10 results on '"Nicoletta Mainini"'
Search Results
2. Neonatal Enterovirus-Associated Myocarditis in Dizygotic Twins: Myocardial Longitudinal Strain Pattern Analysis
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Stefania Giampetruzzi, Domenico Sirico, Nicoletta Mainini, Marta Meneghelli, Enrico Valerio, Sabrina Salvadori, and Giovanni Di Salvo
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enterovirus ,myocarditis ,newborn ,echocardiography ,Pediatrics ,RJ1-570 - Abstract
Enteroviruses (EVs) are the most common causes of viral myocarditis in neonates. Neonatal enterovirus myocarditis manifestations range from nonspecific febrile illness to congestive heart failure and cardiogenic shock with high risk of in-hospital mortality and long-term cardiac sequelae. Early recognition is essential to undertake appropriate therapy and predict outcomes. Echocardiography and echo-derived left ventricular strain measures seem promising for these purposes. We herein report two cases of neonatal enterovirus-associated myocarditis in dichorionic diamniotic twins, with different presentation, clinical course, and intensity of treatments.
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- 2024
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- View/download PDF
3. A global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study
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Pavel Prusakov, PharmD, Debra A. Goff, PharmD, Phillip S. Wozniak, BA, Azraa Cassim, BPharm, Catherine E.A. Scipion, MD, Soledad Urzúa, MD, Andrea Ronchi, MD, Lingkong Zeng, MD, Oluwaseun Ladipo-Ajayi, MBChB, Noelia Aviles-Otero, MD, Chisom R. Udeigwe-Okeke, MBBS, Rimma Melamed, MD, Rita C. Silveira, MD, Cinzia Auriti, MD, Claudia Beltrán-Arroyave, MD, Elena Zamora-Flores, MD, Maria Sanchez-Codez, MD, Eric S. Donkor, PhD, Satu Kekomäki, MD, Nicoletta Mainini, MD, Rosalba Vivas Trochez, MD, Jamalyn Casey, PharmD, Juan M. Graus, MD, Mallory Muller, PharmD, Sara Singh, MBBS, Yvette Loeffen, MD, María Eulalia Tamayo Pérez, MD, Gloria Isabel Ferreyra, MD, Victoria Lima-Rogel, MD, Barbara Perrone, MD, Giannina Izquierdo, MD, María Cernada, MD, Sylvia Stoffella, PharmD, Sebastian Okwuchukwu Ekenze, MD, Concepción de Alba-Romero, MD, Chryssoula Tzialla, MD, Jennifer T. Pham, PharmD, Kenichiro Hosoi, MD, Magdalena Cecilia Calero Consuegra, MD, Pasqua Betta, MD, O. Alvaro Hoyos, MD, Emmanuel Roilides, MD, Gabriela Naranjo-Zuñiga, MD, Makoto Oshiro, MD, Victor Garay, MD, Vito Mondì, MD, Danila Mazzeo, MD, James A. Stahl, PharmD, Joseph B. Cantey, MD, Juan Gonzalo Mesa Monsalve, MD, Erik Normann, MD, Lindsay C. Landgrave, PharmD, Ali Mazouri, MD, Claudia Alarcón Avila, MD, Fiammetta Piersigilli, MD, Monica Trujillo, MD, Sonya Kolman, BPharm, Verónica Delgado, MD, Veronica Guzman, MD, Mohamed Abdellatif, FRCPCH, Luis Monterrosa, MD, Lucia Gabriella Tina, MD, Khalid Yunis, MD, Marco Antonio Belzu Rodriguez, MD, Nicole Le Saux, MD, Valentina Leonardi, MD, Alessandro Porta, MD, Giuseppe Latorre, MD, Hidehiko Nakanishi, MD, Michal Meir, MD, Paolo Manzoni, MD, Ximena Norero, MD, Angela Hoyos, MD, Diana Arias, MD, Rubén García Sánchez, MD, Alexandra K. Medoro, MD, and Pablo J. Sánchez
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Global point prevalence study ,Neonatal infection ,Neonatal antimicrobial stewardship ,Antibiotics ,Antifungal ,Medicine (General) ,R5-920 - Abstract
Background: Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts. Methods: We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy), antimicrobial stewardship program (ASP), and 30-day in-hospital mortality. Findings: On July 1, 2019, 26% of infants (580/2,265; range, 0–100%; median gestational age, 33 weeks; median birth weight, 1800 g) in 84 NICUs (51, high-income; 33, low-to-middle income) from 29 countries (14, high-income; 15, low-to-middle income) in five continents received ≥1 antimicrobial agent (92%, antibacterial; 19%, antifungal; 4%, antiviral). The most common reasons for antibiotic therapy were “rule-out” sepsis (32%) and “culture-negative” sepsis (16%) with ampicillin (40%), gentamicin (35%), amikacin (19%), vancomycin (15%), and meropenem (9%) used most frequently. For definitive treatment of presumed/confirmed infection, vancomycin (26%), amikacin (20%), and meropenem (16%) were the most prescribed agents. Length of therapy for culture-positive and “culture-negative” infections was 12 days (median; IQR, 8–14) and 7 days (median; IQR, 5–10), respectively. Mortality was 6% (42%, infection-related). An NICU ASP was associated with lower rate of antibiotic utilization (p = 0·02). Interpretation: Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation worldwide. Funding: Merck & Co.; The Ohio State University College of Medicine Barnes Medical Student Research Scholarship
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- 2021
- Full Text
- View/download PDF
4. Expect the unexpected: a case of spontaneous thrombosis of a pial arteriovenous fistula in a preterm newborn with review of the literature
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Sabrina, Congedi, Laura, Moschino, Sabrina, Salvadori, Giacomo, Talenti, Nicoletta, Mainini, Elena, Priante, Francesco, Causin, and Eugenio, Baraldi
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- 2023
- Full Text
- View/download PDF
5. Expect the unexpected: a case of spontaneous thrombosis of a pial arteriovenous fistula in a preterm newborn with review of the literature
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Sabrina, Congedi, primary, Laura, Moschino, additional, Sabrina, Salvadori, additional, Giacomo, Talenti, additional, Nicoletta, Mainini, additional, Elena, Priante, additional, Francesco, Causin, additional, and Eugenio, Baraldi, additional
- Published
- 2022
- Full Text
- View/download PDF
6. Neonatal Early Onset Sepsis: Impact of Kaiser Calculator in an Italian Tertiary Perinatal Center
- Author
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Eleonora Pontello, Francesca Tormena, Nicoletta Mainini, Paola Lago, Valentina Favero, Anna Chiara Frigo, Beatrice Galeazzo, and Michela Giovannini
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Microbiology (medical) ,Male ,Pediatrics ,medicine.medical_specialty ,newborns ,medicine.drug_class ,Antibiotics ,Population ,antibiotics ,early onset sepsis ,infection ,sepsis calculator ,Sepsis ,Risk Factors ,medicine ,Humans ,Blood culture ,education ,Retrospective Studies ,education.field_of_study ,medicine.diagnostic_test ,Neonatal sepsis ,business.industry ,Incidence (epidemiology) ,Infant, Newborn ,Gestational age ,medicine.disease ,Decision Support Systems, Clinical ,Anti-Bacterial Agents ,Infectious Diseases ,Pediatrics, Perinatology and Child Health ,Gestation ,Female ,Neonatal Sepsis ,business - Abstract
BACKGROUND Suspected early-onset sepsis (EOS) results in antibiotic treatment and blood withdraw of a substantial number of neonates who are uninfected. We evaluated if the EOS calculator can reduce antibiotic exposure and invasive procedures for suspected EOS in term and late preterm neonates, without any significant increase in adverse outcomes. METHODS The proportion of EOS risk in neonates ≥35 weeks gestation exposed to antibiotics, intensive monitoring and blood withdrawal was compared between a baseline period (January 2018-May 2018), when Centers for Disease Control guidelines approach was used, and a post-EOS calculator-implementation period (June 2018-December 2019). RESULTS We included 4363 newborn infants with gestational age ≥35 weeks, respectively 824 in baseline period and 3539 in the EOS calculator period. Among them, 1021 (23.4%) infants presented risk factors for neonatal sepsis. There was a halving in empirical antibiotics exposure: 3% in the baseline and 1.4% in the post-EOS-implementation period, P < 0.05. Blood culture and laboratory evaluations had fallen from 30.6% to 15.4% (P < 0.05). Close monitoring of vital parameters decreased from 25.4% to 4.8% (P < 0.05). The number of antibiotic days per 100 live births decreased from 15.05 to 6.36 days (P
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- 2021
7. A global point prevalence survey of antimicrobial use in neonatal intensive care units : The no-more-antibiotics and resistance (NO-MAS-R) study
- Author
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Diana Arias, Nicoletta Mainini, Chryssoula Tzialla, Claudia Beltrán-Arroyave, Soledad Urzúa, Victoria Lima-Rogel, Alessandro Porta, Pasqua Betta, Oluwaseun Ladipo-Ajayi, Sonya Kolman, Paolo Manzoni, Yvette G.T. Loeffen, Sara Singh, Maria Sanchez-Codez, Alexandra K Medoro, Lucia Gabriella Tina, Jennifer T. Pham, Marco Antonio Belzu Rodriguez, Juan Gonzalo Mesa Monsalve, Fiammetta Piersigilli, Erik Normann, Lingkong Zeng, Andrea Ronchi, Gloria Isabel Ferreyra, Pablo J. Sánchez, James A Stahl, Hidehiko Nakanishi, Juan M Graus, Magdalena Cecilia Calero Consuegra, Noelia Aviles-Otero, María Eulalia Tamayo Pérez, Khalid Yunis, Giuseppe Latorre, Rosalba Vivas Trochez, Eric S. Donkor, Joseph B. Cantey, Rimma Melamed, Claudia Alarcón Avila, Verónica Delgado, Makoto Oshiro, Mohamed Abdellatif, Giannina Izquierdo, Satu Kekomäki, Victor Garay, Michal Meir, Chisom R Udeigwe-Okeke, Rubén García Sánchez, Rita de Cássia dos Santos Silveira, Nicole Le Saux, Kenichiro Hosoi, Vito Mondì, Phillip S. Wozniak, Cinzia Auriti, Monica Trujillo, Ali Mazouri, Catherine E A Scipion, Pavel Prusakov, Lindsay C Landgrave, Gabriela Naranjo-Zuñiga, Danila Mazzeo, Debra A. Goff, Emmanuel Roilides, Veronica Guzman, Jamalyn Casey, Mallory Muller, Barbara Perrone, Sylvia Stoffella, Angela Hoyos, Azraa Cassim, Concepción de Alba-Romero, Elena Zamora-Flores, O Alvaro Hoyos, Valentina Leonardi, Sebastian O. Ekenze, Ximena Norero, María Cernada, Luis Monterrosa, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de néonatologie, Children's Hospital, Clinicum, HUS Children and Adolescents, and Helsinki University Hospital Area
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medicine.medical_specialty ,Infectious Medicine ,Neonatal intensive care unit ,Antibiotics ,Antifungal ,Global point prevalence study ,Neonatal antimicrobial stewardship ,Neonatal infection ,Infektionsmedicin ,01 natural sciences ,Meropenem ,03 medical and health sciences ,0302 clinical medicine ,Intensive care ,Internal medicine ,medicine ,Antimicrobial stewardship ,030212 general & internal medicine ,0101 mathematics ,lcsh:R5-920 ,Antiinfective agent ,business.industry ,010102 general mathematics ,General Medicine ,Amoxicillin ,3. Good health ,Amikacin ,3121 General medicine, internal medicine and other clinical medicine ,lcsh:Medicine (General) ,business ,Research Paper ,medicine.drug - Abstract
Background Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts. Methods We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy), antimicrobial stewardship program (ASP), and 30-day in-hospital mortality. Findings On July 1, 2019, 26% of infants (580/2,265; range, 0-100%; median gestational age, 33 weeks; median birth weight, 1800 g) in 84 NICUs (51, high-income; 33, low-to-middle income) from 29 countries (14, high-income; 15, low-to-middle income) in five continents received ≥1 antimicrobial agent (92%, antibacterial; 19%, antifungal; 4%, antiviral). The most common reasons for antibiotic therapy were "rule-out" sepsis (32%) and "culture-negative" sepsis (16%) with ampicillin (40%), gentamicin (35%), amikacin (19%), vancomycin (15%), and meropenem (9%) used most frequently. For definitive treatment of presumed/confirmed infection, vancomycin (26%), amikacin (20%), and meropenem (16%) were the most prescribed agents. Length of therapy for culture-positive and "culture-negative" infections was 12 days (median; IQR, 8-14) and 7 days (median; IQR, 5-10), respectively. Mortality was 6% (42%, infection-related). An NICU ASP was associated with lower rate of antibiotic utilization (p = 0·02). Interpretation Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation worldwide. Funding Merck & Co.; The Ohio State University College of Medicine Barnes Medical Student Research Scholarship.
- Published
- 2021
8. Trends in respiratory management of transferred very preterm infants in the last two decades
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Nicoletta Doglioni, Enrico Valerio, Nicoletta Mainini, Cristina Loddo, Elisabetta Lolli, Daniele Trevisanuto, Rebecca Luisa Peloso, Maria Elena Cavicchiolo, Mariella Magarotto, Eugenio Baraldi, Laura Brombin, Francesco Cavallin, Veronica Mardegan, Elena Priante, Daniele Piva, and Daniel Nardo
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Pulmonary and Respiratory Medicine ,very preterm infant ,medicine.medical_specialty ,Very Preterm Infant ,Birth weight ,medicine.medical_treatment ,Infant, Premature, Diseases ,respiratory management ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,030225 pediatrics ,Oxygen therapy ,Medicine ,Humans ,In patient ,Respiratory system ,neonatal transport ,Mechanical ventilation ,Respiratory Distress Syndrome, Newborn ,Continuous Positive Airway Pressure ,business.industry ,Obstetrics ,Infant, Newborn ,Infant ,Pulmonary Surfactants ,Very preterm ,Low birth weight ,trend ,030228 respiratory system ,Infant, Extremely Low Birth Weight ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business ,Infant, Premature - Abstract
Background Among infants needing urgent transfer after birth, very preterm infants are a high-risk sub-group requiring special attention. This study aimed to assess trends in early respiratory management in a large series of very preterm infants undergoing postnatal transfer. Methods Trends in patient characteristics and early respiratory management were assessed in 798 very preterm infants who were transferred by the Eastern Veneto Neonatal Emergency Transport Service in 2000-2019. Trends were analyzed using joinpoint regression analysis and summarized as annual percentage changes (APCs). Results Proportion of neonates with birth weight less than 1 kg decreased from 33% to 16% (APC -3.82%). Use of nasal-continuous-positive-airway pressure increased (at call: APC 15.39%; during transfer: APC 15.60%), while use of self-inflating bag (at call: APC -12.09%), oxygen therapy (at call: APC -13.00%; during transfer: APC -23.77%) and mechanical ventilation (at call: APC -2.71%; during transfer: APC -2.99%) decreased. Use of oxygen concentrations at 21% increased (at call: APC 6.26%; during transfer: APC 7.14%), while oxygen concentrations above 40% decreased (at call: APC -5.73%; at transfer APC -8.89%). Surfactant administration at call increased (APC 3%-10%), while surfactant administration when arriving at referring hospital remained around 7-11% (APC 2.55%). Conclusion Relevant trends toward "gentle" approaches in early respiratory management of very preterm infants undergoing postnatal transfer occurred during the last twenty years. In addition, the proportion of transferred extremely low birth weight infants halved. Clinicians and stakeholders should consider such information when allocating assets to both hospitals and transfer services and planning regional perinatal programs.
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- 2021
9. Use of spiramycin in pregnancy and the enigma of persistent neonatal thrombocytopenia: A case-report
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Georgios Eleftheriou, Nicoletta Mainini, Raffaella Butera, Paolo Grotto, Cristina Pizzato, and Marta Mattiuzzo
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Pregnancy ,Pediatrics ,medicine.medical_specialty ,business.industry ,Spiramycin ,Medicine ,Toxicology ,business ,medicine.disease ,Neonatal Thrombocytopenia ,medicine.drug - Published
- 2018
10. Pulmonary surfactant disaturated-phosphatidylcholine (DSPC) turnover and pool size in newborn infants with congenital diaphragmatic hernia (CDH)
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Luc J I Zimmermann, Linda Bordignon, Nicoletta Mainini, Luisa Meneghini, Vincenzo Suma, Marika Buffo, Paola Cogo, Virgilio P. Carnielli, Kindergeneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, and Pediatrics
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medicine.medical_specialty ,Pathology ,medicine.medical_treatment ,Birth weight ,Gestational Age ,Pediatrics ,chemistry.chemical_compound ,Congenital ,Extracorporeal Membrane Oxygenation ,Pulmonary surfactant ,Internal medicine ,Phosphatidylcholine ,Extracorporeal membrane oxygenation ,Medicine ,Animals ,Humans ,Radioactive Tracers ,Lung Compliance ,Hernias ,business.industry ,Respiration ,Respiratory disease ,Infant, Newborn ,Phosphatidylcholines ,Pulmonary Surfactants ,Respiration, Artificial ,Hernias, Diaphragmatic, Congenital ,Pediatrics, Perinatology and Child Health ,Gestational age ,Congenital diaphragmatic hernia ,Infant ,Perinatology and Child Health ,medicine.disease ,Newborn ,Postnatal age ,Endocrinology ,chemistry ,Artificial ,business ,Diaphragmatic - Abstract
Pulmonary surfactant disaturated-phosphatidylcholine (DSPC) turnover and pool size in newborn infants with congenital diaphragmatic hernia (CDH).Cogo PE, Zimmermann LJ, Meneghini L, Mainini N, Bordignon L, Suma V, Buffo M, Carnielli VP.Department of Pediatrics, University of Padova, Padova, Italy. paolac@child.pedi.unipd.itIn animal CDH models, surfactant deficiency contributes to the pathophysiology of the condition but information on human disease is very limited. The aim of our study was to investigate surfactant kinetics in CDH newborns. We studied surfactant disaturated-phosphatidylcholine (DSPC) half-life, turnover and apparent pool size by stable isotope methodology in CDH newborns with no ExtraCorporeal Membrane Oxygenation (ECMO) support (n = 13, birth weight (BW) 3.2 +/- 2.2 kg, gestational age (GA) 39 +/- 0.4 wks, postnatal age 43 +/- 11 h) and in 8 term infants with no lung disease (CONTROLS, BW 2.7 +/- 0 kg, GA 38 +/- 0.8 wks, postnatal age 96 +/- 26 h). We administered a trace dose of 13C-palmitic acid dipalmitoyl-phosphatidylcholine (DPPC) through the endotracheal (ET) tube and we measured DSPC kinetics by gas chromatography-mass spectrometry from DSPC13C-enrichment decay curves obtained from sequential tracheal aspirates. DSPC amount from tracheal aspirates (TA-DSPC) was measured by gas chromatography. In CDH infants DSPC half-life was shorter (24 +/- 4 and 53 +/- 11 h, p = 0.01), turnover faster (0.6 +/- 0.1 and 1.5 +/- 0.3 d-1 p = 0.01), apparent pool size smaller (34 +/- 6 and 57 +/- 7 mg/kg body weight, p = 0.02) and tracheal aspirates DSPC amount lower (2.4 +/- 0.4 and 4.6 +/- 0.5 mg/mL Epithelial Lining Fluid (ELF), p = 0.007) than in CONTROLS. In conclusion surfactant kinetics is grossly abnormal in mechanically ventilated CDH. Whether alterations of DSPC kinetics in CDH infants are caused by a primary surfactant deficiency or are secondary to oxygen therapy and ventilator support has still to be determined
- Published
- 2003
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