, Veronica, Rojo, David, Lara, Yunni, Crespo Gomez, Elizabeth Blanca, Rojas, Patricia, Gamboa, Herlan, Villagran, Ana Liz, Cosmi, Francesco, Monasterio, Joaquin, Cancrini, Gabriella, and Bartoloni, Alessandro

Published
2022

8. Multidisciplinary care use in neurodegenerative complex diseases: The example of progressive supranuclear palsy and advanced Parkinson's disease in real-life

Author

Serio, Marina, Zibetti, Maurizio, Bissacco, Jacopo, Satolli, Sara, Sambati, Luisa, Bacchin, Ruggero, Longo, Chiara, Marchese, Roberta, Panetta, Salvatore, Magistrelli, Luca, Contaldi, Elena, Moschella, Vincenzo, Altavista, Maria Concetta, Costanzo, Matteo, Fabbrini, Giovanni, Olivola, Enrica, Modugno, Nicola, Cincotta, Massimo, Piccininni, Maristella, Capecci, Marianna, Baldini, Nicolò, Ciammola, Andrea, Ticozzi, Nicola, Raffaella, Di Giacopo, De Togni, Laura, Sala, Francesca, Nicoletti, Alessandra, Cicero, Edoardo, Ceravolo, Roberto, Del Prete, Eleonora, Fabbri, Margherita, Ledda, Claudia, Schirinzi, Tommaso, Artusi, Carlo Alberto, Avallone, Anna Rosa, Zenuni, Henri, De Micco, Rosa, Aloisio, Simone, Cani, Ilaria, Malaguti, Maria Chiara, Di Biasio, Francesca, Calandra-Buonaura, Giovanna, Stefani, Alessandro, Lopiano, Leonardo, Barone, Paolo, and Picillo, Marina

Published
2024
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12. Do demographic and clinical features and comorbidities affect the risk of spread to an additional body site in functional motor disorders?

Author

Ercoli, Tommaso, Tinazzi, Michele, Geroin, Christian, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele, Eleopra, Roberto, Zappia, Mario, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Spano, Giorgio, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra-Buonaura, Giovanna, Petracca, Martina, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Stocchi, Fabrizio, and Defazio, Giovanni

Published
2022
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13. The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
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16. Relationship between risk and protective factors and clinical features of Parkinson's disease

Author

Belvisi, Daniele, Pellicciari, Roberta, Fabbrini, Andrea, Costanzo, Matteo, Ressa, Gaia, Pietracupa, Sara, De Lucia, Maria, Modugno, Nicola, Magrinelli, Francesca, Dallocchio, Carlo, Ercoli, Tommaso, Nicoletti, Alessandra, Zappia, Mario, Solla, Paolo, Bologna, Matteo, Fabbrini, Giovanni, Tinazzi, Michele, Conte, Antonella, Berardelli, Alfredo, and Defazio, Giovanni

Published
2022
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19. Functional motor phenotypes: to lump or to split?

Author

Tinazzi, Michele, Geroin, Christian, Marcuzzo, Enrico, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele, Eleopra, Roberto, Zappia, Mario, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Magro, Giuseppe, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Zanolin, Elisabetta, Albanese, Alberto, Ferrazzano, Gina, De Micco, Rosa, Lopiano, Leonardo, Calandra-Buonaura, Giovanna, Petracca, Martina, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Ercoli, Tommaso, Morgante, Francesca, and Erro, Roberto

Published
2021
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25. Correction to: The Italian tremor Network (TITAN): rationale, design and preliminary findings

Author

Erro, Roberto, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Nicoletti, Alessandra, Lazzeri, Giulia, Magistrelli, Luca, Dallocchio, Carlo, Marchese, Roberta, Bologna, Matteo, Tessitore, Alessandro, Misceo, Salvatore, Gigante, Angelo Fabio, Terranova, Carmen, Moschella, Vincenzo, di Biase, Lazzaro, Di Giacopo, Raffaella, Morgante, Francesca, Valentino, Francesca, De Rosa, Anna, Trinchillo, Assunta, Malaguti, Maria Chiara, Brusa, Livia, Matinella, Angela, Di Biasio, Francesca, Paparella, Giulia, De Micco, Rosa, Contaldi, Elena, Modugno, Nicola, Di Fonzo, Alessio, Padovani, Alessandro, and Barone, Paolo

Published
2022
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29. Genetic characterization of a cohort with familial parkinsonism and cognitive-behavioral syndrome: A Next Generation Sequencing study

Author

Picillo, Marina, Ginevrino, Monia, Dati, Giovanna, Scannapieco, Sara, Vallelunga, Annamaria, Siano, Pietro, Volpe, Giampiero, Ceravolo, Roberto, Nicoletti, Valentina, Cicero, Edoardo, Nicoletti, Alessandra, Zappia, Mario, Peverelli, Silvia, Silani, Vincenzo, Pellecchia, Maria Teresa, Valente, Enza Maria, and Barone, Paolo

Published
2021
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32. Elderly Onset of Functional Motor Disorders: Clinical Correlates from the Italian Registry

Author

Geroin, Christian, Petracca, Martina, Di Tella, Sonia, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele Antonio, Eleopra, Roberto, Zappia, Mario Carmelo, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Laterza, Vincenzo, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra‐buonaura, Giovanna, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Camozzi, Serena, Ercoli, Tommaso, Stocchi, Fabrizio, Coletti Moja, Mario, Defazio, Giovanni, Tinazzi, Michele, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Romito, Luigi Michele, Zappia, Mario, Albanese, Alberto (ORCID:0000-0002-5864-0006), Geroin, Christian, Petracca, Martina, Di Tella, Sonia, Marcuzzo, Enrico, Erro, Roberto, Cuoco, Sofia, Ceravolo, Roberto, Mazzucchi, Sonia, Pilotto, Andrea, Padovani, Alessandro, Romito, Luigi Michele Antonio, Eleopra, Roberto, Zappia, Mario Carmelo, Nicoletti, Alessandra, Dallocchio, Carlo, Arbasino, Carla, Bono, Francesco, Laterza, Vincenzo, Demartini, Benedetta, Gambini, Orsola, Modugno, Nicola, Olivola, Enrica, Bonanni, Laura, Albanese, Alberto, Ferrazzano, Gina, Tessitore, Alessandro, Lopiano, Leonardo, Calandra‐buonaura, Giovanna, Morgante, Francesca, Esposito, Marcello, Pisani, Antonio, Manganotti, Paolo, Tesolin, Lucia, Teatini, Francesco, Camozzi, Serena, Ercoli, Tommaso, Stocchi, Fabrizio, Coletti Moja, Mario, Defazio, Giovanni, Tinazzi, Michele, Di Tella, Sonia (ORCID:0000-0002-2248-5120), Romito, Luigi Michele, Zappia, Mario, and Albanese, Alberto (ORCID:0000-0002-5864-0006)

Abstract

BackgroundFunctional motor disorders (FMD) are a frequent neurological condition affecting patients with movement disorders. Commonly described in younger adults, their manifestation can be also associated to an elderly onset.ObjectiveTo assess the prevalence and describe the clinical manifestations of FMD with elderly and younger onset and their relationship with demographical and clinical variables.MethodsWe recruited patients with a "clinically definite" diagnosis of FMD from the Italian Registry of FMD. Patients underwent extensive clinical assessments. For elderly onset, we set a chronological cut-off at 65 years or older according to WHO definition. Multivariate regression models were implemented to estimate adjusted odds ratio of elderly FMD onset related to clinical characteristics.ResultsAmong the 410 patients, 34 (8.2%) experienced elderly-onset FMD, with a mean age at onset of 70.9 years. The most common phenotype was tremor (47.1%), followed by gait disorders, weakness, and dystonia (29.4%, 23.5%, 14.7%, respectively). Eleven elderly patients had a combined phenomenology: 9 exhibited two phenotypes, 2 had three phenotypes. Weakness was isolated in 3/8 patients and combined with another phenotype in 5/8, manifesting as paraplegia (n = 4); upper limb diplegia (n = 2), hemiparesis/hemiplegia (n = 1), and tetraparesis/tetraplegia (n= 1). Non-motor and other functional neurological disorders occurred more frequently in the younger group (89.1%) than the elderly (73.5%). Neurological and non-neurological comorbidities were more prevalent in the elderly group (82.4%) as opposed to the younger (32.7%). In a multivariate regression analysis, elderly-onset FMD was significantly associated with neurological comorbidities, including parkinsonism (OR 6.73) and cerebrovascular diseases (OR 5.48).ConclusionsThese results highlight the importance of achieving an accurate diagnosis of FMD in the elderly, as it is crucial for effectively managing FMD symptoms and addressi

Published
2024

34. Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia: The TITAN Study.

Author

Erro, Roberto, Lazzeri, Giulia, Terranova, Carmen, Paparella, Giulia, Gigante, Angelo Fabio, De Micco, Rosa, Magistrelli, Luca, Di Biasio, Francesca, Valentino, Francesca, Moschella, Vincenzo, Pilotto, Andrea, Esposito, Marcello, Olivola, Enrica, Malaguti, Maria Chiara, Ceravolo, Roberto, Dallocchio, Carlo, Spagnolo, Francesca, Nicoletti, Alessandra, De Rosa, Anna, and Di Giacopo, Raffaella

Subjects
ESSENTIAL tremor, TREMOR, DYSTONIA, SEX distribution, REGRESSION analysis, QUALITY of life
Abstract

Background: Tremor disorders remain as clinical diagnoses and the rate of misdiagnosis between the commonest non‐parkinsonian tremors is relatively high. Objectives: To compare the clinical features of Essential Tremor without other features (pure ET), ET plus soft dystonic signs (ET + DS), and tremor combined with dystonia (TwD). Methods: We compared the clinical features of patients with pure ET, ET + DS, and TwD enrolled in The ITAlian tremor Network (TITAN). Linear regression models were performed to determine factors associated with health status and quality of life. Results: Three‐hundred‐eighty‐three patients were included. Sex distribution was significantly different between the groups with males being more represented in pure ET and females in TwD. The initial site of tremor was different between the groups with about 40% of TwD having head tremor and ET + DS unilateral upper limb tremor at onset. This pattern mirrored the distribution of overt dystonia and soft dystonic signs at examination. Sensory trick, task‐specificity, and position‐dependence were more common, but not exclusive, to TwD. Pure ET patients showed the lowest degree of alcohol responsiveness and ET + DS the highest. Midline tremor was more commonly encountered and more severe in TwD than in the other groups. Regression analyses demonstrated that tremor severity, sex, age, and to a lesser degree the variable "group", independently predicted health status and quality of life, suggesting the existence of other determinants beyond tremor. Conclusions: Pure ET and TwD manifest with a phenotypic overlap, which calls for the identification of diagnostic biomarkers. ET + DS shared features with both syndromes, suggesting intra‐group heterogeneity. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Fluxgate Magnetometer and Performance for Measuring Iron Compounds

Author

Trigona, Carlo, Sinatra, Valentina, Andò, Bruno, Baglio, Salvatore, Mostile, Giovanni, Nicoletti, Alessandra, Zappia, Mario, Bulsara, Adi R., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Andò, Bruno, editor, Baldini, Francesco, editor, Di Natale, Corrado, editor, Ferrari, Vittorio, editor, Marletta, Vincenzo, editor, Marrazza, Giovanna, editor, Militello, Valeria, editor, Miolo, Giorgia, editor, Rossi, Marco, editor, Scalise, Lorenzo, editor, and Siciliano, Pietro, editor

Published
2019
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46. Validation of the Italian version of the PSP Quality of Life questionnaire

Author

Picillo, Marina, Cuoco, Sofia, Amboni, Marianna, Bonifacio, Francesco Paolo, Bruschi, Fabio, Carotenuto, Immacolata, De Micco, Rosa, De Rosa, Anna, Del Prete, Eleonora, Di Biasio, Francesca, Elifani, Francesca, Erro, Roberto, Fabbri, Margherita, Falla, Marika, Franco, Giulia, Frosini, Daniela, Galantucci, Sebastiano, Lazzeri, Giulia, Magistrelli, Luca, Malaguti, Maria Chiara, Milner, Anna Vera, Minafra, Brigida, Olivola, Enrica, Pilotto, Andrea, Rascunà, Cristina, Rizzetti, Maria Cristina, Schirinzi, Tommaso, Borroni, Barbara, Ceravolo, Roberto, Di Fonzo, Alessio, Marchese, Roberta, Mercuri, Nicola B., Modugno, Nicola, Nicoletti, Alessandra, Padovani, Alessandro, Santangelo, Gabriella, Stefani, Alessandro, Tessitore, Alessandro, Volontè, Maria Antonietta, Zangaglia, Roberta, Zappia, Mario, Zibetti, Maurizio, and Barone, Paolo

Published
2019
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49. Epilepsy and neurocysticercosis in rural areas of the Bolivian Chaco: What has changed during the last 30 years?

Author

Nicoletti, Alessandra, Edoardo Cicero, Calogero, Todaro, Valeria, Colli, Chiara, Cosmi, Francesco, Anselmi, Mariella, Caicedo, Cintia, Vilte, Estela, Mario Camargo, Walter, Bartoloni, Alessandro, Crespo Gomez, Elizabeth Blanca, and Giuliano, Loretta

Abstract

Objective: Neurocysticercosis (NCC) is considered the major cause of epilepsy in endemic regions. In the rural areas of the Bolivian Chaco prevalence of NCC among people with epilepsy (PWE) was 27.4%, according to a population‐based survey carried out in 1994. The aim of the study was to estimate the prevalence of Epilepsy Associated with Tonic–Clonic Seizures (EATCS) and to evaluate the prevalence of NCC among PWE in the rural communities of the Bolivian Chaco after 30 years. Methods: Twenty‐two rural communities (total population 12 852) were involved in the study. PWE in the study area were ascertained by multiple sources and the diagnosis was confirmed by a neurologist. All PWE identified were invited to undergo brain CT scan examination and diagnosis of NCC was sought according to the revised Del Brutto criteria. Results: Seventy‐eight PWE (30 men, 38.4%; mean age at onset was 12.7 ± 13.2 years) with EATCS were identified giving a crude prevalence of 6.1/1000 (95% CI: 4.7–7.3). Due to the COVID‐19 lockdown, the study was interrupted in 2020 and only 36 PWE (46%) of the whole sample underwent CT scan examination. Of these, 8 (22.2%) fulfilled the criteria for NCC of whom 6 (75%) presented only single or multiple calcifications. Significance: This is the first study reassessing the prevalence of NCC among PWE after 30 years, in the same rural area and using a population‐based design. T. solium is still endemic in the Bolivian Chaco where more than 20% of EATCS may be attributable to NCC. Our findings show a substantially unchanged prevalence of NCC over the past 30 years despite improved knowledge, underlining the need for active intervention programs to control T. solium transmission in this area. Plain Language Summary: Neurocysticercosis is still endemic in the Bolivian Chaco. The proportion of epilepsy attributable to neurocysticercosis is about 22%. Systematic efforts towards elimination of neurocysticercosis in these areas should be implemented. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Retinal Thickness in Essential Tremor and Early Parkinson Disease: Exploring Diagnostic Insights.

Author

Terravecchia, Claudio, Mostile, Giovanni, Chisari, Clara G., Rascunà, Cristina, Terranova, Roberta, Cicero, Calogero E., Giuliano, Loretta, Donzuso, Giulia, Sciacca, Giorgia, Luca, Antonina, Preux, Pierre-Marie, Jankovic, Joseph, Zappia, Mario, Nicoletti, Alessandra, Fraser, Clare, and Mollan, Susan

Abstract

Background: Essential tremor (ET) represents a heterogeneous condition which may overlap with Parkinson disease (PD) even at early stages, by sharing some subtle clinical aspects. Longstanding ET demonstrated also higher risk of developing PD, especially with a Tremor-dominant (TD-PD) phenotype. Therefore, differential diagnosis between ET and early PD could be quite challenging. Optical coherence tomography (OCT) has been recognized as a reliable tool to assess the retina as a proxy of neurodegeneration. We aimed to explore the possible role of retinal assessment in differential diagnosis between ET and early PD. Methods: Macular layers and peripapillary retinal nerve fiber layer (RNFL) thickness among ET, early PD, and healthy controls (HCs) were assessed using OCT. Results: Forty-two eyes from 23 ET, 41 eyes from 21 early PD, and 33 eyes from 17 HCs were analyzed. Macular RNFL, ganglion cell layer, inner plexiform layer, and inner nuclear layer were thinner in PD as compared with ET and even more in HCs. Differences between ET and PD were more evident when considering the TD-PD subgroup, especially for RNFL. Among ET patients, thickness of the inner macular layers showed negative linear relationship with both age at onset and disease duration. Peripapillary temporal quadrant thinning was found in ET compared with HCs. Conclusions: Macular inner retina was thinner in patients with ET and early PD compared with HCs. These findings suggest that the retinal assessment may have a utility in the differential diagnosis between ET and PD. [ABSTRACT FROM AUTHOR]

Published
2024
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